Sleep Deprivation Increases Blood Pressure in Healthy Normotensive Elderly and Attenuates the Blood Pressure Response to Orthostatic Challenge
Open accessAbstract
STUDY OBJECTIVES: To determine how aging affects the impact of sleep deprivation on blood pressure at rest and under orthostatic challenge. DESIGN: Subjects underwent a night of sleep and 24.5 h of sleep deprivation in a crossover counterbalanced design. SETTING: Sleep laboratory. PARTICIPANTS: Sixteen healthy normotensive men and women: 8 young adults (mean 24 years [SD 3.1], range 20-28 years) and 8 elderly adults (mean 64.1 years [SD 3.4], range 60-69 years). INTERVENTIONS: Sleep deprivation. MEASUREMENTS AND RESULTS: Brachial cuff arterial blood pressure and heart rate were measured in semi-recumbent and upright positions. These measurements were compared across homeostatic sleep pressure conditions and age groups. Sleep deprivation induced a significant increase in systolic and diastolic blood pressure in elderly but not young adults. Moreover, sleep deprivation attenuated the systolic blood pressure orthostatic response in both age groups. CONCLUSIONS: Our results suggest that sleep deprivation alters the regulatory mechanisms of blood pressure and might increase the risk of hypertension in healthy normotensive elderly.
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In a crossover trial, normotensive older adults experienced a 13-mm Hg increase in systolic blood pressure and a 7-mm Hg increase in diastolic blood pressure after sleep deprivation compared with habitual sleep.
“Normotensive older adults experienced a 13–mm Hg increase in systolic blood pressure and a 7–mm Hg increase in diastolic blood pressure after sleep deprivation compared with habitual sleep.102”
From Sleep Duration and Quality: Impact on Lifestyle Behaviors and Cardiometabolic Health: A Scientific Statement From the American Heart Association (2016) · cites this paper as [102]
Small-scale experimental studies have shown that short-term sleep deprivation may lead to metabolic dysregulation, elevated inflammation, and elevated blood pressure.
“Small-scale experimental studies have shown that short-term sleep deprivation may lead to metabolic dysregulation[29-34], elevated inflammation[35, 36], and elevated blood pressure[37].”
From Habitual sleep duration associated with self-reported and objectively determined cardiometabolic risk factors (2014) · cites this paper as [37]
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- Authors
- Robillard, R., Lanfranchi, P. A., Prince, F., Filipini, D., & Carrier, J.
- Affiliations
- Hôpital du Sacré-Cœur de Montréal (CA)
- Université de Montréal (CA)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-03
- Volume
- 34
- Issue
- 3
- Pages
- 335-339
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC3041709
- OpenAlex
- W146265137
- Cited by
- 72
- References
- 26
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 6 · 2012: 5
- FWCI
- 7.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- SLEEP (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail
- Canadian Institutes of Health Research
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep deprivation, blood pressure, orthostatic challenge, aging, older adults, hypertension risk, heart rate, arterial blood pressure, autonomic regulation of blood pressure
- MeSH terms
- Adult, Age Factors, Aged, Blood Pressure, Female, Humans, Hypotension, Orthostatic, Male, Middle Aged, Sleep, Sleep Deprivation, Cross-Over Studies, Young Adult
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