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OBESE, A NEW MUTATION IN THE HOUSE MOUSE*
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“Leptin is secreted by white adipocytes proportionally to TG stores 35, 36, 37.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [36]
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Effect of adipose tissue extracts on the insulin activity of human serum
Shaw, W. N. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050168 · Cited by 2
Pascual, F. L., Grevengoed, T. J., Zhao, L., Willis, M. S., & Coleman, R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.24.918961 · Cited by 2
“Acsl1 [17] and ob/+ [20] mice were bred to generate an ob-Acsl1 double knockout model (Fig.”
MethodDie spontan-diabetischen Tiere
Herberg, L. (1975) · Springer eBooks · doi:10.1007/978-3-642-66033-7_13 · Cited by 2
Wellmann, K. F., & Volk, B. W. (1977) · Springer eBooks · doi:10.1007/978-1-4684-2325-9_1 · Cited by 2
Dole, V. P. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050103 · Cited by 2
Morgan, R. C., & Considine, R. V. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.03843-5 · Cited by 2
Morros-Nuevo, A., Salt, C., Pavey, J., Wainwright, J. F., Dittmann, M. T., Keep, B., Wallis, N. J., & Raffan, E. (2026) · BMC Veterinary Research · doi:10.1186/s12917-025-04990-8 · Cited by 1
“Since dogs within a breed are genetically homogeneous but between breeds there is genetic diversity, this strongly suggests that food motivation is a highly heritable trait in dogs, as in other species [29, 51, 64].”
Leptin increases lipid storage in Sertoli cells: Signaling pathways and cellular mechanisms involved
Dasso, M. E., Centola, C. L., Tabares, F. N., Galardo, M. N., Meroni, S. B., & Riera, M. F. (2026) · Biochimie · doi:10.1016/j.biochi.2026.01.009 · Cited by 3
Gut microbiota as a novel therapeutic target for eating disorders and obesity
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Development of Improved Animal Models for the Study of Diabetes
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Katsuura, G., Kawamura, N., Nishida, M., Amitani, H., Asakawa, A., & Inui, A. (2014) · Springer eBooks · doi:10.1007/978-3-319-12766-8_10 · Cited by 1
“This mutation, named ob [24], was subsequently intro-”
BackgroundMetabolic syndrome in mice induced by expressing a transcriptional activator in adipose tissue
Zhang, L., Zhou, Y., Zhu, A. Y., Li, X.-Q., Mundt, S. S., Gao, L., Lisnock, J., Hernandez, M., Alonso‐Galicia, M., Springer, M. S., et al. (2011) · Transgenic Research · doi:10.1007/s11248-011-9562-2 · Cited by 1
“Recognition of the genetic link to obesity in ob/ob mice (Ingalls et al. 1950), db/db mice (Hummel et al.”
BackgroundObesity Genes and Insulin Resistance Syndrome
Kahle, E., Leibel, R. L., DOMASCHKO, D. W., Raney, S. G., & MANN, K. T. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51820.x · Cited by 1
Herling, A. W. (2014) · Springer eBooks · doi:10.1007/978-3-642-27728-3_73-1 · Cited by 1
Role of NPY in Brown Adipocytes and Obesity
Bi, S. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8069-3_9 · Cited by 1
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Modelos experimentais de obesidade: análise crítica do perfil metabólico e da aplicabilidade
de Castro, B. B. A., Arriel, K., Renó, P. F., & Sanders‐Pinheiro, H. (2019) · HU Revista · doi:10.34019/1982-8047.2018.v44.14053 · Cited by 1
Membrane and nuclear initiated estrogenic regulation of homeostasis
Stincic, T. L., Rønnekleiv, O. K., & Kelly, M. J. (2019) · Steroids · doi:10.1016/j.steroids.2019.108428 · Cited by 1
“Mutations in leptin production and signaling result in an infertile, obese phenotype [107, 108]; however, GnRH neurons lack leptin receptors [109, 110].”
