Cited by 1,090Genetic and phenotypic traits in livestockRegulation of Appetite and ObesityGenetic Mapping and Diversity in Plants and Animals

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OBESE, A NEW MUTATION IN THE HOUSE MOUSE*

INGALLS, ANN M., DICKIE, MARGARET M., SNELL, G. D.·1950·Journal of Heredity

DOI 10.1093/oxfordjournals.jhered.a106073

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Self-citation
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Deficient Leptin Cellular Signaling Plays a Key Role in Brain Ultrastructural Remodeling in Obesity and Type 2 Diabetes Mellitus
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Ecoimmunology: is there any room for the neuroendocrine system?
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Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk
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The fine structure of adipose tissues
Napolitano, L. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050112 · Cited by 42
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“103 The ob/ob mouse, first described in 1950, 104 is one of the most studied genetic animal models of obesity.”
Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz
Ruiz, M., Sánchez, D., Canal, I., Acebes, Á., & Ganfornina, M. D. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.02.014 · Cited by 40
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β-Cell Function in Obese-Hyperglycemic Mice [ob/ob Mice]
Lindström, P. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-90-481-3271-3_20 · Cited by 39
“JacksonMemorial Laboratory, Bar Harbor, Maine (Ingalls et al. 1950) and was transferred to the already wellcharacterized C57Bl mice colony that had been established during the 1930s.”
Background
Pathological changes in adipose tissue of obese mice
Hausberger, F. X. (1966) · The Anatomical Record · doi:10.1002/ar.1091540311 · Cited by 38
Steatosis-Induced Proteomic Changes in Liver Mitochondria Evidenced by Two-Dimensional Differential In-Gel Electrophoresis
Douette, P., Navet, R., Gerkens, P., Pauw, E. D., Leprince, P., Sluse‐Goffart, C. M., & Sluse, F. E. (2005) · Journal of Proteome Research · doi:10.1021/pr050187z · Cited by 38
Genetic and Environmental Aspects of Obesity in Broilers
Lin, C. Y., Friars, G. W., & Moran, E. T. (1980) · World s Poultry Science Journal · doi:10.1079/wps19800005 · Cited by 38
Relative importance of different tissues in the synthesis of fatty acids
Favarger, P. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050104 · Cited by 39
Comparative physiology of adipose tissue in different sites and in different species
Shafrir, E., & Wertheimer, E. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050143 · Cited by 40
Visceral Obesity without Insulin Resistance in Late-Onset Obesity Rats
Bains, R. K., Wells, S. E., Flavell, D., Fairhall, K. M., Strom, M., Tissier, P. L., & Robinson, I. C. A. F. (2004) · Endocrinology · doi:10.1210/en.2003-1608 · Cited by 37
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Mutation of SLC35D3 Causes Metabolic Syndrome by Impairing Dopamine Signaling in Striatal D1 Neurons
Zhang, Z., Hao, C., Li, C., Zang, D., Zhao, J. C., Li, X., Wei, A., Wei, Z., Yang, L., He, X., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004124 · Cited by 39
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Egami, R., Kokaji, T., Hatano, A., Yugi, K., Eto, M., Morita, K., Ohno, S., Fujii, M., Hironaka, K., Uematsu, S., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102217 · Cited by 39
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Federico, M., de la Fuente, S., Palomeque, J., & Sheu, S. (2021) · The Journal of Physiology · doi:10.1113/jp279376 · Cited by 37
Variation of Leptin During Menstrual Cycle and Its Relation to the Hypothalamic–Pituitary–Gonadal (HPG) Axis: A Systematic Review
Salem, A. M. (2021) · International Journal of Women s Health · doi:10.2147/ijwh.s309299 · Cited by 36
“The association between leptin and reproduction was first described by observing that ob/ob gene deficient female mice were obese and sterile.(6) Humans with congenital leptin deficiency also have obesity and infertilely and Correspondence: Ayad Mohammed Salem Department of Physiology, College of Medicine, Imam Abdulr…”
