Cited by 783Cytokine Signaling Pathways and InteractionsImmune Response and InflammationInflammasome and immune disorders

The DOI matches its Crossref record.

The interleukin‐1 family: 10 years of discovery 1

Dinarello, Charles A.·1994·The FASEB Journal

DOI 10.1096/fasebj.8.15.8001745

Open this paper in CoChat — free account

Abstract

Ten years ago the cloning of two interleukin-1 molecules (IL-1 alpha and IL-1 beta) resolved the question of whether a single polypeptide could evoke a wide variety of biological effects. During the past decade, the biology of IL-1 has greatly expanded our understanding of how the host responds to external challenges, such as injury and infection, as well as its role in several diseases. We learned of the remarkable potency of IL-1 in the femtomolar range and of its ability to induce a response by triggering only one or two receptors per cell. Unexpectedly, the IL-1 family of genes, receptors and associated molecules have been linked to those of Drosophila, nematodes, and microorganisms and IL-1 signal transduction is similar to that observed after cellular stress. The cloning of IL-1 opened other avenues of fundamental biological interest. For example, in addition to the two agonist molecules IL-1 alpha and IL-1 beta, a third member of the IL-1 gene family is a specific, high affinity receptor antagonist (IL-1 receptor antagonist). That this third member of the IL-1 family inhibits the other two is characteristic of the tight control over production and activity exerted on IL-1. Although IL-1 contributes to the pathogenesis of many diseases, a small amount appears to be needed to combat infection and initiate healing processes. This article highlights 10 years of discoveries on IL-1.

Integrity signals

Registry

Crossref · 10.1096/fasebj.8.15.8001745

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 501–600 of 783

Interleukin-6 Receptor rs7529229 T/C Polymorphism Is Associated with Left Main Coronary Artery Disease Phenotype in a Chinese Population
He, F., Teng, X., Gu, H., Liu, H., Zhou, Z., Zhao, Y., Hu, S., & Zheng, Z. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15045623 · Cited by 15
“) plays a major role in inflammation by affecting antigen recognition patterns and lymphocyte function [9].”
Background
The Preferential Use of Anakinra in Various Settings of FMF: A Review Applied to an Updated Treatment-Related Perspective of the Disease
Giat, E., Ben‐Zvi, I., Lidar, M., & Livneh, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073956 · Cited by 15
The effect of clonidine on VEGF expression in human retinal pigment epithelial cells (ARPE-19)
Watanabe, K., Zhang, X., Kitagawa, K., et al. (2008) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-008-0990-5 · Cited by 16
“IL-1β is the primary inflammatory cytokine produced by a variety of cells, and plays a fundamental role in inflammatory responses [12].”
Background
Vaccination with an Attenuated Strain of Francisella novicida Prevents T-Cell Depletion and Protects Mice Infected with the Wild-Type Strain from Severe Sepsis
Sharma, J., Li, Q., Mishra, B. B., Georges, M. J., & Teale, J. M. (2009) · Infection and Immunity · doi:10.1128/iai.00654-09 · Cited by 16
“Unbridled production of inflammatory immune mediators during severe sepsis can result in capillary leakage, tissue injury, lethal organ failure, and mitochondrial dysfunction leading to inhibition of oxidative respiration (6, 12, 18, 51, 62).”
Background
Rheumatoid Arthritis and Tumor Necrosis Factor α
Abe, T., & Takeuchi, T. (2001) · Autoimmunity · doi:10.3109/08916930109014698 · Cited by 16
Positive inotropic effect of ceramide in adult ventricular myocytes: mechanisms dissociated from its reduction in Ca2+influx
Liu, S. J., & Kennedy, R. H. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01098.2002 · Cited by 16
Synthesis of type II interleukin-1 receptors by human corneal epithelial cells but not by keratocytes.
Cubitt, C. L., Lausch, R. N., & Oakes, J. E. (2001) · PubMed · Cited by 16
Cytokines, Adhesion Molecules, Antiendothelial Cell Autoantibodies and Vascular Disease
Carvalho, D., & Savage, C. O. S. (1997) · Cardiovascular Pathology · doi:10.1016/s1054-8807(96)00065-8 · Cited by 16
Cytokines and preterm labour
Mazor, M., Cohen, J., Romero, R. J., Ghezzi, F., Tolosa, J. E., & Gómez, R. (1995) · Fetal and Maternal Medicine Review · doi:10.1017/s0965539500001339 · Cited by 15
Cytochrome P450 down-regulation by serum from humans with a viral infection and from rabbits with an inflammatory reaction.
