Lifelong Exposure to Bisphenol A Alters Cardiac Structure/Function, Protein Expression, and DNA Methylation in Adult Mice

Patel, Bhavini B.; Raad, Mohamad; Sebag, Igal A.; Chalifour, Lorraine E.

doi:10.1093/toxsci/kft026

Cited by 114Effects and risks of endocrine disrupting chemicalsEpigenetics and DNA MethylationEstrogen and related hormone effects

Lifelong Exposure to Bisphenol A Alters Cardiac Structure/Function, Protein Expression, and DNA Methylation in Adult Mice

Patel, Bhavini B., Raad, Mohamad, Sebag, Igal A., Chalifour, Lorraine E.·2013·Toxicological Sciences

DOI 10.1093/toxsci/kft026

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Abstract

Bisphenol A (BPA) is an estrogenizing endocrine disruptor compound of concern. Our objective was to test whether lifelong BPA would impact cardiac structure/function, calcium homeostasis protein expression, and the DNA methylation of cardiac genes. We delivered 0.5 and 5.0 µg/kg/day BPA lifelong from gestation day 11 or 200 µg/kg/day from gestation day 11 to postnatal day 21 via the drinking water to C57bl/6n mice. BPA 5.0 males and females had increased body weight, body mass index, body surface area, and adiposity. Echocardiography identified concentric remodeling in all BPA-treated males. Systolic and diastolic cardiac functions were essentially similar, but lifelong BPA enhanced male and reduced female sex-specific differences in velocity of circumferential shortening and ascending aorta velocity time integral. Diastolic blood pressure was increased in all BPA females. The calcium homeostasis proteins sarcoendoplasmic reticulum ATPase 2a (SERCA2a), sodium calcium exchanger-1, phospholamban (PLB), phospho-PLB, and calsequestrin 2 are important for contraction and relaxation. Changes in their expression suggest increased calcium mobility in males and reduced calcium mobility in females supporting the cardiac function changes. DNA methyltransferase 3a expression was increased in all BPA males and BPA 0.5 females and reduced in BPA 200 females. Global DNA methylation was increased in BPA 0.5 males and reduced in BPA 0.5 females. BPA induced sex-specific altered DNA methylation in specific CpG pairs in the calsequestrin 2 CpG island. These results suggest that continual exposure to BPA impacts cardiac structure/function, protein expression, and epigenetic DNA methylation marks in males and females.

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Epigenetic alterations have been implicated in BPA-associated changes in pathology and function in several hormone-responsive tissues including the brain.
“Epigenetic alterations have been implicated in BPA-associated changes in pathology and function in several hormone-responsive tissues including the brain [ 49 , 130 , 138–141 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [140]