Background
Failure of successful intrasplenic transplantation of islets from lean mice to cure obese-hyperglycaemic mice, despite islet growth
Andersson, A., Eriksson, U. J., Petersson, B., et al. (1981) · Diabetologia · doi:10.1007/bf00252634 · Cited by 36
Obesity and Cancer: Overview of Mechanisms
Nock, N. L., & Berger, N. A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-5515-9_5 · Cited by 35
Metabolic surgery—principles and current concepts
Gass, M., Beglinger, C., & Peterli, R. (2011) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-011-0834-3 · Cited by 34
Sensory and autonomic function and structure in footpads of a diabetic mouse model
Liu, Y., Sebastian, B., Liu, B., Zhang, Y., Fissel, J. A., Pan, B., Polydefkis, M. J., & Farah, M. H. (2017) · Scientific Reports · doi:10.1038/srep41401 · Cited by 36
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Borges, B. C., García-Galiano, D., Cruz‐Machado, S. D. S., Han, X., Gavrilina, G. B., Saunders, T. L., Auchus, R. J., Hammoud, S. S., Smith, G. D., & Elias, C. F. (2017) · Endocrinology · doi:10.1210/en.2017-00295 · Cited by 35
Differentiation-dependent expression of obese (ob) gene by preadipocytes and adipocytes in primary cultures of porcine stromal-vascular cells
Chen, X., Hausman, D. B., Dean, R. G., & Hausman, G. J. (1997) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(97)00083-9 · Cited by 35
Spontaneous Diabetes and/or Obesity in Laboratory Rodents
Renold, A. E. (1968) · Advances in metabolic disorders · doi:10.1016/b978-1-4831-9943-6.50008-6 · Cited by 35
Modeling Wound Chronicity In Vivo: The Translational Challenge to Capture the Complexity of Chronic Wounds
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Genome Scans for Transmission Ratio Distortion Regions in Mice
Casellas, J., Gularte‐Mérida, R., Farber, C. R., et al. (2012) · Genetics · doi:10.1534/genetics.111.135988 · Cited by 34
“Assuming Jeffreys’ (1984) scale of evidence, the analyses provided decisive evidence (BF .”
BackgroundInfluential
Sensory perception drives food avoidance through excitatory basal forebrain circuits
Patel, J. M., Swanson, J., Ung, K., Herman, A. M., Hanson, E., Ortiz‐Guzman, J., Selever, J., Tong, Q., & Arenkiel, B. R. (2019) · eLife · doi:10.7554/elife.44548 · Cited by 35
“For this, we implemented leptin-deficient mice (Lep) which show hyperphagia and become obese through increased food intake and subsequent altered metabolism (Drel et al., 2006; Ingalls et al., 1950; Lindström, 2007).”
Method
Gastric Leptin and Tumorigenesis: Beyond Obesity
Inagaki‐Ohara, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112622 · Cited by 34
The role of molecular modelling in biomedical research
Tramontano, A. L. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.011 · Cited by 34
Leptin reduces food intake but does not alter weight regain following food deprivation in the rat
Velkoska, E., Morris, M. J., Burns, P. L., & Weisinger, R. S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802193 · Cited by 33
Adipose tissue in migratory birds
Odum, E. P. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050106 · Cited by 33
Adipokines Expression and Effects in Oocyte Maturation, Fertilization and Early Embryo Development: Lessons from Mammals and Birds
Estienne, A., Brossaud, A., Reverchon, M., Ramé, C., Froment, P., & Dupont, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103581 · Cited by 33
Effects of metabolic state on the regulation of melanocortin circuits
Lieu, L., Chau, D., Afrin, S., Dong, Y., Alhadeff, A. L., Betley, J. N., & Williams, K. W. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113039 · Cited by 35
“The synaptic structure/activity of NPY and POMC neurons from ob/ob mice corresponds with the phenotype of the mice, as they were obese and diabetic [113, 162, 212].”
Background
Ciliary dysfunction and obesity
Mok, C. A., Héon, E., & Zhen, M. (2009) · Clinical Genetics · doi:10.1111/j.1399-0004.2009.01305.x · Cited by 33
Leptin regulates ACE activity in mice