Bleau, A., Fradette, C., El‐Kadi, A. O. S., et al. (2001) · PubMed · Cited by 16
The Role of Antibiotic Therapy in the Prevention of Prematurity
Mazor, M., Chaim, W., Maymon, E., Hershkovitz, R., & Romero, R. J. (1998) · Clinics in Perinatology · doi:10.1016/s0095-5108(18)30104-0 · Cited by 15
Matrix Metalloproteinases and the Pathogenesis of Recurrent Corneal Erosions and Epithelial Basement Membrane Dystrophy
Jadczyk-Sorek, K., Garczorz, W., Bubała-Stachowicz, B., et al. (2023) · Biology · doi:10.3390/biology12091263 · Cited by 15
“IL-1 also intensiﬁes the chemotactic effects of PDGF on corneal ﬁbroblasts [30,44].”
Joint Application of Multiple Inflammatory Cytokines in Diagnosis of Gout Flare
Yu, H., Xue, W., Yu, H., Gu, H., Qin, L., & Peng, A. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s408929 · Cited by 16
Evolution of cytokine responses: IL-1β directly affects intracellular Ca2+ concentration of teleost fish leukocytes through a receptor-mediated mechanism
Benedetti, S., Randelli, E., Buonocore, F., Zou, J., Secombes, C. J., & Scapigliati, G. (2006) · Cytokine · doi:10.1016/j.cyto.2006.03.009 · Cited by 15
“The cytokine IL-1b is a potent mediator of inflammatory and immune responses to injury and infection [44], and its multiple biological activities are exerted through receptor-mediated processes and complex intracellular pathways of second messengers.”
Background
INTERLEUKIN-1 RECEPTOR ANTAGONIST GENE POLYMORPHISM AND TRADITIONAL CLASSIFICATION IN OBESE WOMEN
Um, J., Kim, H., MUN, S.-W., Song, Y., & Hong, S. (2005) · International Journal of Neuroscience · doi:10.1080/00207450690962334 · Cited by 15
“The third component, IL-1ra, is an endogenous inhibitor that antagonizes many of the biological actions of IL-1β by competitive inhibition (Dinarello, 1994).”
Background
Nucleoside Diphosphate Kinase and Flagellin from Pseudomonas aeruginosa Induce Interleukin 1 Expression via the Akt/NF-κB Signaling Pathways
Kim, Y., Lee, J., Lee, Y., Jia, J., Paek, S., Kim, H.-B., Jin, S., & Ha, U. (2014) · Infection and Immunity · doi:10.1128/iai.02007-14 · Cited by 16
“IL-1 and IL-1 are proinflammatory cytokines produced by diverse cell types, including epithelial cells, endothelial cells, fibroblasts, and macrophages (4).”
Background
Scaffolds for corneal tissue engineering
Yousaf, S., Keshel, S. H., Farzi, G. A., Momeni-Moghadam, M., Ahmadi, E. D., Asencio, Í. O., Mozafari, M., & Sefat, F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102561-1.00026-9 · Cited by 18
The association between Interleukin-1β gene polymorphisms and the risk of breast cancer: a systematic review and meta-analysis
Wang, B., & Yuan, F. (2021) · Archives of Medical Science · doi:10.5114/aoms/99839 · Cited by 15
“Interleukin 1β can be produced by various cells and it modifies the process of host response to microbial invasion, tissue injury and inflammation [7].”