Recommendations for Chamber Quantification: A Report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, Developed in Conjunction with the European Association of Echocardiography, a Branch of the European Society of Cardiology
Lang, R. M., Bierig, M., Devereux, R. B., Flachskampf, F. A., Foster, E., Pellikka, P. A., Picard, M. H., Roman, M. J., Seward, J., Shanewise, J. S., et al. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.10.005 · Cited by 11,318 · see citing works
Functions of DNA methylation: islands, start sites, gene bodies and beyond
Jones, P. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3230 · Cited by 6,061 · see citing works
Doppler Tissue Imaging: A Noninvasive Technique for Evaluation of Left Ventricular Relaxation and Estimation of Filling Pressures
Nagueh, S. F., Middleton, K. J., Kopelen, H. A., Zoghbi, W. A., & Quiñones, M. A. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00344-6 · Cited by 3,024 · see citing works
Building the mammalian heart from two sources of myocardial cells
BUCKINGHAM, M. E., Meilhac, S. M., & Zaffran, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1710 · Cited by 1,196 · see citing works
In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147 · see citing works
A review of dietary and non-dietary exposure to bisphenol-A
Geens, T., Aerts, D., Berthot, C., Bourguignon, J.-P., Goeyens, L., Lecomte, P., Maghuin‐Rogister, G., Pironnet, A.-M., Pussemier, L., Scippo, M., et al. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.07.059 · Cited by 976 · see citing works
Environmental chemicals in pregnant women in the United States: NHANES 2003–2004
Woodruff, T. J., Zota, A. R., & Schwartz, J. M. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002727 · Cited by 930 · see citing works
The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity
Saal, F. S. V., Nagel, S. C., Coe, B., Angle, B. M., & Taylor, J. A. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.01.001 · Cited by 449 · see citing works
Child Health
Clarke, M. E., Knight, S., & Prozesky, D. R. (2003) · Cited by 440 · see citing works
Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra
Timms, B. G., Howdeshell, K. L., Barton, L., Bradley, S., Richter, C. A., & vom Saal, F. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502544102 · Cited by 394 · see citing works
Gestational Exposure to Bisphenol A Produces Transgenerational Changes in Behaviors and Gene Expression
Wolstenholme, J. T., Edwards, M., Shetty, S. R. J., Gatewood, J. D., Taylor, J. A., Rissman, E. F., & Connelly, J. J. (2012) · Endocrinology · doi:10.1210/en.2012-1195 · Cited by 319 · see citing works
Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women
Melzer, D. R., Osborne, N. J., Henley, W., Cipelli, R., Young, A., Money, C., McCormack, P., Luben, R., Khaw, K., Wareham, N. J., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.069153 · Cited by 303 · see citing works
Bisphenol‐A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response
Bromer, J. G., Zhou, Y., Taylor, M. B., Doherty, L. F., & Taylor, H. S. (2010) · The FASEB Journal · doi:10.1096/fj.09-140533 · Cited by 303 · see citing works
Bisphenol A: Perinatal exposure and body weight
Rubin, B. S., & Soto, A. M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.02.023 · Cited by 272 · see citing works
Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A
Yaoi, T., Itoh, K., Nakamura, K., Ogi, H., Fujiwara, Y., & Fushiki, S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.09.028 · Cited by 229 · see citing works
Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderly
Lind, P., & Lind, L. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.05.001 · Cited by 218 · see citing works
Sex is a potent modifier of the cardiovascular system
Leinwand, L. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19429 · Cited by 190 · see citing works
Bisphenol A and Peripheral Arterial Disease: Results from the NHANES
Shankar, A., Teppala, S., & Sabanayagam, C. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104114 · Cited by 190 · see citing works
Noninvasive Assessment of Murine Pulmonary Arterial Pressure
Thibault, H., Kurtz, B., Raher, M. J., Shaik, R. S., Waxman, A. B., Dérumeaux, G., Halpern, E. F., Bloch, K. D., & Scherrer‐Crosbie, M. (2009) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.109.887109 · Cited by 182 · see citing works
Associations of Bisphenol A Exposure With Heart Rate Variability and Blood Pressure
Bae, S., Kim, J. H., Lim, Y., Park, H. Y., & Hong, Y. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.197715 · Cited by 177 · see citing works
Histology Atlas of the Developing Mouse Heart with Emphasis on E11.5 to E18.5
Savolainen, S. M., Foley, J. F., & Elmore, S. A. (2009) · Toxicologic Pathology · doi:10.1177/0192623309335060 · Cited by 175 · see citing works
Transgenerational neuroendocrine disruption of reproduction
Walker, D. M., & Gore, A. C. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.215 · Cited by 167 · see citing works
Neonatal Exposure to Estradiol/Bisphenol A Alters Promoter Methylation and Expression of Nsbp1 and Hpcal1 Genes and Transcriptional Programs of Dnmt3a/b and Mbd2/4 in the RatProstate Gland Throughout Life
Tang, W.-Y., Morey, L. M., Cheung, Y. Y., Birch, L., Prins, G. S., & Ho, S.-M. (2012) · Endocrinology · doi:10.1210/en.2011-1308 · Cited by 164 · see citing works
Sex is a potent modifier of the cardiovascular system
Leinwand, L. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319429 · Cited by 161 · see citing works
Bisphenol A and 17β-Estradiol Promote Arrhythmia in the Female Heart via Alteration of Calcium Handling
