The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
Open accessAbstract
Classically, adult humans have been considered not to possess active brown adipose tissue (BAT). However, positron‐emission‐tomography has shown fluorodeoxyglucose uptake that is distributed in such a way ( e.g. , in the neck) that it would seem to be BAT. Until now this has not been supported by direct evidence that these areas truly represented BAT, that is, the presence of the BAT‐unique uncoupling protein‐1 (UCP1). Samples of adipose tissue from the neck of 35 patients undergoing surgery for thyroid diseases were obtained and analyzed. In 1/3 of the subjects (the younger and leaner), distinct islands composed of UCP1 immunoreactive brown adipocytes could clearly be discerned, accounting for up to 1/3 of all adipocytes. The brown‐adipose islands were richlysympathetically innervated (indicating acute central control); adjacent white adipose areas were not. The capillary density was high, implying a high capacity for oxygen delivery. Cells with features of brown adipocyte precursors were found in pericapillary areas. These data demonstrate that human adults indeed possess BAT and thus imply possibilities of future therapeutic strategies for the treatment of obesity, including maintenance of brown adipocytes and stimulation of the growth of preexisting brown precursors.—Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., Cinti, S. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J. 23, 3113–3120 (2009). www.fasebj.org
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Second, recent studies have shown that adult humans maintain potentially active brown adipose tissue, making this high energetic tissue a real therapeutic target 13–17.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“However, it was only during the past year PET/CT imaging was used to prove conclusively that adult humans possess physiologically active UCP1-positive BAT,13–17.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“Given the scanning data and the finding of brown adipocyte precursors in human tissues 17, it is likely that virtually every adult human has the capacity to develop some functional BAT.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“However, histological analysis of cervical fat biopsies show rates three times higher 17, and prospective studies using cold stimulation to increase BAT activity and detection via PET/CT show that among younger people, 96% have functional BAT 14.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“Although it has only recently been proven that adult human BAT is functional and may be involved in protecting against weight loss 13–17, attempts to exploit BAT energy expenditure for treating obesity have been around for decades.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“Such depots appear to be less active as a function of aging and/or obesity (151, 164 -167).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [167]
Citations
Cites
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
Self-citationUnexpected evidence for active brown adipose tissue in adult humans
Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824
Self-citationFeldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318
Self-citationCinti, S. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.010 · Cited by 720
Self-citationNedergaard, J., Golozoubova, V., Matthias, A., Asadi, A., Jacobsson, A., & Cannon, B. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00247-4 · Cited by 615
Self-citationBrown adipose tissue and heat production in the newborn infant
Aherne, W., & Hull, D. (1966) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700910126 · Cited by 284
Murano, I., Barbatelli, G., Giordano, A., & Cinti, S. (2009) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.01001.x · Cited by 208
Self-citationBrown adipose tissue in humans
Lean, M. E. J. (1989) · Proceedings of The Nutrition Society · doi:10.1079/pns19890036 · Cited by 199
Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol
Söderlund, V., Larsson, S., & Jacobsson, H. (2007) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-006-0318-9 · Cited by 177
