Cited by 783Cytokine Signaling Pathways and InteractionsImmune Response and InflammationInflammasome and immune disorders

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The interleukin‐1 family: 10 years of discovery 1

Dinarello, Charles A.·1994·The FASEB Journal

DOI 10.1096/fasebj.8.15.8001745

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Abstract

Ten years ago the cloning of two interleukin-1 molecules (IL-1 alpha and IL-1 beta) resolved the question of whether a single polypeptide could evoke a wide variety of biological effects. During the past decade, the biology of IL-1 has greatly expanded our understanding of how the host responds to external challenges, such as injury and infection, as well as its role in several diseases. We learned of the remarkable potency of IL-1 in the femtomolar range and of its ability to induce a response by triggering only one or two receptors per cell. Unexpectedly, the IL-1 family of genes, receptors and associated molecules have been linked to those of Drosophila, nematodes, and microorganisms and IL-1 signal transduction is similar to that observed after cellular stress. The cloning of IL-1 opened other avenues of fundamental biological interest. For example, in addition to the two agonist molecules IL-1 alpha and IL-1 beta, a third member of the IL-1 gene family is a specific, high affinity receptor antagonist (IL-1 receptor antagonist). That this third member of the IL-1 family inhibits the other two is characteristic of the tight control over production and activity exerted on IL-1. Although IL-1 contributes to the pathogenesis of many diseases, a small amount appears to be needed to combat infection and initiate healing processes. This article highlights 10 years of discoveries on IL-1.

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Authors: Dinarello, C. A.
Affiliations: Tufts University (US)
Corresponding author: Dinarello, Charles A.
ORCID: Dinarello, Charles A.
Venue: The FASEB Journal
Publisher: Wiley
Published: 1994-12
Volume: 8
Issue: 15
Pages: 1314-1325
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fasebj.8.15.8001745
OpenAlex: W1514081838
Cited by: 783
References: 0
Citations by year: 2025: 8 · 2024: 8 · 2023: 8 · 2022: 14 · 2021: 17 · 2020: 21 · 2019: 14 · 2018: 11 · 2017: 19 · 2016: 17 · 2015: 23 · 2014: 27 · 2013: 23 · 2012: 26
FWCI: 18.09
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI‑15614)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: interleukin-1, IL-1α, IL-1β, interleukin-1 receptor antagonist, IL-1 receptor, Drosophila, nematodes, microorganisms, host response to infection, host response to injury, pathogenesis, cytokine regulation
MeSH terms: Animals, Humans, Interleukin-1, Structure-Activity Relationship, Signal Transduction, Receptors, Interleukin-1

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