Yan, S., Chen, Y., Dong, M., Song, W., Belcher, S. M., & Wang, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025455 · Cited by 157 · see citing works
Formation of the Building Plan of the Human Heart
Sizarov, A., Ya, J., de Boer, B. A., Lamers, W. H., Christoffels, V. M., & Moorman, A. F. M. (2011) · Circulation · doi:10.1161/circulationaha.110.980607 · Cited by 154 · see citing works
Sex-based cardiac physiology
Luczak, E. D., & Leinwand, L. A. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163156 · Cited by 143 · see citing works
Preimplantation exposure to bisphenol A (BPA) affects embryo transport, preimplantation embryo development, and uterine receptivity in mice
Xiao, S., Diao, H., Smith, M. A., Song, X., & Ye, X. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.08.010 · Cited by 126 · see citing works
Use of NHANES Data to Link Chemical Exposures to Chronic Diseases: A Cautionary Tale
LaKind, J. S., Goodman, M. G., & Naiman, D. Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051086 · Cited by 116 · see citing works
Maternal and Social Origins of Hypertension
Barker, D. J. P., Osmond, C., Forsén, T., Kajantie, E., & Eriksson, J. G. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.091512 · Cited by 112 · see citing works
Body Surface Area Prediction in Normal, Hypermuscular, and Obese Mice
Cheung, M. C., Spalding, P. B., Gutierrez, J. C., Balkan, W., Namias, N., Koniaris, L. G., & Zimmers, T. A. (2008) · Journal of Surgical Research · doi:10.1016/j.jss.2008.05.002 · Cited by 107 · see citing works
Rapid Estrogen Receptor-Mediated Mechanisms Determine the Sexually Dimorphic Sensitivity of Ventricular Myocytes to 17β-Estradiol and the Environmental Endocrine Disruptor Bisphenol A
Belcher, S. M., Chen, Y., Yan, S., & Wang, H. (2011) · Endocrinology · doi:10.1210/en.2011-1772 · Cited by 102 · see citing works
Quantitative Assessment of Regional Myocardial Function in Mice by Tissue Doppler Imaging
Sebag, I. A., Handschumacher, M. D., Ichinose, F., Morgan, J. G., Hataishi, R., Rodrigues, A. C. T., Guerrero, J. L., Steudel, W., Raher, M. J., Halpern, E. F., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.474411 · Cited by 98 · see citing works
Self-citation
Doppler echocardiographic estimation of left ventricular end-diastolic pressure after MI in rats
Prunier, F., Gaertner, R., Louedec, L., Michel, J., Mercadier, J.-J., & Escoubet, B. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01050.2001 · Cited by 91 · see citing works
Bisphenol A Binds to the Local Anesthetic Receptor Site to Block the Human Cardiac Sodium Channel
O’Reilly, A. O., Eberhardt, E., Weidner, C., Alzheimer, C., Wallace, B. A., & Lampert, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041667 · Cited by 69 · see citing works
Unraveling the secrets of a double life: Contractile versus signaling Ca2+ in a cardiac myocyte
Goonasekera, S. A., & Molkentin, J. D. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.05.001 · Cited by 67 · see citing works
Sex hormone control of left ventricular structure/function: mechanistic insights using echocardiography, expression, and DNA methylation analyses in adult mice
Sebag, I. A., Gillis, M., Calderone, A., Kasneci, A., Meilleur, M., Haddad, R., Noiles, W., Patel, B. B., & Chalifour, L. E. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00088.2011 · Cited by 54 · see citing works
Self-citation
Exposure to bisphenol A in Canada: invoking the precautionary principle
Vandenberg, L. N. (2011) · Canadian Medical Association Journal · doi:10.1503/cmaj.101408 · Cited by 50 · see citing works
Perspectives on endocrine disruptor effects on metabolic sensors
Migliarini, B., Piccinetti, C. C., Martella, A., Maradonna, F., Gioacchini, G., & Carnevali, O. (2010) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2010.11.025 · Cited by 48 · see citing works
Factors controlling the activity of the SERCA2a pump in the normal and failing heart
Vandecaetsbeek, I., Raeymaekers, L., Wuytack, F., & Vangheluwe, P. (2009) · BioFactors · doi:10.1002/biof.63 · Cited by 47 · see citing works
Regulation of sarco(endo)plasmic reticulum Ca 2+ -ATPase and calsequestrin gene expression in the heart
Zarain‐Herzberg, Á., Estrada‐Avilés, R., & Fragoso-Medina, J. A. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-057 · Cited by 34 · see citing works
Obesity and the developmental origins of health and disease
Kemp, M. W., Kallapur, S. G., Jobe, A. H., & Newnham, J. P. (2011) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2010.01940.x · Cited by 31 · see citing works
Egr-1 negatively regulates calsequestrin expression and calcium dynamics in ventricular cells
Kasneci, A., Kemeny-Suss, N. M., Komarova, S. V., & Chalifour, L. E. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn357 · Cited by 29 · see citing works
Self-citation
Gestational exposure to diethylstilbestrol alters cardiac structure/function, protein expression and DNA methylation in adult male mice progeny
Haddad, R., Kasneci, A., Mepham, K., Sebag, I. A., & Chalifour, L. E. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.10.018 · Cited by 21 · see citing works
Self-citation
Developmental exposure to bisphenol A leads to cardiometabolic dysfunction in adult mouse offspring
Cagampang, F. R. A., Torrens, C., Anthony, F. W., & Hanson, M. A. (2012) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174412000153 · Cited by 19 · see citing works
Modulation of SR C a 2 +release by the triadin-to-calsequestrin ratio in ventricular myocytes
Kučerová, D., Baba, H. A., Boknı́k, P., Fabritz, L., Heinick, A., Máťuš, M., Müller, F. U., Neumann, J., Schmitz, W. L., & Kirchhefer, U. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00457.2011 · Cited by 19 · see citing works

