The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
Open accessAbstract
Classically, adult humans have been considered not to possess active brown adipose tissue (BAT). However, positron‐emission‐tomography has shown fluorodeoxyglucose uptake that is distributed in such a way ( e.g. , in the neck) that it would seem to be BAT. Until now this has not been supported by direct evidence that these areas truly represented BAT, that is, the presence of the BAT‐unique uncoupling protein‐1 (UCP1). Samples of adipose tissue from the neck of 35 patients undergoing surgery for thyroid diseases were obtained and analyzed. In 1/3 of the subjects (the younger and leaner), distinct islands composed of UCP1 immunoreactive brown adipocytes could clearly be discerned, accounting for up to 1/3 of all adipocytes. The brown‐adipose islands were richlysympathetically innervated (indicating acute central control); adjacent white adipose areas were not. The capillary density was high, implying a high capacity for oxygen delivery. Cells with features of brown adipocyte precursors were found in pericapillary areas. These data demonstrate that human adults indeed possess BAT and thus imply possibilities of future therapeutic strategies for the treatment of obesity, including maintenance of brown adipocytes and stimulation of the growth of preexisting brown precursors.—Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., Cinti, S. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J. 23, 3113–3120 (2009). www.fasebj.org
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Second, recent studies have shown that adult humans maintain potentially active brown adipose tissue, making this high energetic tissue a real therapeutic target 13–17.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“However, it was only during the past year PET/CT imaging was used to prove conclusively that adult humans possess physiologically active UCP1-positive BAT,13–17.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“Given the scanning data and the finding of brown adipocyte precursors in human tissues 17, it is likely that virtually every adult human has the capacity to develop some functional BAT.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“However, histological analysis of cervical fat biopsies show rates three times higher 17, and prospective studies using cold stimulation to increase BAT activity and detection via PET/CT show that among younger people, 96% have functional BAT 14.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“Although it has only recently been proven that adult human BAT is functional and may be involved in protecting against weight loss 13–17, attempts to exploit BAT energy expenditure for treating obesity have been around for decades.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [17]
In the citing paper
“Such depots appear to be less active as a function of aging and/or obesity (151, 164 -167).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [167]
Citations
Cites
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
Self-citationUnexpected evidence for active brown adipose tissue in adult humans
Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824
Self-citationFeldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318
Self-citationCinti, S. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.010 · Cited by 720
Self-citationNedergaard, J., Golozoubova, V., Matthias, A., Asadi, A., Jacobsson, A., & Cannon, B. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00247-4 · Cited by 615
Self-citationBrown adipose tissue and heat production in the newborn infant
Aherne, W., & Hull, D. (1966) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700910126 · Cited by 284
Murano, I., Barbatelli, G., Giordano, A., & Cinti, S. (2009) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.01001.x · Cited by 208
Self-citationBrown adipose tissue in humans
Lean, M. E. J. (1989) · Proceedings of The Nutrition Society · doi:10.1079/pns19890036 · Cited by 199
Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol
Söderlund, V., Larsson, S., & Jacobsson, H. (2007) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-006-0318-9 · Cited by 177
Parysow, O., Mollerach, A. M., Jager, V., Racioppi, S., Román, J. S., & Gerbaudo, V. H. (2007) · Clinical Nuclear Medicine · doi:10.1097/01.rlu.0000259570.69163.04 · Cited by 147
Research works printed but not linked: 1
- Lean M. E. J., 1986, Brown Adipose Tissue, 339
Cited by
Sorted by citations
Brown adipose tissue activity controls triglyceride clearance
Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Weller, H., Waurisch, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2297 · Cited by 1,608
Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., & Nedergaard, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053942 · Cited by 1,263
Self-citationAdipose tissue browning and metabolic health
Bartelt, A., & Heeren, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.204 · Cited by 1,177
Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist
Cypess, A. M., Weiner, L. S., Roberts‐Toler, C., Franquet, E., Kessler, S., Kahn, P. A., English, J., Chatman, K., Trauger, S. A., Doria, A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.009 · Cited by 1,053
Ouellet, V., Labbé, S. M., Blondin, D. P., Phoenix, S., Guérin, B., Haman, F., Turcotte, É. E., Richard, D., & Carpentier, A. C. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60433 · Cited by 985
Adaptive thermogenesis in adipocytes: Is beige the new brown?
