Cited by 1,090Genetic and phenotypic traits in livestockRegulation of Appetite and ObesityGenetic Mapping and Diversity in Plants and Animals

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OBESE, A NEW MUTATION IN THE HOUSE MOUSE*

INGALLS, ANN M., DICKIE, MARGARET M., SNELL, G. D.·1950·Journal of Heredity

DOI 10.1093/oxfordjournals.jhered.a106073

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“Their phenotype can be partially attributed to the lack of adipokines such as leptin as ob/ob mice lacking leptin share several of these features despite an overabundance of adipose (8,9).”
Background
Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required
Petrick, H. L., Foley, K. P., Zlitni, S., Brunetta, H. S., Paglialunga, S., Miotto, P. M., Politis‐Barber, V., O’Dwyer, C., Philbrick, D. J., Fullerton, M. D., et al. (2020) · Function · doi:10.1093/function/zqaa013 · Cited by 27
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“This includes loss of function mutations in both mice and humans in both leptin and its receptor [99,100].”
Background
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“Murine (Ingalls et al., 1950) and human (Farooqi et al.”
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OB gene not linked to human obesity in Mexican American affected sib pairs from Starr County, Texas
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“We previously compared Ca sensitization and contractile protein expression in gastric antrummuscles from 7- and 12-week-old wild-type C57BL/6J mice and ob/ob mice, a model of obesity and type 2 diabetes [32].”
Background
Microdissection of proximal mouse Chromosome 6: identification of RFLPs tightly linked to the ob mutation
Bahary, N., Siegel, D. A., Walsh, J., Zhang, Y., Leopold, L., Leibel, R. L., Proenca, R., & Friedman, J. M. (1993) · Mammalian Genome · doi:10.1007/bf00364786 · Cited by 23
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Etiologic Factors in Obesity and Leanness
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Enzymes involved in carbohydrate metabolism in adipose tissue
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Synthesis and Degradation of Liver Acetyl Coenzyme A Carboxylase in Genetically Obese Mice
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“An absence of its biological activity either because of a lack of the protein or a lack of the functional receptor resulted in profound obesity (33, 75).”
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“The IL-6 ( p = 0.0108) and TNF-α levels ( p = 0.0075) were higher in the adipose tissue of the obese ( ob/ob ) than the non-obese ( ob/ + ) mice (Fig.”
BackgroundInfluential
A self-correcting indirect calorimeter system for the measurement of energy balance in small animals
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Kinetics of glucose 6-phosphatase in pancreatic islets as revealed by staining histochemistry
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“For example, the genes that encode leptin and leptin receptor which arose as spontaneous deficiency mutations in ob/ob and db/db obese mice respectively (Ingalls et al., 1950; Hummel et al., 1966) were shown to regulate satiety after gene cloning was possible (Zhang et al.”
Background
Contribution of animal models to diabetes research: Its history, significance, and translation to humans
Yagihashi, S. (2023) · Journal of Diabetes Investigation · doi:10.1111/jdi.14034 · Cited by 25
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Diabetic mouse models
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Regulation of fatty-acid synthesis in higher animals
Numa, S. (1974) · Springer eBooks · doi:10.1007/3-540-06498-2_2 · Cited by 21
Perfusion of isolated adipose tissue: FFA release and blood flow in rat parametrial fat body
Scow, R. O. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050145 · Cited by 22
Morphology of adipose tissue: a microscopic anatomy of fat
Sheldon, H. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050113 · Cited by 21
Lipogenesis from glucose and pyruvate in fat cells from genetically obese rats
Bray, G. A. (1968) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42678-1 · Cited by 21
Leptin: From structural insights to the design of antagonists
Zabeau, L., Peelman, F., & Tavernier, J. H. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.04.015 · Cited by 20
Genome-wide linkage screen for stature and body mass index in 3.032 families: evidence for sex- and population-specific genetic effects
