Effects of sleep deprivation on neural circulatory control
Abstract
Effects of sleep deprivation on neural cardiovascular control may have important clinical implications. We tested the hypothesis that sleep deprivation increases heart rate, blood pressure, and sympathetic activity and potentiates their responses to stressful stimuli. We studied 8 healthy subjects (aged 40+/-5 years, 6 men and 2 women). Blood pressure, heart rate, forearm vascular resistance, and muscle sympathetic nerve activity were measured at rest and during 4 stressors (sustained handgrip, maximal forearm ischemia, mental stress, and cold pressor test). Measurements were obtained twice, once after normal sleep and once after a night of sleep deprivation. All measurements were obtained in a blinded, randomized manner. In comparison with normal sleep, sleep deprivation resulted in an increase in blood pressure (normal sleep versus sleep deprivation=82+/-8 versus 86+/-7 mm Hg, mean+/-SEM, P=0.012) and a decrease in muscle sympathetic nerve activity (normal sleep versus sleep deprivation=28+/-6 versus 22+/-6 bursts/min, P=0.017). Heart rate, forearm vascular resistance, and plasma catecholamines were not significantly changed by sleep deprivation, nor did sleep deprivation affect autonomic and hemodynamic responses to stressful stimuli. Sleep deprivation results in increased resting blood pressure, decreased muscle sympathetic nerve activity, and no change in heart rate. Thus, the pressor response to sleep deprivation is not mediated by muscle sympathetic vasoconstriction or tachycardia.
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After a night of total sleep deprivation in 8 healthy men and women, systolic blood pressure (p=0.002) and diastolic blood pressure (p=0.05) were significantly higher than after a night of regular sleep; morning plasma catecholamines and heart rate remained unchanged.
“After a night of total sleep deprivation in 8 healthy men and women, the systolic BP (SBP) (p=0.002) and diastolic BP (DBP) (p=0.05) were significantly higher than after a night of regular sleep. However, the morning plasma catecholamines and heart rate remain unchanged [65].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [65]
These two studies attribute the effects of sleep deprivation on baroreflex to changes in peripheral and central mechanisms but did not observe an increase in their measures of sympathetic nervous activity.
“These two studies attribute the effects of sleep deprivation on baroreflex to changes in peripheral and central mechanisms but did not observe an increase in their measures of sympathetic nervous activity.”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [65]
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- Authors
- Kato, M., Phillips, B. G., Sigurdsson, G., Narkiewicz, K., Pesek, C. A., & Somers, V. K.
- Affiliations
- University of Iowa (US)
- From the Division of Clinical and Administrative Pharmacy (M.K., B.G.P.), College of Pharmacy, and Department of Internal Medicine (G.S., C.A.P.), College of Medicine, University of Iowa, Iowa City, Iowa; Department of Hypertension and Diabetology (K.N.), Medical University of Gdansk, Gdansk, Poland; and Department of Internal Medicine (V.K.S.), Mayo Clinic, Rochester, Minn.
- Venue
- Hypertension
- Published
- 2000-05
- Volume
- 35
- Issue
- 5
- Pages
- 1173-1175
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2155552942
- Cited by
- 348
- References
- 21
- Citations by year
- 2026: 9 · 2025: 23 · 2024: 11 · 2023: 16 · 2022: 14 · 2021: 16 · 2020: 17 · 2019: 16 · 2018: 9 · 2017: 9 · 2016: 19 · 2015: 15 · 2014: 18 · 2013: 18 · 2012: 19
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association (14388)
- National Institutes of Health (14388, 65176, HL14388)
- National Heart, Lung, and Blood Institute (HL65176, HL-14388, R01HL065176, HL61560, P01HL014388, R01HL061560)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- sleep deprivation, blood pressure, heart rate, muscle sympathetic nerve activity, forearm vascular resistance, sympathetic vasoconstriction, stress response, cold pressor test, handgrip exercise, psychological stress, forearm ischemia, catecholamines, autonomic nervous system
- MeSH terms
- Adult, Blood Pressure, Female, Heart Rate, Humans, Male, Middle Aged, Sleep Deprivation, Sympathetic Nervous System, Vascular Resistance
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