The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
"Cognitive Dysmetria" as an Integrative Theory of Schizophrenia: A Dysfunction in Cortical-Subcortical-Cerebellar Circuitry?
Abstract
Earlier efforts to localize the symptoms of schizophrenia in a single brain region have been replaced by models that postulate a disruption in parallel distributed or dynamic circuits. Based on empirical data derived from both magnetic resonance and positron emission tomography, we have developed a model that implicates connectivity among nodes located in prefrontal regions, the thalamic nuclei, and the cerebellum. A disruption in this circuitry produces "cognitive dysmetria," difficulty in prioritizing, processing, coordinating, and responding to information. This "poor mental coordination" is a fundamental cognitive deficit in schizophrenia and can account for its broad diversity of symptoms.
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Cites
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Large-scale neurocognitive networks and distributed processing for attention, language, and memory
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The cognitive neuropsychology of schizophrenia
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Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function
Middleton, F. A., & Strick, P. L. (1994) · Science · doi:10.1126/science.7939688 · Cited by 1,356
A functional neuroanatomy of hallucinations in schizophrenia
Silbersweig, D. A., Stern, E., Frith, C., Cahill, C., Holmes, A., Grootoonk, S., Seaward, J., McKenna, P., Chua, S. E., Schnorr, L., et al. (1995) · Nature · doi:10.1038/378176a0 · Cited by 906 · cited 2×
“The thalamus was one of the regions observed by Silbersweig et al. (1995) to be abnormally activated when patients suffering from schizophrenia experienced auditory hallucinations.”
BackgroundDissociation of the lateral and medial cerebellum in movement timing and movement execution
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Self-citationRemembering the past: two facets of episodic memory explored with positron emission tomography
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.11.1576 · Cited by 593
Self-citation
Cited by
Exploring the brain network: A review on resting-state fMRI functional connectivity
van den Heuvel, M. P., & Hulshoff Pol, H. E. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.03.008 · Cited by 3,326
Neurobiology of emotion perception II: implications for major psychiatric disorders
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00171-9 · Cited by 1,736
The neurobiological consequences of early stress and childhood maltreatment
Teicher, M. H., Andersen, S. L., Polcari, A., Anderson, C. M., Navalta, C. P., & Kim, D. M. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00007-1 · Cited by 1,465
Identification of separable cognitive factors in schizophrenia
Nuechterlein, K. H., Barch, D. M., Gold, J. M., Goldberg, T. E., Green, M. F., & Heaton, R. K. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.09.007 · Cited by 1,304
The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging
Buckner, R. L. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.044 · Cited by 1,173
Metadata
- Authors
- Andreasen, N. C., Paradiso, S., & O'Leary, D. S.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-01-01
- Volume
- 24
- Issue
- 2
- Pages
- 203-218
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- OpenAlex
- W2126159475
- Cited by
- 1,174
- References
- 11
- FWCI
- 20.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: "Cognitive Dysmetria" as an Integrative Theory of Schizophrenia: A Dysfunction in Cortical-Subcortical-Cerebellar Circuitry? https://app.cochat.ai/papers/10.1093/oxfordjournals.schbul.a033321
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- Andreasen, N. C., Paradiso, S., & O'Leary, D. S. (1998). "Cognitive Dysmetria" as an Integrative Theory of Schizophrenia: A Dysfunction in Cortical-Subcortical-Cerebellar Circuitry? Schizophrenia Bulletin. https://doi.org/10.1093/oxfordjournals.schbul.a033321
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