BackgroundGrant, S. F. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8642-8_5 · Cited by 1
β-Cell Function in Obese-Hyperglycemic Mice (ob /ob Mice)
Lindström, P. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_15 · Cited by 1
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Ibrahim, M. A. (2010) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmsott.s9099 · Cited by 1
Molder, J., Guiu‐Jurado, E., Moulla, Y., Stroh, C., Dietrich, A., Schön, M. R., Gärtner, D., Lohmann, T., Dreßler, M., Stümvoll, M., et al. (2023) · Genes · doi:10.3390/genes14020378 · Cited by 1
Precision Nutrition and Obesity
Bell, J. D., & Heber, D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15315-0.00020-1 · Cited by 1
Lebl, J., Dušátková, P., & Malíková, J. K. (2024) · Česko-slovenská pediatrie · doi:10.55095/cspediatrie2024/017 · Cited by 1
Effects of Lifestyle on Female Reproductive Features and Success: Lessons from Animal Models
Gonzalez‐Bulnes, A., & Astiz, S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800872-0.00017-2 · Cited by 1
Regional Differences in Adipose Tissue of the Sinclair Minipig
Booker, S. L. (2010) · Cited by 1
Functional Anatomy of the ‘Adipose Organ’
Cinti, S. (2007) · Springer eBooks · doi:10.1007/978-88-470-0552-5_1 · Cited by 2
“In December 1994, the team of Friedman at New York Rockefeller University discovered the gene of obesity [8]; their subjects were mice, which in the 1950s had developed a spontaneous mutation resulting in hyperphagia, infertility and reduced activity of the sympathetic nervous system, and consequently in early, massiv…”
BackgroundCurrent Understanding of Eating and Dieting
Miller, C. H. (1964) · Psychosomatics · doi:10.1016/s0033-3182(64)72465-6 · Cited by 1
Pathophysiology of Obesity and the Metabolic Syndrome: Rodent Models
Sánchez‐Infantes, D., Elks, C. M., & Stephens, J. M. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0548-5_4 · Cited by 1
The Endocrine Society Centennial: Genes and Hormones in Obesity…or How Obesity Met Endocrinology
Tena‐Sempere, M. (2016) · Endocrinology · doi:10.1210/en.2016-1058 · Cited by 1
Obesity research: Status quo and future outlooks
Gammal, A. T. E. (2014) · World Journal of Translational Medicine · doi:10.5528/wjtm.v3.i3.119 · Cited by 1
The Physiological Role of Leptin: A Review
Patani, P. V. (2012) · Cited by 1
The Effects of Sinetrol-XPur on Lipolysis of Leptin-Deficient Obese Mice
Lee, M., Kwon, H. O., Choi, S. G., Bae, M. H., & Kim, O. (2017) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2017.46.3.389 · Cited by 1
A Framework for Elucidating Causes and Consequences of Malnutrition in Anorexia Nervosa
Zeltser, L. M., & Madra, M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813693-5.00006-x · Cited by 1
Richard, A. J., & Stephens, J. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813814-4.00020-1 · Cited by 1
Yonis, R. A., & Al-Doski, F. S. (2023) · Tikrit Journal of Pharmaceutical Sciences · doi:10.25130/tjphs.2013.9.2.5.231.244 · Cited by 1
Modeling heart failure with preserved ejection fraction in rodents: Where do we stand?
Chou, C., & Chin, M. T. (2022) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2022.948407 · Cited by 1
“2 ob/ob mice (H2FPEF score 3–4) The leptin-deficient ob/obmice develop obesity and type II diabetes secondary to hyperphagia, hyperglycemia and insulin resistance (Ingalls et al., 1950; Lindstrom, 2007).”
BackgroundΟ ρόλος της λεπτίνης και της συγκυτίνης στη λειτουργία του πλακούντα
Μουσιώλης, Α. (2011) · doi:10.12681/eadd/28617 · Cited by 1
Pathological anatomy of adipose tissue 1
Tedeschi, C. G. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050114 · Cited by 2
Metabolic pathways in the insect fat body 1
Tietz, A. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050107 · Cited by 1
New approach in the interpretation of the adipose tissue
Antal, M., & Regöly‐Mérei, A. (2010) · Orvosi Hetilap · doi:10.1556/oh.2010.28901 · Cited by 1
Lipid composition and metabolism of subcutaneous adipose tissue and lipoma of man
Gellhorn, A., & Benjamin, W. B. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050166 · Cited by 1
Operationszwischenfall und Narkose
Gostomzyk, J. G., & Leithoff, H. (1973) · International Journal of Legal Medicine · doi:10.1007/bf02114886 · Cited by 1
Fat media-hype greets obesity genes: is industry among the potential losers?