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Vandenberg, L. N., Ehrlich, S., Belcher, S. M., Ben‐Jonathan, N., Dolinoy, D. C., Hugo, E. R., Hunt, P. A., Newbold, R. R., Rubin, B. S., Saili, K. S., et al. (2013) · Endocrine Disruptors · doi:10.4161/endo.26490 · Cited by 238 · see citing works
DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?
Keil, K. P., & Lein, P. J. (2016) · Environmental Epigenetics · doi:10.1093/eep/dvv012 · Cited by 167 · see citing works
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Gao, X., & Wang, H. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph110808399 · Cited by 168 · see citing works
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Lombó, M., Fernández-Díez, C., González-Rojo, S., Navarro, C., Robles, V., & Herráez, M. P. (2015) · Environmental Pollution · doi:10.1016/j.envpol.2015.08.016 · Cited by 150 · see citing works
Cardiovascular toxicity and mechanism of bisphenol A and emerging risk of bisphenol S
Zhang, Y., Shan, C., Wang, Y., Qian, L.-L., Jia, D., Zhang, Y., Hao, X., & Xu, H. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137952 · Cited by 143 · see citing works
Effects of bisphenol A on cardiovascular disease: An epidemiological study using National Health and Nutrition Examination Survey 2003–2016 and meta-analysis
Moon, S., Yu, S. H., Lee, C. B., Park, Y. J., Yoo, H. J., & Kim, D. S. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142941 · Cited by 133 · see citing works
The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats
Ezz, H. S. A., Khadrawy, Y. A., & Mourad, I. M. (2013) · Cytotechnology · doi:10.1007/s10616-013-9672-1 · Cited by 126 · see citing works
Association Between Bisphenol A Exposure and Risk of All-Cause and Cause-Specific Mortality in US Adults
Bao, W., Liu, B., Rong, S., Dai, S. Y., Trasande, L., & Lehmler, H. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.11620 · Cited by 128 · see citing works
The Adverse Cardiac Effects of Di(2-ethylhexyl)phthalate and Bisphenol A
Posnack, N. G. (2014) · Cardiovascular Toxicology · doi:10.1007/s12012-014-9258-y · Cited by 116 · see citing works
Early-Life Lead Exposure Results in Dose- and Sex-Specific Effects on Weight and Epigenetic Gene Regulation in Weanling Mice
Faulk, C. D., Barks, A. K., Liu, K., Goodrich, J. M., & Dolinoy, D. C. (2013) · Epigenomics · doi:10.2217/epi.13.49 · Cited by 114 · see citing works
CLARITY‐BPA academic laboratory studies identify consistent low‐dose Bisphenol A effects on multiple organ systems
Prins, G. S., Patisaul, H. B., Belcher, S. M., & Vandenberg, L. N. (2018) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13125 · Cited by 107 · see citing works
Early-Life Exposure to Bisphenol A Induces Liver Injury in Rats Involvement of Mitochondria-Mediated Apoptosis
Xia, W., Jiang, Y., Li, Y., Wan, Y., Liu, J., Ma, Y., Mao, Z., Chang, H., Li, G., Xu, B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090443 · Cited by 102 · see citing works
Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes
Ramadan, M., Cooper, B. L., & Posnack, N. G. (2020) · Birth Defects Research · doi:10.1002/bdr2.1752 · Cited by 98 · see citing works
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Fonseca, M. I., Lorigo, M., & Cairrão, E. (2022) · Journal of Xenobiotics · doi:10.3390/jox12030015 · Cited by 99 · see citing works
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Kim, S. S., Hwang, K.-S., Yang, J. Y., Chae, J. S., Kim, G. R., Kan, H., Jung, M. H., Lee, H.-Y., Song, J. S., Ahn, S., et al. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.124751 · Cited by 83 · see citing works
The Promises and Challenges of Toxico-Epigenomics: Environmental Chemicals and Their Impacts on the Epigenome
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Marked for Life: Epigenetic Effects of Endocrine Disrupting Chemicals
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Bae, S., Lim, Y.-H., Lee, Y. A., Shin, C. H., Oh, S., & Hong, Y. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.08281 · Cited by 60 · see citing works
Effects of bisphenol A on incidence and severity of cardiac lesions in the NCTR-Sprague-Dawley rat: A CLARITY-BPA study
Gear, R. B., Kendziorski, J. A., & Belcher, S. M. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.05.011 · Cited by 59 · see citing works
Cardiogenesis impairment promoted by bisphenol A exposure is successfully counteracted by epigallocatechin gallate
