The influence of aging on plasma sex hormones in men: the Telecom study.

Simon, Dominique; Preziosi, Paul; Barrett-Connor, Elizabeth; Roger, Marc; Saint-Paul, Michel; Nahoul, Khalil; Papoz, Laure

doi:10.1093/oxfordjournals.aje.a116365

Cited by 169Hormonal and reproductive studiesSperm and Testicular FunctionHypothalamic control of reproductive hormones

The influence of aging on plasma sex hormones in men: the Telecom study.

Simon, Dominique, Preziosi, Paul, Barrett-Connor, Elizabeth, Roger, Marc, Saint-Paul, Michel, Nahoul, Khalil, Papoz, Laure·1992·American Journal of Epidemiology

DOI 10.1093/oxfordjournals.aje.a116365

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Abstract

From April 1985 to July 1987, 1,408 healthy white men aged 20-60 years in Paris, France, recruited on an occupational basis, underwent a physical examination and measurements of plasma sex hormones in a cross-sectional study. Both total testosterone and estradiol showed a significant stepwise decrease with age (p less than 0.001) starting in the early adult years, while estrone did not vary. These relations of testosterone and estradiol with age remained significant after adjustment for body mass index, subscapular skinfold, and tobacco and alcohol consumptions, and they were not modified by exclusion of the men who reported chronic disease. Both the mechanism for the early decrease in testosterone and its clinical significance merit further investigation.

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The decline of testosterone and DHEA with age could be at least partially responsible for sarcopenia in older men and women.
“The decline of testosterone and DHEA (23,26,321,322) with age could be at least partially responsible for sarcopenia in older men and women.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [321]

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Authors: Simon, D., Preziosi, P., Barrett-Connor, E., Roger, M., Saint-Paul, M., Nahoul, K., & Papoz, L.
Affiliations: Inserm (FR)
University of California San Diego (US)
Corresponding author: Simon, Dominique
ORCID: Simon, Dominique
Barrett-Connor, Elizabeth
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 1992-04-01
Volume: 135
Issue: 7
Pages: 783-791
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/oxfordjournals.aje.a116365
OpenAlex: W2290002423
Cited by: 166
References: 0
Citations by year: 2023: 1 · 2022: 2 · 2021: 3 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 7 · 2013: 2 · 2012: 8
FWCI: 2.04
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: aging, plasma sex hormones, testosterone, estradiol, estrone, men, age-related decline, body mass index, skinfold thickness, alcohol and tobacco use, chronic disease
MeSH terms: Adult, Aging, Alcohol Drinking, Cross-Sectional Studies, Estradiol, Estrone, Humans, Male, Middle Aged, Regression Analysis, Smoking, Testosterone, Body Mass Index

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The influence of aging on plasma sex hormones in men: the Telecom study.

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