Cited by 783Cytokine Signaling Pathways and InteractionsImmune Response and InflammationInflammasome and immune disorders

The DOI matches its Crossref record.

The interleukin‐1 family: 10 years of discovery 1

Dinarello, Charles A.·1994·The FASEB Journal

DOI 10.1096/fasebj.8.15.8001745

Open this paper in CoChat — free account

Abstract

Ten years ago the cloning of two interleukin-1 molecules (IL-1 alpha and IL-1 beta) resolved the question of whether a single polypeptide could evoke a wide variety of biological effects. During the past decade, the biology of IL-1 has greatly expanded our understanding of how the host responds to external challenges, such as injury and infection, as well as its role in several diseases. We learned of the remarkable potency of IL-1 in the femtomolar range and of its ability to induce a response by triggering only one or two receptors per cell. Unexpectedly, the IL-1 family of genes, receptors and associated molecules have been linked to those of Drosophila, nematodes, and microorganisms and IL-1 signal transduction is similar to that observed after cellular stress. The cloning of IL-1 opened other avenues of fundamental biological interest. For example, in addition to the two agonist molecules IL-1 alpha and IL-1 beta, a third member of the IL-1 gene family is a specific, high affinity receptor antagonist (IL-1 receptor antagonist). That this third member of the IL-1 family inhibits the other two is characteristic of the tight control over production and activity exerted on IL-1. Although IL-1 contributes to the pathogenesis of many diseases, a small amount appears to be needed to combat infection and initiate healing processes. This article highlights 10 years of discoveries on IL-1.