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Monoglyceride hydrolase in adipose tissue of obese hyperglycemic mice
Stein, J. M., Bewsher, P. D., & Ross, I. S. (1971) · Metabolism · doi:10.1016/0026-0495(71)90011-4 · Cited by 1
Rakow, L., Paulini, K., & Beneke, G. (1975) · Beiträge zur Pathologie · doi:10.1016/s0005-8165(75)80189-2 · Cited by 1
NRF2 AS A NUTRIENT SENSITIVE TRANSCRIPTION FACTOR
Kulkarni, S. R. (2012) · Digital Commons - URI (University of Rhode Island) · doi:10.23860/diss-kulkarni-supriya-2012 · Cited by 1
The role of CADM1 in energy and glucose homeostasis
Matthäus, D. (2014) · doi:10.18452/16905 · Cited by 1
Nucleotide regulation of AMP-activated protein kinase
Underwood, E. (2013) · UCL Discovery (University College London) · Cited by 1
Some etiological factors in obesity
Kaunitz, H. (1966) · Journal of the American Oil Chemists Society · doi:10.1007/bf02641083 · Cited by 1
OBESITY — LESSONS FROM EXPERIMENTAL MEDICINE
Bray, G. A., & Fisler, J. S. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-715950-8.50027-5 · Cited by 1
Control of Weight: How Do We Get Fat?
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Reproductive characteristics of high body condition mares with high versus low leptin concentrations
Waller, C. A. (2005) · doi:10.31390/gradschool_theses.2804 · Cited by 1
“One of the earliest models of animal obesity was the ob/ob mouse, which was identified in 1950 (Ingalls et al., 1950).”
BackgroundSenior, B. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050167 · Cited by 1
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Immune Disorders Connecting Type2 Diabetes and Cardiovascular ComplicationsPreprint
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García, M. R. (2013) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/3603 · Cited by 1
Der Hypogonadismus des männlichen Zuckerkranken
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Regulation of Atp10c , a Novel Type 4 P-type ATPase, in 3T3-L1 Mouse Adipocytes
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Role of immune mediators in metabolic syndrome and atherosclerosis
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“Leptin The obese gene, commonly labeled ob gene, was discovered in 1949 (Ingalls et al., 1950).”
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Selective labeling of adipose tissue in vivo
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“The most profound neuroendocrine disturbance in mice with homozygous mutations in the leptin receptor gene (db/db mice) or in the leptin gene (ob/ob mice) [27] is infertility.”
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Fatty substances containing ether linkages
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Leptin ve periodontal hastalıklar
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Metadata
- Authors
- INGALLS, A. M., DICKIE, M. M., & SNELL, G. D.
- Affiliations
- Jackson Laboratory (US)
- Venue
- Journal of Heredity
- Publisher
- Oxford University Press (OUP)
- Published
- 1950-12
- Volume
- 41
- Issue
- 12
- Pages
- 317-318
- ISSN
- 0022-1503 (ISSN-L)
- 1465-7333
- OpenAlex
- W1896220440
- Cited by
- 1,090
- References
- 0
- Citations by year
- 2026: 14 · 2025: 27 · 2024: 22 · 2023: 22 · 2022: 31 · 2021: 44 · 2020: 28 · 2019: 35 · 2018: 23 · 2017: 42 · 2016: 33 · 2015: 38 · 2014: 56 · 2013: 52 · 2012: 50
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Heredity (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- obesity, genetic mutations, house mouse, Mus musculus domesticus, genetic obesity, mutant phenotypes
- MeSH terms
- Animals, Genetics, Mutation, Mice
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