Lombó, M., González-Rojo, S., Fernández-Díez, C., & Herráez, M. P. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.01.004 · Cited by 57 · see citing works
Effect of perinatal exposure to Bisphenol-A on DNA methylation and histone acetylation in cerebral cortex and hippocampus of postnatal male mice
Kumar, D., & Thakur, M. K. (2017) · The Journal of Toxicological Sciences · doi:10.2131/jts.42.281 · Cited by 54 · see citing works
Physiological response of cardiac tissue to bisphenol a: alterations in ventricular pressure and contractility
Posnack, N. G., Brooks, D. M., Chandra, A. A., Jaimes, R., Sarvazyan, N. A., & Kay, M. W. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00272.2015 · Cited by 53 · see citing works
Epigenetic effects of low perinatal doses of flame retardant BDE-47 on mitochondrial and nuclear genes in rat offspring
Byun, H., Bénachour, N., Zalko, D., Frisardi, M. C., Colicino, E., Takser, L., & Baccarelli, A. (2014) · Toxicology · doi:10.1016/j.tox.2014.12.019 · Cited by 52 · see citing works
High-Throughput Screening to Identify Chemical Cardiotoxic Potential
Krishna, S., Berridge, B., & Kleinstreuer, N. (2021) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.0c00382 · Cited by 52 · see citing works
Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use
Sirasanagandla, S. R., Al‐Huseini, I., Sakr, H. F., Moqadass, M., Das, S., Juliana, N., & Abu, I. F. (2022) · Molecules · doi:10.3390/molecules27175384 · Cited by 50 · see citing works
Estrogenic Mechanisms and Cardiac Responses Following Early Life Exposure to Bisphenol A (BPA) and Its Metabolite 4-Methyl-2,4-bis(p-hydroxyphenyl)pent-1-ene (MBP) in Zebrafish
Moreman, J., Takesono, A., Trznadel, M., Winter, M. J., Perry, A., Wood, M. E., Rogers, N. J., Kudoh, T., & Tyler, C. R. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b01095 · Cited by 49 · see citing works
Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling
Jiménez‐Chillarón, J. C., Nijland, M. J., Ascensão, A. A. M. R., Sardão, V. A., Magalhães, J., Hitchler, M. J., Domann, F. E., & Oliveira, P. J. (2015) · Epigenetics · doi:10.1080/15592294.2015.1020267 · Cited by 45 · see citing works
The protective activity of nanomicelle curcumin in bisphenol A‐induced cardiotoxicity following subacute exposure in rats
Valokola, M. G., Karimi, G., Razavi, B. M., Kianfar, M., Jafarian, A. H., Jaafari, M. R., & Imenshahidi, M. (2018) · Environmental Toxicology · doi:10.1002/tox.22687 · Cited by 45 · see citing works
Bisphenol S rapidly depresses heart function through estrogen receptor-β and decreases phospholamban phosphorylation in a sex-dependent manner
Ferguson, M., Lorenzen‐Schmidt, I., & Pyle, W. G. (2019) · Scientific Reports · doi:10.1038/s41598-019-52350-y · Cited by 45 · see citing works
Chronic Exposure to Bisphenol A Reduces Successful Cardiac Remodeling After an Experimental Myocardial Infarction in Male C57bl/6n Mice
Patel, B. B., Kasneci, A., Bolt, A. M., Lalla, V. D., Iorio, M. R. D., Raad, M., Mann, K. K., & Chalifour, L. E. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv073 · Cited by 43 · see citing works
Self-citation
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Neff, A. M., Blanco, S. C., Flaws, J. A., Bagchi, I. C., & Bagchi, M. K. (2019) · Endocrinology · doi:10.1210/en.2018-00872 · Cited by 41 · see citing works
From the Cover: Lifelong Exposure of C57bl/6n Male Mice to Bisphenol A or Bisphenol S Reduces Recovery From a Myocardial Infarction
Kasneci, A., Lee, J. S., Yun, T. J., Shang, J., Lampen, S. I. R., Gomolin, T., Cheong, C., & Chalifour, L. E. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx133 · Cited by 39 · see citing works
Self-citation
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Awada, Z., Nasr, R., Akika, R., Cahais, V., Cuenin, C., Zhivagui, M., Herceg, Z., Ghantous, A., & Zgheib, N. K. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0725-y · Cited by 41 · see citing works
Cardiac toxicity from bisphenol A exposure in human-induced pluripotent stem cell-derived cardiomyocytes
Hyun, S., Lee, C. Y., Ko, M. Y., Chon, S., Kim, Y., Seo, J., Kim, K. K., & Ka, M. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115696 · Cited by 37 · see citing works
The State of Research and Weight of Evidence on the Epigenetic Effects of Bisphenol A
Nia, A. B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097951 · Cited by 36 · see citing works
Disruption of neonatal cardiomyocyte physiology following exposure to bisphenol-a
