Changes in cortico-subcortical and subcortico-subcortical connectivity impact cognitive control to emotional cues across development
Open accessAbstract
The capacity to suppress inappropriate thoughts, emotions and actions in favor of appropriate ones shows marked changes throughout childhood and adolescence. Most research has focused on pre-frontal circuit development to explain these changes. Yet, subcortical circuitry involving the amygdala and ventral striatum (VS) has been shown to modulate cue-triggered motivated behaviors in rodents. The nature of the interaction between these two subcortical regions in humans is less well understood, especially during development when there appears to be heightened sensitivity to emotional cues. In the current study, we tested how task-based cortico-subcortical and subcortico-subcortical functional connectivity in 155 participants ages from 5 to 32 impacted cognitive control performance on an emotional go/nogo task. Functional connectivity between the amygdala and VS was inversely correlated with age and predicted cognitive control to emotional cues, when controlling for performance to neutral cues. In contrast, increased medial pre-frontal-amygdala connectivity was associated with better cognitive control to emotional cues and this cortical-subcortical connectivity mediated the association between amygdala-VS connectivity and emotional cognitive control. These findings suggest a dissociation in how subcortical-subcortical and cortical-subcortical connectivity impact cognitive control across development.
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- Authors
- Heller, A. S., Cohen, A. O., Dreyfuss, M. F. W., & Casey, B. J.
- Affiliations
- University of Miami (US)
- Weill Cornell Medicine (US)
- Venue
- Social Cognitive and Affective Neuroscience
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-07-21
- Volume
- 11
- Issue
- 12
- Pages
- nsw097
- ISSN
- 1749-5016 (ISSN-L)
- 1749-5024
- PMC
- PMC5141951
- OpenAlex
- W2505575367
- Cited by
- 65
- References
- 20
- Citations by year
- 2025: 8 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 5 · 2020: 7 · 2019: 14 · 2018: 5 · 2017: 4
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institute of Mental Health (P50MH079513)
- National Institute of General Medical Sciences (T32GM007739)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- cognitive control, emotional cues, amygdala, ventral striatum, medial prefrontal cortex, cortico-subcortical connectivity, development (biology), childhood, adolescence
- MeSH terms
- Adolescent, Adult, Age Factors, Brain, Child, Child Development, Child, Preschool, Cognition, Cues, Emotions, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Adolescent Development, Young Adult
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