The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
The small leucine‐rich proteoglycan biglycan modulates BMP‐4‐induced osteoblast differentiation
Abstract
Biglycan (bgn) is a small leucine‐rich proteoglycan enriched in extracellular matrices of skeletal tissues. Bgn ‐deficient mice develop age‐related osteopenia with a phenotype that resembles osteoporosis and premature arthritis. In the present study, we have examined the differentiation of ftgw‐deficient osteoblasts from neonatal murine calvariae and found that the absence of bgn caused less BMP‐4 binding, which reduced the sensitivity of osteoblasts to BMP‐4 stimulation. The loss of sensitivity resulted in a reduction of Cbfa1 expression, which ultimately led to a defect in the differentiation of osteoblasts. However, the response of ftgw‐deficient osteoblasts to BMP‐4 was completely rescued by reintroduction of biglycan by viral transfection. We propose that biglycan modulates BMP‐4‐induced signaling to control osteoblast differentiation.—Chen, X.‐D., Fisher, L. W., Robey, P. G., Young, M. F. The small leucine‐rich proteoglycan biglycan modulates BMP‐4‐induced osteoblast differentiation. FASEB J. 18, 948–958 (2004)
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Cites
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Hogan, B. L. (1996) · Genes & Development · doi:10.1101/gad.10.13.1580 · Cited by 1,962
MATRIX PROTEOGLYCANS: From Molecular Design to Cellular Function
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Negative regulation of transforming growth factor-β by the proteoglycan decorin
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MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways
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Cited by
Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction
Schaefer, L., & Iozzo, R. V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800020200 · Cited by 549
Proteoglycans: from structural compounds to signaling molecules
Schaefer, L., & Schaefer, R. M. (2010) · Cell and Tissue Research · doi:10.1007/s00441-009-0821-y · Cited by 548
Iozzo, R. V., & Schaefer, L. (2010) · The FEBS Journal · doi:10.1111/j.1742-4658.2010.07797.x · Cited by 292
Biological interplay between proteoglycans and their innate immune receptors in inflammation
Frey, H., Schroeder, N., Manon‐Jensen, T., Iozzo, R. V., & Schaefer, L. (2013) · The FEBS Journal · doi:10.1111/febs.12145 · Cited by 274
To divide or not to divide: revisiting liver regeneration
Miyaoka, Y., & Miyajima, A. (2013) · Cell Division · doi:10.1186/1747-1028-8-8 · Cited by 156
Metadata
- Authors
- Chen, X.-D., Fisher, L. W., Robey, P. G., & Young, M. F.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2004-06
- Volume
- 18
- Issue
- 9
- Pages
- 948-958
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2137376744
- Cited by
- 295
- References
- 33
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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