Nonsuicidal self-injury and suicidal behaviors in girls: The case for targeted prevention in preadolescence
Open accessAbstract
Non-suicidal self-injury (NSSI) affects 15-20% of adolescents-disproportionately girls-and is a strong predictor of eventual suicide attempts and suicide. Many girls now initiate NSSI before age 10. These early-starters exhibit greater frequency of NSSI, use more diverse methods, and are hospitalized more often, yet there are no empirically supported prevention programs for preadolescents. Obstacles to prevention include ascertaining who is sufficiently vulnerable and specifying mechanistic intervention targets. Recent research indicates that (1) preadolescent girls with ADHD who are also maltreated are at alarming risk for NSSI and suicide attempts by adolescence, and (2) the conjoint effects of these vulnerabilities are sufficiently potent for targeted prevention. Research also indicates that existing interventions are effective in altering child- and family-level mechanisms of NSSI. These interventions alter neurobiological markers of vulnerability, which can be used as proximal efficacy signals of prevention response, without waiting for NSSI and suicide attempts to emerge.
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STB and NSSI have complex etiologies that overlap only partially, implying both shared and distinct vulnerability factors.
“their etiologies are complex and only partially overlap, suggesting both shared and unique vulnerability factors that potentiate STB and NSSI (2, 3).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [2]
Neural alterations interact dynamically with stress.
“Neural alterations do not operate in isolation. Rather, they interact dynamically with stress (2, 3, 36, 37)”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [2]
Small samples cannot adequately examine age, sex, and gender effects.
“small samples are ill-equipped to explore age, sex, and gender effects (2, 3; Table S1–S3 for sample sex characteristics).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [2]
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Research works printed but not linked: 12
- Auerbach RP, Kim JC, Chango JM, Spiro WJ, Cha C, Gold J, Esterman M, & Nock MK (2014). Adolescent nonsuicidal self-injury: Examining the role of child abuse, comorbidity, and disinhibition. Psychiatry Research, 220, 579– 584. doi: 10.1016/j.psychres.2014.07.027 25095754 PMC4252370 · DOI
- Beauchaine TP (in press). A developmental psychopathology perspective on the emergence of antisocial and borderline personality pathologies across the lifespan In Lejuez CW & Gratz KL (Eds.), Handbook of personality disorders. New York: Cambridge University Press.
- Beauchaine TP & Zalewski M (2016). Physiological and developmental mechanisms of emotional lability in coercive relationships In Dishion TJ & Snyder JJ (Eds.), Oxford handbook of coercive relationship dynamics (pp. 39– 52). New York: Oxford University Press.
- Blumenthal SJ, & Kupfer DJ (Eds.). (1990). Suicide over the life cycle. Washington, DC: American Psychiatric Press.
- Crowell SE, Kaufman E, & Beauchaine TP (2014). A biopsychosocial model of borderline personality development: Theory and empirical evidence In Tackett J & Sharp C (Eds.), Handbook of borderline personality disorder in children and adolescents (pp. 143– 158). New York: Springer.
- Ellis BJ, Del Giudice M, & Shirtcliff EA (2017). The adaptive calibration model of stress responsivity: Concepts, findings, and implications for developmental psychopathology In Beauchaine TP & Hinshaw SP (Eds.), Child and adolescent psychopathology (3rd ed., pp. 237– 276). Hoboken, NJ: Wiley.
- Hinshaw SP (2017). Developmental psychopathology as a scientific discipline: A twenty-first century perspective In Beauchaine TP & Hinshaw SP (Eds.), Child and adolescent psychopathology (3rd ed., pp. 3– 32). Hoboken, NJ: Wiley.
- Hostinar CE, & Cicchetti D (2018). Emotion dysregulation and internalizing spectrum disorders In Beauchaine TP & Crowell SE (Eds.), Oxford handbook of emotion dysregulation. New York: Oxford University Press. Epublished ahead of print.
- Jacoby N, Overfeld J, Binder E, & Heim C (2017). Stress neurobiology and developmental psychopathology In Cicchetti D (Ed.), Developmental psychopathology, Vol. 2: Developmental neuroscience (3rd ed., pp. 787– 831). Hoboken, NJ: Wiley.
- Kehoe C, & Havighurst S (in press). Treating emotion dysregulation in internalizing disorders In Beauchaine TP & Crowell SE (Eds.), Oxford handbook of emotion dysregulation. New York: Oxford University Press.
- Swanson JM, Sibley MH, Arnold LE, Hechtman LT, Stehli A, Molina BSG, … MTA Cooperative Group. (in press). Outcomes in the 16-year follow-up of the Multimodal Treatment Study of ADHD (MTA): Persistence of symptoms and medication side effects in early adulthood. Journal of Child Psychology and Psychiatry.
- Winiarski DA, Brown AL, Karnik NS, & Brennan PA (in press). Treating emotion dysregulation in externalizing disorders In Beauchaine TP & Crowell SE (Eds.), Oxford handbook of emotion dysregulation. New York: Oxford University Press.
Cited by
Sorted by citations
Hinshaw, S. P., Nguyen, P. T., O’Grady, S. M., & Rosenthal, E. A. (2022) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13480 · Cited by 424 · see citing works
Self-citationEmotion Dysregulation and Emerging Psychopathology: A Transdiagnostic, Transdisciplinary Perspective
Beauchaine, T. P., & Cicchetti, D. (2019) · Development and Psychopathology · doi:10.1017/s0954579419000671 · Cited by 301 · see citing works
Self-citationNeural correlates associated with suicide and nonsuicidal self-injury in youth
Auerbach, R. P., Pagliaccio, D., Allison, G. O., Alqueza, K. L., & Alonso, M. F. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.06.002 · Cited by 204 · see citing works
Beauchaine, T. P., Sauder, C. L., Derbidge, C. M., & Uyeji, L. L. (2019) · Development and Psychopathology · doi:10.1017/s0954579418000822 · Cited by 49 · see citing works
Self-citationFalgares, G., Costanzo, G., Manna, G., & Lamis, D. A. (2024) · Research in Psychotherapy: Psychopathology, Process and Outcome · doi:10.4081/ripppo.2024.745 · Cited by 7 · see citing works
- Authors
- Beauchaine, T. P., Hinshaw, S. P., & Bridge, J. A.
- Affiliations
- The Ohio State University (US)
- University of California, San Francisco (US)
- Nationwide Children's Hospital (US)
- Corresponding author
- Beauchaine, Theodore P.
- Venue
- Clinical Psychological Science
- Publisher
- SAGE Publications
- Published
- 2019-01-28
- Volume
- 7
- Issue
- 4
- Pages
- 643-667
- ISSN
- 2167-7026 (ISSN-L)
- 2167-7034
- PMC
- PMC6726409
- OpenAlex
- W2912792747
- Cited by
- 80
- References
- 226
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 12 · 2023: 21 · 2022: 5 · 2021: 11 · 2020: 11 · 2019: 3 · 2018: 1
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Psychological Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (MH074196, MH12209, MH63699, MH67192, MH86198)
- National Institutes of Health Science of Behavior Change Common Fund
- National Institute of Dental and Craniofacial Research (DE025980)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Sociology and Political Science › Homicide, Infanticide, and Child Abuse
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- non-suicidal self-injury, suicide attempts, preadolescent girls, targeted prevention, attention deficit hyperactivity disorder, child abuse, neurobiological markers, family intervention
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