At issue: stress, hippocampal neuronal turnover, and neuropsychiatric disorders

Neurogenesis in the adult human hippocampus

Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works

Hippocampal atrophy in recurrent major depression

Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932 · see citing works

Cortisol levels during human aging predict hippocampal atrophy and memory deficits

Lupien, S. J., de Leon, M., de Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., Thakur, M., McEwen, B. S., Hauger, R. L., & Meaney, M. J. (1998) · Nature Neuroscience · doi:10.1038/271 · Cited by 1,653 · see citing works

Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress

Gould, E., Tanapat, P., McEwen, B. S., Flügge, G., & Fuchs, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3168 · Cited by 1,395 · see citing works

Schizophrenia: A neural diathesis-stress model.

Walker, E. F., & Diforio, D. (1997) · Psychological Review · doi:10.1037//0033-295x.104.4.667 · Cited by 930 · see citing works

Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder

Gurvits, T. V., Shenton, M. E., Hokama, H., Ohta, H., Lasko, N. B., Gilbertson, M. W., Orr, S. P., Kikinis, R., Jolesz, F. A., McCarley, R. W., et al. (1996) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00229-6 · Cited by 899 · see citing works

Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome

Starkman, M. N., Gebarski, S. S., Berent, S., & Schteingart, D. E. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90079-f · Cited by 840 · see citing works

Schizophrenia After Prenatal Famine

Susser, E. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830010027005 · Cited by 741 · see citing works

A Selective Review of Recent North American Long-term Followup Studies of Schizophrenia

McGlashan, T. H. (1988) · Schizophrenia Bulletin · doi:10.1093/schbul/14.4.515 · Cited by 551 · see citing works

A Follow-up Magnetic Resonance Imaging Study of Schizophrenia: Relationship of Neuroanatomical Changes to Clinical and Neurobehavioral Measures

Gur, R. E., Cowell, P., Turetsky, B. I., Gallacher, F., Cannon, T., Bilker, W., & Gur, R. C. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.2.145 · Cited by 540 · see citing works

Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia

DeLisi, L. E., Sakuma, M., Tew, W. P., Kushner, M., Hoff, A. L., & GRIMSON, R. C. (1997) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(97)00012-7 · Cited by 512 · see citing works

Neurotoxicity of Glucocorticoids in the Primate Brain

Uno, H., Eisele, S., Sakai, A., Shelton, S. E., Baker, E. H., DeJesus, O. T., & Holden, J. E. (1994) · Hormones and Behavior · doi:10.1006/hbeh.1994.1030 · Cited by 511 · see citing works

Epidemiology of Schizophrenia

Häfner, H., & der Heiden, W. A. (1997) · The Canadian Journal of Psychiatry · doi:10.1177/070674379704200204 · Cited by 437 · see citing works

Prenatal Loss of Father and Psychiatric Disorders

HUTTUNEN, M. O. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770280039004 · Cited by 372 · see citing works

Hippocampal Volume in First-Episode Psychoses and Chronic Schizophrenia

Velakoulis, D., Pantelis, C., McGorry, P. D., Dudgeon, P., Brewer, W. J., Cook, M. J., Desmond, P. M., Bridle, N., Tierney, P., Murrie, V., et al. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.2.133 · Cited by 354 · see citing works

Hippocampus-amygdala volumes and psychopathology in chronic schizophrenia

Bogerts, B., Lieberman, J. A., Ashtari, M., Bilder, R. M., Degreef, G., Lerner, G., Johns, C. A., & Masiar, S. J. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90289-p · Cited by 338 · see citing works

Lower Left Temporal Lobe MRI Volumes in Patients With First-Episode Schizophrenia Compared With Psychotic Patients With First-Episode Affective Disorder and Normal Subjects

Hirayasu, Y., Shenton, M. E., Salisbury, D. F., Dickey, C. C., Fischer, I. A., Mazzoni, P., Kisler, T., Arakaki, H., Kwon, J. S., Anderson, J. E., et al. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.10.1384 · Cited by 312 · see citing works

Obstetric complications and risk of schizophrenia

Thomas, H. V., Dalman, C., David, A. S., Gentz, J., Lewis, G., & Alle­beck, P. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.179.5.409 · Cited by 277 · see citing works