Background
Comparison study of Korean and Chinese ginsengs on the regulation of lymphocyte proliferation and cytokine production
이범준 (2008) · Journal of Ginseng Research · doi:10.5142/jgr.2008.32.3.250 · Cited by 15
High-mobility-group box chromosomal protein 1 as a new target for modulating stress response
Suda, K., Takeuchi, H., Ishizaka, A., & Kitagawa, Y. (2010) · Surgery Today · doi:10.1007/s00595-009-4232-1 · Cited by 15
IN VITRO MODULATION OF CISPLATIN RESISTANCE BY CYTOKINES
Poppenborg, H., Knüpfer, M. M., Galla, H.-J., et al. (1999) · Cytokine · doi:10.1006/cyto.1998.0473 · Cited by 15
Interleukin-1 System and Sex Steroid Receptor Gene Expression in Human Endometrial Cancer
Singer, C. F., Kronsteiner, N., Marton, E., et al. (2002) · Gynecologic Oncology · doi:10.1006/gyno.2002.6598 · Cited by 15
Molecular regulation of the brain interleukin-1β system in obese (fa/fa) and lean (Fa/Fa) Zucker rats
Ilyin, S. E., & Plata‐Saláman, C. R. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00178-7 · Cited by 15
IL-1RN VNTR polymorphism as a susceptibility marker for nasopharyngeal carcinoma in Portugal
de Sousa, H. M. L., Breda, E. R., Santos, A. M., et al. (2013) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2013.02.004 · Cited by 14
Novel imaging tools for investigating the role of immune signalling in the brain
Jacobsen, J. H. W., Parker, L. M., Everest‐Dass, A., Schartner, E. P., Tsiminis, G., Staikopoulos, V., Hutchinson, M. R., & Mustafa, S. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.04.014 · Cited by 14
Anti-Inflammatory Role of Natural Polyphenols and Their Degradation Products
Veres, B. (2012) · InTech eBooks · doi:10.5772/27889 · Cited by 14
“Similar to TNF-┙ and HMGB1, several proinflammatory cytokines and factors, such as IL-1 (Dinarello, 1994), IL-6, IL-8 (Calandra et al., 1990; Hotchkiss et al., 2000) macrophage migration inhibitory factor (Parrish et al., 2008) and lysophosphatidylcholine (Kabarowski et al., 2001), contribute to…”
BackgroundInfluential
The association of IL1α and IL1β polymorphisms with susceptibility to systemic lupus erythematosus: A meta-analysis
Wang, B., Zhu, J., Fan, Y., Feng, C.-C., Chen, G.-M., Chen, H., Pan, H., & Ye, D. (2013) · Gene · doi:10.1016/j.gene.2013.05.059 · Cited by 14
Is interleukin-1α a luteotrophic or luteolytic agent in cattle?
Majewska, M., Wocławek-Potocka, I., Bah, M. M., et al. (2009) · Reproduction · doi:10.1530/rep-09-0328 · Cited by 14
MABp1 for the treatment of colorectal cancer
Coyne, G. O., & Burotto, M. (2017) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2017.1347631 · Cited by 14
“Both isoforms are not only crucial for the immune response, they additionally induce a cascade of biological reactions including metabolic, neurological, and hematological changes, which have been well documented various decades ago [10].”
Background
Regulation of interleukin-6 and interleukin-1β gene expression in the mouse deciduum
Liang, L., Kover, K. L., Dey, S. K., & Andrews, G. K. (1996) · Journal of Reproductive Immunology · doi:10.1016/0165-0378(95)00953-1 · Cited by 14
Differential effects of protein kinase C inhibitors on fibronectin‐induced interleukin‐β gene transcription, protein synthesis and secretion in human monocytic cells
Ritzenthaler, RITZENTHALER, ROMAN, et al. (1998) · Immunology · doi:10.1046/j.1365-2567.1998.00597.x · Cited by 14
Antígeno prostático-específico, citoquinas pro-inflamatorias y patología prostática (Hiperplasia benigna y Cáncer): Relación con la malignidad
Alcaide, J. R. C., Martín, R. V. S., de Bethencourt, F. R., Bouraoui, Y., Berriguete, G. R., Oueslati, R., Pérez-Utrilla, M., Barthel, J. D. L. P., Paniagua, R., & García, M. R. (2009) · Archivos Españoles de Urología · doi:10.4321/s0004-06142009000500005 · Cited by 13
Mitogen‐activated protein kinases mediate interleukin‐1β‐induced receptor activator of nuclear factor‐κB ligand expression in human periodontal ligament cells
Oikawa, A., Kobayashi, M., Okamatsu, Y., Shinki, T., Kamijo, R., Yamamoto, M., & Hasegawa, K. (2007) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2006.00959.x · Cited by 13
Impact of IL 1R1 and IL 1R2 gene polymorphisms on risk of osteonecrosis of the femoral head from a case–control study
An, F., Wang, J., Wang, J., et al. (2019) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.557 · Cited by 13
“Study showed that IL1R1 and IL1R2 genes could regulate the cell metabolism, and the response of immune inflammatory induced by many cytokines (Dinarello, 1994; Rock, Hardiman, Timans, Kastelein, & Bazan, 1998).”