Integrity signals

Registry

Crossref · 10.1096/fasebj.8.15.8001745

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 701–783 of 783

IL-1 antagonist discovery
Bowlin, T. L., Yanofsky, S. D., & Schreuder, H. (2000) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8462-4_11
Molecular Characterization of IL-1-Like Molecules From Lower Vertebrates and Invertebrates
Beck, G., & Truong, N. T. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1291-2_4
The role of the cytokines IL-17A and IL-33 in inflammatory arthritis and psoriasis
Hueber, A. J. (2011) · Enlighten: Theses (The University of Glasgow) · doi:10.5525/gla.thesis.2629
Factores inmunológicos y genéticos de la infección por el virus del papiloma humano en la neoplasia cervical intraepitelial: estudio de poblaciones linfocitarias y polimorfismos genéticos asociados a inflamación
Paredes, A. G. (2011)
Docking-dependent regulation of checkpoint kinase chk1 by the growth regulator p21WAF1
Toh, Y. K. (2009) · ERA
Persistent enteric mycobacterial infection sensitizes mice to intestinal epithelial injury
Johnson, C. S. (2010) · Iowa State University Digital Repository (Iowa State University) · doi:10.31274/etd-180810-2147
Gender and Cocaine Use Influence the Expression of Urinary Markers of Inflammation and Oxidative Stress
Bourgeois, M. (2010) · Digital Commons - University of South Florida (University of South Florida)
Inflammatory Mediator Action on the Anterior Pituitary Gland
Giacomini, D., Acuña, M., Nagashima, A. C., et al. (2007) · Neuroimmune biology · doi:10.1016/s1567-7443(07)00213-x
The Denaturing and Renaturing are Critical Steps in the Purification of Recombinant Protein in Prokaryotic System
Xiang, D., Yu, Y. X., & Haidong, W. (2012) · InTech eBooks · doi:10.5772/29893
Identificación de nuevos factores pronósticos clínicos e inmunogenéticos en el adenocarcinoma renal
Alonso, F. V. (2014)
Validering av ELISA för analys av equint IL-1 RA iplasma
Ahlberg, M. (2014)
Ácido eicosapentanóico no tratamento da caquexia neoplásica : monografia : Eicosapentaenoic acid in the treatment of cancer cachexia
Marques, C. M. D. S. (2008)
Dissecting the Role of Cytosolic Nucleic Acid Sensors in the Type I Interferon Response to Herpes Simplex Virus-1 and other Ligands: A Dissertation
Thompson, M. (2014) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/m20w37
“IL-18 increases the cytolytic activity and IFNγ production of natural killer (NK) cells and influences neutrophil recruitment and activation (154,155).”
Background
Understanding adipokine secretion and adipocyte-macrophage cellular interactions, in search for the molecular basis of insulin sensitivity and resistance
Xie, L. (2008) · K-State Research Exchange (Kansas State University)
Modelling the inhibitory components of the Interleukin-1β network
Kelsey, J. (2012) · UCL Discovery (University College London)
Utilization of antigen-specific host responses in the evaluation of Mycobacterium tuberculosis infection, development of disease and treatment effect
Menezes, Â. (2013) · SUNScholar (Stellenbosch University)
Regulation of cytokines and chemokines during the progression of acute inflammation in the human whole blood model
Horton, D. L. (2009) · Deep Blue (University of Michigan)
Transcription Factor NF-κ B: Function, Structure, Regulation, Pathways, and Applications
Cheong, R., & Levchenko, A. (2006) · Encyclopedia of Molecular Cell Biology and Molecular Medicine · doi:10.1002/3527600906.mcb.200500006
Einfluss proinflammatorischer Zytokine auf die Expression von humanem ß2-Defensin in Darmepithelien — In-vitro-Untersuchungen im Modell mit der epithelialen Zelllinie HT-29
Coordes, A., Andreou, A., Erben, U., Stroh, T., Blunert, K., Slavova, N., Buhr, J. H., & Kroesen, A. J. (2008) · Langenbecks Archiv für Chirurgie. Supplement · doi:10.1007/978-3-540-78833-1_53
Animal models of arthritis generated by gene transfer
Ghivizzani, S. C., Lechman, E. R., Jaffurs, D., et al. (2000) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8478-5_13
Cytokine suppressive agent prevents pancreatic injuries induced by ischemia-reperfusion in rats
Hirano, T. (2005) · International Journal of Angiology · doi:10.1007/bf01623901
IL-1.ALPHA. Stimulates the Formation of Osteoclast-like Cells via RANK-RANKL Signaling System by Osteoblasts and Monocytes