Childhood-onset schizophrenia: progressive brain changes during adolescence

Giedd, J. N., Jeffries, N. O., Blumenthal, J. D., Castellanos, F. X., Vaituzis, A. C., Fernandez, T. V., Hamburger, S. D., Liu, H. S., Nelson, J. E., Bedwell, J. S., et al. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00072-4 · Cited by 225 · see citing works

Progressive Reduction of Temporal Lobe Structures in Childhood-Onset Schizophrenia

Jacobsen, L. K., Giedd, J. N., Castellanos, F. X., Vaituzis, A. C., Hamburger, S. D., Kumra, S., Lenane, M., & Rapoport, J. L. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.5.678 · Cited by 185 · see citing works

The role of stress and dopamine-GABA interactions in the vulnerability for schizophrenia

Benes, F. M. (1997) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(96)00044-1 · Cited by 102 · see citing works

Limbic-hypothalamic-pituitary-adrenal axis activity and ventricular-to-brain ratio studies in affective illness and schizophrenia.

Risch, S. C., Lewine, R. J., Kalin, N. H., Jewart, R. D., Risby, E. D., Caudle, J. M., Stipetic, M. D., Turner, J., Eccard, M. B., & Pollard, W. E. (1992) · PubMed · Cited by 78 · see citing works

The effects of metabolic stress on plasma progesterone in healthy volunteers and schizophrenic patients

Breier, A. F., & Buchanan, R. W. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90563-5 · Cited by 56 · see citing works

Preventive strategies for mental health

Arango, C., Díaz-Caneja, C. M., McGorry, P. D., Rapoport, J., Sommer, I. E., Vorstman, J. A., McDaid, D., Marín, O., Serrano-Drozdowskyj, E., Freedman, R., et al. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30057-9 · Cited by 1,271 · see citing works

Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat

Weiss, I. C., Pryce, C. R., Jongen-Rêlo, A. L., Nanz-Bahr, N. I., & Feldon, J. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.10.015 · Cited by 512 · see citing works

Neurogenesis in Adult Mammals: Some Progress and Problems

Gould, E., & Gross, C. G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00619.2002 · Cited by 510 · see citing works

Neurobiology and consequences of social isolation stress in animal model—A comprehensive review

Mumtaz, F., Khan, M. I., Zubair, M., & Dehpour, A. R. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.086 · Cited by 369 · see citing works

The impact of environmental factors in severe psychiatric disorders

Schmitt, A., Malchow, B., Hasan, A., & Falkai, P. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00019 · Cited by 322 · see citing works

Focal Gray Matter Changes in Schizophrenia across the Course of the Illness: A 5-Year Follow-Up Study

van Haren, N. E. M., Pol, H. E. H., Schnack, H. G., Cahn, W., Mandl, R. C. W., Collins, D. L., Evans, A. C., & Kahn, R. S. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301347 · Cited by 311 · see citing works

The role of stress in neurodegenerative diseases and mental disorders.

Esch, T., Stefano, G. B., Fricchione, G. L., & Benson, H. (2002) · PubMed · Cited by 309 · see citing works

Association and linkage analyses of RGS4 polymorphisms in schizophrenia

Chowdari, K. V. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.12.1373 · Cited by 368 · see citing works

Hippocampal neurogenesis as a target for the treatment of mental illness: A critical evaluation

DeCarolis, N. A., & Eisch, A. J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.12.013 · Cited by 252 · see citing works

Hippocampal Pathology in Schizophrenia

Heckers, S., & Konradi, C. L. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_43 · Cited by 208 · see citing works

Childhood Trauma in Schizophrenia: Current Findings and Research Perspectives

Popovic, D., Schmitt, A., Kaurani, L., Senner, F., Papiol, S., Malchow, B., Fischer, A., Schulze, T. G., Koutsouleris, N., & Falkai, P. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00274 · Cited by 194 · see citing works

Inflammation in schizophrenia: A question of balance

Leza, J. C., García‐Bueno, B., Bioque, M., Arango, C., Parellada, M., Kim, Q., O’Donnell, P., & Bernardo, M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.014 · Cited by 183 · see citing works

Quetiapine: preclinical studies, pharmacokinetics, drug interactions, and dosing.