Background
A traditional Japanese medicine mitigates TNBS-induced colitis in rats
Fukuda, Y., Tao, Y., Tomita, T., et al. (2006) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520600575704 · Cited by 13
“IL-1b is a potent mediator that activates a number of immune and inflammatory cells [31].”
Background
Temperature Regulation and the Pathogenesis of Fever
Mackowiak, P. A. (2010) · Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases · doi:10.1016/b978-0-443-06839-3.00050-3 · Cited by 12
Polymorphism of interleukin-1 receptor antagonist gene and obesity
Um, J., Lee, K., & Kim, H. (2003) · Clinica Chimica Acta · doi:10.1016/j.cccn.2003.10.016 · Cited by 13
Soluble IL‐1 receptor type I binds to human dermal fibroblasts and induces calcium flux
Spörri, B., Wiesmann, U. N., Ochsenbein, R. M., et al. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00995-8 · Cited by 13
EARLY DETECTION AND MARKERS OF SEPSIS
Parsons, P. E., & Moss, M. M. (1996) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(05)70309-9 · Cited by 13
Inhibition of interleukin-1 type I receptor expression in human cell-lines by an antisense phosphorothioate oligodeoxynucleotide
Miraglia, L. J., Geiger, T. M., Bennett, C. F., et al. (1996) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(96)84502-4 · Cited by 13
Adenosine A3 receptors negatively regulate the engulfment-dependent apoptotic cell suppression of inflammation
Duró, E., Pallai, A., Köröskényi, K., Sarang, Z., & Szondy, Z. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.014 · Cited by 12
Polymorphisms in host immune response associated genes and risk of nasopharyngeal carcinoma development in Portugal
de Sousa, H. M. L., Mesquita, L., Ribeiro, J., et al. (2015) · Immunobiology · doi:10.1016/j.imbio.2015.09.015 · Cited by 12
“The interleukin 1 (IL-1) family, considered crucial in the reguation of immune response, includes Interleukin 1 alpha (IL-1 ), nterleukin 1 beta (IL-1 ) and Interleukin 1 receptor antagonist IL-1RN) (Dinarello, 1994; Dinarello and Wolff, 1993).”
Background
Signalling in response to sub‐picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity
Civciristov, S., & Halls, M. L. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14636 · Cited by 14
“The IL family of cytokines are highly potent molecules (potency in the femtomolar range) that are able to evoke a cellular response by activating only one or two receptors per cell (reviewed in Dinarello, 1994).”
Background
Role of Cytokines
Khan, M. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-30273-7_2 · Cited by 12
Pro- and anti-inflammatory mediators change leukotriene B4 and leukotriene C4 synthesis and secretion in an inflamed porcine endometrium
Czarzasta, J., Andronowska, A., & Jana, B. (2014) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2014.05.001 · Cited by 12
An insertion/deletion polymorphism at the microRNA-122 binding site in the interleukin-1α 3′-untranslated region is associated with a risk for osteoarthritis
Yang, F., HU, A., Zhao, D., Guo, L., Yang, L., Wang, B., Tian, F., Liu, B., Huang, S., & Xie, H. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4121 · Cited by 12
Insertion/deletion polymorphism in IL1A 3′‐UTR is associated with susceptibility to endometrial cancer in Chinese Han women
Yu, X., Zhou, B., Zhang, Z., et al. (2016) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12989 · Cited by 12
“It seems to play an important role in tissue-lytic processes and affects physiological tissue shedding and menstrual bleeding.(22,23) Interestingly, while Chopra et al.”
Background
Endometrial injection of embryo culture supernatant for subfertile women in assisted reproduction
Siristatidis, C. S., Sertedaki, E., Karageorgiou, V., & Vaidakis, D. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013063.pub2 · Cited by 12
“[DOI: 10.1016/S1472-6483(10)60626-8] Dinarello 1994 Dinarello CA.”