Hilzendeger, A. M., Morais, R. L., Todiraş, M., Plehm, R., Gonçalves, A. C. D. C., Qadri, F., Araújo, R. C., Groß, V., Nakaie, C. R., Casarini, D. E., et al. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0649-7 · Cited by 33
Metabolic Characterization of a Mouse Deficient in All Known Leptin Receptor Isoforms
Osborn, O., Sánchez-Alavez, M., Brownell, S. E., Ross, B. S., Klaus, J., Dubins, J. S., Beutler, B., Conti, B., & Bartfai, T. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9427-x · Cited by 35
Self‐renewal of factor‐dependent hemopoietic progenitor cell‐lines derived from long‐term bone marrow cultures demonstrates significant mouse strain genotypic variation
Greenberger, J. S. (1980) · Journal of Supramolecular Structure · doi:10.1002/jss.400130409 · Cited by 33
Mouse chromosome 6
Elliott, R. W., & Moore, K. J. (1997) · Mammalian Genome · doi:10.1007/s003359900318 · Cited by 33
Systemic leptin dose-dependently increases STAT3 phosphorylation within hypothalamic and hindbrain nuclei
Maniscalco, J. W., & Rinaman, L. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00017.2014 · Cited by 34
An Updated View of Leptin on Implantation and Pregnancy: A Review
Herrid, M., Palanisamy, S., Ciller, U. A., Fan, R.-Q., Moens, P., Smart, N. A., & McFarlane, J. R. (2014) · Physiological Research · doi:10.33549/physiolres.932674 · Cited by 31
“The morbidly obese (ob/ob) mouse (Ingalls et al. 1950) discovered many decades ago was found to be leptin deficient (Zhang et al. 1994) and thus has been used to inform much of today’s research.”
Background
How mice are indispensable for understanding obesity and diabetes genetics
Attie, A., Churchill, G. A., & Nadeau, J. H. (2017) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000321 · Cited by 33
Development of lipogenesis and insulin sensitivity in tissues of the ob/ob mouse
Kaplan, M. L., & Leveille, G. A. (1981) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1981.240.2.e101 · Cited by 32
Brain deviations in adult obese-hyperglycemic mice (ob/ob)
van der Kroon, P. H. W., & Speijers, G. J. A. (1979) · Metabolism · doi:10.1016/0026-0495(79)90160-4 · Cited by 32
Triacylglycerol biosynthesis in the adipose tissue of the obese-hyperglycaemic mouse
Jamdar, S. C., Shapiro, D. J., & Fallon, H. J. (1976) · Biochemical Journal · doi:10.1042/bj1580327 · Cited by 32
Dynamic 5-HT2C Receptor Editing in a Mouse Model of Obesity
Schellekens, H., Clarke, G. A., Jeffery, I. B., Dinan, T. G., & Cryan, J. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032266 · Cited by 31
Obesity-induced metabolic disturbance drives oxidative stress and complement activation in the retinal environment.
Natoli, R., Fernando, N., Dahlenburg, T., Jiao, H., Aggio‐Bruce, R., Barnett, N. L., de la Barca, J. M. C., Tcherkez, G. G. B., Reynier, P., Fang, J., et al. (2018) · PubMed Central · Cited by 31
The role of the nucleus accumbens and ventral pallidum in feeding and obesity
Gendelis, S., Inbar, D., & Kupchik, Y. M. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110394 · Cited by 30
Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis
Xia, H., Scholtes, C., Dufour, C. R., Ouellet, C., Ghahremani, M., & Giguère, V. (2022) · Nature Communications · doi:10.1038/s41467-022-29722-6 · Cited by 33
Adipose Tissue as Endocrine Organ
Sinal, C. J., & Goralski, K. B. (2009) · Oxidative stress and disease · doi:10.1201/9781420091311.ch2 · Cited by 33
Leptin, liver, and obese mice—Fibrosis in the fat lane
Anania, F. A. (2002) · Hepatology · doi:10.1053/jhep.2002.34359 · Cited by 31
A morphological and immunohistochemical investigation of endocrine pancreata from obese ob+/ob+ mice
Starich, G. H., Zafirova, M., Jablenska, R., et al. (1991) · Acta Histochemica · doi:10.1016/s0065-1281(11)80167-4 · Cited by 31
Obesity
Capel, F. (2007) · CRC Press eBooks · doi:10.3109/9781420020137 · Cited by 31
Growth of adipose and lean tissue mass in hindlimbs of genetically obese mice during preobese and obese phases of development
Bergen, W. G., Kaplan, M., Merkel, R. A., & Leveille, G. A. (1975) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/28.2.157 · Cited by 31
Autonomic nervous system and adipose tissue