Ramadan, M., Sherman, M. G., Jaimes, R., Chaluvadi, A., Swift, L., & Posnack, N. G. (2018) · Scientific Reports · doi:10.1038/s41598-018-25719-8 · Cited by 36 · see citing works
Bisphenol A and its effects on the systemic organs of children
Zulkifli, S., Rahman, A. A., Kadir, S. H. S. A., & Nor, N. S. M. (2021) · European Journal of Pediatrics · doi:10.1007/s00431-021-04085-0 · Cited by 37 · see citing works
Regulation of sarco(endo)plasmic reticulum Ca 2+ -ATPase and calsequestrin gene expression in the heart
Zarain‐Herzberg, Á., Estrada‐Avilés, R., & Fragoso-Medina, J. A. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-057 · Cited by 34 · see citing works
Epigenetic Regulation of Non-Lymphoid Cells by Bisphenol A, a Model Endocrine Disrupter: Potential Implications for Immunoregulation
Khan, D., & Ahmed, S. A. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00091 · Cited by 34 · see citing works
Tiny trouble: microplastics, nanoplastics, and their heartfelt impact on cardiovascular health
Zhang, T., Liao, Y., Ling, J., Zhang, J., Zhang, D., Yin, X., Yu, P., & Liu, X. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf068 · Cited by 32 · see citing works
MicroRNA expression in response to bisphenol A is associated with high blood pressure
Kim, J. H., Cho, Y. H., & Hong, Y. (2020) · Environment International · doi:10.1016/j.envint.2020.105791 · Cited by 31 · see citing works
Evaluation of green tea extract and epigallocatechin gallate effects on bisphenol A‐induced vascular toxicity in isolated rat aorta and cytotoxicity in human umbilical vein endothelial cells
Mohsenzadeh, M. S., Razavi, B. M., Imenshahidi, M., Mohajeri, S. A., Rameshrad, M., & Hosseinzadeh, H. (2020) · Phytotherapy Research · doi:10.1002/ptr.6861 · Cited by 31 · see citing works
Elevated Serum Bisphenol A Level in Patients with Dilated Cardiomyopathy
Xiong, Q., Liu, X., Shen, Y., Yu, P., Chen, S., Hu, J., Yu, J., Li, J., Wang, H., Cheng, X., et al. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph120505329 · Cited by 32 · see citing works
Bisphenol A vascular toxicity: Protective effect of Vitis vinifera (grape) seed extract and resveratrol
Rameshrad, M., Imenshahidi, M., Razavi, B. M., Iranshahi, M., & Hosseinzadeh, H. (2018) · Phytotherapy Research · doi:10.1002/ptr.6175 · Cited by 29 · see citing works
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Escarda‐Castro, E., Herráez, M. P., & Lombó, M. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117567 · Cited by 29 · see citing works
Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health
Singh, R. D., Koshta, K., Tiwari, R., Khan, H., Sharma, V., & Srivastava, V. K. (2021) · Frontiers in Toxicology · doi:10.3389/ftox.2021.663372 · Cited by 30 · see citing works
Sex-specific cardiovascular responses to control or high fat diet feeding in C57bl/6 mice chronically exposed to bisphenol A.
Patel, B. B., Raad, M., Sebag, I. A., & Chalifour, L. E. (2015) · Toxicology Reports · doi:10.1016/j.toxrep.2015.09.008 · Cited by 27 · see citing works
Self-citation
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Klint, H., Lejonklou, M. H., Karimullina, E. M., Rönn, M., Lind, L., Lind, P., & Brittebo, E. B. (2016) · Upsala Journal of Medical Sciences · doi:10.1080/03009734.2016.1225870 · Cited by 27 · see citing works
Effects of Environment and Lifestyle Factors on Premature Ovarian Failure
Yang, Y., Huang, W., & Yuan, L. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-4187-6_4 · Cited by 26 · see citing works
Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats
Camacho, L., Basavarajappa, M. S., Chang, C., Han, T., Kobets, T., Koturbash, I., Surratt, G., Lewis, S. M., Vanlandingham, M. M., Fuscoe, J. C., et al. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.04.009 · Cited by 25 · see citing works
Altered heart proteome in fructose-fed Fisher 344 rats exposed to bisphenol A
Ljunggren, S., Iggland, M., Rönn, M., Lind, L., Lind, P., & Karlsson, H. (2016) · Toxicology · doi:10.1016/j.tox.2016.02.007 · Cited by 23 · see citing works
Liver DNA methylation analysis in adult female C57BL/6JxFVB mice following perinatal exposure to bisphenol A
van Esterik, J. C. J., Vitins, A. P., Hodemaekers, H. M., Kamstra, J. H., Legler, J., Pennings, J. L. A., Steegenga, W. T., Lute, C., Jelı́nek, J., Issa, J. J., et al. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.10.021 · Cited by 22 · see citing works
