The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
The Effects of Sleep Deprivation on Pain Inhibition and Spontaneous Pain in Women
Abstract
Impaired central pain modulation is implicated in the pathophysiology of chronic pain. In this controlled experiment, we evaluated whether partial sleep loss altered endogenous pain inhibition and reports of spontaneous pain. Thirty-two healthy females were studied polysomnographically for 7 nights. On Nights 1-2 (Baseline), subjects slept undisturbed for 8 hours. After Night 2, subjects were randomized to Control (N = 12), Forced Awakening (FA, N = 10), or Restricted Sleep Opportunity (RSO, N = 10) conditions. Controls continued to sleep undisturbed. FA underwent 8 forced awakenings (one per hour) on Nights 3-5. RSO subjects were yoked to FA on total sleep time (TST), receiving partial sleep deprivation by delayed bedtime. On Night 6, both FA & RSO underwent 36 hours total sleep deprivation (TSD), followed by 11-hour recovery sleep (Night 7). Subjects completed twice-daily psychophysical assessments of mechanical pain thresholds and pain inhibition (Diffuse Noxious Inhibitory Controls), via use of a conditioning stimulus (i.e., cold pressor) paradigm. FA and RSO demonstrated 50% reductions in total sleep time and increases in nonpainful somatic symptoms during partial sleep deprivation. While sleep deprivation had no effect on pain thresholds, during partial sleep deprivation the FA group demonstrated a significant loss of pain inhibition and an increase in spontaneous pain; neither of the other 2 groups showed changes in pain inhibition or spontaneous pain during partial sleep deprivation. These data suggest that sleep continuity disturbance, but not simple sleep restriction, impairs endogenous pain-inhibitory function and increases spontaneous pain, supporting a possible pathophysiologic role of sleep disturbance in chronic pain.
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“Sleep durations of 7–8 or 8–9 hours were consistently associated with reduced pain symptoms.18,105–109”
From Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion (2015) · cites this paper as [109]
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“Sleep durations below 5 hours were associated with increased pain in all of these study types.18,19,105–110”
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“Sleep durations of 7-8 or 8-9 hours were consistently associated with reduced pain symptoms.”
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“Sleep durations below 5 hours were associated with increased pain in all of these study types.”
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Citations
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Cited by
Sorted by citations
The association of sleep and pain: an update and a path forward
Finan, P. H., Goodin, B. R., & Smith, M. T. (2013) · The Journal of Pain · doi:10.1016/j.jpain.2013.08.007 · Cited by 1,620
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Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update
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Metadata
- Authors
- Smith, M. T., Edwards, R. R., McCann, U. D., & Haythornthwaite, J. A.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Smith, Michael T.
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04
- Volume
- 30
- Issue
- 4
- Pages
- 494-505
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W190565509
- Cited by
- 539
- References
- 54
- Citations by year
- 2026: 24 · 2025: 27 · 2024: 18 · 2023: 40 · 2022: 42 · 2021: 32 · 2020: 24 · 2019: 37 · 2018: 27 · 2017: 23 · 2016: 19 · 2015: 34 · 2014: 32 · 2013: 32 · 2012: 37
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (K23 NS47168, R21NS051771, K23NS047168)
- National Center for Research Resources (M01RR002719)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep deprivation, pain inhibition, spontaneous pain, central pain modulation, chronic pain, sleep continuity, sleep restriction, mechanical pain threshold, diffuse noxious inhibitory control, cold pressor pain, women, recovery sleep
- MeSH terms
- Adult, Chronic Disease, Female, Humans, Neural Inhibition, Pain, Pain Measurement, Reference Values, Sick Role, Sleep Deprivation, Sleep Wake Disorders, Wakefulness, Polysomnography, Pain Threshold
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