Tanabe, N., Suzuki, N., & Maeno, M. (2005) · Journal of Hard Tissue Biology · doi:10.2485/jhtb.14.208
Moraxella catarrhalis Adhesin UspA1-derived Recombinant Fragment rD-7 Induces Monocyte Differentiation to CD14+CD206+ Phenotype
Xie, Q., Brackenbury, L. S., Hill, D. J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090999
Gene expression profiling of human keratinocytes exposed to the hair-dying agent, m-aminophenol
So, Y.-J., Shin, C., Song, M., et al. (2013) · Molecular & Cellular Toxicology · doi:10.1007/s13273-013-0007-2
Instilação nasal de LPS ou suco gástrico como fator exacerbador da inflamação pulmonar ocasionada pela isquemia e reperfusão intestinal em camundongos.
Soares, A. L. (2009) · doi:10.11606/t.42.2009.tde-06102009-151646
The occurance of genetic variations in the MYH9 gene and their association with CKD in a mixed South African population
Masconi, K. L. (2012) · SUNScholar (Stellenbosch University)
Neuroendocrine-immune interactions in carp: a role for cortisol and interleukin-1
Engelsma, M. Y. (2002) · doi:10.18174/198418
“Dinarello CA (1994). The interleukin-1 family: 10 years of discovery.”
BackgroundInfluential
Regulation of hematopoietic stem cells during mouse development
Orelio, C. C. (2003) · RePub (Erasmus University Rotterdam)
Prostate Cancer and Inflammatory Genes
Lindmark, F. (2005) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Canakinumab in autoimmune and autoinflammatory rheumatic diseases
Kadavath, S. M., & Efthimiou, P. (2013) · Expert Opinion on Orphan Drugs · doi:10.1517/21678707.2014.868802
“Sequence analysis and X-ray crystallography have shown that IL-1 consists of two similarly structured, albeit distinct protein subunits: IL-1a and IL-1b, with the first being the acidic and the latter the neutral isoform of the molecule [2].”
Background
Rheumatoid arthritis and the evolution of therapy: from symptomatic to bench-to-bedside biological drugs
Lukas, C., Combe, B. G., & Morel, J. (2007) · Future Rheumatology · doi:10.2217/17460816.2.2.143
“Moreover, identification of closerange protein mediators, termed cytokines, increased rapidly during the 1980s, first with interferon molecules [6], interleukin (IL)-1 [7] and -2 [8], followed by tumor necrosis factor (TNF) [9] and lymphotoxin [10], gradually adding potential targets and producing new specific drugs.”
Background
Inflammatory cytokines and cytokine gene polymorphisms in chronic lymphocytic leukaemia, in primary Sjögren's syndrome and in healthy subjects
Hulkkonen, J. (2002) · Tampere University Institutional Repository (Tampere University)
Mode of Adjuvant Action of the Nasally Delivered Cytokine Interleukin 1 Alpha
Thompson, A. L. (2011) · DukeSpace (Duke University)
CITOCINAS DO FLUIDO SULCULAR COMO POSSÍVEIS FERRAMENTAS NO DIAGNÓSTICO PRECOCE DA DOENÇA PERI-IMPLANTAR.
Rocha, F. S. (2010) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
C YTOKINE P ATHWAYS AND J OINT I NFLAMMATION IN R HEUMATOID A RTHRITIS
Pstein, F. R. H. E., & Anayi, G. A. S. P. (2001)
Effects of Chinese green tea on cigarette smoke-induced oxidative stress, inflammation and proteases/anti-proteases in rat lung in vivo
Ka-ho, J. C. (2010) · doi:10.5353/th_b4519933
The biocompatibility of novel phosphorylcholine based biomaterials
Barraud, J. E. (2001) · University of Brighton Repository (University of Brighton)
Managing Stress with Music: Issues in Research
Gao, Z. (2007) · Australian journal of music education/Australian journal of music education (Online)
IL-1α Enhancement of Platinum-Mediated Anti-Tumor Activity
Johnson, C. S., Chang, M.-J., Yu, W., Modzelewski, R. A., Russell, D. M., Logan, T. F., Vlock, D. R., Reyno, L. M., Egorin, M. J., Erkmen, K., et al. (1996) · Springer eBooks · doi:10.1007/978-1-4899-0218-4_23
High Cell Density Cultivation to Produce Heterologous Proteins by S. cerevisiae Strains: a Holistic Approach to Investigate and Optimize the System
Landi, C. (2014) · Università degli Studi di Salerno · doi:10.14273/unisa-294
“It was around 1984-1985 when scientists confirmed that IL-1β was actually composed of two distinct proteins, now called IL-1α and IL-1β (Dinarello, 1994).”
Background
Endometriale Rezeptivität und Embryoimplantation
Diedrich, K., & Hess, A. P. (2008)
Lutealphase
Hess, A. P., Krüssel, J.-S., & Schanz, A. (2008) · Gynäkologische Endokrinologie · doi:10.1007/s10304-008-0274-5
