The DOI matches its Crossref record; 164 of the 166 references it cites were found in a registry or an index.
Functional Neuroimaging Insights into the Physiology of Human Sleep.
Open accessAbstract
Functional brain imaging has been used in humans to noninvasively investigate the neural mechanisms underlying the generation of sleep stages. On the one hand, REM sleep has been associated with the activation of the pons, thalamus, limbic areas, and temporo-occipital cortices, and the deactivation of prefrontal areas, in line with theories of REM sleep generation and dreaming properties. On the other hand, during non-REM (NREM) sleep, decreases in brain activity have been consistently found in the brainstem, thalamus, and in several cortical areas including the medial prefrontal cortex (MPFC), in agreement with a homeostatic need for brain energy recovery. Benefiting from a better temporal resolution, more recent studies have characterized the brain activations related to phasic events within specific sleep stages. In particular, they have demonstrated that NREM sleep oscillations (spindles and slow waves) are indeed associated with increases in brain activity in specific subcortical and cortical areas involved in the generation or modulation of these waves. These data highlight that, even during NREM sleep, brain activity is increased, yet regionally specific and transient. Besides refining the understanding of sleep mechanisms, functional brain imaging has also advanced the description of the functional properties of sleep. For instance, it has been shown that the sleeping brain is still able to process external information and even detect the pertinence of its content. The relationship between sleep and memory has also been refined using neuroimaging, demonstrating post-learning reactivation during sleep, as well as the reorganization of memory representation on the systems level, sometimes with long-lasting effects on subsequent memory performance. Further imaging studies should focus on clarifying the role of specific sleep patterns for the processing of external stimuli, as well as the consolidation of freshly encoded information during sleep.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Prospective cognition during sleep also differs from that during wake in that some brain regions supporting episodic future stimulation in wake are conspicuously deactivated during sleep, including dorsolateral prefrontal cortex and regions of the posterior parietal lobes [64–66].”
From Constructive episodic simulation in dreams (2022) · cites this paper as [65]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Wolpert, E. (1969) · Archives of General Psychiatry · doi:10.1001/archpsyc.1969.01740140118016 · Cited by 9,850
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760
Reactivation of hippocampal ensemble memories during sleep
Wilson, M. A., & McNaughton, B. L. (1994) · Science · doi:10.1126/science.8036517 · Cited by 3,118
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151
Huber, R., Felice Ghilardi, M., Massimini, M., & Tononi, G. (2004) · Nature · doi:10.1038/nature02663 · Cited by 1,854
Boosting slow oscillations during sleep potentiates memory
Marshall, L., Helgadóttir, H., Mölle, M., & Born, J. (2006) · Nature · doi:10.1038/nature05278 · Cited by 1,792
A Method for Removing Imaging Artifact from Continuous EEG Recorded during Functional MRI
Allen, P. J., Josephs, O., & Turner, R. (2000) · NeuroImage · doi:10.1006/nimg.2000.0599 · Cited by 1,301
Research works printed but not linked: 9
- 1963, L#x2019;activite electrique du systeme visuel au cours de la phase paradoxale du sommeil chez le chat, J Physiol (Paris), 55, 305
- 1997, Regional cerebral blood flow throughout the sleep-wake cycle, 1173
- 1999, PGO wave generation: mechanism and functional significance, 91
- 1964, L#x2019;activite electrique du cortex et du thalamus au cours du sommeil desynchronise chez le chat, C R Soc Biol (Paris), 158, 2131
- 1959, Correlations electromyographiques du sommeil chez le Chat decortique et mesencephalique chronique, C R Soc Biol (Paris), 153, 422
- 1961, EEG desynchronization during behavioral sleep associated with spike discharges from the thalamus of the cat, Fed Proc, 20, 327
- 2006, Locus coeruleus firing during SWS is time locked to slow oscillations: possible contribution of the noradrenergic system to off-line information processing in rats, J Sleep Res, 15, 11
- 2000, Auditory processing across the sleep-wake cycle: simultaneous EEG and fMRI monitoring in humans, Neuron, 28, 991, 10.1016/S0896-6273(00)00169-0 · DOI · Paper page
- 2007, Sleep transforms the cerebral trace of declarative memories, 18778
Cited by
Sorted by citations
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
“, parietal and prefrontal cortices) (189, 253, 764, 769, 1335).”
The role of sleep in emotional brain function
Goldstein, A. N., & Walker, M. P. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153716 · Cited by 1,052
“…the brain areas recognized to support fear acquisition and extinction (mPFC, amygdala, hippocampus) are all reactivated during REM sleep (Dang-Vu et al 2010, Miyauchi et al 2009, Nofzinger 2005, Phelps et al 2004), and through such REM sleep brain network restoration, may aide the…”
BackgroundSleep and Alzheimer disease pathology--a bidirectional relationship
Ju, Y.-E. S., Lucey, B. P., & Holtzman, D. M. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.269 · Cited by 996
Vyazovskiy, V. V., Olcese, U., Hanlon, E. C., Nir, Y., Cirelli, C., & Tononi, G. (2011) · Nature · doi:10.1038/nature10009 · Cited by 865
Sleep and anxiety: From mechanisms to interventions
Chellappa, S. L., & Aeschbach, D. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101583 · Cited by 509
Metadata
- Authors
- Dang-Vu, T. T., Schabus, M., Desseilles, M., Sterpenich, V., Bonjean, M., & Maquet, P.
- Affiliations
- University of Liège (BE)
- University of Geneva (CH)
- Howard Hughes Medical Institute (US)
- Venue
- SLEEP
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-12
- Volume
- 33
- Issue
- 12
- Pages
- 1589-1603
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC2982729
- OpenAlex
- W2101059856
- Cited by
- 284
- References
- 166
- Citations by year
- 2026: 17 · 2025: 27 · 2024: 15 · 2023: 14 · 2022: 20 · 2021: 10 · 2020: 13 · 2019: 38 · 2018: 15 · 2017: 13 · 2016: 12 · 2015: 19 · 2014: 21 · 2013: 26 · 2012: 19
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- Repository of the University of Namur (submittedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R01EB009282)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- sleep physiology, REM sleep, NREM sleep, sleep stages, dreams, sleep spindles, slow waves, sleep oscillations, brain energy homeostasis, medial prefrontal cortex, sleep and memory, memory consolidation
- MeSH terms
- Brain, Electroencephalography, Humans, Learning, Magnetic Resonance Imaging, Memory, Sleep, Wakefulness, Positron-Emission Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