Parysow, O., Mollerach, A. M., Jager, V., Racioppi, S., Román, J. S., & Gerbaudo, V. H. (2007) · Clinical Nuclear Medicine · doi:10.1097/01.rlu.0000259570.69163.04 · Cited by 147
Research works printed but not linked: 1
- Lean M. E. J., 1986, Brown Adipose Tissue, 339
Cited by
Sorted by citations
Items 401–500 of 715
Mukaida, S., Evans, B. A., Bengtsson, T., Hutchinson, D. S., & Sato, M. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.12.022 · Cited by 33
Zhang, Y., Xu, Q., Liu, Y. H., Zhang, X. S., Wang, J., Xiao, Y., Zhang, R. X., Xue, C., Yang, X. Y., & Xue, C. Y. (2015) · PubMed · doi:10.3967/bes2015.012 · Cited by 32
Evaluation and optimization of differentiation conditions for human primary brown adipocytes
Wang, X., You, L., Cui, X., Li, Y., Wang, X., Xu, P., Zhu, L., Wen, J., Pang, L., Guo, X., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-23700-z · Cited by 32
Choi, H., Kim, W. K., Kim, E. Y., Han, B., Min, J., Chi, S., Park, S. G., Bae, K., & Lee, S. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072340 · Cited by 32
Of mice and men: novel insights regarding constitutive and recruitable brown adipocytes
Townsend, K. L., & Tseng, Y.-H. (2015) · International Journal of Obesity Supplements · doi:10.1038/ijosup.2015.5 · Cited by 32
Zhang, H., Hao, Y., Wei, C., Yao, B., Liu, S., Zhou, H., Huang, D., Zhang, C., & Wu, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108781 · Cited by 31
Functional characterization of human brown adipose tissue metabolism
Richard, M. A., Pallubinsky, H., & Blondin, D. P. (2020) · Biochemical Journal · doi:10.1042/bcj20190464 · Cited by 31
Brown and beige fat: the metabolic function, induction, and therapeutic potential
Qian, S., Huang, H., & Tang, Q. (2015) · Frontiers of Medicine · doi:10.1007/s11684-015-0382-2 · Cited by 33
Shabalina, I. G., Kramarova, T. V., Mattsson, C. L., Petrovič, N., Qazi, M. R., Csikasz, R. I., Chang, S., Butenhoff, J. L., DePierre, J. W., Cannon, B., et al. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv098 · Cited by 31
Self-citationGRK2 contribution to the regulation of energy expenditure and brown fat function
Vila‐Bedmar, R., García‐Guerra, L., Nieto-Vázquez, I., Mayor, F., Lorenzo, M., Murga, C., & Fernández‐Veledo, S. (2012) · The FASEB Journal · doi:10.1096/fj.11-202267 · Cited by 30
Bauters, D., Cobbaut, M., Geys, L., Lint, J. V., Hemmeryckx, B., & LIJNEN, H. R. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.05.004 · Cited by 30
Klingenspor, M., & Fromme, T. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0965-6_3 · Cited by 30
Rose, G., Crocco, P., D’Aquila, P., Montesanto, A., Bellizzi, D., & Passarino, G. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.07.011 · Cited by 30
Small non coding RNAs in adipocyte biology and obesity
Amri, E., & Scheideler, M. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.04.009 · Cited by 32
Xiang, A. S., Meikle, P. J., Carey, A. L., & Kingwell, B. A. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.07.002 · Cited by 29
Darcy, J., Fang, Y., McFadden, S., Lynes, M. D., Leiria, L. O., Dreyfuss, J. M., Bussburg, V., Tolstikov, V., Greenwood, B. P., Narain, N. R., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00221-0 · Cited by 29
Ferreira, V., Folgueira, C., Guillén, M., Zubiaur, P., Navares, M., Sarsenbayeva, A., López-Larrubia, P., Eriksson, J. W., Pereira, M. J., Abad‐Santos, F., et al. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155335 · Cited by 29
Smith, D. L., Yang, Y., Hu, P., Zhai, G., & Nagy, T. R. (2013) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24138 · Cited by 29
Haq, T., Crane, J. D., Kanji, S., Gunn, E., Tarnopolsky, M. A., Gerstein, H. C., Steinberg, G. R., & Morrison, K. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-11537-x · Cited by 29
Thermogenic adipocytes: lineage, function and therapeutic potential
Pollard, A., & Carling, D. (2020) · Biochemical Journal · doi:10.1042/bcj20200298 · Cited by 30
Nogueiras, R. (2021) · European Journal of Endocrinology · doi:10.1530/eje-21-0277 · Cited by 29
The role of oestrogen in determining sexual dimorphism in energy balance
Jesus, A. N. D. D., & Henry, B. A. (2022) · The Journal of Physiology · doi:10.1113/jp279501 · Cited by 29
