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OBESE, A NEW MUTATION IN THE HOUSE MOUSE*
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“Leptin is secreted by white adipocytes proportionally to TG stores 35, 36, 37.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [36]
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Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss
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Conversion of amino acids to fatty acids
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Potentialities for and Present Status of Pharmacological Research in Genetically Controlled Mice
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Sexualstörungen bei diabetischen Männern
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Fat Accretion and Growth in the Rat
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Lipolytic esterase activity of adipose tissue from mice with three types of hereditary obesity
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INHERITED DIFFERENCES IN AMOUNT OF FAT IN PECTORAL MUSCLES OF CHICKENS WITH MUSCULAR DYSTROPHY
Asmundson, V. S., Julian, L. M., & Jordan, J. P. (1961) · Canadian Journal of Genetics and Cytology · doi:10.1139/g61-036 · Cited by 5
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“This is associated with their lower fitness [70], and homozygosity has been linked many times to pathologic phenotypes (e.g., [71–73]).”
BackgroundPostweaning Consumption of Aqueous Extract of Hibiscus sabdariffa May Predispose Rats to Obesity
Iyare, E. E., & Nwagha, U. I. (2009) · Pakistan Journal of Nutrition · doi:10.3923/pjn.2009.1760.1765 · Cited by 4
“Several papers have testified to the reproductive shortcomings of ob/ob mice after the first published work on this mutant (Ingalls et al., 1950).”
BackgroundLeptin as an open secret in the physiopathology of rheumatic diseases
Mercado, M. V.-D., & Martínez-García, E. A. (2020) · Clinical Rheumatology · doi:10.1007/s10067-019-04908-4 · Cited by 4
“Since 1949, the phenotype of a mutated mouse leptin was identified with the ob symbol resulting in diabetes and obesity, later known as ob or lep gen [1].”
BackgroundCara, A. L., Myers, M. G., & Elias, C. F. (2020) · Endocrinology · doi:10.1210/endocr/bqaa110 · Cited by 4
Tissue-specific gene expression in obese hyperglycemic mice
Ahmed, M., Elashkar, O., Lee, J. Y., Jeong, E. A., Kim, K. E., Roh, G. S., & Kim, D. R. (2022) · All Life · doi:10.1080/26895293.2022.2078896 · Cited by 4
Vogel, H. G. (2007) · Springer eBooks · doi:10.1007/978-3-540-70995-4_13 · Cited by 4
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Lee, M., Nam, D., Kim, O. K., Shim, T. J., Kim, J. H., & Lee, J. (2014) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2014.43.10.1477 · Cited by 4
A rapid, microplate SNP genotype assay for the leptin allele
Oler, A. T., & Attie, A. (2008) · Journal of Lipid Research · doi:10.1194/jlr.d800002-jlr200 · Cited by 4
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Valli‐Jaakola, K. (2007) · Työväentutkimus Vuosikirja · Cited by 4
Action of lipomobilizing hormones on adipose tissue
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Regulation of apoptosis and steroidogenesis in ovarian preovulatory granulosa cells
Svensson, E. (2000) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 4
Adaptive enzyme responses in liver of obese hyperglycemic mice
Kaplan, M. L., & Fried, G. H. (1975) · International Journal of Biochemistry · doi:10.1016/0020-711x(75)90020-8 · Cited by 4
Editorial: Molecular Obesity Research: Lessons Learned?
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In Vivo Fluorescence Microscopy of Microcirculation in the Renal Cortex of Mice
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“In the summer of 1949, ‘some very plump young mice’ were discovered in C57BL/6 J mice at the Jackson Labaratory in Bar Harbor, Maine [14].”
BackgroundT cells with increased responsiveness cause obesity in mice without diet intervention
Gregersen, I., Kong, X. Y., Kooijman, S., Foyn, H., Grannes, H., Olsen, M. B., Lone, A. M., Yang, K., Quiles‐Jiménez, A., Tran, M., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109471 · Cited by 3
Hohlstein, P., Salvarcioglu, C., Pollmanns, M. R., Adams, J. K., Jhaisha, S. A., Kabak, E., Eisert, A., Hamesch, K., Weiskirchen, R., Koch, A. H., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12061170 · Cited by 3
Recent Advances in Angiogenesis Assessment Methods and their Clinical Applications
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Lipid‐mobilizing activity during fasting
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Metabolism of adipose tissue in experimental obesity
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In vivo fluorescence microscopy of microcirculation in the renal cortex of mice
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Medical Aspects of Morbid Obesity
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“Indeed, individuals with genetic leptin deficiency experience an unrelenting drive to both consume and mobilize fuels (14, 15), which can result in obesity and a form of type 2 diabetes (16, 17).”
이선희, Lim, S.-W., 응웬반민, Hur, J., 송봉준, 이영미, 이회선, & Kim, D.-K. (2011) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2011.40.3.401 · Cited by 2
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“Genetic studies on monogenic obesity can be traced back to several key discoveries, starting with the observation of severely obese mice at the Jackson laboratory in 1949 [55].”
Gene-by-environment Interactions and Adaptive Body Size Variation in Mice From the Americas
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““Regarding the mechanism underlying weight reduction, we demonstrated in the revised manuscript that GD2TIF-GLP-1 cells significantly reduced food intake in mice (Fig.”
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Immune Function in Obese, Diabetic, Hyperinsulinemic C57BL/KsJ-db+/db+ and C57BL/6J-ob/ob Mice
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Neuroendocrine Regulation of Energy Metabolism
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Hypothalamic Alterations in Obesity
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“Humans and mice lacking leptin have hyperphagic obesity, hyperinsulinemia, and decreased energy expenditure [22,23] demonstrating the prominent role that leptin plays in energy homeostasis.”
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“Lep KO mice are a useful model for metabolic studies as they display hyperphagia, early-onset obesity, and symptoms of metabolic disease, including increased fatty acid synthesis in fat and liver, impaired glucose tolerance, insulin sensitivity, and hepatic steatosis (18, 21).”
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Metadata
- Authors
- INGALLS, A. M., DICKIE, M. M., & SNELL, G. D.
- Affiliations
- Jackson Laboratory (US)
- Venue
- Journal of Heredity
- Publisher
- Oxford University Press (OUP)
- Published
- 1950-12
- Volume
- 41
- Issue
- 12
- Pages
- 317-318
- ISSN
- 0022-1503 (ISSN-L)
- 1465-7333
- OpenAlex
- W1896220440
- Cited by
- 1,090
- References
- 0
- Citations by year
- 2026: 14 · 2025: 27 · 2024: 22 · 2023: 22 · 2022: 31 · 2021: 44 · 2020: 28 · 2019: 35 · 2018: 23 · 2017: 42 · 2016: 33 · 2015: 38 · 2014: 56 · 2013: 52 · 2012: 50
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Heredity (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- obesity, genetic mutations, house mouse, Mus musculus domesticus, genetic obesity, mutant phenotypes
- MeSH terms
- Animals, Genetics, Mutation, Mice
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