ANALYSE DER ZYTOKINSYNTHESE- KAPAZITÄT VON MONOZYTEN POLYTRAUMATISIERTER PATIENTEN
Mutschler, W. (2006)
Biological agents in rheumatoid arthritis Biological agents in rheumatoid arthritis Biological agents in rheumatoid arthritis Biological agents in rheumatoid arthritis Biological agents in rheumatoid arthritis
Shankar, S., & Handa, R. (2004)
the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N. N., Eaton, J. W., & Tracey, K. J. (2000)
Use of liposomes and cytokines as immunological adjuvants in vaccines
Gürsel, M. (1995) · OpenGrey (Institut de l'Information Scientifique et Technique)
Processing and Release The P2X7 Receptor: A Key Player in IL-1
Curti, A., Idzko, M., Panther, E., Ferrari, D., Pizzirani, C., & Adinolfi, E. (2013)
Interleukin 1 System and Sex Steroid Receptor Expression in Human Breast Cancer
Singer, C. F., Kronsteiner, N., Hudelist, G., et al. (2003)
Revisªo/AtualizaÁªo em Nefrologia ClÌnica: Citocinas e progressªo de doenÁa renal
de Almeida, E. B., & Prado (1997)
Relevance of Growth Factors for the Gastrointestinal Tract and Other Organs
Playford, R. J., & Ghosh, S. K. (2005) · Nutraceutical science and technology · doi:10.1201/9781420028836.ch11
Bioscience Frontiers in Neuromedical Interventions Following Brain Injury
Ashley, M. J., Weintraub, A. H., & Ripley, D. L. (2010) · CRC Press eBooks · doi:10.1201/9781439849828-c12
Alteration of Cytoskeleton and Membrane Proteins in Human Gingival Epithelial Cells by Treatment with Interleukin-1.BETA.: in Vitro Study.
長谷川, 郁. (1998) · 日本歯周病学会会誌 · doi:10.2329/perio.40.188
Die Anwendung des EVEIT-Tests in der Bewertung von Chemikalien und Medikamenten
Goß, M., & Schrage, N. F. (2012) · RWTH Publications (RWTH Aachen)
Recombinant Equine Interleukin-1 Induced Models of Equine Joint Disease
Takafuji, V. (2003) · VTechWorks (Virginia Tech)
Development of mRNA patterns for screening of anabolic steroids in bovine and primate tissues
Riedmaier, I. (2009)
In vivo effects of GnRH on expression of interleukin 1 (IL-1) system members in bovine preovulatory follicles and the influence of IL-1β on cumulus-oocyte complexes cultured in vitro
Silva, A. W. B., Passos, J. R. S., Dau, A. M. P., Cesaro, M. P. D., Ferst, J. G., dos Santos, J. T., Bezerra, F. T. G., Costa, J. J. N., Paulino, L. R. F. M., Donato, M. A. M., et al. (2017) · Livestock Science · doi:10.1016/j.livsci.2017.11.002
Mice Deficient in Interleukin-1β Converting Enzyme
Kuida, K., Lippke, J. A., Su, M. S. S., et al. (1998) · doi:10.1007/978-1-4757-2753-1_11
Molecular Insights into the Distinct Mechanisms Regulating the TLR4 Mediated Activation, Shut Down, and Endotoxin Tolerance of the IL1B and TNF Genes
Adamik, J. (2013)
Lien entre la prééclampsie et les facteurs de risque cardiovasculaire : étude de gènes impliqués dans le processus inflammatoire et associés au syndrome métabolique
Laroche, M. (2009) · Corpus Université Laval (Université Laval)
Production of IL-1β, IL-6 and CXCL8 by endometrium of crossbred heifers stimulated with various pathogen-associated molecular patterns
Nunes, P. P., Martins, T. D. M., Leite, A. C., et al. (2021) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2021.106736
Use of Antisense Oligonucleotides to Modify Inflammatory Processes
Bennett, P. R. (1998)
Recombinant proteins and genomics in cancer therapy
Mehta, K., Gohil, K., & Aggarwal, B. B. (2003) · Springer eBooks · doi:10.1007/978-94-017-2757-0_4
Disease-Modifying Antirheumatic Drug Use in Older Rheumatoid Arthritis Patients
Amjadi, S., Ranganath, V. K., & Fürst, D. E. (2011) · Springer eBooks · doi:10.1007/978-1-4419-5792-4_17
P38 Inhibition
Young, P. R., & Gum, R. J. (2000) · CRC Press eBooks · doi:10.1201/9780203904244.ch12
Interleukins, -1 (IL-1), -6 (IL-6), -18 (IL-18)
Rohleder, N. (2020) · Springer eBooks · doi:10.1007/978-3-030-39903-0_26
Endometrial injection of embryo culture supernatant for subfertile women in assisted reproduction
Siristatidis, C. S., Sertedaki, E., & Vaidakis, D. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013063
Interleukins
Mire‐Sluis, A. R. (2007) · Van Nostrand's Scientific Encyclopedia · doi:10.1002/9780471743989.vse9973
Treatment Regimes in Diabetes and Their Impact on Biomarkers
Magalhães, J. P., Hetherington‐Rauth, M., & Sardinha, L. B. (2022) · Biomarkers in disease · doi:10.1007/978-3-030-81303-1_3-1