Bahler, L., Molenaars, R. J., Verberne, H. J., & Holleman, F. (2015) · Diabetes & Metabolism · doi:10.1016/j.diabet.2015.08.005 · Cited by 28
Wells, T., Davies, J. R., Guschina, I. A., Ball, D. J., Davies, J. S., Davies, V., Evans, B. A. J., & Votruba, M. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds315 · Cited by 28
Chalfant, J. S., Smith, M. L., Hu, P., Dorey, F. J., Goodarzian, F., Fu, C. H., & Gilsanz, V. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.030650 · Cited by 28
Kim, Y. J., & Bi, S. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00174.2015 · Cited by 28
A critical appraisal of brown adipose tissue metabolism in humans
Blondin, D. P., Labbé, S. M., Turcotte, É. E., Haman, F., Richard, D., & Carpentier, A. C. (2015) · Clinical Lipidology · doi:10.2217/clp.15.14 · Cited by 29
Fernández‐Galilea, M., Félix‐Soriano, E., Colón-Mesa, I., Escoté, X., & Moreno-Aliaga, M. J. (2019) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-019-00720-5 · Cited by 27
The Transcriptional Role of Vitamin A and the Retinoid Axis in Brown Fat Function
Herz, C. T., & Kiefer, F. W. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00608 · Cited by 27
Pyrżak, B., Demkow, U., & Kucharska, A. M. (2015) · Advances in experimental medicine and biology · doi:10.1007/5584_2015_149 · Cited by 26
Contribution of adaptive thermogenesis to the hypothalamic regulation of energy balance
Lage, R., Fernø, J., Nogueiras, R., Diéguez, C., & López, M. (2016) · Biochemical Journal · doi:10.1042/bcj20160012 · Cited by 28
Franco, A. D., Guasti, D., Mazzanti, B., Ercolino, T., Francalanci, M., Nesi, G., Bani, D., Forti, G., Mannelli, M., Valeri, A., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1431 · Cited by 28
Novel nuances of human brown fat
Schéele, C., Larsen, T. J., & Nielsen, S. J. (2013) · Adipocyte · doi:10.4161/adip.26520 · Cited by 27
Contributors to Metabolic Disease Risk Following Spinal Cord Injury
Smith, D. L., & Yarar‐Fisher, C. (2016) · Current Physical Medicine and Rehabilitation Reports · doi:10.1007/s40141-016-0124-7 · Cited by 26
Translational Pharmacology and Physiology of Brown Adipose Tissue in Human Disease and Treatment
Larson, C. J. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_184 · Cited by 26
Influences of ovarian hormones on physiological responses to cold in women
Greenfield, A. M., Charkoudian, N., & Alba, B. K. (2021) · Temperature · doi:10.1080/23328940.2021.1953688 · Cited by 25
Iacono, M. L., Modica, C., Porcelli, G., Brancato, O. R., Muratore, G., Bianca, P., Gaggianesi, M., Turdo, A., Veschi, V., Todaro, M., et al. (2022) · Biomolecules · doi:10.3390/biom12050702 · Cited by 25
Translational issues in targeting brown adipose tissue thermogenesis for human obesity management
Dulloo, A. G. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12304 · Cited by 25
Metabolic syndrome and functional ability in older age: The InCHIANTI study
Laudisio, A., Bandinelli, S., Gemma, A., Ferrucci, L., & Incalzi, R. A. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.08.005 · Cited by 25
Clarke, S. D., Lee, K., Andrews, Z. B., Bischof, R. J., Fahri, F., Evans, R. G., Clarke, I. J., & Henry, B. A. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00036.2012 · Cited by 25
Hao, M., Guan, Z., Gao, Y. T., Xing, J., Zhou, X., Wang, C., Xu, J., & Li, W. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153292 · Cited by 25
SRF and MKL1 Independently Inhibit Brown Adipogenesis
Rosenwald, M., Efthymiou, V., Opitz, L., & Wolfrum, C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170643 · Cited by 24
A synopsis of brown adipose tissue imaging modalities for clinical research
Sun, L., Yan, J., Sun, L., Velan, S. S., & Leow, M. K. (2017) · Diabetes & Metabolism · doi:10.1016/j.diabet.2017.03.008 · Cited by 25
Mouse model of the adipose organ: the heterogeneous anatomical characteristics
Chun, K. (2021) · Archives of Pharmacal Research · doi:10.1007/s12272-021-01350-6 · Cited by 27
Brown Fat Develops a Brite Future
Klingenspor, M., Herzig, S., & Pfeifer, A. (2012) · Obesity Facts · doi:10.1159/000346337 · Cited by 27
Brown Adipose Tissue: A Metabolic Regulator in a Hypothalamic Cross Talk?
