Cited by 783Cytokine Signaling Pathways and InteractionsImmune Response and InflammationInflammasome and immune disorders

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The interleukin‐1 family: 10 years of discovery 1

Dinarello, Charles A.·1994·The FASEB Journal

DOI 10.1096/fasebj.8.15.8001745

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Abstract

Ten years ago the cloning of two interleukin-1 molecules (IL-1 alpha and IL-1 beta) resolved the question of whether a single polypeptide could evoke a wide variety of biological effects. During the past decade, the biology of IL-1 has greatly expanded our understanding of how the host responds to external challenges, such as injury and infection, as well as its role in several diseases. We learned of the remarkable potency of IL-1 in the femtomolar range and of its ability to induce a response by triggering only one or two receptors per cell. Unexpectedly, the IL-1 family of genes, receptors and associated molecules have been linked to those of Drosophila, nematodes, and microorganisms and IL-1 signal transduction is similar to that observed after cellular stress. The cloning of IL-1 opened other avenues of fundamental biological interest. For example, in addition to the two agonist molecules IL-1 alpha and IL-1 beta, a third member of the IL-1 gene family is a specific, high affinity receptor antagonist (IL-1 receptor antagonist). That this third member of the IL-1 family inhibits the other two is characteristic of the tight control over production and activity exerted on IL-1. Although IL-1 contributes to the pathogenesis of many diseases, a small amount appears to be needed to combat infection and initiate healing processes. This article highlights 10 years of discoveries on IL-1.

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“The interleukin-1 (IL-1) system plays a central role in the regulation of both immune and inflammatory responses (Dinarello, 1994).”
Background
Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitis-associated pain
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“The IL-1 system also includes the endogenous antagonist IL-1Ra that can abrogate the effect(s) of IL-1A (24).”
Fluorescence Resonance Energy Transfer Reveals Interleukin (IL)-1-dependent Aggregation of IL-1 Type I Receptors That Correlates with Receptor Activation
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Polymorphisms within the interleukin-1$beta; gene cluster and preeclampsia*1
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A quantitative in situ hybridization and polymerase chain reaction study of microglial-macrophage expression of interleukin-1β mRNA following permanent middle cerebral artery occlusion in mice
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“Thus, IL-1, which is recognized as a proinflammatory cytokine (24), is known to control the expression of other inflammatory genes, including TNF and interferon through a well-defined transduction signaling pathway (24).”
Background
Immobilization Stress Increases mRNA Levels of Interleukin-1 Receptor Antagonist in Various Rat Brain Regions
Suzuki, E., Shintani, F., Kanba, S., Asai, M., & Nakaki, T. (1997) · Cellular and Molecular Neurobiology · doi:10.1023/a:1026319107528 · Cited by 51
“Elevation of IL-IRa mRNA may be involved in the protective response against stress-induced fever, anorexia, and pain, all of which have been shown to be caused by IL-1 (Dinarello, 1994).”
Background
Interleukin-1β regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1α
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The effect of covalently immobilized rhIL-1ra-ELP fusion protein on the inflammatory profile of LPS-stimulated human monocytes
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“Here, we utilize the IL-1 family of cytokines that consists of two agonists (IL-1a and IL-1b), a specific receptor antagonist (IL-1ra), and two transmembrane receptors, types I and II [9].”
BackgroundMethodInfluential
Therapeutic effects of total alkaloids of Tripterygium wilfordii Hook f. on collagen-induced arthritis in rats
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Effects of Porphyromonas gingivalis and Escherichia coli lipopolysaccharides on mononuclear phagocytes
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Authors: Dinarello, C. A.
Affiliations: Tufts University (US)
Corresponding author: Dinarello, Charles A.
ORCID: Dinarello, Charles A.
Venue: The FASEB Journal
Publisher: Wiley
Published: 1994-12
Volume: 8
Issue: 15
Pages: 1314-1325
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fasebj.8.15.8001745
OpenAlex: W1514081838
Cited by: 783
References: 0
Citations by year: 2025: 8 · 2024: 8 · 2023: 8 · 2022: 14 · 2021: 17 · 2020: 21 · 2019: 14 · 2018: 11 · 2017: 19 · 2016: 17 · 2015: 23 · 2014: 27 · 2013: 23 · 2012: 26
FWCI: 18.09
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI‑15614)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: interleukin-1, IL-1α, IL-1β, interleukin-1 receptor antagonist, IL-1 receptor, Drosophila, nematodes, microorganisms, host response to infection, host response to injury, pathogenesis, cytokine regulation
MeSH terms: Animals, Humans, Interleukin-1, Structure-Activity Relationship, Signal Transduction, Receptors, Interleukin-1

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