Brodie, B. B., Maickel, R. P., & Stern, D. N. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050159 · Cited by 31
History and future of leptin: Discovery, regulation and signaling
Münzberg, H., Heymsfield, S. B., Berthoud, H., & Morrison, C. D. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156026 · Cited by 37
Impaired contractile responses and altered expression and phosphorylation of Ca2+ sensitization proteins in gastric antrum smooth muscles from ob/ob mice
Bhetwal, B. P., An, C., Baker, S. A., Lyon, K. L., & Perrino, B. A. (2013) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-013-9341-1 · Cited by 30
Long-Acting PASylated Leptin Ameliorates Obesity by Promoting Satiety and Preventing Hypometabolism in Leptin-Deficient Lepob/ob Mice
Bolze, F., Morath, V., Bast‐Habersbrunner, A., Rink, N., Schlapschy, M., Mocek, S., Skerra, A., & Klingenspor, M. (2015) · Endocrinology · doi:10.1210/en.2015-1519 · Cited by 31
Established and emerging strategies to crack the genetic code of obesity
Tam, V., Turcotte, M., & Meyre, D. (2018) · Obesity Reviews · doi:10.1111/obr.12770 · Cited by 31
“(160,161) and later attributed to mutations in the leptin and leptin receptor genes, respectively, using positional”
Leptin as a link between the immune system and kidney‐related diseases: leading actor or just a coadjuvant?
Moraes‐Vieira, P. M., Bassi, Ê. J., Araújo, R. C., & Câmara, N. O. S. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.00997.x · Cited by 30
Some metabolic aspects of the obese-hyperglycemic syndrome in mice
Hellman, B. (1967) · Diabetologia · doi:10.1007/bf01222199 · Cited by 30
The obese (ob) gene and its product leptin--a new route toward obesity treatment in man?
Lönnqvist, F. (1996) · QJM · doi:10.1093/qjmed/89.5.327 · Cited by 31
Obesity and Diabetes
Smith, M. E., & Levine, R. (1964) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)33408-3 · Cited by 29
Obesity: a 100 year perspective
Bray, G. A. (2024) · International Journal of Obesity · doi:10.1038/s41366-024-01530-6 · Cited by 37
Fatty acids role on obesity induced hypothalamus inflammation: From problem to solution – A review
Salsinha, A. S., Rodríguez-Alcalá, L. M., Relvas, J. B., & Pintado, M. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.03.042 · Cited by 29
Impact of Obesity on Development and Progression of Mammary Tumors in Preclinical Models of Breast Cancer
Cleary, M. P. (2013) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-013-9300-x · Cited by 31
Physiological Mechanisms Integrating Metabolism and Reproduction
Krasnow, S. M., & Steiner, R. D. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50052-x · Cited by 33
Distribution of adrenergic nerve fibers in brown and white adipose tissue
Wirsén, C. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050119 · Cited by 31
Cerebellar Prediction and Feeding Behaviour
Iosif, C. I., Bashir, Z. I., Apps, R., & Pickford, J. (2022) · The Cerebellum · doi:10.1007/s12311-022-01476-3 · Cited by 28
“Low circulating levels of leptin are a hallmark of obesity [119, 125, 126] and deficiencies in leptin production, transport and signalling are known causes of increased weight [127, 128, 129, 130].”

Authors: INGALLS, A. M., DICKIE, M. M., & SNELL, G. D.
Affiliations: Jackson Laboratory (US)
Venue: Journal of Heredity
Publisher: Oxford University Press (OUP)
Published: 1950-12
Volume: 41
Issue: 12
Pages: 317-318
ISSN: 0022-1503 (ISSN-L)
1465-7333
DOI: 10.1093/oxfordjournals.jhered.a106073
OpenAlex: W1896220440
Cited by: 1,090
References: 0
Citations by year: 2026: 14 · 2025: 27 · 2024: 22 · 2023: 22 · 2022: 31 · 2021: 44 · 2020: 28 · 2019: 35 · 2018: 23 · 2017: 42 · 2016: 33 · 2015: 38 · 2014: 56 · 2013: 52 · 2012: 50
FWCI: 9.18
Type: journal article
Language: en
Open access: closed
Locations: Journal of Heredity (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Keywords: obesity, genetic mutations, house mouse, Mus musculus domesticus, genetic obesity, mutant phenotypes
MeSH terms: Animals, Genetics, Mutation, Mice

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OBESE, A NEW MUTATION IN THE HOUSE MOUSE*

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