BackgroundInfluential
Interleukin-1 system in the human fallopian tube—No spatial but a temporal regulation of mRNA and protein expression
Hess, A. P., Baston-Buest, D. M., Schanz, A., Hirchenhain, J., Bielfeld, P., & Krüssel, J.-S. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.01.017 · Cited by 12
Adenosine triphosphate affects interleukin -1β release by T98G glioblastoma cells through a purinoceptor-independent mechanism
de Joannon, A. C., Mancini, F. R., Landolfi, C., et al. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01051-x · Cited by 12
Molecular decoys: antidotes, therapeutics and immunomodulators
Gershoni, J. M. (2008) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2008.10.001 · Cited by 12
“Interleukin I was one of the first cytokines to be discovered and is responsible for triggering a diversity of physiological effects such as fever, augmentation of lymphocyte responses and induction of degenerative changes in joints [48].”
Background
Localization and regulation of IL-1α in rat myometrium during late pregnancy and the postpartum period
Melendez, J. A., Vinci, J. M., Jeffrey, J. J., & Wilcox, B. D. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.3.r879 · Cited by 12
Disease-Modifying Antirheumatic Drug use in the Elderly Rheumatoid Arthritis Patient
Ranganath, V. K., & Fürst, D. E. (2005) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2005.02.010 · Cited by 12
Expression of the mRNA for Types I and II Interleukin-1 Receptors in Dental Tissues of Mice During Tooth Development
Xu, L. X., Kukita, T., Hai, Y., et al. (1998) · Calcified Tissue International · doi:10.1007/s002239900539 · Cited by 12
3-chloro-4-carboxamido-6-arylpyridazines as a non-peptide class of interleukin-1β converting enzyme inhibitor
Dolle, R. E., Hoyer, D., Rinker, J. M., et al. (1997) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(97)00145-5 · Cited by 12
CHOP, a Basic Leucine Zipper Transcriptional Factor, Contributes to the Antiproliferative Effect of IL-1 on A375 Human Melanoma Cells Through Augmenting Transcription of IL-6
Hattori, T., Itoh, S., Hayashi, H., et al. (2001) · Journal of Interferon & Cytokine Research · doi:10.1089/107999001300177510 · Cited by 12
Interleukin-1β switches electrophysiological states of synovial fibroblasts
Kolomytkin, O. V., Marino, A. A., Sadasivan, K. K., et al. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.5.r1822 · Cited by 12
Both IRAK3 and IRAK1 Activate the MyD88–TRAF6 Pathway in Zebrafish
Weng, P., Lan, M., Zhang, H., Fan, H., Wang, X., Ran, C., Yue, Z., Hu, J., Xu, A., & Huang, S. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2400054 · Cited by 11
Keeping the bad bacteria in check: interactions of the host immune system with oral cavity biofilms
Lang, M. L., Zhu, L. D., & Kreth, J. (2010) · Endodontic Topics · doi:10.1111/j.1601-1546.2012.00278.x · Cited by 11
Enhancement of Impaired MRSA-Infected Fracture Healing by Combinatorial Antibiotics and Modulation of Sustained Inflammation
Yu, K. E., Kwon, H., Dussik, C. M., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4570 · Cited by 11
“diate systemic VR therapy and those that were left untreated, F (5, 12) = 28.”
Background
A follow-up to "Anti-cytokine therapy in chronic destructive arthritis" by Wim B van den Berg.
