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OBESE, A NEW MUTATION IN THE HOUSE MOUSE*
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“Leptin is secreted by white adipocytes proportionally to TG stores 35, 36, 37.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [36]
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In vitro metabolism of epididymal adipose tissue from New Zealand obese hyperglycemic mice
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“This autosomal recessive mutation disrupts leptin signaling pathways, leading to obesity, insulin resistance, and eventually hyperglycemia [62–64].”
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“In this study, we used db/db mice, a model of spontane-ous obesity due to the leptin receptor de fi ciency [37], to explore the antiobesity e ff ect of JLD. Consistent with the previous study [20], our study also con fi rmed this point.”
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“…group identified a strain of obese mouse, which displays a mutation in the OB gene generating to a deficiency in leptin, so called ob/ob mouse (Ingalls et al. 1950), while the db/db mouse came in 1966 (Hummel et al. 1966) by Dr. Hummel's group; this obese and diabetic mouse exhibits a…”
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Extrahypothalamic Effects of Leptin: A Therapeutic for Depression and Dementia?
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“A genetic defect causing a severely obese phenotype due to overeating and decreased energy expenditure was identifi ed in mice at the Jackson Laboratories in the 1950s and these mice were called ob/ob [ 5 ].”
BackgroundMilenković, D., Nuthikattu, S., Norman, J., & Villablanca, A. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011169 · Cited by 6
“The most common murine model of obesity is the leptin-deficient ob / ob mouse [75,76].”
BackgroundObesity and chronic leptin resistance foster insulin resistance
Dey, S., Murmu, N., Böse, M., Ghosh, S., & Giri, B. (2021) · BLDE University Journal of Health Sciences · doi:10.4103/bjhs.bjhs_29_20 · Cited by 9
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“[43] in 1994 and mapped to chromosome 7 in 1995 [44], although an obesity causing mutation in mice was described long before [45, 46].”
BackgroundNeurotrophic Factors and Dendritic Spines
Halbach, O. V. B. U. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-36159-3_5 · Cited by 6
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“Since the first ob/ob mouse was discovered by chance in 1949 at the Jackson Laboratory, scientists have been intrigued by the possible use of leptin as an obesity therapy to prevent type II diabetes [19].”
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Norman, J., Milenković, D., Nuthikattu, S., & Villablanca, A. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063475 · Cited by 6
“Due to a homozygous mutation, ob/ob mice lack leptin, a hormone important in the regulation of body weight, and become obese as early as four weeks of age [23,24].”
BackgroundGenetic Factors for Overweight and CAD
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Animal Models of Nonalcoholic Fatty Liver Disease
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STUDIES OF THE CHROMOSOMES IN AMERICAN OBESE-HYPERGLYCAEMIC MICE
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The Study of Carbohydrate Metabolism
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Newer Concepts of Experimental Obesity
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Influence of restricting the diet on breeding in genetically obese mice
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“REVIEW 8 of 31 Another murine strain, ob/ob, has genetic leptin de fi ciency which can be supplemented externally [94].”
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Khusainova, R. I., Minniakhmetov, I. R., Vasyukova, O. V., Yalaev, B. I., Ринатович, С. Р., Kopytina, D. A., Guseinova, R. M., Dobreva, E. A., Mel'nichenko, G. A., Dedov, I. I., et al. (2025) · Journal of Obesity · doi:10.1155/jobe/9186826 · Cited by 8
“Many of the candidate genes and metabolic pathways associated with body weight regulation were initially identifed in obese mice, which spontaneously develop severe hyperphagia and obesity [49].”
Neuroendocrinology and the Genetics of Obesity
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Nutritionally Responsive PMv DAT Neurons Are Dynamically Regulated During Pubertal Transition
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Adipocyte Versus Somatotrope Leptin: Regulation of Metabolic Functions in the Mouse
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Obesity and Female Fertility: The Bridging Role of Leptin
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Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice
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“Leptin-de fi cient mice develop obesity, and fatty livers due to inherent de fi ciency of the appetite-suppressing hormone, leptin (41 – 45).”
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Genetic Factors That Act As An Effect Modifier for Environmental Risk Factors of Obesity
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Animal Models of Fibrosis in Human Disease
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Generation and phenotypic characterisation of a cytochrome P450 4x1 knockout mouse
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“It was late onset, and a relatively modest increase in body weight compared to some other genetic mouse models of obesity, for example the leptin deficient ob/ob mouse [25].”
BackgroundGenetically Modified Animal Models
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Seasonal food intake and energy balance: Neuronal and non-neuronal control mechanisms
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“Disruption in leptin signalling such as the mutation in either the leptin gene (as in ob/ob mice) or its receptor (as in db/db mice) leads to severe hyperphagia and obesity (Hummel et al., 1966; Ingalls et al., 1950).”
BackgroundLeptin rhythmicity and its relationship with other rhythm markers
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Neuroendocrine Control of Energy Stores
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Metadata
- Authors
- INGALLS, A. M., DICKIE, M. M., & SNELL, G. D.
- Affiliations
- Jackson Laboratory (US)
- Venue
- Journal of Heredity
- Publisher
- Oxford University Press (OUP)
- Published
- 1950-12
- Volume
- 41
- Issue
- 12
- Pages
- 317-318
- ISSN
- 0022-1503 (ISSN-L)
- 1465-7333
- OpenAlex
- W1896220440
- Cited by
- 1,090
- References
- 0
- Citations by year
- 2026: 14 · 2025: 27 · 2024: 22 · 2023: 22 · 2022: 31 · 2021: 44 · 2020: 28 · 2019: 35 · 2018: 23 · 2017: 42 · 2016: 33 · 2015: 38 · 2014: 56 · 2013: 52 · 2012: 50
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Heredity (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- obesity, genetic mutations, house mouse, Mus musculus domesticus, genetic obesity, mutant phenotypes
- MeSH terms
- Animals, Genetics, Mutation, Mice
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