Nemeroff, C. B., Kinkead, B. L., & Goldstein, J. M. (2002) · PubMed · Cited by 159 · see citing works

Neuroplasticity: from MRI to depressive symptoms

Fossati, P., Radtchenko, A., & Boyer, P. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2004.09.001 · Cited by 154 · see citing works

Progressive Brain Changes in Children and Adolescents With First-Episode Psychosis

Arango, C. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.150 · Cited by 147 · see citing works

Combined neonatal stress and young‐adult glucocorticoid stimulation in rats reduce BDNF expression in hippocampus: Effects on learning and memory

Choy, K. H. C., de Visser, Y. P., Nichols, N. R., & van den Buuse, M. (2008) · Hippocampus · doi:10.1002/hipo.20425 · Cited by 137 · see citing works

Neurobiological Correlates of Violent Behavior Among Persons With Schizophrenia

Naudts, K. H., & Hodgins, S. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj036 · Cited by 96 · see citing works

From Clinical Research to Clinical Practice: A 4-Year Review of Ziprasidone

Masand, P. S., Nemeroff, C. B., Newcomer, J. W., Lieberman, J. A., Schatzberg, A. F., Weiden, P. J., Kilts, C. D., Harvey, P. D., & Daniel, D. G. (2005) · CNS Spectrums · doi:10.1017/s1092852900019842 · Cited by 90 · see citing works

Hippocampal volume and cell proliferation after acute and chronic clozapine or haloperidol treatment

Schmitt, A., Weber, S., Jatzko, A., Braus, D. F., & Henn, F. A. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-003-0070-2 · Cited by 60 · see citing works

The mechanism of life-threatening water imbalance in schizophrenia and its relationship to the underlying psychiatric illness

Goldman, M. B. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.06.004 · Cited by 60 · see citing works

What Is the Functional Significance of Hippocampal Pathology in Schizophrenia?

Goldman, M. B., & Mitchell, C. P. (2004) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007086 · Cited by 60 · see citing works

Schizophrenia and violence: a search for neurobiological correlates

Naudts, K. H., & Hodgins, S. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000238484.12023.aa · Cited by 23 · see citing works

Brain circuit dysfunction in a distinct subset of chronic psychotic patients

Goldman, M. B. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.06.001 · Cited by 21 · see citing works

Effects of neurosteroids on glucocorticoid receptor-mediated gene transcription in LMCAT cells—A possible interaction with psychotropic drugs

Basta‐Kaim, A., Budziszewska, B., Jaworska-Feil, L., Leśkiewicz, M., Tetich, M., Otczyk, M., Kubera, M., & Lasoń, W. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.02.004 · Cited by 18 · see citing works

Familial and environmental influences on brain volumes in twins with schizophrenia

Picchioni, M., Rijsdijk, F. V., Toulopoulou, T., Chaddock, C., Cole, J. H., Ettinger, U., Oses, A., Metcalfe, H., Murray, R. M., & McGuire, P. K. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140277 · Cited by 17 · see citing works

Limited influence of olanzapine on adult forebrain neural precursors in vitro

Tucker, E. S., Haskell, G., Maynard, T. M., Meechan, D. W., Hamer, R. M., Lieberman, J. A., & LaMantia, A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.014 · Cited by 16 · see citing works

Efectos del estrés sobre los procesos de plasticidad y neurogénesis: una revisión

Zárate, S., Acevedo-Triana, C. A., Sarmiento-Bolaños, M. J., Cárdenas, F. P., & León, L. A. (2014) · Universitas Psychologica · doi:10.11144/javeriana.upsy13-3.eepp · Cited by 10 · see citing works

Effects of lipopolysaccharide and chlorpromazine on glucocorticoid receptor-mediated gene transcription and immunoreactivity: a possible involvement of p38-MAP kinase

Basta‐Kaim, A., Budziszewska, B., Jaworska-Feil, L., Tetich, M., Kubera, M., Zajı́cová, A., Holáň, V., & Lasoń, W. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2004.02.005 · Cited by 8 · see citing works

Beyond the human touch: A critical review of the promise and challenges of animal- and robot-assisted therapy in loneliness and mental healthcare

Bertin, L., Katz, J. S., Deshpande, G., & Krüeger, F. (2025) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2025.104615 · Cited by 7 · see citing works