Brennan, F. M. (2001) · Arthritis Research · doi:10.1186/ar302 · Cited by 11
Cell-type specificity of interleukins 1α and 1β on prostaglandin and plasminogen activator production in bovine endometrial cells
Tanikawa, M., Kim, T., Okuda, K., et al. (2008) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2008.09.003 · Cited by 11
Strain-dependent behavioral alterations induced by peripheral interleukin-1 challenge in neonatal mice
Tsuda, N., Tohmi, M., Mizuno, M., & Nawa, H. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.07.007 · Cited by 11
Differential gene regulation of interleukin-1 ligands and receptors in bovine peripheral blood neutrophils and mononuclear cells in response to E. coli lipopolysaccharide (LPS)
Beckman, M. J., Sotos, J., Leite, F. P. L., et al. (2000) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(00)00242-7 · Cited by 11
Growth factors and gut function
Seare, N. J., & Playford, R. J. (1998) · Proceedings of The Nutrition Society · doi:10.1079/pns19980057 · Cited by 11
Cytokines and Endocrine Function
Spangelo, B. L. (1997) · Humana Press eBooks · doi:10.1007/978-1-59259-641-6_8 · Cited by 11
The Function of Myostatin in Ameliorating Bone Metabolism Abnormalities in Individuals with Type 2 Diabetes Mellitus by Exercise
Zhong, C., Zeng, X., Yi, X., Yang, Y., Hu, J., Yin, R., & Chen, X. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47030158 · Cited by 11
Preliminary Study on TNF-Blocker Activity of Amygdalus lycioides Spach Extracts
Gaggeri, R., Rossi, D., Hajikarimian, N., et al. (2010) · The Open Natural Products Journal · doi:10.2174/1874848101003010020 · Cited by 10
Protein kinase C modulates the pulmonary inflammatory response in acute pancreatitis
Zhao, X., Shi, C., Wang, X., & Andersson, R. E. (2005) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2005.07.005 · Cited by 10
Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice
Pozsgai, G., Sándor, K., Perkecz, A., et al. (2007) · Inflammation Research · doi:10.1007/s00011-007-7065-7 · Cited by 10
“It can be produced by many cell types: mononuclear cells, fi broblasts, synoviocytes and endothelial cells on tissue damage [33].”
Background
Efficacy of Cytokine Removal by Plasmadiafiltration Using a Selective Plasma Separator: In Vitro Sepsis Model
Li, M., Xue, J., Liu, J., et al. (2010) · Therapeutic Apheresis and Dialysis · doi:10.1111/j.1744-9987.2010.00850.x · Cited by 10
Novel irreversible caspase-1 inhibitor attenuates the maturation of intracellular interleukin-1β
Ma, X., Zhang, H.-J., Zhang, Y., et al. (2007) · Biochemistry and Cell Biology · doi:10.1139/o06-149 · Cited by 10
Proteome and cytokine serum profiling to diagnose a mycosis fungoides
Moshkovskii, S. A., Sokolova, E., Brattseva, E. V., et al. (2011) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201000165 · Cited by 10
“IL-1ra (IL 1 receptor antagonist) is a cytokine that is competitive with IL-1a and IL-1b molecules for binding to IL-1-receptor and modulating in such a way their inflammatory activity [24].”
Background
Enprostil, a Prostaglandin‐E2 Analogue, Inhibits Interleukin‐8 Production of Human Colonic Epithelial Cell Lines
Toshina, K., Hirata, I., Maemura, K., et al. (2000) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2000.00815.x · Cited by 10
IL-1β mediates diethyldithiocarbamate-induced granulocyte colony-stimulating factor production and hematopoiesis
Kennedy, S. M., & Borch, R. F. (1999) · Experimental Hematology · doi:10.1016/s0301-472x(98)00033-2 · Cited by 10
Intracellular Interleukin-1α Production in Human Gingival Fibroblasts is Differentially Regulated by Various Cytokines
Kobayashi, M., Okada, N., Okamatsu, Y., Mugikura, K., Nishihara, T., Hanazawa, S., Kitano, S., & Hasegawa, K. (1999) · Journal of Dental Research · doi:10.1177/00220345990780040401 · Cited by 10
Protective Effects of Interleukin‐1 Inhibition With Anakinra in Mouse Models of Ischemic Stroke With and Without Reperfusion
Chaparro‐Cabanillas, N., Aliena‐Valero, A., Pedragosa, J., Pedrosa, L., Honores, M., Rossinyol‐Boladeres, M., Salom, J. B., Chamorro, Á., Aróstegui, J. I., Urra, X., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.040474 · Cited by 8
Negative regulation of interleukin 1β expression in response to DnaK from Pseudomonas aeruginosa via the PI3K/PDK1/FoxO1 pathways
Lee, J., Jeon, J., Bai, F., Wu, W., & Ha, U. (2020) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2020.101543 · Cited by 8