Bisphenol A exposure and risk of ischemic heart disease in the Spanish European Prospective Investigation into cancer and nutrition study
Salamanca‐Fernández, E., Rodríguez‐Barranco, M., Petrova, D., Larrañaga, N., Guevara, M., Moreno‐Iribas, C., Chirlaque, M. D., Colorado-Yohar, S. M., Arrebola, J. P., Vela-Soria, F., et al. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.127697 · Cited by 22 · see citing works
Bisphenol A induced neuronal apoptosis and enhanced autophagy in vitro through Nrf2/HO-1 and Akt/mTOR pathways
Shen, Y., Li, X., Wang, H., Wang, Y., Tao, L., Wang, P., & Zhang, H. (2023) · Toxicology · doi:10.1016/j.tox.2023.153678 · Cited by 22 · see citing works
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Shang, J., Corriveau, J., Champoux-Jenane, A., Gagnon, J., Moss, E., Dumas, P., Gaudreau, É., Chevrier, J., & Chalifour, L. E. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy276 · Cited by 21 · see citing works
Self-citation
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Cheng, M.-D., Li, C., Pei, X.-Y., Zhang, Y., Jia, D., Zuo, Y.-B., Cai, S., Li, P., Xin, H., & Zhang, Y. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115391 · Cited by 20 · see citing works
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Ma, J., Hong, K., & Wang, H. (2017) · Endocrinology · doi:10.1210/en.2016-1702 · Cited by 20 · see citing works
The effects of bisphenols on the cardiovascular system ex vivo and in vivo
Tvrdý, V., Dias, P., Najmanová, I., Carazo, A., Jirkovský, E., Pourová, J., Fadraersada, J., Moravcová, M., Mašič, L. P., Dolenc, M. S., et al. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.137565 · Cited by 19 · see citing works
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Filice, M., Leo, S., Mazza, R., Amelio, D., Garofalo, F., Imbrogno, S., Cerra, M. C., & Gattuso, A. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.116177 · Cited by 17 · see citing works
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Liu, J., Chen, T., Wang, S., Wu, H., & Xu, S. (2022) · Toxicology · doi:10.1016/j.tox.2022.153190 · Cited by 17 · see citing works
Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placenta
Zou, Z., Harris, L. K., Forbes, K. A., & Heazell, A. E. P. (2022) · Biology of Reproduction · doi:10.1093/biolre/ioac044 · Cited by 16 · see citing works
Evaluation of the bisphenol A-induced vascular toxicity on human umbilical artery
Fonseca, M. I., Lorigo, M., & Cairrão, E. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115628 · Cited by 16 · see citing works
Cardiac structure/function, protein expression, and DNA methylation are changed in adult female mice exposed to diethylstilbestrol in utero
Haddad, R., Kasneci, A., Sebag, I. A., & Chalifour, L. E. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2013-0014 · Cited by 16 · see citing works
Self-citation
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Visker, J. R., Dangott, L. J., Leszczynski, E. C., & Ferguson, D. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249459 · Cited by 6 · see citing works
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Olasunkanmi, O. I., Aremu, J., Wong, M., Licinio, J., & Zheng, P. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.10.028 · Cited by 6 · see citing works
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Jenzri, M., Bouraoui, Z., Guerbèj, H., Jebali, J., & Gharred, T. (2025) · Ecotoxicology · doi:10.1007/s10646-025-02925-5 · Cited by 3 · see citing works
The EDCs as epigenetic disruptors: Implications for development and health
Herráez, M. P., Lombó, M., & González-Rojo, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824464-7.00022-2 · Cited by 3 · see citing works
Environmental Medical Epigenetics: A Review of Epigenetically Induced Medical Risks Generated From Exposures in our Air, Food, and Personal Products
Miller, R. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803239-8.00007-7 · Cited by 3 · see citing works
Epigenetic Effects of Bisphenol A (BPA): A Literature Review in the Context of Human Dietary Exposure
Camacho, L., & Pogribny, I. P. (2017) · Springer eBooks · doi:10.1007/978-3-319-31143-2_32-1 · Cited by 2 · see citing works
Sexually dimorphic cardiovascular impacts of prenatal exposure to a real-life environmental chemical mixture in adult offspring
Khan, N. M., Scott, V., Ghasemzadeh‐Hasankolaei, M., Padmanabhan, V., Vyas, A. K., Evans, N. P., & Bellingham, M. (2025) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2025.104669 · Cited by 2 · see citing works