Wu, J., Cohen, P., & Spiegelman, B. M. (2013) · Genes & Development · doi:10.1101/gad.211649.112 · Cited by 828
Bi-directional interconversion of brite and white adipocytes
Rosenwald, M., Perdikari, A., Rülicke, T., & Wolfrum, C. (2013) · Nature Cell Biology · doi:10.1038/ncb2740 · Cited by 833
Barbatelli, G., Murano, I., Madsen, L., Hao, Q., Jimenez, M., Kristiansen, K., Giacobino, J., Matteis, R. D., & Cinti, S. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00600.2009 · Cited by 788
Self-citationAdipose tissue in control of metabolism
Luo, L., & Liu, M. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0211 · Cited by 764
Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis
Sidossis, L. S., & Kajimura, S. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78362 · Cited by 715
Cypess, A. M., White, A. P., Vernochet, C., Schulz, T. J., Xue, R., Sass, C. A., Huang, T. L., Roberts‐Toler, C., Weiner, L. S., Sze, C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3112 · Cited by 683
Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells
Sharp, L. Z., Shinoda, K., Ohno, H., Scheel, D. W., Tomoda, E., Ruiz, L., Hu, H., Wang, L. L., Pavlova, Z., Gilsanz, V., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049452 · Cited by 652
Cellular bioenergetics as a target for obesity therapy
Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591
BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions
Whittle, A. J., Carobbio, S., Martins, L., Slawik, M., Hondares, E., Vázquez, M. J., Morgan, D., Csikasz, R. I., Gallego, R., Rodriguez-Cuenca, S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.066 · Cited by 573
Self-citationOuellet, V., Routhier-Labadie, A., Bellemare, W., Lakhal‐Chaieb, L., Turcotte, É. E., Carpentier, A. C., & Richard, D. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0989 · Cited by 578
White, Brown, Beige/Brite: Different Adipose Cells for Different Functions?
Giralt, M., & Villarroya, F. (2013) · Endocrinology · doi:10.1210/en.2013-1403 · Cited by 586
The role of mitochondria in the pathogenesis of type 2 diabetes
Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551
Goetze, J. P., Bruneau, B. G., Ramos, H. R., Ogawa, T., de Bold, M. L. K., & de Bold, A. J. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0381-0 · Cited by 572
Mapping of human brown adipose tissue in lean and obese young men
Leitner, B. P., Huang, S., Brychta, R. J., Duckworth, C. J., Baskin, A. S., McGehee, S., Tal, I., Dieckmann, W., Gupta, G., Kolodny, G. M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705287114 · Cited by 530
Jespersen, N. Z., Larsen, T. J., Peijs, L., Daugaard, S., Homøe, P., Loft, A., de Jong, J. M. A., Mathur, N., Cannon, B., Nedergaard, J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.011 · Cited by 550
Self-citationYoneshiro, T., Aita, S., Matsushita, M., Okamatsu‐Ogura, Y., Kameya, T., Kawai, Y., Miyagawa, M., Tsujisaki, M., & Saito, M. (2011) · Obesity · doi:10.1038/oby.2011.125 · Cited by 507
The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes
Vitali, A., Murano, I., Zingaretti, M. C., Frontini, A., Ricquier, D., & Cinti, S. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m018846 · Cited by 487
Self-citationBrown versus White Adipose Tissue: A Mini-Review
Saely, C. H., Geiger, K. D., & Drexel, H. (2010) · Gerontology · doi:10.1159/000321319 · Cited by 487
Sympathetic and sensory innervation of brown adipose tissue
Bartness, T. J., Vaughan, C. H., & Song, C. K. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.182 · Cited by 459
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
Schulz, T. J., Huang, T. L., Tran, T. T., Zhang, H., Townsend, K. L., Shadrach, J. L., Cerletti, M., McDougall, L. E., Giorgadze, N., Tchkonia, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010929108 · Cited by 479