Treatment Regimes in Diabetes and Their Impact on Biomarkers
Magalhães, J. P., Hetherington‐Rauth, M., & Sardinha, L. B. (2022) · Biomarkers in disease · doi:10.1007/978-3-031-08014-2_3
Prostate cancer: genetic changes and viral-mediated immune regulation
Sosse, S. A., Abumsimir, B., Mahasneh, I. A., Mrabti, M., Laraqui, A., & Ennaji, M. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85496-2.00020-8
Establishment and Analysis of a Combined Diagnostic Model of Acute Myocardial Infarction Based on Random Forests and Artificial Neural Networks
Zhan, Z., Bi, X., Yang, J., Tang, X., & Zhao, T. (2023) · Lecture notes in electrical engineering · doi:10.1007/978-981-16-6775-6_28
Computer modeling of the peculiarities in the interaction of IL-1 with its receptors in schizophrenia
Chasovskikh, N. Y., Bobrysheva, A. A., & Chizhik, E. E. (2024) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-24-38
“The IL-1RA protein, which is an antagonist of IL-1 receptors and has an antiinflammatory function (Dinarello, 1994), has also been found to be associated with schizophrenia (Kim et al., 2004).”
Background
10.1016/b978-1-4557-5414-4.00001-2
(2000) · Time to knit · doi:10.1016/b978-1-4557-5414-4.00001-2
Overview of biomarkers of synovial fluid in joint diseases
Bystronova, I., Kušnierová, P., Walder, P., Hlubek, R., Rolová, J., & Stejskal, D. (2021) · Klinická biochemie a metabolismus · doi:10.61568/kbm.2021.003
EFICÁCIA DO TOCILIZUMABE NOS ASPECTOS CLÍNICOS DE PACIENTES COM SARS-COV-2: UMA REVISÃO SISTEMÁTICA E META-ANÁLISE
Silva, J. P. R., Silva, M. J. D. S., Lima, P. V. P., et al. (2025) · Revista Contemporânea · doi:10.56083/rcv5n10-006
Designing lysate-based hydrogels for on-demand therapy
Lv, Y., Tieng, S., Xu, X., & Chen, W. (2025) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2025.101514
Immunological and behavioral consequences of high-fat diet feeding in mice
Lavin, D. N. (2010) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Análise da citocina IL-1ß e do polimorfismo do gene IL-1B + 3954 em pacientes com implantes osseointegrados
Melo, R. F. (2006) · Americanae (AECID Library)
Exposition précoce aux toxiques et déséquilibres nutritionnels : l’inflammation et les lésions précancéreuses de la prostate
Gharieb, K. (2017) · theses.fr (ABES) · doi:10.70675/a9408190zea1bz4519z8d78z6cae1bea68f7
S-nitrosoglutathion et perméabilité intestinale : de la mise en place d’un modèle de chambre de Ussing à l’étude de l’impact de ce donneur de monoxyde d’azote sur la barrière intestinale
Schmitt, R. (2019) · theses.fr (ABES) · doi:10.70675/52e13b4az08c5z4784zb89bzeeaf1caf5623
Etude de la voie de la kynurénine dans la symptomatologie du sujet obèse
Huet, L. (2019) · theses.fr (ABES) · doi:10.70675/ff26d7c8z4c5fz4c86z9e6ezd8d843268447
The roles of Lcn2 in the inflammatory lung and liver
Liu, Y. (2007) · doi:10.31274/rtd-180813-4555
“of four proteins: IL-1α, IL-1β, IL-1ra (IL-1 receptor antagonist) and a new member, IL-18 (Dinarello and Wolff 1993; Dinarello 1994; Huising, Stet et al. 2004).”
Background
Solution structure of interleukin-1β bound to a potential therapeutic antibody
Wilkinson, I. C. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)

Authors: Dinarello, C. A.
Affiliations: Tufts University (US)
Corresponding author: Dinarello, Charles A.
ORCID: Dinarello, Charles A.
Venue: The FASEB Journal
Publisher: Wiley
Published: 1994-12
Volume: 8
Issue: 15
Pages: 1314-1325
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fasebj.8.15.8001745
OpenAlex: W1514081838
Cited by: 783
References: 0
Citations by year: 2025: 8 · 2024: 8 · 2023: 8 · 2022: 14 · 2021: 17 · 2020: 21 · 2019: 14 · 2018: 11 · 2017: 19 · 2016: 17 · 2015: 23 · 2014: 27 · 2013: 23 · 2012: 26
FWCI: 18.09
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI‑15614)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: interleukin-1, IL-1α, IL-1β, interleukin-1 receptor antagonist, IL-1 receptor, Drosophila, nematodes, microorganisms, host response to infection, host response to injury, pathogenesis, cytokine regulation
MeSH terms: Animals, Humans, Interleukin-1, Structure-Activity Relationship, Signal Transduction, Receptors, Interleukin-1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The interleukin‐1 family: 10 years of discovery 1

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks