The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
The Consortium on the Genetics of Schizophrenia: Neurocognitive Endophenotypes
Open accessAbstract
The Consortium on the Genetics of Schizophrenia (COGS) is a 7-site collaboration that examines the genetic architecture of quantitative endophenotypes in families with schizophrenia. Here we review the background and rationale for selecting neurocognitive tasks as endophenotypic measures in genetic studies. Criteria are outlined for the potential of measures as endophenotypic vulnerability markers. These include association with illness, state independence (ie, adequate test-retest stability, adequate between-site reliability, impairments in patients not due to medications, impairments observed regardless of illness state), heritability, findings of higher rates in relatives of probands than in the general population, and cosegregation within families. The COGS required that, in addition, the measures be "neurocognitive" and thus linked to neurobiology and that they be feasible in multisite studies. The COGS neurocognitive assessment includes measures of attention, verbal memory, working memory, and a computerized neurocognitive battery that also includes facial processing tasks. Here we describe data demonstrating that these neurobehavioral measures meet criteria for endophenotypic candidacy. We conclude that quantitative neurocognitive endophenotypes need further evidence for efficacy in identifying genetic effects but have the potential of providing unprecedented insight into gene-environment interaction related to dimensions of brain and behavior in health and disease.
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Cites
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“While cognitive control of attention and selective attention have strong conceptual relationships to WM,(19) a recent integration of factor analytic studies of cognition in schizophrenia indicates that sustained focused attention is separable from other neurocognitive factors.(20) Furthermore, it is the deficit in sus…”
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Cited by
Schizophrenia, “Just the Facts” What we know in 2008. 2. Epidemiology and etiology
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Endophenotype: a conceptual analysis
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Thalamic dysfunction in schizophrenia suggested by whole-night deficits in slow and fast spindles
Ferrarelli, F., Peterson, M. J., Sarasso, S., Riedner, B. A., Murphy, M. J., Benca, R. M., Bria, P., Kalin, N. H., & Tononi, G. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09121731 · Cited by 301
“An alternative approach employed in schizophrenia research involves measuring cognitive/neurophysiological parameters in healthy subjects and schizophrenia patients (4).”
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Metadata
- Authors
- Gur, R. E., Calkins, M. E., Gur, R. C., Horan, W. P., Nuechterlein, K. H., Seidman, L. J., & Stone, W. S.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-12-07
- Volume
- 33
- Issue
- 1
- Pages
- 49-68
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- OpenAlex
- W2131612765
- Cited by
- 383
- References
- 27
- FWCI
- 13.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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