Henningsen, J. B., & Schéele, C. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-032420-042950 · Cited by 24
Therapeutic prospects of metabolically active brown adipose tissue in humans
Betz, M. J. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00086 · Cited by 24
Gifford, A., Towse, T. F., Walker, R. C., Avison, M. J., & Welch, E. B. (2015) · Journal of Visualized Experiments · doi:10.3791/52415 · Cited by 23
Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis
Liang, X., Tao, C., Pan, J., Zhang, L., Liu, L., Zhao, Y. L., Fan, Y., Cao, C., Liu, J., Zhang, J., et al. (2020) · Protein & Cell · doi:10.1007/s13238-020-00770-2 · Cited by 23
Organization of sympathetic innervation of interscapular brown adipose tissue in the mouse
Huesing, C., Zhang, R., Gummadi, S., Lee, N., Qualls‐Creekmore, E., Yu, S., Morrison, C. D., Burk, D. H., Berthoud, H. R., Neuhuber, W., et al. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25281 · Cited by 23
Baboota, R. K., Sarma, S. M., Boparai, R. K., Kondepudi, K. K., Mantri, S. S., & Bishnoi, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127701 · Cited by 25
Cloning and ontogenetic expression of the uncoupling protein 1 gene UCP1 in sheep
Yuan, Y., Liu, W., Liu, J., Qiao, L., & Jian-liang, W. (2012) · Journal of Applied Genetics · doi:10.1007/s13353-012-0086-0 · Cited by 23
Uncoupling protein 1 dependent reactive oxygen species production by thymus mitochondria
Clarke, K. J., & Porter, R. K. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.09.023 · Cited by 23
OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes
Chu, D., Tao, Y., & Taskén, K. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0043-100384 · Cited by 23
Jones, T. A., Wayte, S. C., Reddy, N. L., Adesanya, O., Dimitriadis, G. K., Barber, T. M., & Hutchinson, C. E. (2018) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2018.04.013 · Cited by 23
Skowronek, A. K., Jaskulak, M., & Zorena, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010090 · Cited by 22
Imaging Metabolically Active Fat: A Literature Review and Mechanistic Insights
Frankl, J. A., Sherwood, A., Clegg, D. J., Scherer, P. E., & Öz, O. K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215509 · Cited by 22
Sugatani, J., Sadamitsu, S., Yamaguchi, M., Yamazaki, Y., Higa, R., Hattori, Y., Uchida, T., Ikari, A., Sugiyama, W., Watanabe, T., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-233262 · Cited by 22
Campos, R. M. D. S., Dâmaso, A. R., Masquio, D. C. L., Duarte, F. O., Sene‐Fiorese, M., de Aquino, A. E., Savioli, F. A., Quintiliano, P. C. L., Kravchychyn, A. C. P., Guimarães, L. I., et al. (2018) · Lasers in Medical Science · doi:10.1007/s10103-018-2465-1 · Cited by 22
Targeting skeletal muscle mitochondrial health in obesity
Pileggi, C. A., Hooks, B. G., McPherson, R., Dent, R. R. M., & Harper, M.-E. (2022) · Clinical Science · doi:10.1042/cs20210506 · Cited by 21
MECHANISMS IN ENDOCRINOLOGY: Brown adipose tissue in humans: regulation and metabolic significance
Thuzar, M., & Ho, K. K. Y. (2016) · European Journal of Endocrinology · doi:10.1530/eje-15-1217 · Cited by 22
Klingenspor, M., Bast‐Habersbrunner, A., Bolze, F., Li, Y., Maurer, S., Schweizer, S., Willershäuser, M., & Fromme, T. (2017) · Springer eBooks · doi:10.1007/978-3-319-52031-5_4 · Cited by 21
Nedergaard, J., von Essen, G., & Cannon, B. (2023) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2022.0220 · Cited by 21
Self-citationHolmström, T. E., Mattsson, C. L., Wang, Y., Iakovleva, I., Petrovič, N., & Nedergaard, J. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.05.029 · Cited by 21
Self-citationErnande, L., Stanford, K. I., Thoonen, R., Zhang, H., Clerté, M., Hirshman, M. F., Goodyear, L. J., Bloch, K. D., Buys, E. S., & Scherrer‐Crosbie, M. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00634.2015 · Cited by 21
Fischer, A. W., Behrens, J. R., Sass, F., Schlein, C., Heine, M., Pertzborn, P., Scheja, L., & Heeren, J. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000455 · Cited by 21