Interleukin-1 receptor antagonist: From synthesis to therapeutic applications
Rehman, K., Afzaal, A., Akash, M. S. H., Imran, M., & Assiri, M. A. (2023) · Biocell · doi:10.32604/biocell.2023.025850 · Cited by 8
IL-1β alters hemodynamics in newborn intestine: role of endothelin
Nowicki, P. T. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00042.2006 · Cited by 9
Injection of day 2 embryo culture supernatant into the uterine cavity did not improve the pregnancy rate of day 3 embryo transfer in patients who underwent in vitro fertilization-embryo transfer: a randomized clinical trial
Zhu, W., Li, X., Fu, Z., et al. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.01.098 · Cited by 9
“Interleukin-1 (IL-1) system that is composed of two agonists, Interleukin-1a (IL-1a) and –b (IL-1b), one antagonist, the Interleukin-1receptor antagonist (IL-1ra) and two membrane-bound receptors, Interleukin-1 receptor type I (IL-1RtI) and II (IL-1RtII) (6) has been identified as a major factor that modulates the com…”
Background
Regulation of uterine function by cytokines in cows: Possible actions of tumor necrosis factor‐α, interleukin‐1α and interferon‐τ
Okuda, K., & Sakumoto, R. (2006) · Animal Science Journal · doi:10.1111/j.1740-0929.2006.00348.x · Cited by 9
Effect of suppression of postpartum ovulation on endometrial inflammation in dairy cows
Heppelmann, M., Brömmling, A., Ulbrich, S. E., Weinert, M., Piechotta, M., Wrenzycki, C., Merbach, S., Schoon, H., Hoedemaker, M., & Bollwein, H. (2015) · Theriogenology · doi:10.1016/j.theriogenology.2015.03.003 · Cited by 9
“proinflammatory cytokines play a key role in early inflammation by stimulating acute-phase proteins and other cytokines (IL-6) and enhancing lymphocyte response and neutrophil recruitment [28,41].”
Background
The Impact of Photoperiod on the Leptin Sensitivity and Course of Inflammation in the Anterior Pituitary
Wójcik, M., Herman, A. P., Zieba, D. A., & Krawczyńska, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114153 · Cited by 9
“The IL1 receptor family consists of type I (IL1R1) and type II (IL1R2) receptors [68].”
Background
Interleukin-1β Gene Transcription in U937 Cells Is Modulated by Type I Collagen and Cytoskeletal Integrity via Distinct Signaling Pathways
Ritzenthaler, J. D., & Roman, J. (2001) · Journal of Interferon & Cytokine Research · doi:10.1089/107999001750069971 · Cited by 9
Phosphatidylinositol 3-kinase translocation to the nucleus is an early event in the Interleukin-1 signalling mechanism in human osteosarcoma SAOS-2 cells
Maraldi, N. M., Marmiroli, S., Rizzoli, R., et al. (1999) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(98)00021-1 · Cited by 9
Impaired regulation of immune responses in cognitive decline and Alzheimer’s disease: lessons from genetic association studies
Chiappelli, M., Tumini, E., Porcellini, E., & Licastro, F. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.9.1327 · Cited by 10
Src-Regulated Extracellular Signal-Related Kinase and Syk-Regulated c-Jun N-Terminal Kinase Pathways Act in Conjunction to Induce IL-1 Synthesis in Response to Microtubule Disruption in HL60 Cells
Cambien, B., Millet, M.-A., Schmid‐Antomarchi, H., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.9.5079 · Cited by 9
Inhibition of acetylcholinesterase activity by rivastigmine decreases lipopolysaccharide-induced IL-1β expression in the hypothalamus of ewes
Herman, A. P., Krawczyńska, A., Bochenek, J., Haziak, K., Antushevich, H., Herman, A., & Tomaszewska-Zaremba, D. (2012) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2012.10.003 · Cited by 8
“It is initially synthesized as a 31-kDa precursor, which exhibits a low biological activity, and is converted to the active 17-kDa form and released into the extracellular space [6].”
Influential
The benefit of minocycline on negative symptoms in early-phase psychosis in addition to standard care - extent and mechanism (BeneMin): study protocol for a randomised controlled trial
Lisiecka, D. M., John Suckling, A., Barnes, T. R. E., Chaudhry, I. B., Dazzan, P., Husain, N., Jones, P. B., Joyce, E. M., Lawrie, S. M., Upthegrove, R., et al. (2015) · Trials · doi:10.1186/s13063-015-0580-x · Cited by 8
“Measurements of IL-6, IL-1RA and MCP-1 will follow a method applied in previous studies of stroke [91,92] and will use multiplex (Luminex®, Manchester, UK) assays.”