Distribution and Development of Brown Adipocytes in the Murine and Human Adipose Organ
Frontini, A., & Cinti, S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.004 · Cited by 484
Self-citationAdipose tissue stem cells meet preadipocyte commitment: going back to the future
Cawthorn, W. P., Scheller, E. L., & MacDougald, O. A. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r021089 · Cited by 467
Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
Berbée, J. F. P., Boon, M. R., Khedoe, P. P. S. J., Bartelt, A., Schlein, C., Worthmann, A., Kooijman, S., Hoeke, G., Mol, I. M., John, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7356 · Cited by 440
The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions
Nedergaard, J., & Cannon, B. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.007 · Cited by 434
Self-citationBrown Adipose Tissue, Whole‐Body Energy Expenditure, and Thermogenesis in Healthy Adult Men
Yoneshiro, T., Aita, S., Matsushita, M., Kameya, T., Nakada, K., Kawai, Y., & Saito, M. (2010) · Obesity · doi:10.1038/oby.2010.105 · Cited by 428
Impact of Age on the Relationships of Brown Adipose Tissue With Sex and Adiposity in Humans
Pfannenberg, C., Werner, M. K., Ripkens, S., Stef, I., Deckert, A., Schmadl, M., Reimold, M., Häring, H., Claussen, C. D., & Stefan, N. (2010) · Diabetes · doi:10.2337/db10-0004 · Cited by 428
Insulin resistance and impaired adipogenesis
Gustafson, B., Hedjazifar, S., Gogg, S., Hammarstedt, A., & Smith, U. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.01.006 · Cited by 407
Transcriptional Regulation of Adipogenesis
de Sá, P. M., Richard, A. J., Hang, H., & Stephens, J. M. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160022 · Cited by 406
Cao, L., Choi, E., Liu, X., Martin, A. S., Wang, C., Xu, X., & During, M. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.020 · Cited by 390
Transdifferentiation properties of adipocytes in the adipose organ
Cinti, S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00183.2009 · Cited by 379
Self-citationThe Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells
Tran, K., Gealekman, O., Frontini, A., Zingaretti, M. C., Morroni, M., Giordano, A., Smorlesi, A., Perugini, J., Matteis, R. D., Sbarbati, A., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.008 · Cited by 396
Self-citationBrown fat as a therapy for obesity and diabetes
Cypess, A. M., & Kahn, C. R. (2010) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e328337a81f · Cited by 376
Brown Adipose Tissue in Morbidly Obese Subjects
Vijgen, G. H. E. J., Bouvy, N. D., Teule, G. J. J., Brans, B. T., Schrauwen, P., & Lichtenbelt, W. D. V. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017247 · Cited by 390
Pospisilik, J. A., Schramek, D., Schnidar, H., Cronin, S. J. F., Nehme, N. T., Zhang, X., Knauf, C., Cani, P. D., Aumayr, K., Todoric, J., et al. (2010) · Cell · doi:10.1016/j.cell.2009.12.027 · Cited by 374
Enerbäck, S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.008 · Cited by 382
Cinti, S. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009662 · Cited by 370
Self-citationTan, D. ‐., Manchester, L. C., Fuentes‐Broto, L., Paredes, S. D., & Reiter, R. J. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00756.x · Cited by 353
Brown fat fuel utilization and thermogenesis
Townsend, K. L., & Tseng, Y. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.12.004 · Cited by 343
Sarjeant, K., & Stephens, J. M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008417 · Cited by 328
Transplantation of adipose tissue and stem cells: role in metabolism and disease
Tran, T. T., & Kahn, C. R. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.20 · Cited by 335
Brown Adipose Tissue Energy Metabolism in Humans