Sammalisto, S., Hiekkalinna, T., Schwander, K., Kardia, S. L. R., Weder, A. B., Rodríguez, B. L., Doria, A., Kelly, J. A., Bruner, G. R., Harley, J. B., et al. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.152 · Cited by 21
Beyond Leptin: Emerging Candidates for the Integration of Metabolic and Reproductive Function during Negative Energy Balance
True, C. A., Grove, K. L., & Smith, M. S. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00053 · Cited by 21
Insights from engraftable immunodeficient mouse models of hyperinsulinaemia
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Enhanced oxidative metabolism in liver mitochondria from genetically obese mice
Katyare, S. S., & Howland, J. L. (1978) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(78)90349-1 · Cited by 20
Rodent models for diabetes
Patil, R., Aswar, U. M., Akotkar, L., Bodhankar, S. L., & Gurav, S. S. (2023) · 3 Biotech · doi:10.1007/s13205-023-03488-0 · Cited by 22
“The advantages of NOD mice are that they develop spontaneous autoimmunity by generating autoantibodies, increased circulating autoreactive T cells, and inhibit cytokines, namely interleukins, tumor necrosis factor, interferon-γ (Gregori et al. 2003; Ingalls et al. 1950; Kawasaki et al. 2004; Melanitou et al. 2004).”
Background
A spontaneous leptin receptor point mutation causes obesity and differentially affects leptin signaling in hypothalamic nuclei resulting in metabolic dysfunctions distinct from db/db mice
Piattini, F., Foll, C. L., Kisielow, J., Rosenwald, E., Nielsen, P., Lutz, T. A., Schneider, C., & Köpf, M. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.04.010 · Cited by 21
Defective allosteric regulation of phosphofructokinase in genetically‐obese mice
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Obese locus in Musmusculus: A gene dosage effect
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Adipose tissue in diabetes
Winegrad, A. I. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050132 · Cited by 17
Glyceride biosynthesis, glyceride breakdown and glycogen breakdown in adipose tissue: mechanisms and regulation
Vaughan, M. M., & Steinberg, D. H. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050124 · Cited by 19
Effects of aging on the composition and metabolism of adipose tissue in the rat
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Genetically Obese Mice: Resistance to Metastasis of B16 Melanoma and Enhanced T-Lymphocyte Mitogenic Responses
Thompson, C. I., Kreider, J. W., Black, P. L., et al. (1983) · Science · doi:10.1126/science.6602379 · Cited by 19
Attenuated pain response of obese mice (B6.Cg-lep) is affected by aging and leptin but not sex
Rodgers, H. M., Liban, S., & Wilson, L. M. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.10.007 · Cited by 18
Minireview: Metabolic Control of the Reproductive Physiology: insights from genetic mouse models
Bellefontaine, N., & Elias, C. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.04.007 · Cited by 15
Leptin Signaling Is Not Required for Anorexigenic Estradiol Effects in Female Mice
Kim, J. S., Rizwan, M. Z., Clegg, D. J., & Anderson, G. M. (2016) · Endocrinology · doi:10.1210/en.2015-1594 · Cited by 18
Leptin receptor null mice with reexpression of LepR in GnRHR expressing cells display elevated FSH levels but remain in a prepubertal state
Allen, S. J., García-Galiano, D., Borges, B. C., Burger, L. L., Boehm, U., & Elias, C. F. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00529.2015 · Cited by 19
The role of orexin in controlling the activity of the adipo-pancreatic axis
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Authors: INGALLS, A. M., DICKIE, M. M., & SNELL, G. D.
Affiliations: Jackson Laboratory (US)
Venue: Journal of Heredity
Publisher: Oxford University Press (OUP)
Published: 1950-12
Volume: 41
Issue: 12
Pages: 317-318
ISSN: 0022-1503 (ISSN-L)
1465-7333
DOI: 10.1093/oxfordjournals.jhered.a106073
OpenAlex: W1896220440
Cited by: 1,090
References: 0
Citations by year: 2026: 14 · 2025: 27 · 2024: 22 · 2023: 22 · 2022: 31 · 2021: 44 · 2020: 28 · 2019: 35 · 2018: 23 · 2017: 42 · 2016: 33 · 2015: 38 · 2014: 56 · 2013: 52 · 2012: 50
FWCI: 9.18
Type: journal article
Language: en
Open access: closed
Locations: Journal of Heredity (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Keywords: obesity, genetic mutations, house mouse, Mus musculus domesticus, genetic obesity, mutant phenotypes
MeSH terms: Animals, Genetics, Mutation, Mice

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OBESE, A NEW MUTATION IN THE HOUSE MOUSE*

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