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Cited by 46Advanced Neuroimaging Techniques and ApplicationsCognitive Abilities and TestingNeural and Behavioral Psychology Studies

Heritability of the limbic networks

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Budisavljevic, Sanja, Kawadler, Jamie M., Dell'Acqua, Flavio, Rijsdijk, Frühling V., Kane, Fergus, Picchioni, Marco, McGuire, Philip, Toulopoulou, Timothea +7 more·2016·Social Cognitive and Affective Neuroscience
DOI 10.1093/scan/nsv156PMC PMC4847695
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Abstract

Individual differences in cognitive ability and social behaviour are influenced by the variability in the structure and function of the limbic system. A strong heritability of the limbic cortex has been previously reported, but little is known about how genetic factors influence specific limbic networks. We used diffusion tensor imaging tractography to investigate heritability of different limbic tracts in 52 monozygotic and 34 dizygotic healthy adult twins. We explored the connections that contribute to the activity of three distinct functional limbic networks, namely the dorsal cingulum ('medial default-mode network'), the ventral cingulum and the fornix ('hippocampal-diencephalic-retrosplenial network') and the uncinate fasciculus ('temporo-amygdala-orbitofrontal network'). Genetic and environmental variances were mapped for multiple tract-specific measures that reflect different aspects of the underlying anatomy. We report the highest heritability for the uncinate fasciculus, a tract that underpins emotion processing, semantic cognition, and social behaviour. High to moderate genetic and shared environmental effects were found for pathways important for social behaviour and memory, for example, fornix, dorsal and ventral cingulum. These findings indicate that within the limbic system inheritance of specific traits may rely on the anatomy of distinct networks and is higher for fronto-temporal pathways dedicated to complex social behaviour and emotional processing.

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  • To better reflect the cingulum's changing anatomical properties, reconstructions increasingly distinguished between the 'dorsal' and 'ventral' cingulum, i.e., above or below the splenium, which roughly corresponds to the distinction between cingulum cingulate gyrus and cingulum angular bundle.

    “However, to better reflect its changing anatomical properties, reconstructions increasingly distinguished between the ‘dorsal’ and ‘ventral’ cingulum, i.e., above or below the splenium (e.g., Budisavljevic et al., 2015; Fig. 6B) which roughly corresponds to the distinction between cingulum cingulate gyrus and cingulum angular bundle (e.g., Ezzati et al., 2016).”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Budisavljevic et al., 2015

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Authors
Budisavljevic, S., Kawadler, J. M., Dell'Acqua, F., Rijsdijk, F. V., Kane, F., Picchioni, M., McGuire, P., Toulopoulou, T., Georgiades, A., Kalidindi, S., Kravariti, E., Murray, R. M., Murphy, D. G., Craig, M. C., & Catani, M.
Affiliations
King's College London (GB)
ORCID
Venue
Social Cognitive and Affective Neuroscience
Publisher
Oxford University Press (OUP)
Published
2015-12-28
Volume
11
Issue
5
Pages
746-757
ISSN
  • 1749-5016 (ISSN-L)
  • 1749-5024
DOI
10.1093/scan/nsv156
PMC
PMC4847695
OpenAlex
W2295552295
Cited by
46
References
18
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FWCI
4.05
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, cc-by)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by)
  • HighWire Press Open Archive (submittedVersion)
  • St Andrews Research Repository (St Andrews Research Repository) (submittedVersion, cc-by)
  • Padua Research Archive (University of Padova) (submittedVersion, cc-by)
Funders
  • South London and Maudsley NHS Foundation Trust
  • Wellcome Trust (103759)
  • National Institute for Health and Care Research (RP-PG-0606-1045, NF-SI-0512-10110, RP-PG-0606-1049, G0400061)
  • King's College London
  • Medical Research Council (G0400061, MR/K004867/1, MR/K013807/1, MR/N026063/1)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
heritability, limbic system, limbic network, uncinate fasciculus, fornix, default mode network, monozygotic twins, dizygotic twins, genetic variance, shared environmental effects, emotional processing, social behavior, memory, diffusion tensor tractography
MeSH terms
Adult, Cerebral Cortex, Female, Humans, Limbic System, Male, Middle Aged, Nerve Net, Neural Pathways, Registries, Twins, Inheritance Patterns, Young Adult, Diffusion Tensor Imaging

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