Carpentier, A. C., Blondin, D. P., Virtanen, K. A., Richard, D., Haman, F., & Turcotte, É. E. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00447 · Cited by 338
Evidence against a Beneficial Effect of Irisin in Humans
Raschke, S., Elsen, M., Gassenhuber, J., Sommerfeld, M. R., Schwahn, U., Brockmann, B., Jung, R., Wisløff, U., Tjønna, A. E., Raastad, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073680 · Cited by 327
Lee, P., Greenfield, J. R., Ho, K. K. Y., & FULHAM, M. J. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00298.2010 · Cited by 323
Cold but not sympathomimetics activates human brown adipose tissue in vivo
Cypess, A. M., Chen, Y., Sze, C., Wang, K., English, J., Chan, O., Holman, A. R., Tal, I., Palmer, M. R., Kolodny, G. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207911109 · Cited by 312
Implications of nonshivering thermogenesis for energy balance regulation in humans
Lichtenbelt, W. D. V. M., & Schrauwen, P. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00652.2010 · Cited by 318
Yin, H., Pasut, A., Soleimani, V. D., Bentzinger, C. F., Antoun, G., Thorn, S., Seale, P., Fernando, P., van IJcken, W., Grosveld, F., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.004 · Cited by 293
A stringent validation of mouse adipose tissue identity markers
de Jong, J. M. A., Larsson, O. S., Cannon, B., & Nedergaard, J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00023.2015 · Cited by 303
Self-citationXue, R., Lynes, M. D., Dreyfuss, J. M., Shamsi, F., Schulz, T. J., Zhang, H., Huang, T. L., Townsend, K. L., Li, Y., Takahashi, H., et al. (2015) · Nature Medicine · doi:10.1038/nm.3881 · Cited by 302
HOCKING, S. L., Samocha‐Bonet, D., Milner, K., Greenfield, J. R., & Chisholm, D. J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1041 · Cited by 295
Giordano, A., Smorlesi, A., Frontini, A., Barbatelli, G., & Cinti, S. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-0945 · Cited by 298
Self-citationCellular origins of cold‐induced brown adipocytes in adult mice
Lee, Y., Petkova, A. P., Konkar, A. A., & Granneman, J. G. (2014) · The FASEB Journal · doi:10.1096/fj.14-263038 · Cited by 291
Anatomical Locations of Human Brown Adipose Tissue
Sacks, H. S., & Symonds, M. E. (2013) · Diabetes · doi:10.2337/db12-1430 · Cited by 292
Brown Adipose Tissue and Seasonal Variation in Humans
Au-Yong, I. T. H., Thorn, N., Ganatra, R. H., Perkins, A. C., & Symonds, M. E. (2009) · Diabetes · doi:10.2337/db09-0833 · Cited by 272
Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity
Bi, P., Shan, T., Liu, W., Yue, F., Yang, X., Liang, X.-R., Wang, J., Li, J., Carlesso, N., Liu, X., et al. (2014) · Nature Medicine · doi:10.1038/nm.3615 · Cited by 271
Adipocyte lineages: Tracing back the origins of fat
Sánchez-Gurmaches, J., & Guertin, D. A. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.027 · Cited by 277
Brown and beige fat: Molecular parts of a thermogenic machine
Cohen, P., & Spiegelman, B. M. (2015) · Diabetes · doi:10.2337/db15-0318 · Cited by 259
Wikström, J. D., Mahdaviani, K., Liesa, M., Sereda, S. B., Si, Y., Las, G., Twig, G., Petrovič, N., Zingaretti, C. M., Graham, A., et al. (2014) · The EMBO Journal · doi:10.1002/embj.201385014 · Cited by 267
Self-citationThe role of thyroid hormone in metabolism and metabolic syndrome
Teixeira, P. D. F. D. S., dos Santos, P. B., & Pazos-Moura, C. C. (2020) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018820917869 · Cited by 258
Brown fat biology and thermogenesis
Richard, D. (2010) · Frontiers in bioscience · doi:10.2741/3786 · Cited by 251
Mitochondrial fatty acid oxidation in obesity
Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4875 · Cited by 246
15O PET Measurement of Blood Flow and Oxygen Consumption in Cold-Activated Human Brown Fat
Muzik, O., Mangner, T. J., Leonard, W. R., Kumar, A., Janisse, J. J., & Granneman, J. G. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.111336 · Cited by 250
Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells
Mori, M., Nakagami, H., Rodriguez-Araujo, G., Nimura, K., & Kaneda, Y. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001314 · Cited by 243
“[2–6] have highlighted BAT as a new therapeutic target for treating obesity and its associated diseases, such as type 2 diabetes mellitus”
Backgroundβ3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis
Cero, C., Lea, H. J., ZHU, K. Y., Shamsi, F., Tseng, Y., & Cypess, A. M. (2021) · JCI Insight · doi:10.1172/jci.insight.139160 · Cited by 250
Brown Adipose Tissue: an Update on Recent Findings
Marlatt, K. L., & Ravussin, É. (2017) · Current Obesity Reports · doi:10.1007/s13679-017-0283-6 · Cited by 243
Convertible visceral fat as a therapeutic target to curb obesity
Giordano, A., Frontini, A., & Cinti, S. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.31 · Cited by 241
Self-citationTupone, D., Madden, C. J., Cano, G., & Morrison, S. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3909-11.2011 · Cited by 228
Brown adipose tissue and thermogenesis
Fenzl, A., & Kiefer, F. W. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0022 · Cited by 239
Human Brown Adipose Tissue: What We Have Learned So Far
Betz, M. J., & Enerbäck, S. (2015) · Diabetes · doi:10.2337/db15-0146 · Cited by 223
Myokines in insulin resistance and type 2 diabetes
Eckardt, K., Görgens, S. W., Raschke, S., & Eckel, J. (2014) · Diabetologia · doi:10.1007/s00125-014-3224-x · Cited by 234
Pardo, M., Crujeiras, A. B., Amil, M., Agüera, Z., Jiménez‐Múrcia, S., Baños, R., Botella, C., de la Torre, R., Estivill, X., Fagundo, A. B., et al. (2014) · International Journal of Endocrinology · doi:10.1155/2014/857270 · Cited by 219
Emerging Complexities in Adipocyte Origins and Identity
Sánchez-Gurmaches, J., Hung, C., & Guertin, D. A. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.01.004 · Cited by 225
Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism
Schéele, C., & Wolfrum, C. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz007 · Cited by 224
Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes
Lo, K. A., & Sun, L. (2013) · Bioscience Reports · doi:10.1042/bsr20130046 · Cited by 225
White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma
Frontini, A., Vitali, A., Perugini, J., Murano, I., Romiti, C., Ricquier, D., Guerrieri, M., & Cinti, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.02.005 · Cited by 218
Self-citationAdult Epicardial Fat Exhibits Beige Features
Sacks, H. S., Fain, J. N., Bahouth, S. W., Ojha, S., Frontini, A., Budge, H., Cinti, S., & Symonds, M. E. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1265 · Cited by 218
Self-citationBrown Adipose Tissue in Adult Humans: A Metabolic Renaissance
Lee, P. C., Swarbrick, M. M., & Ho, K. K. Y. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1081 · Cited by 224
Aging, obesity, sarcopenia and the effect of diet and exercise intervention
Colleluori, G., & Villareal, D. T. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111561 · Cited by 217
Functional thermogenic beige adipogenesis is inducible in human neck fat
Lee, P., Werner, C., Kebebew, E., & Celi, F. S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.82 · Cited by 213
Browning of white adipose tissue: lessons from experimental models
Bargut, T. C. L., Souza‐Mello, V., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0051 · Cited by 212
The origin and definition of brite versus white and classical brown adipocytes
Rosenwald, M., & Wolfrum, C. (2013) · Adipocyte · doi:10.4161/adip.26232 · Cited by 220
Paniagua, J. A. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i19.483 · Cited by 197
De novo lipogenesis in metabolic homeostasis: More friend than foe?