Lifelong exposure to environmentally relevant doses of Bisphenol A (BPA) alters adult heart structure function
Patel, B. (2012) · doi:10.82308/7656
Self-citation
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Belcher, S. M., Gear, R. B., & Kendig, E. L. (2015) · Endocrinology · doi:10.1210/en.2014-1847 · Cited by 74 · see citing works
Sex-specific cardiovascular responses to control or high fat diet feeding in C57bl/6 mice chronically exposed to bisphenol A.
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Self-citation
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Jiang, Y., Xia, W., Yang, J., Zhu, Y., Chang, H., Liu, J., Huo, W., Xu, B., Chen, X., Li, Y., et al. (2015) · Toxicology · doi:10.1016/j.tox.2015.01.001 · Cited by 60 · see citing works
Developmental exposure to bisphenol A leads to cardiometabolic dysfunction in adult mouse offspring
Cagampang, F. R. A., Torrens, C., Anthony, F. W., & Hanson, M. A. (2012) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174412000153 · Cited by 19 · see citing works

Authors: Patel, B. B., Raad, M., Sebag, I. A., & Chalifour, L. E.
Affiliations: Jewish General Hospital (CA)
ORCID: Raad, Mohamad
Chalifour, Lorraine E.
Venue: Toxicological Sciences
Publisher: Oxford University Press (OUP)
Published: 2013-02-15
Volume: 133
Issue: 1
Pages: 174-185
ISSN: 1096-0929 (ISSN-L)
1096-6080
DOI: 10.1093/toxsci/kft026
OpenAlex: W2163044427
Cited by: 114
References: 45
Citations by year: 2026: 5 · 2025: 6 · 2024: 9 · 2023: 7 · 2022: 8 · 2021: 6 · 2020: 16 · 2019: 7 · 2018: 7 · 2017: 12 · 2016: 6 · 2015: 12 · 2014: 7 · 2013: 5 · 2012: 1
FWCI: 7.34
Type: journal article
Language: en
Open access: closed
Locations: Toxicological Sciences (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Canadian Institutes of Health Research (MOP -89788)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: bisphenol A, endocrine disruptors, cardiac structure and function, calcium homeostasis, DNA methylation, sex differences, cardiac remodeling, SERCA2a, phospholamban, CASQ2, DNMT3A, global DNA methylation, CpG islands, diastolic blood pressure, adiposity, epigenetics
MeSH terms: DNA Methyltransferase 3A, Bisphenol A Compounds, Animals, Benzhydryl Compounds, Blood Pressure, Body Weight, Calcium-Binding Proteins, Carrier Proteins, Dose-Response Relationship, Drug, Echocardiography, Female, Gestational Age, Heart, Heart Function Tests, Male, Organ Size, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Sex Factors, Time Factors, DNA Methylation, Sodium-Calcium Exchanger, Mice, Endocrine Disruptors, Sarcoplasmic Reticulum Calcium-Transporting ATPases

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Lifelong Exposure to Bisphenol A Alters Cardiac Structure/Function, Protein Expression, and DNA Methylation in Adult Mice

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