The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
P2X7 receptor‐stimulation causes fever via PGE2 and IL‐1β release
Open accessAbstract
Prostaglandins (PGs) are important lipid mediators involved in the development of inflammatory associated pain and fever. PGE2 is a well‐established endogenous pyrogen activated by proinflammatory cytokine interleukin (IL)‐1β. P2X7 receptors (P2X7Rs) expressed by inflammatory cells are stimulated by the danger signal extracellular ATP to activate the inflammasome and release IL‐1β. Here we show that P2X7R activation is required for the release of PGE2 and other autacoids independent of inflammasome activation, with an ATP EC 50 for PGE2 and IL‐1β release of 1.58 and 1.23 mM, respectively. Furthermore, lack of P2X7R or specific antagonism of P2X7R decreased the febrile response in mice triggered after intraperitoneal LPS or IL‐1β inoculation. Accordingly, LPS inoculation caused intraperitoneal ATP accumulation. Therefore, P2X7R antagonists emerge as novel therapeutics for the treatment for acute inflammation, pain and fever, with wider anti‐inflammatory activity than currently used cyclooxygenase inhibitors.—Barberà‐Cremades, M., Baroja‐Mazo, A., Gomez, A. I., Machado, F., Di Virgilio, F., Pelegrín, P. P2X7 receptor‐stimulation causes fever via PGE2 and IL‐1β release. FASEB J. 26, 2951–2962 (2012). www.fasebj.org
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“Conversely, in a disease state as infection or brain disease, extracellular ATP levels largely increase and activate P2X7 receptors [68–70].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [70]
In the citing paper
“In fact, the role of P2X7 receptor as a modulator of inflammatory response is well-established [16, 70].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [70]
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Metadata
- Authors
- Barberà‐Cremades, M., Baroja‐Mazo, A., Gomez, A. I., Machado, F., Di Virgilio, F., & Pelegrín, P.
- Affiliations
- Inflammation and Experimental Surgery Unit Centro de Investigación Biomédica en Red de Enfermedades Hepaticas y Digestivas (CIBERhed)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Hospital Universitario Virgen de la Arrixaca (ES)
- Section of General Pathology, Department of Experimental and Diagnostic Medicine University of Ferrara Ferrara Italy
- ORCID
- Baroja‐Mazo, Alberto
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2012-04-06
- Volume
- 26
- Issue
- 7
- Pages
- 2951-2962
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2147692999
- Cited by
- 142
- References
- 62
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 5 · 2019: 18 · 2018: 4 · 2017: 16 · 2016: 13 · 2015: 12 · 2014: 17 · 2013: 11 · 2012: 3
- FWCI
- 9.66
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Hispana (publishedVersion, cc-by-nc-nd)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- P2X7 receptor, fever, prostaglandin E2, IL-1β, extracellular ATP, inflammasome, lipopolysaccharide, endogenous pyrogen, P2X7 receptor antagonists, acute inflammation, inflammatory pain, autacoids
- MeSH terms
- Adenosine Triphosphate, Animals, Fever, Humans, Injections, Intraperitoneal, Leukotriene B4, Lipopolysaccharides, Macrophages, Mice, Inbred C57BL, Recombinant Proteins, Thromboxane B2, Dinoprostone, Mice, Knockout, Inflammation Mediators, Calcium Signaling, MAP Kinase Signaling System, Mice, Cyclooxygenase 2, Interleukin-1beta, Receptors, Purinergic P2X7, Receptors, Purinergic P2X4, Purinergic P2X Receptor Agonists, Purinergic P2X Receptor Antagonists, In Vitro Techniques
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