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Cited by 295

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

The small leucine‐rich proteoglycan biglycan modulates BMP‐4‐induced osteoblast differentiation

Chen, Xiao-Dong, Fisher, Larry W., Robey, Pamela Gehron, Young, Marian F.·2004·The FASEB Journal
DOI 10.1096/fj.03-0899com
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Abstract

Biglycan (bgn) is a small leucine‐rich proteoglycan enriched in extracellular matrices of skeletal tissues. Bgn ‐deficient mice develop age‐related osteopenia with a phenotype that resembles osteoporosis and premature arthritis. In the present study, we have examined the differentiation of ftgw‐deficient osteoblasts from neonatal murine calvariae and found that the absence of bgn caused less BMP‐4 binding, which reduced the sensitivity of osteoblasts to BMP‐4 stimulation. The loss of sensitivity resulted in a reduction of Cbfa1 expression, which ultimately led to a defect in the differentiation of osteoblasts. However, the response of ftgw‐deficient osteoblasts to BMP‐4 was completely rescued by reintroduction of biglycan by viral transfection. We propose that biglycan modulates BMP‐4‐induced signaling to control osteoblast differentiation.—Chen, X.‐D., Fisher, L. W., Robey, P. G., Young, M. F. The small leucine‐rich proteoglycan biglycan modulates BMP‐4‐induced osteoblast differentiation. FASEB J. 18, 948–958 (2004)

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Metadata

Authors
Chen, X.-D., Fisher, L. W., Robey, P. G., & Young, M. F.
Venue
The FASEB Journal
Publisher
Wiley
Published
2004-06
Volume
18
Issue
9
Pages
948-958
ISSN
  • 0892-6638 (ISSN-L)
  • 1530-6860
DOI
10.1096/fj.03-0899com
OpenAlex
W2137376744
Cited by
295
References
33
FWCI
6.89
Type
journal article
Language
en
Open access
closed

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