White Matter Heritability Using Diffusion Tensor Imaging in Neonatal Brains
Open accessAbstract
Understanding genetic and environmental effects on white matter development in the first years of life is of great interest, as it provides insights into the etiology of neurodevelopmental disorders. In this study, the genetic and environmental effects on white matter were estimated using data from 173 neonatal twin subjects. Diffusion tensor imaging scans were acquired around 40 days after birth and were non-rigidly registered to a group-specific atlas and parcellated into 98 ROIs. A model of additive genetic, and common and specific environmental variance components was used to estimate overall and regional genetic and environmental contributions to diffusion parameters of fractional anisotropy, radial diffusivity, and axial diffusivity. Correlations between the regional heritability values and diffusion parameters were also examined. Results indicate that individual differences in overall white matter microstructure, represented by the average diffusion parameters over the whole brain, are heritable, and estimates are higher than found in studies in adults. Estimates of genetic and environmental variance components vary considerably across different white matter regions. Significant positive correlations between radial diffusivity heritability and radial diffusivity values are consistent with regional genetic variation being modulated by maturation status in the neonatal brain: the more mature the region is, the less genetic variation it shows. Common environmental effects are present in a few regions that tend to be characterized by low radial diffusivity. Results from the joint diffusion parameter analysis suggest that multivariate modeling approaches might be promising to better estimate maturation status and its relationship with genetic and environmental effects.
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Genetic factors account for 56% of variance in neonatal global grey-matter volume.
“56% variance in neonatal global grey-matter volume146.”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [146]
Genetic factors account for 85% of variance in neonatal global white-matter volume.
“genetic factors account for 85% variance in neonatal global white-matter volume”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [146]
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A Twin Study of Altered White Matter Heritability in Youth With Autism Spectrum Disorder
Hegarty, J. P., Monterrey, J. C., Tian, Q., Cleveland, S. C., Gong, J., Phillips, J. M., Wolke, O. N., McNab, J. A., Hallmayer, J. F., Reiss, A. L., et al. (2023) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2023.05.030 · Cited by 8 · see citing works
Bilgi, M. M., Şimşek, F., Şebnem, A. K. A. N., Özkul, B., Kitiş, Ö., & Gönül, A. S. (2015) · Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology · doi:10.5455/bcp.20150815033406 · Cited by 7 · see citing works
Neuroimaging and Genetics: Exploring, Searching, and Finding
Smit, D. J. A., Ent, D. V. ‘., de Zubicaray, G. I., & Stein, J. L. (2012) · Twin Research and Human Genetics · doi:10.1017/thg.2012.20 · Cited by 7 · see citing works
Moody, J. F., Aggarwal, N., Dean, D., Tromp, D., Kecskemeti, S. R., Oler, J. A., Kalin, N. H., & Alexander, A. L. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.118989 · Cited by 6 · see citing works
Le, H., Bonthrone, A., Uus, A., Fenchel, D., Lautarescu, A., Dimitrakopoulou, K., Edwards, A., Hajnal, J., Counsell, S., Cordero-Grande, L., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03252-3 · Cited by 2 · see citing works
Genetics of brain networks and connectivity
Dennis, E. L., Thompson, P. M., & Jahanshad, N. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813838-0.00008-x · Cited by 3 · see citing works
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THG volume 15 issue 3 Cover and Front matter
(2012) · Twin Research and Human Genetics · doi:10.1017/thg.2012.18
Neuroeducación: Comprendiendo el cerebro para mejorar el aprendizaje
López, U. E. N. M., Vizuete, K. H. A., Vizuete, S. M. A., Vizuete, C. A. A., de Octubre, E. 1., Trávez, R. G. V., Maná, U. E. L., Alcívar, E. Y. P., & de Mayo, C. T. E. 1. (2024) · doi:10.16921/naciones.60
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The Impact of OXTR, COMT, and GRIN2B Polymorphisms on Brain Development in Preterm Infants
Kim, E. Y., Kim, H. A., Jang, Y. H., Hwang, W., Hur, J. K., Kim, Y.-E., Lim, S., Ye, D.-H., & Lee, H. J. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14228233
Study of the normal and pathological ageing of cortico-cortical fiber bundles by diffusion MRI
Vindas, N. (2024) · theses.fr (ABES) · doi:10.70675/5166708az37d4z4446za4b4ze88c8e1b8a49
- Authors
- Geng, X., Prom-Wormley, E. C., Perez, J., Kubarych, T., Styner, M., Lin, W., Neale, M. C., & Gilmore, J. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Virginia Commonwealth University (US)
- Corresponding author
- Geng, Xiujuan
- Venue
- Twin Research and Human Genetics
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-06
- Volume
- 15
- Issue
- 3
- Pages
- 336-350
- ISSN
- 1832-4274 (ISSN-L)
- 1839-2628
- PMC
- PMC3549568
- OpenAlex
- W2167339403
- Cited by
- 53
- References
- 42
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 8 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Twin Research and Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (MH-20030, MH070890)
- National Institute of Mental Health (U01MH070890, MH-20030, MH070890, R01MH065322, 20030, MH 65322, R01MH091645, R01MH070890, T32MH020030)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- neonatal brain, twin studies, genetic and environmental effects, fractional anisotropy, radial diffusivity, axial diffusivity, white matter microstructure, brain maturation, regional genetic variation, neurodevelopmental disorders
- MeSH terms
- Birth Weight, Brain, Female, Gestational Age, Humans, Infant, Newborn, Male, Twins, Quantitative Trait, Heritable, Diffusion Tensor Imaging, Gene-Environment Interaction
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