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Cited by 105Neurogenesis and neuroplasticity mechanismsStress Responses and CortisolMemory and Neural Mechanisms

Chronic but not acute foot-shock stress leads to temporary suppression of cell proliferation in rat hippocampus

Dagytė, G., Van der Zee, E.A., Postema, F., Luiten, P.G.M., Den Boer, J.A., Trentani, A., Meerlo, P.·2009·Neuroscience
DOI 10.1016/j.neuroscience.2009.05.053
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Abstract

Stressful experiences, especially when prolonged and severe are associated with psychopathology and impaired neuronal plasticity. Among other effects on the brain, stress has been shown to negatively regulate hippocampal neurogenesis, and this effect is considered to be exerted via glucocorticoids. Here, we sought to determine the temporal dynamics of changes in hippocampal neurogenesis after acute and chronic exposure to foot-shock stress. Rats subjected to a foot-shock procedure showed strong activation of the hypothalamic-pituitary-adrenal (HPA) axis, even after exposure to daily stress for 3 weeks. Despite a robust release of corticosterone, acute foot-shock stress did not affect the rate of hippocampal cell proliferation. In contrast, exposure to foot-shock stress daily for 3 weeks led to reduced cell proliferation 2 hours after the stress procedure. Interestingly, this stress-induced effect did not persist and was no longer detected 24 hours later. Also, while chronic foot-shock stress had no impact on survival of hippocampal cells that were born before the stress procedure, it led to a decreased number of doublecortin-positive granule neurons that were born during the chronic stress period. Thus, whereas a strong activation of the HPA axis during acute foot-shock stress is not sufficient to reduce hippocampal cell proliferation, repeated exposure to stressful stimuli for prolonged period of time ultimately results in dysregulated neurogenesis. In sum, this study supports the notion that chronic stress may lead to cumulative changes in the brain that are not seen after acute stress. Such changes may indicate compromised brain plasticity and increased vulnerability to neuropathology.

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  • Stress inhibits adult neurogenesis by suppressing the proliferation of radial stem cells and amplifying progenitors, leading to a reduction in neuroblasts.

    “Stress seems to inhibit adult neurogenesis by having a suppressive action on the proliferation of radial stem cells and amplifying progenitors, leading to a reduction in neuroblasts (Dagytė et al., 2009; Mirescu et al., 2004; Opendak et al., 2016) (Table 1).”

    From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Dagytė et al., 2009

  • Many different types of stress (social and physical) diminish the number of new neurons in the hippocampus.

    “Many different types of stress (social and physical) diminish the number of new neurons in the hippocampus (Dagytė et al., 2009; De Miguel et al., 2018; Llorens-Martín et al., 2016; Mirescu et al., 2004; Opendak et al., 2016).”

    From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Dagytė et al., 2009

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Authors
Dagytė, G., Van der Zee, E. A., Postema, F., Luiten, P. G. M., Den Boer, J. A., Trentani, A., & Meerlo, P.
Affiliations
  • University Medical Center Groningen (NL)
  • University of Groningen (NL)
Corresponding author
Dagytė, G.
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2009-09
Volume
162
Issue
4
Pages
904-913
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2009.05.053
OpenAlex
W1997864984
Cited by
105
References
85
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 11 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 13 · 2013: 6 · 2012: 4
FWCI
3.04
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
chronic stress, acute stress, footshock stress, hippocampal neurogenesis, cell proliferation, doublecortin, hypothalamic-pituitary-adrenal axis, corticosterone, glucocorticoids, neuroplasticity
MeSH terms
Doublecortin Protein, Adrenocorticotropic Hormone, Animals, Body Weight, Cell Differentiation, Cell Survival, Corticosterone, Eating, Hippocampus, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Stress, Psychological, Time Factors, Vocalization, Animal, Rats, Wistar, Cell Proliferation, Rats

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