The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
Open accessAbstract
Classically, adult humans have been considered not to possess active brown adipose tissue (BAT). However, positron‐emission‐tomography has shown fluorodeoxyglucose uptake that is distributed in such a way ( e.g. , in the neck) that it would seem to be BAT. Until now this has not been supported by direct evidence that these areas truly represented BAT, that is, the presence of the BAT‐unique uncoupling protein‐1 (UCP1). Samples of adipose tissue from the neck of 35 patients undergoing surgery for thyroid diseases were obtained and analyzed. In 1/3 of the subjects (the younger and leaner), distinct islands composed of UCP1 immunoreactive brown adipocytes could clearly be discerned, accounting for up to 1/3 of all adipocytes. The brown‐adipose islands were richlysympathetically innervated (indicating acute central control); adjacent white adipose areas were not. The capillary density was high, implying a high capacity for oxygen delivery. Cells with features of brown adipocyte precursors were found in pericapillary areas. These data demonstrate that human adults indeed possess BAT and thus imply possibilities of future therapeutic strategies for the treatment of obesity, including maintenance of brown adipocytes and stimulation of the growth of preexisting brown precursors.—Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., Cinti, S. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J. 23, 3113–3120 (2009). www.fasebj.org
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“Second, recent studies have shown that adult humans maintain potentially active brown adipose tissue, making this high energetic tissue a real therapeutic target 13–17.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“However, it was only during the past year PET/CT imaging was used to prove conclusively that adult humans possess physiologically active UCP1-positive BAT,13–17.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“Given the scanning data and the finding of brown adipocyte precursors in human tissues 17, it is likely that virtually every adult human has the capacity to develop some functional BAT.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“However, histological analysis of cervical fat biopsies show rates three times higher 17, and prospective studies using cold stimulation to increase BAT activity and detection via PET/CT show that among younger people, 96% have functional BAT 14.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“Although it has only recently been proven that adult human BAT is functional and may be involved in protecting against weight loss 13–17, attempts to exploit BAT energy expenditure for treating obesity have been around for decades.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“Such depots appear to be less active as a function of aging and/or obesity (151, 164 -167).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [167]
Citations
Cites
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
Self-citationUnexpected evidence for active brown adipose tissue in adult humans
Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824
Self-citationFeldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318
Self-citationCinti, S. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.010 · Cited by 720
Self-citationNedergaard, J., Golozoubova, V., Matthias, A., Asadi, A., Jacobsson, A., & Cannon, B. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00247-4 · Cited by 615
Self-citationBrown adipose tissue and heat production in the newborn infant
Aherne, W., & Hull, D. (1966) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700910126 · Cited by 284
Murano, I., Barbatelli, G., Giordano, A., & Cinti, S. (2009) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.01001.x · Cited by 208
Self-citationBrown adipose tissue in humans
Lean, M. E. J. (1989) · Proceedings of The Nutrition Society · doi:10.1079/pns19890036 · Cited by 199
Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol
Söderlund, V., Larsson, S., & Jacobsson, H. (2007) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-006-0318-9 · Cited by 177
Parysow, O., Mollerach, A. M., Jager, V., Racioppi, S., Román, J. S., & Gerbaudo, V. H. (2007) · Clinical Nuclear Medicine · doi:10.1097/01.rlu.0000259570.69163.04 · Cited by 147
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- Lean M. E. J., 1986, Brown Adipose Tissue, 339
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Souza‐Mello, V. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27370-4.00003-2
Salej, L., Camara, H., Chaves, N., Kodani, S. D., Monahan-Earley, R. A., Huntington, S., Cypess, A. M., Asara, J. M., Tseng, Y., James, B. C., et al. (2025) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaf178
Kokubun, T., Kudo, T., Tominami, K., Ishigaki, H., Matsushita, A., Izumi, S., Tanaka, T., Kawaguchi, K., Hayashi, Y., Sato, H., et al. (2026) · Life · doi:10.3390/life16030499
López‐Mejía, I. C. (2011) · theses.fr (ABES) · doi:10.70675/c07b5c77zba4dz4e8az9f16z542c1070dc7a
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Soussi, H. (2016) · theses.fr (ABES) · doi:10.70675/77e61e80zde3cz4030z95f1z194698d236d8
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Mastrandrea, C. J. (2019) · theses.fr (ABES) · doi:10.70675/c1d4791dzb281z4dc8zbeaez9e57830c6a06
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Zekri, Y. (2022) · theses.fr (ABES) · doi:10.70675/f8d646ffzf184z40e1z848az174a3d652f5d
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Valentini, T. J., Spek, A. C., & Quinlan, K. G. R. (2026) · Clinical Science · doi:10.1042/cs20250051
Ortega, M. P. C., Peña-Peña, M., Carbó, R., Medina-Urrutia, A. X., Osorio‐Alonso, H., Jiang, B., Almanza-Pérez, J. C., Blancas‐Flores, G., Villafaña, S., Romero‐Nava, R., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156693
Zhao, X., Gan, M., Wang, X., Chen, Y., Zhu, J., Ye, Q., Zan, J., Lei, Y., Zhou, X., Chen, L., et al. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113640
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Umali, S. (2011) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/vbwv-1t33
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Metadata
- Authors
- Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., & Cinti, S.
- Affiliations
- Marche Polytechnic University (IT)
- Stockholm University (SE)
- Corresponding author
- Cinti, Saverio
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2009-05-05
- Volume
- 23
- Issue
- 9
- Pages
- 3113-3120
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2115313813
- Cited by
- 725
- References
- 15
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 8 · 2023: 25 · 2022: 30 · 2021: 32 · 2020: 43 · 2019: 46 · 2018: 41 · 2017: 57 · 2016: 37 · 2015: 60 · 2014: 59 · 2013: 80 · 2012: 69
- FWCI
- 42.11
- Type
- journal article
- Language
- en
- Open access
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- RVC Research Online (Royal Veterinary College) (submittedVersion, cc-by)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Funders
- Vetenskapsrådet (BBR57M_005)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- brown adipose tissue, UCP1, brown adipocytes, sympathetic innervation, capillary density, obesity treatment
- MeSH terms
- Uncoupling Protein 1, Adolescent, Adult, Adipose Tissue, Brown, Capillaries, Female, Humans, Ion Channels, Male, Neck, Thyroid Diseases, Mitochondrial Proteins, Adipocytes, Brown, Young Adult
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