The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
The N‐myc downstream regulated gene (NDRG) family: diverse functions, multiple applications
Abstract
The N‐myc downstream regulated gene (NDRG) family of proteins consists of 4 members, NDRG1–4, which are well conserved through evolution. The first member to be discovered and responsible for the family name was NDRG1, because its expression is repressed by the proto‐oncogenes MYCN and MYC. All family members are characterized by an α/β hydrolase‐fold motif; however, the precise molecular and cellular function of these family members has not been fully elucidated. Although the exact function of NDRG family members has not been clearly elucidated, emerging evidence suggests that mutations in these genes are associated with diverse neurological and electrophysiological syndromes. In addition, aberrant expression as well as tumor suppressor and oncogenic functions affecting key hallmarks of carcinogenesis such as cell proliferation, differentiation, migration, invasion, and stress response have been reported for several of the NDRG proteins. In this review, we summarize the current literature on the NDRG family members concerning their structure, origin, and tissue distribution. In addition, we review the current knowledge regarding the regulation and signaling of the NDRG family members in development and normal physiology. Finally, their role in disease and potential clinical applications (their role as detection or prognostic markers) are discussed.—Melotte, V., Qu, X., Ongenaert, M., van Criekinge, W., de BruÏne, A. P., Baldwin, H. S., van Engeland, M. The N‐myc downstream regulated gene (NDRG) family: diverse functions, multiple applications. FASEB J . 24,4153–4166 (2010). www.fasebj.org
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Clustal W and Clustal X version 2.0
Larkin, M. A., Blackshields, G., Brown, N. P., Chenna, R., McGettigan, P. A., McWilliam, H., Valentin, F., Wallace, I. M., Wilm, A., Lopez, R., et al. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm404 · Cited by 28,358
Tree View: An application to display phylogenetic trees on personal computers
Page, R. D. M. (1996) · Bioinformatics · doi:10.1093/bioinformatics/12.4.357 · Cited by 10,178
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
CpG Islands in vertebrate genomes
Gardiner-Garden, M., & Frommer, M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90689-9 · Cited by 3,353
The Consensus Coding Sequences of Human Breast and Colorectal Cancers
Sjöblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D., Leary, R. J., Ptak, J., Silliman, N., et al. (2006) · Science · doi:10.1126/science.1133427 · Cited by 3,169
Boutet, E., Lieberherr, D., Tognolli, M., Schneider, M., & Bairoch, A. (2007) · Plant Bioinformatics · doi:10.1007/978-1-59745-535-0_4 · Cited by 763
Drugs That Induce Repolarization Abnormalities Cause Bradycardia in Zebrafish
Milan, D. J., Peterson, T. A., Ruskin, J. N., Peterson, R. T., & MacRae, C. A. (2003) · Circulation · doi:10.1161/01.cir.0000061912.88753.87 · Cited by 440
Common variants at ten loci influence QT interval duration in the QTGEN Study
Newton-Cheh, C., Eijgelsheim, M., Rice, K. M., de Bakker, P. I. W., Yin, X., Estrada, K., Bis, J. C., Marciante, K., Rivadeneira, F., Noseworthy, P. A., et al. (2009) · Nature Genetics · doi:10.1038/ng.364 · Cited by 413
Common variants at ten loci modulate the QT interval duration in the QTSCD Study
Pfeufer, A., Sanna, S., Arking, D. E., Müller, M., Gateva, V., Fuchsberger, C., Ehret, G. B., Orrú, M., Pattaro, C., Köttgen, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.362 · Cited by 389
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway
Unoki, M., & Nakamura, Y. (2001) · Oncogene · doi:10.1038/sj.onc.1204608 · Cited by 381
Cited by
Iron and cancer: more ore to be mined
Torti, S. V., & Torti, F. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3495 · Cited by 1,621
Hickok, J. R., Sahni, S., Mikhed, Y., Bonini, M. G., & Thomas, D. D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.287052 · Cited by 80
Schonkeren, S. L., Massen, M., van der Horst, R., Koch, A., Vaes, N., & Melotte, V. (2019) · neurogenetics · doi:10.1007/s10048-019-00587-0 · Cited by 57
Self-citationWatari, K., Shibata, T., Nabeshima, H., Shinoda, A., Fukunaga, Y., Kawahara, A., Karasuyama, K., Fukushi, J.-I., Iwamoto, Y., Kuwano, M., et al. (2016) · Scientific Reports · doi:10.1038/srep19470 · Cited by 36
Marechal, D., Dansu, D. K., Castro, K., Patzig, J., Magri, L., Inbar, B., Gacias, M., Moyon, S., & Casaccia, P. (2022) · Glia · doi:10.1002/glia.24108 · Cited by 17
Metadata
- Authors
- Melotte, V., Qu, X., Ongenaert, M., van Criekinge, W., de Bruïne, A. P., Baldwin, H. S., & van Engeland, M.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2010-07-28
- Volume
- 24
- Issue
- 11
- Pages
- 4153-4166
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2145304819
- Cited by
- 285
- References
- 94
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The N‐myc downstream regulated gene (NDRG) family: diverse functions, multiple applications. https://app.cochat.ai/papers/10.1096/fj.09-151464
- The paper
- Melotte, V., Qu, X., Ongenaert, M., van Criekinge, W., de Bruïne, A. P., Baldwin, H. S., & van Engeland, M. (2010). The N‐myc downstream regulated gene (NDRG) family: diverse functions, multiple applications. The FASEB Journal. https://doi.org/10.1096/fj.09-151464
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
