Sleep and Alzheimer disease pathology--a bidirectional relationship
Open accessAbstract
Factors other than age and genetics may increase the risk of developing Alzheimer disease (AD). Accumulation of the amyloid-β (Aβ) peptide in the brain seems to initiate a cascade of key events in the pathogenesis of AD. Moreover, evidence is emerging that the sleep-wake cycle directly influences levels of Aβ in the brain. In experimental models, sleep deprivation increases the concentration of soluble Aβ and results in chronic accumulation of Aβ, whereas sleep extension has the opposite effect. Furthermore, once Aβ accumulates, increased wakefulness and altered sleep patterns develop. Individuals with early Aβ deposition who still have normal cognitive function report sleep abnormalities, as do individuals with very mild dementia due to AD. Thus, sleep and neurodegenerative disease may influence each other in many ways that have important implications for the diagnosis and treatment of AD.
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- Authors
- Ju, Y.-E. S., Lucey, B. P., & Holtzman, D. M.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Holtzman, David M.
- Venue
- Nature Reviews Neurology
- Published
- 2013-12-24
- Volume
- 10
- Issue
- 2
- Pages
- 115-119
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- PMC
- PMC3979317
- OpenAlex
- W1992999217
- Cited by
- 996
- References
- 40
- Citations by year
- 2026: 103 · 2025: 113 · 2024: 100 · 2023: 90 · 2022: 92 · 2021: 103 · 2020: 72 · 2019: 87 · 2018: 54 · 2017: 71 · 2016: 47 · 2015: 40 · 2014: 22
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (KL2TR000450, UL1TR000448)
- National Institute of Neurological Disorders and Stroke (P01NS074969)
- National Center for Research Resources (KL2RR024994, UL1RR024992)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, sleep disruption, amyloid-beta deposition, sleep-wake cycle, sleep deprivation, sleep extension, bidirectional relationship, disease progression, risk factors, neurodegeneration
- MeSH terms
- Alzheimer Disease, Brain, Humans, Sleep Wake Disorders
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