Cited by 1,395Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsStress Responses and Cortisol

Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress

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Gould, Elizabeth, Tanapat, Patima, McEwen, Bruce S., Flügge, Gabriele, Fuchs, Eberhard·1998·Proceedings of the National Academy of Sciences

Abstract

Although granule cells continue to be added to the dentate gyrus of adult rats and tree shrews, this phenomenon has not been demonstrated in the dentate gyrus of adult primates. To determine whether neurons are produced in the dentate gyrus of adult primates, adult marmoset monkeys (Callithrix jacchus) were injected with BrdU and perfused 2 hr or 3 weeks later. BrdU is a thymidine analog that is incorporated into proliferating cells during S phase. A substantial number of cells in the dentate gyrus of adult monkeys incorporated BrdU and approximately 80% of these cells had morphological characteristics of granule neurons and expressed a neuronal marker by the 3-week time point. Previous studies suggest that the proliferation of granule cell precursors in the adult dentate gyrus can be inhibited by stress in rats and tree shrews. To test whether an aversive experience has a similar effect on cell proliferation in the primate brain, adult marmoset monkeys were exposed to a resident-intruder model of stress. After 1 hr in this condition, the intruder monkeys were injected with BrdU and perfused 2 hr later. The number of proliferating cells in the dentate gyrus of the intruder monkeys was compared with that of unstressed control monkeys. We found that a single exposure to this stressful experience resulted in a significant reduction in the number of these proliferating cells. Our results suggest that neurons are produced in the dentate gyrus of adult monkeys and that the rate of precursor cell proliferation can be affected by a stressful experience.

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Research works printed but not linked: 2

  1. [8]Fuchs E, Flugge G, McEwen B S, Tanapat P, Gould E. Soc Neurosci Abstr. 1997;23:317. [Google Scholar]
  2. [17]Galea L A M, Tanapat P, Gould E. Soc Neurosci Abstr. 1996;22:1196. [Google Scholar]

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Authors
Gould, E., Tanapat, P., McEwen, B. S., Flügge, G., & Fuchs, E.
Affiliations
Princeton University (US)
Venue
Proceedings of the National Academy of Sciences
Published
1998-03-17
Volume
95
Issue
6
Pages
3168-3171
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2085417640
Cited by
1,395
References
28
Citations by year
2026: 10 · 2025: 14 · 2024: 20 · 2023: 20 · 2022: 26 · 2021: 29 · 2020: 30 · 2019: 29 · 2018: 36 · 2017: 37 · 2016: 37 · 2015: 42 · 2014: 66 · 2013: 42 · 2012: 51
FWCI
19.44
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29mh052423-05)
  • National Institute of Mental Health (MH 52423)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
adult neurogenesis, dentate gyrus, granule cell precursors, cell proliferation, stress, marmoset monkey, BrdU labeling, aversive experience, primate brain
MeSH terms
Animals, Callithrix, Cell Division, Male, Neurons, Species Specificity, Stem Cells, Stress, Physiological, Tissue Distribution, Dentate Gyrus

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