Neuroneogenese

Thome, J., & Eisch, A. J. (2004) · Der Nervenarzt · doi:10.1007/s00115-004-1775-7 · Cited by 7 · see citing works

Psychiatric Disorders - New Frontiers in Affective Disorders

Schoepf, D. (2013) · InTech eBooks · doi:10.5772/2039 · Cited by 6 · see citing works

Neurodegenerative models of schizophrenia

Jarskog, L. F., Gilmore, J. H., & Lieberman, J. A. (2004) · Cambridge University Press eBooks · doi:10.1017/cbo9780511735103.022 · Cited by 4 · see citing works

You'd Have to Be Sick Not to Be Crazy

Silvestri, A., & Joffe, J. (2003) · Journal of Primary Prevention · doi:10.1023/b:jopp.0000024803.84954.69 · Cited by 3 · see citing works

Behavioral and hippocampal changes after prenatal invasive interventions with possible relevance to schizophrenia

Sprick, U., von Wilmsdorff, M., Bouvier, M.-L., Schulz, D., & Gäebel, W. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.014 · Cited by 3 · see citing works

Neurobiological Background of Affective Disorders

Falkai, P., Malchow, B., & Schmitt, A. (2013) · InTech eBooks · doi:10.5772/51801 · Cited by 2 · see citing works

Neuroprotective effect of ziprasidone: Preliminary results compared to haloperidol

Cinar, N., Karaoğlan, A., Midi, A., Çal, M. A., Kelten, B., Ünsal, M. A., & Şahin, Ş. (2014) · Journal of Experimental and Clinical Medicine · doi:10.5835/jecm.omu.31.02.002 · Cited by 1 · see citing works

You Need Guts to Make New Neurons

Wolf, S. A., & Mattei, D. (2017) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-017-0127-4 · Cited by 1 · see citing works

Early Nutritional Deficiencies in Brain Development: Implications for Psychopathology

Schmidt, A., & Georgieff, M. (2015) · Wiley eBooks · doi:10.1002/9780470939390.ch6 · Cited by 1 · see citing works

The Role of Early Nutritional Deficiencies in the Development of Psychopathology

Schmidt, A., Osterholm, E. A., & Georgieff, M. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy206 · Cited by 1 · see citing works

A contemporary appraisal of the role of stress in schizophrenia

Lewine, R. R. J. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80060-4

NEL R E VIEW - H AR V A RD R E POR T The role of stress in neurodegenerative diseases and mental disorders

Esch, T., Stefano, G. B., Fricchione, G. L., Benson, H., & Ma, B. (2002)

INFANCIA Y ADOLESCENCIA: UNA VENTANA ABIERTA PARA LA PREVENCIÓN DE TRASTORNOS MENTALES CHILDHOOD AND ADOLESCENCE: AN OPEN WINDOW FOR THE PREVENTION OF MENTAL DISORDERS

Arango, C., & Serrano-Drozdowskyj, E. (2016)

Hippocampus

Heckers, S. (2009) · Springer eBooks · doi:10.1007/978-0-387-30410-6_9

Adult Neurogenesis and Stress

Briones, B. A., & Gould, E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813146-6.00007-2 · Cited by 9 · see citing works

Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus

Chetty, S., Friedman, A., Taravosh-Lahn, K., Kirby, E. D., Mirescu, C., Guo, F., Krupik, D., Nicholas, A., Geraghty, A., Krishnamurthy, A., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.190 · Cited by 245 · see citing works

Стресс, кортикостероидные повреждения гиппокампа и нервно-психическая патология

Должиков, А. А., Бобынцев, И. И., Белых, А. Е., & Dolzhikova, I. N. (2017) · Человек и его здоровье · doi:10.21626/vestnik/2017-2/17

Chronic Stress and Hippocampal Dysfunction: Mechanisms, Models, and Therapeutic Avenues for Drug Development

research, N. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.19468226

Proliferation, survival and differentiation of nerve stem cell in rat hippocampal after chronic stress

Qian, W.-J., & Sui, Y. (2016) · Zhonghua xingwei yixue yu naokexue zazhi · doi:10.3760/cma.j.issn.1674-6554.2012.01.004