Cited by 229Epigenetics and DNA MethylationEffects and risks of endocrine disrupting chemicalsBirth, Development, and Health

Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A

Yaoi, Takeshi, Itoh, Kyoko, Nakamura, Keiko, Ogi, Hiroshi, Fujiwara, Yasuhiro, Fushiki, Shinji·2008·Biochemical and Biophysical Research Communications

Abstract

Bisphenol A (BPA) is one of endocrine disrupting chemicals, being distributed widely in the environment. We have been studying the low dose effects of BPA on murine forebrain development. Here, we have investigated the genome-wide effect of maternal exposure to BPA on the epigenome in mouse forebrain at E12.5 and at E14.5. We scanned CpG methylation status in 2500 NotI loci, representing 48 (de)methylated unique loci. Methylation status in most of them was primarily developmental stage-dependent. Each of almost all cloned NotI loci was located in a CpG island (CGI) adjacent to 5' end of the transcriptional unit. The mRNA expression of two functionally related genes changed with development as well as the exposure to BPA. In both genes, changes at the transcriptional level correlated well with the changes in NotI methylation status. Taken together, epigenetic alterations in promoter-associated CGIs after exposure to BPA may underlie some effects on brain development.

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Crossref · 10.1016/j.bbrc.2008.09.028

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Authors
Yaoi, T., Itoh, K., Nakamura, K., Ogi, H., Fujiwara, Y., & Fushiki, S.
Affiliations
Kyoto Prefectural University of Medicine (JP)
Corresponding author
Fushiki, Shinji
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2008-11
Volume
376
Issue
3
Pages
563-567
ISSN
0006-291X (ISSN-L)
OpenAlex
W2003636092
Cited by
229
References
23
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 9 · 2019: 11 · 2018: 8 · 2017: 18 · 2016: 16 · 2015: 22 · 2014: 21 · 2013: 19 · 2012: 30
FWCI
6.03
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
bisphenol A, endocrine disruptors, maternal exposure, DNA methylation, CpG islands, promoter methylation, gene expression, low-dose exposure, mouse embryo
MeSH terms
Bisphenol A Compounds, Air Pollutants, Occupational, Animals, Benzhydryl Compounds, Estrogens, Non-Steroidal, Female, Fetus, Major Histocompatibility Complex, Mice, Inbred ICR, Phenols, Promoter Regions, Genetic, Proteins, Gene Expression, Prosencephalon, Genome, Maternal Exposure, CpG Islands, DNA Methylation, Genomics, Vesicular Transport Proteins, Epigenesis, Genetic, Mice

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