A role for lipoxin A4 as an anti-inflammatory mediator in the human endometrium
Open accessAbstract
Lipoxin A4 is a lipid mediator that elicits anti-inflammatory and pro-resolution actions via its receptor, formyl peptide receptor 2 (FPR2/ALX). In this study, we aimed to investigate the expression and potential role of lipoxin A4 and FPR2/ALX in the regulation of inflammation associated with cyclical remodeling of the human endometrium across the menstrual cycle and during early pregnancy. Using quantitative RT-PCR analysis, we found that FPR2/ALX expression is upregulated during the menstrual phase of the cycle and in decidua tissue from the first trimester of pregnancy. We localized the site of expression of FPR2/ALX in menstrual phase endometrium and first-trimester decidua tissue to glandular epithelial cells and cells within the stromal compartment, including cells lining the blood vessels and immune cells. Measurement of serum lipoxin A4 by ELISA revealed no difference in its levels across the menstrual cycle but an elevation in early pregnancy (P<0.001). We found that lipoxin A4 was regulated by human chorionic gonadotrophin (hCG) during early pregnancy, because treatment of human decidua tissue with hCG increased lipoxin A4 release (P<0.01). Finally, we have shown that lipoxin A4 can suppress phorbol myristate acetate-induced expression of the inflammatory cytokines interleukin 6 and 8 in human endometrium and decidua tissue. These results demonstrate for the first time that lipoxin A4 and its receptor FPR2/ALX can regulate inflammatory events in the human endometrium and decidua of early pregnancy.
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Lipoxin A4 and its receptor FPR2/ALX can regulate inflammatory events in the human endometrium and decidua of early pregnancy.
“Conversely, it has been shown that lipoxin A4 and its receptor FPR2/ALX can regulate inflammatory events in the human endometrium and decidua of early pregnancy.66”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [66]
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- Authors
- Macdonald, L. J., Boddy, S. C., Denison, F. C., Sales, K. J., & Jabbour, H. N.
- Affiliations
- The Queen's Medical Research Institute (GB)
- Corresponding author
- Jabbour, Henry N
- Venue
- Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-08-01
- Volume
- 142
- Issue
- 2
- Pages
- 345-352
- ISSN
- 1470-1626 (ISSN-L)
- 1741-7899
- PMC
- PMC3139491
- OpenAlex
- W2097930657
- Cited by
- 65
- References
- 47
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 10 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 11 · 2012: 1
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Reproduction (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (publishedVersion, other-oa)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- lipoxin A4, FPR2/ALX, endometrium, decidua, menstrual cycle, early pregnancy, inflammation resolution, human chorionic gonadotropin, interleukin-6, interleukin-8, endometrial remodeling, lipid mediators
- MeSH terms
- Adult, Decidua, Endometrium, Epithelial Cells, Female, Gene Expression Regulation, Chorionic Gonadotropin, Humans, Interleukins, Menstrual Cycle, Pregnancy, Pregnancy Trimester, First, RNA, Messenger, Tetradecanoylphorbol Acetate, Stromal Cells, Inflammation Mediators, Receptors, Formyl Peptide, Lipoxins, Receptors, Lipoxin, Tissue Culture Techniques, Young Adult
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