Sánchez‐Delgado, G., Martínez‐Téllez, B., Acosta, F. M., Virtue, S., Vidal‐Puig, A., Gil, Á., Elvira, J. M. L., & Ruiz, J. R. (2021) · Diabetes · doi:10.2337/db21-0011 · Cited by 20
The heat is on: Molecular mechanisms of drug-induced hyperthermia
Dao, C. K., Nowinski, S. M., & Mills, E. (2014) · Temperature · doi:10.4161/23328940.2014.985953 · Cited by 21
Heart hormones fueling a fire in fat
Collins, S., & Bordicchia, M. (2013) · Adipocyte · doi:10.4161/adip.22515 · Cited by 20
Brown Adipose Tissue in Children and Its Metabolic Function
Tews, D., & Wabitsch, M. (2021) · Hormone Research in Paediatrics · doi:10.1159/000518353 · Cited by 19
Aragón‐Vela, J., Carrillo, J. A.-B., Moreno-Racero, A., & Plaza‐Díaz, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315413 · Cited by 19
Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice
Soler‐Vázquez, M. C., Romero, M. D. M., Todorčević, M., Delgado, K., Calatayud, C., Amaro, A. B., Lhoëst, M. T. L. C., Mera, P., Zagmutt, S., Bastías-Pérez, M., et al. (2023) · Metabolic Engineering · doi:10.1016/j.ymben.2023.04.010 · Cited by 19
Nadal-Casellas, A., Proenza, A. M., Gianotti, M., & Lladó, I. (2010) · Stress · doi:10.3109/10253890.2010.524681 · Cited by 20
A method for the automatic segmentation of brown adipose tissue
Prakash, B., Srour, H., Velan, S. S., & Chuang, K. (2016) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-015-0517-0 · Cited by 19
García-Casarrubios, E., de Moura, C., Arroba, A. I., Pescador, N., Calderón‐Domínguez, M., Garcia, L., Herrero, L., Serra, D., Cadenas, S., Reis, F., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.09.016 · Cited by 20
Automated segmentation of human cervical-supraclavicular adipose tissue in magnetic resonance images
Lundström, E., Strand, R., Forslund, A. H., Bergsten, P., Weghuber, D., Ahlström, H. K., & Kullberg, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-01586-7 · Cited by 19
Modulation of thermogenesis and metabolic health: a built environment perspective
Lichtenbelt, W. D. V. M., Pallubinsky, H., & Kulve, M. T. (2018) · Obesity Reviews · doi:10.1111/obr.12789 · Cited by 19
Rose hip supplementation increases energy expenditure and induces browning of white adipose tissue
Cavalera, M., Axling, U., Berger, K., & Holm, C. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0151-5 · Cited by 21
Brown Adipose Tissue Bioenergetics: A New Methodological Approach
Calderón‐Domínguez, M., Alcalá, M., Sebastián, D., Antonio Zorzano, A., Viana, M., Serra, D., & Herrero, L. (2017) · Advanced Science · doi:10.1002/advs.201600274 · Cited by 19
Hojná, S., Jordan, M. D., Kollias, H., & Pausová, Z. (2011) · Hypertension Research · doi:10.1038/hr.2011.188 · Cited by 19
Sánchez‐Delgado, G., Acosta, F. M., Martínez‐Téllez, B., Finlayson, G., Gibbons, C., Labayen, I., Elvira, J. M. L., Gil, Á., Blundell, J. E., & Ruiz, J. R. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz300 · Cited by 18
From development to future prospects: The adipose tissue & adipose tissue organoids
Okumuş, E. B., Böke, Ö. B., Şenkal, S., & Doğan, A. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122758 · Cited by 19
Brown adipocyte progenitor population is modified in obese and diabetic skeletal muscle
Russell, A. P., Crisan, M., Léger, B., Corselli, M., McAinch, A. J., O’Brien, P. E., Cameron‐Smith, D., Péault, B., Casteilla, L., & Giacobino, J.-P. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.85 · Cited by 18
Hu, P., & Gilsanz, V. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00033 · Cited by 18
Implications of thermogenic adipose tissues for metabolic health
Schlein, C., & Heeren, J. (2016) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2016.08.002 · Cited by 18
Worthmann, A., Schlein, C., Berbée, J. F. P., Rensen, P. C. N., Heeren, J., & Bartelt, A. (2019) · Nutrients · doi:10.3390/nu11020463 · Cited by 18