Solinas, G., Borén, J., & Dulloo, A. G. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.03.004 · Cited by 208
Madsen, L., Pedersen, L. M., Lillefosse, H. H., Fjære, E., Brønstad, I., Hao, Q., Petersen, R. K., Hallenborg, P., Ma, T., Matteis, R. D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011391 · Cited by 204
Self-citationHypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity
Trayhurn, P. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161156 · Cited by 194
Ephedrine activates brown adipose tissue in lean but not obese humans
Carey, A. L., Formosa, M. F., van Every, B., Bertovic, D. A., Eikelis, N., Lambert, G. W., Kalff, V., Duffy, S. J., Cherk, M. H., & Kingwell, B. A. (2012) · Diabetologia · doi:10.1007/s00125-012-2748-1 · Cited by 196
Adipose Organ Development and Remodeling
Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 197
Self-citationAlcalá, M., Calderón‐Domínguez, M., Araya, M. E. B., Ramos, P., Casals, N., Serra, D., Viana, M., & Herrero, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-16463-6 · Cited by 192
UCP1 in adipose tissues: two steps to full browning
Kalinovich, A., de Jong, J. M. A., Cannon, B., & Nedergaard, J. (2017) · Biochimie · doi:10.1016/j.biochi.2017.01.007 · Cited by 190
Self-citationRutin ameliorates obesity through brown fat activation
Yuan, X., Wei, G., You, Y., Huang, Y., Lee, H. J., Dong, M., Lin, J., Hu, T., Zhang, H., Zhang, C.-H., et al. (2016) · The FASEB Journal · doi:10.1096/fj.201600459rr · Cited by 184
The adipose organ: white‐brown adipocyte plasticity and metabolic inflammation
Smorlesi, A., Frontini, A., Giordano, A., & Cinti, S. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01039.x · Cited by 189
Self-citationVosselman, M. J., van der Lans, A. A. J. J., Brans, B. T., Wierts, R., van Baak, M. A., Schrauwen, P., & Lichtenbelt, W. D. V. M. (2012) · Diabetes · doi:10.2337/db12-0288 · Cited by 185
Tejido adiposo: heterogeneidad celular y diversidad funcional
Esteve, M. (2013) · Endocrinología y Nutrición · doi:10.1016/j.endonu.2013.03.011 · Cited by 192
Cannon, B., & Nedergaard, J. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.177 · Cited by 176
Self-citationBrown adipose tissue: Development, metabolism and beyond
Schulz, T. J., & Tseng, Y.-H. (2013) · Biochemical Journal · doi:10.1042/bj20130457 · Cited by 173
Townsend, K. L., & Tseng, Y. (2012) · Adipocyte · doi:10.4161/adip.18951 · Cited by 182
Metadata
- Authors
- Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., & Cinti, S.
- Affiliations
- Marche Polytechnic University (IT)
- Stockholm University (SE)
- Corresponding author
- Cinti, Saverio
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2009-05-05
- Volume
- 23
- Issue
- 9
- Pages
- 3113-3120
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2115313813
- Cited by
- 725
- References
- 15
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 8 · 2023: 25 · 2022: 30 · 2021: 32 · 2020: 43 · 2019: 46 · 2018: 41 · 2017: 57 · 2016: 37 · 2015: 60 · 2014: 59 · 2013: 80 · 2012: 69
- FWCI
- 42.11
- Type
- journal article
- Language
- en
- Open access
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- RVC Research Online (Royal Veterinary College) (submittedVersion, cc-by)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Funders
- Vetenskapsrådet (BBR57M_005)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- brown adipose tissue, UCP1, brown adipocytes, sympathetic innervation, capillary density, obesity treatment
- MeSH terms
- Uncoupling Protein 1, Adolescent, Adult, Adipose Tissue, Brown, Capillaries, Female, Humans, Ion Channels, Male, Neck, Thyroid Diseases, Mitochondrial Proteins, Adipocytes, Brown, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