Bead Packing and Release Using Flexible Polydimethylsiloxane Membrane for Semi‐Continuous Biosensing
Yoo, S. K., Kim, Y., Yoon, S. Y., et al. (2011) · Artificial Organs · doi:10.1111/j.1525-1594.2011.01240.x · Cited by 8
“Systemic inflammatory response is induced by activation of complement, neutrophils, and platelets, as well as the release of proinflammatory cytokines including tumor necrosis factor a and several different interleukins (IL-1, IL-6, and IL-8) (23).”
Background
Vascular hyperpermeability as a hallmark of phacomatoses: is the etiology angiogenesis related to or comparable with mechanisms seen in inflammatory pathways? Part II: angiogenesis- and inflammation-related molecular pathways, tumor-associated macrophages, and possible therapeutic implications: a comprehensive review
Laviv, Y., Kasper, B. S., & Kasper, E. M. (2017) · Neurosurgical Review · doi:10.1007/s10143-017-0837-9 · Cited by 8
Multiple Urinary Cytokine Levels of Bacterial Cystitis
Davidoff, R., Yamaguchi, R., Leach, G. E., et al. (1997) · The Journal of Urology · doi:10.1097/00005392-199705000-00125 · Cited by 8
Acute Cytokine Responses to Inhaled Swine Confinement Building Dust
Wang, Z. (1997) · Figshare · Cited by 8
Immune system benefits of pulmonary rehabilitation in chronic obstructive pulmonary disease
Abbasi, A., Wang, D., Stringer, W. W., Casaburi, R. H., & Rossiter, H. B. (2024) · Experimental Physiology · doi:10.1113/ep091678 · Cited by 7
Cancer-Associated Stromal Cells Promote the Contribution of MMP2-Positive Bone Marrow-Derived Cells to Oral Squamous Cell Carcinoma Invasion
Oo, M. W., Kawai, H., Takabatake, K., Shan, Q., Eain, H. S., Sukegawa, S., Nakano, K., & Nagatsuka, H. (2021) · Cancers · doi:10.3390/cancers14010137 · Cited by 7
“IL1B is expressed in a wide range of tissues and a variety of cells including macrophages, neutrophils, endothelial cells, and fibroblasts [35,36].”
Assessing the impact of acidifiers on growth performance, innate immune capacity, response to ammonia nitrogen stress, digestive enzyme activity, intestinal histology, and gene expression of Nile tilapia (Oreochromis niloticus)
Ruenkoed, S., Pholoeng, A., Nontasan, S., et al. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110315 · Cited by 7
Effects of mannan oligosaccharide on immune function and disease resistance in pigs
Minh, T. (2010) · Cited by 7
Comparison of Tissue Factors in the Ontogenetic Aspects of Human Cholesteatoma
Dambergs, K., Sumeraga, G., & Pilmane, M. (2024) · Diagnostics · doi:10.3390/diagnostics14060662 · Cited by 7
Promotion of a cancer-like phenotype, through chronic exposure to inflammatory cytokines and hypoxia in a bronchial epithelial cell line model
Baird, A., Gray, S. G., Richard, D. J., & O'Byrne, K. J. (2016) · Scientific Reports · doi:10.1038/srep18907 · Cited by 7

Authors: Dinarello, C. A.
Affiliations: Tufts University (US)
Corresponding author: Dinarello, Charles A.
ORCID: Dinarello, Charles A.
Venue: The FASEB Journal
Publisher: Wiley
Published: 1994-12
Volume: 8
Issue: 15
Pages: 1314-1325
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fasebj.8.15.8001745
OpenAlex: W1514081838
Cited by: 783
References: 0
Citations by year: 2025: 8 · 2024: 8 · 2023: 8 · 2022: 14 · 2021: 17 · 2020: 21 · 2019: 14 · 2018: 11 · 2017: 19 · 2016: 17 · 2015: 23 · 2014: 27 · 2013: 23 · 2012: 26
FWCI: 18.09
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI‑15614)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: interleukin-1, IL-1α, IL-1β, interleukin-1 receptor antagonist, IL-1 receptor, Drosophila, nematodes, microorganisms, host response to infection, host response to injury, pathogenesis, cytokine regulation
MeSH terms: Animals, Humans, Interleukin-1, Structure-Activity Relationship, Signal Transduction, Receptors, Interleukin-1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The interleukin‐1 family: 10 years of discovery 1

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks