Cited by 473Hormonal and reproductive studiesSperm and Testicular FunctionMenopause: Health Impacts and Treatments

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Sex Hormones and Age: A Cross-sectional Study of Testosterone and Estradiol and Their Bioavailable Fractions in Community-dwelling Men

Ferrini, R. L., Barrett-Connor, E.·1998·American Journal of Epidemiology

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Abstract

The role of endogenous sex hormones in many diseases makes understanding factors that influence levels of these hormones increasingly important. This study examined age-associated variations in total and bioavailable testosterone and estradiol levels among community-dwelling Caucasian men in Rancho Bernardo, California. Plasma samples obtained from 810 men aged 24-90 years in 1984-1987 were analyzed in 1993 using radioimmunoassay. Analyses of age-hormone associations, adjusting for weight, body mass index, alcohol ingestion, smoking, physical activity, caffeine intake, specimen storage time, and disease status, were undertaken. Bioavailable testosterone and bioavailable estradiol levels decreased significantly with age independently of covariates. Total testosterone and estradiol levels decreased with age only when analyses were controlled for confounders. The importance of the age-associated decline in endogenous sex hormone levels, particularly levels of bioavailable testosterone and bioavailable estradiol, and their relation to disease and function in men deserve further research.

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Authors: Ferrini, R. L., & Barrett-Connor, E.
Affiliations: University of California San Diego (US)
ORCID: Barrett-Connor, E.
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 1998-04-15
Volume: 147
Issue: 8
Pages: 750-754
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/oxfordjournals.aje.a009519
OpenAlex: W2016492979
Cited by: 473
References: 0
Citations by year: 2026: 2 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 8 · 2021: 12 · 2020: 16 · 2019: 15 · 2018: 14 · 2017: 15 · 2016: 20 · 2015: 19 · 2014: 19 · 2013: 20 · 2012: 25
FWCI: 10.31
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
Funders: American Cancer Society
World Health Organization
National Institute on Aging (AG07181)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK031801, DK-31801)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: testosterone, estradiol, bioavailable testosterone, bioavailable estradiol, aging, sex hormones, community-dwelling men, men's health
MeSH terms: Adult, Aged, Aged, 80 and over, Aging, Biological Availability, Cross-Sectional Studies, Estradiol, Humans, Male, Middle Aged, Radioimmunoassay, Regression Analysis, Testosterone, Health Behavior, Confounding Factors, Epidemiologic, Body Mass Index

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Sex Hormones and Age: A Cross-sectional Study of Testosterone and Estradiol and Their Bioavailable Fractions in Community-dwelling Men

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