Mast cell proteinases activate precursor forms of collagenase and stromelysin, but not of gelatinases A and B.

LEES, Martyn; TAYLOR, David J.; WOOLLEY, David E.

doi:10.1111/j.1432-1033.1994.tb18980.x

Cited by 178Protease and Inhibitor MechanismsMast cells and histamineBlood Coagulation and Thrombosis Mechanisms

Mast cell proteinases activate precursor forms of collagenase and stromelysin, but not of gelatinases A and B.

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LEES, Martyn, TAYLOR, David J., WOOLLEY, David E.·1994·European Journal of Biochemistry

DOI 10.1111/j.1432-1033.1994.tb18980.x

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Abstract

Mast cell activation in vivo is often associated with areas of oedema and connective-tissue degradation. Tryptase and chymase are the major serine proteinases released by mast cells, but they appear to have little activity on most components of the extracellular matrix. The matrix metalloproteinases (MMP) are purported to degrade almost all connective tissue elements and are secreted by cells in the form of inactive precursors. Since the mechanisms of MMP activation in vivo are poorly understood we have examined the potential of mast cell proteinases to activate the precursor forms of human collagenase (MMP-1), stromelysin (MMP-3), gelatinase A (MMP-2) and gelatinase B (MMP-9). Mast cell proteinases prepared from purified dog mastocytoma cells were shown to process and activate purified precursor forms of both MMP-1 and MMP-3. Using antipain and chymostatin, inhibitors for tryptase and chymase, respectively, it was demonstrated that both pMMP-1 and pMMP-3 were effectively processed and activated by the chymase component. By contrast, tryptase activated only pMMP-3. The mast cell proteinases were unable to process or activate purified precursor forms of MMP-2 and MMP-9. However, MMP-3 previously activated by mast cell proteinases was shown to activate pMMP-9, but not pMMP-2. Since we have no evidence that mast cells express these four metalloenzymes, the release of mast cell serine proteinases following activation/degranulation could contribute to local metalloproteinase activation and subsequent matrix degradation.

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Mast cell tryptases and chymases activate the precursors of MMP2, MMP9, collagenase and stromelysin.
“Moreover, MC tryptases and chymases have been shown to activate the precursors of MMP2 [12], MMP9 [13], collagenase and stromelysin [14].”
From Estradiol and Progesterone Regulate the Migration of Mast Cells from the Periphery to the Uterus and Induce Their Maturation and Degranulation (2010) · cites this paper as [14]

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Authors: LEES, M., TAYLOR, D. J., & WOOLLEY, D. E.
Affiliations: University of Manchester (GB)
Corresponding author: WOOLLEY, David E.
ORCID: TAYLOR, David J.
Venue: European Journal of Biochemistry
Publisher: Wiley
Published: 1994-07
Volume: 223
Issue: 1
Pages: 171-177
ISSN: 0014-2956 (ISSN-L)
1432-1033
DOI: 10.1111/j.1432-1033.1994.tb18980.x
OpenAlex: W1995941626
Cited by: 178
References: 38
Citations by year: 2026: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 3
FWCI: 5.13
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3898 d)
Locations: European Journal of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Keywords: mast cells, matrix metalloproteinase activation, collagenase, stromelysin, MMP-2, MMP-9, tryptase, chymase, serine protease, extracellular matrix degradation, connective tissue, mastocytoma cells, degranulation, edema
MeSH terms: Amino Acid Sequence, Animals, Dogs, Enzyme Activation, Enzyme Precursors, Extracellular Matrix, Humans, Mast Cells, Metalloendopeptidases, Molecular Sequence Data, Endopeptidases, Collagenases, Gelatinases, Matrix Metalloproteinase 3, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9

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Mast cell proteinases activate precursor forms of collagenase and stromelysin, but not of gelatinases A and B.

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