Yue, H., Liu, W., Zhang, W., Jia, M., Huang, F., Du, F., & Xu, T. (2021) · Journal of Food Science · doi:10.1111/1750-3841.15645 · Cited by 18
Thermogenic genes are blunted whereas brown adipose tissue identity is preserved in human obesityPreprint
Jespersen, N. Z., Andersen, M. W., Hirschberg, V., Stærkær, T. W., Severinsen, M. C. K., Peijs, L., Soares, R., Forss, I., Andersen, E. S., Hahn, C. H., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.07.082057 · Cited by 18
Human thermogenic adipose tissue
Blondin, D. P. (2023) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2023.102054 · Cited by 17
Seiler, S. E., Xu, D., Ho, J.-P., Lo, K. A., Buehrer, B. M., Ludlow, Y. J. W., Kovalik, J., & Sun, L. (2015) · Adipocyte · doi:10.1080/21623945.2015.1042192 · Cited by 17
Grenier–Larouche, T., Labbé, S. M., Noll, C., Richard, D., & Carpentier, A. C. (2012) · International Journal of Obesity Supplements · doi:10.1038/ijosup.2012.21 · Cited by 17
Brown adipose tissue clinical impact of a re-discovered thermogenic organ
Vijgen, G. H. E. J. (2013) · Frontiers in Bioscience-Elite · doi:10.2741/e663 · Cited by 17
Bae, J., Chen, J., & Zhao, L. (2015) · Biochemistry and Cell Biology · doi:10.1139/bcb-2014-0139 · Cited by 17
The role of BAT in cardiometabolic disorders and aging
Blondin, D. P., & Carpentier, A. C. (2016) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2016.09.002 · Cited by 17
Browning capabilities of human primary adipose-derived stromal cells compared to SGBS cells
Halbgebauer, D., Dahlhaus, M., Wabitsch, M., Fischer‐Posovszky, P., & Tews, D. (2020) · Scientific Reports · doi:10.1038/s41598-020-64369-7 · Cited by 17
The Endocrine Adipose Organ: A System Playing a Central Role in COVID-19
Cinti, F., & Cinti, S. (2022) · Cells · doi:10.3390/cells11132109 · Cited by 17
Self-citationA Clinical Approach to Brown Adipose Tissue in the Para-Aortic Area of the Human Thorax
Wei, H., Chiba, S., Moriwaki, C., Kitamura, H., Ina, K., Aosa, T., Tomonari, K., Gotoh, K., Masaki, T., Katsuragi, I., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122594 · Cited by 19
Никанорова, А. А., Алексеевич, Б. Н., Пшенникова, В. Г., Teryutin, F. M., Сергеевич, Н. С., Solovyev, A. V., Romanov, G. P., Бурцева, Т. Е., & Федорова, С. А. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814052 · Cited by 18
Festuccia, W. T., Blanchard, P.-G., de Oliveira, T. B., Magdalon, J., Paschoal, V. A., Richard, D., & Deshaies, Y. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00299.2012 · Cited by 17
Searching for ways to switch on brown fat: are we getting warmer?
Whittle, A. J. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0080 · Cited by 16
Metadata
- Authors
- Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., & Cinti, S.
- Affiliations
- Marche Polytechnic University (IT)
- Stockholm University (SE)
- Corresponding author
- Cinti, Saverio
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2009-05-05
- Volume
- 23
- Issue
- 9
- Pages
- 3113-3120
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2115313813
- Cited by
- 725
- References
- 15
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 8 · 2023: 25 · 2022: 30 · 2021: 32 · 2020: 43 · 2019: 46 · 2018: 41 · 2017: 57 · 2016: 37 · 2015: 60 · 2014: 59 · 2013: 80 · 2012: 69
- FWCI
- 42.11
- Type
- journal article
- Language
- en
- Open access
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- RVC Research Online (Royal Veterinary College) (submittedVersion, cc-by)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Funders
- Vetenskapsrådet (BBR57M_005)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- brown adipose tissue, UCP1, brown adipocytes, sympathetic innervation, capillary density, obesity treatment
- MeSH terms
- Uncoupling Protein 1, Adolescent, Adult, Adipose Tissue, Brown, Capillaries, Female, Humans, Ion Channels, Male, Neck, Thyroid Diseases, Mitochondrial Proteins, Adipocytes, Brown, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review