P2X7 receptor‐stimulation causes fever via PGE2 and IL‐1β release

Molecular Physiology of P2X Receptors

North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919

The role of cyclooxygenases in inflammation, cancer, and development

Williams, C. S., Mann, M., & DuBois, R. N. (1999) · Oncogene · doi:10.1038/sj.onc.1203286 · Cited by 1,417

The P2X7 Receptor: A Key Player in IL-1 Processing and Release

Ferrari, D., Pizzirani, C., Adinolfi, E., Lemoli, R. M., Curti, A., Idzko, M., Panther, E., & Di Virgilio, F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.3877 · Cited by 1,025

Altered Cytokine Production in Mice Lacking P2X7Receptors

Solle, M., Labasi, J. M., Perregaux, D. G., Stam, E. J., Petrushova, N., Koller, B. H., Griffiths, R., & Gabel, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006781200 · Cited by 924

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

Chessell, I. P., Hatcher, J. P., Bountra, C., Michel, A. D., Hughes, J. P., Green, P., Egerton, J., Murfin, M., Richardson, J. C., Peck, W. L., et al. (2005) · Pain · doi:10.1016/j.pain.2005.01.002 · Cited by 807

Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages

Netea, M. G., Nold‐Petry, C. A., Nold, M. F., Joosten, L. A. B., Opitz, B., van der Meer, J. H. M., van de Veerdonk, F. L., Ferwerda, G., Heinhuis, B., Devesa, I., et al. (2008) · Blood · doi:10.1182/blood-2008-03-146720 · Cited by 787

Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase

Pellegatti, P., Raffaghello, L., Bianchi, G., Piccardi, F., Pistoia, V., & Di Virgilio, F. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002599 · Cited by 668

Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells

Idzko, M., Hammad, H., van Nimwegen, M., Kool, M., Willart, M. A. M., Muskens, F., Hoogsteden, H. C., Luttmann, W., Ferrari, D., Virgilio, F. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1617 · Cited by 620

Up-Regulation of P2X 4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

Ulmann, L., Hatcher, J. P., Hughes, J. P., Chaumont‐Dubel, S., Green, P. J., Conquet, F., Buell, G. N., Reeve, A. J., Chessell, I. P., & Rassendren, F. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2308-08.2008 · Cited by 572

Pharmacological profiles of cloned mammalian P2Y-receptor subtypes

von Kügelgen, I. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.08.014 · Cited by 549

Anti-Inflammatory Drugs in the 21st Century

Rainsford, K. D. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/1-4020-5688-5_1 · Cited by 465

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

Wilhelm, K., Ganesan, J., Müller, T., Dürr, C., Grimm, M., Beilhack, A., Krempl, C. D., Sorichter, S., Gerlach, U. V., Jüttner, E., et al. (2010) · Nature Medicine · doi:10.1038/nm.2242 · Cited by 435

A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat

Honoré, P., Donnelly‐Roberts, D. L., Namovic, M. T., Hsieh, G. C., Zhu, C., Mikusa, J. P., Hernandez, G., Zhong, C., Gauvin, D. M., Chandran, P., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111559 · Cited by 433

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

Hunot, S., Vila, M., Teismann, P., Davis, R. J., Hirsch, É. C., Przedborski, S., RAKIC, P. T., & Flavell, R. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307453101 · Cited by 430

Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo.

Portanova, J. P., Zhang, Y., Anderson, G., Hauser, S. D., Masferrer, J. L., Seibert, K., Gregory, S. A., & Isakson, P. C. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.3.883 · Cited by 421

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1β in Mouse Macrophage

Pelegrı́n, P., Barroso-Gutierrez, C., & Surprenant, A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7147 · Cited by 413

Extracellular ATP Is a Danger Signal Activating P2X7 Receptor in Lung Inflammation and Fibrosis

Riteau, N., Gasse, P., Fauconnier, L., Gombault, A., Couegnat, M., Fick, L., Kanellopoulos, J., Quesniaux, V. F. J., Marchand-Adam, S., Crestani, B., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201003-0359oc · Cited by 397

Multiple biological activities of human recombinant interleukin 1.

Dinarello, C. A., Cannon, J. G., Mier, J. W., Bernheim, H. A., LoPreste, G., Lynn, D., Love, R. N., Webb, A. C., Auron, P. E., & Reuben, R. C. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112495 · Cited by 366

Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: a possible site of prostaglandin synthesis responsible for fever

Cao, C., Matsumura, K., Yamagata, K., & Watanabe, Y. (1996) · Brain Research · doi:10.1016/0006-8993(96)00575-6 · Cited by 308

Autocrine regulation of T‐cell activation by ATP release and P2X 7 receptors

Yip, L., Woehrle, T., Corriden, R., Hirsh, M., Chen, Y., Inoue, Y., Ferrari, V., Insel, P. A., & JUNGER, W. G. (2009) · The FASEB Journal · doi:10.1096/fj.08-126458 · Cited by 303

A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

Arulkumaran, N., Unwin, R. J., & Tam, F. W. K. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.578068 · Cited by 254

Prostaglandin E2 as a mediator of fever: synthesis and catabolism

Andrei, I. I. (2004) · Frontiers in bioscience · doi:10.2741/1383 · Cited by 239

Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets

Samad, T. A., Sapirstein, A., & Woolf, C. J. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02383-3 · Cited by 229

P2X4 receptors mediate PGE2 release by tissue‐resident macrophages and initiate inflammatory pain

Ulmann, L., Hirbec, H., & Rassendren, F. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.126 · Cited by 229

Lack of the purinergic receptor P2X7 results in resistance to contact hypersensitivity

Weber, F. C., Esser, P. R., Müller, T., Ganesan, J., Pellegatti, P., Simon, M. M., Zeiser, R., Idzko, M., Jakob, T., & Martin, S. F. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092489 · Cited by 221

Cytosolic Phospholipase A2 Is Required for Macrophage Arachidonic Acid Release by Agonists That Do and Do Not Mobilize Calcium

Gijón, M. A., Spencer, D. M., Siddiqi, A. R., Bonventre, J. V., & Leslie, C. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m908941199 · Cited by 220

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

Kuroda, E., Ishii, K. J., Uematsu, S., Ohata, K., Coban, C., Akira, S., Aritake, K., Urade, Y., & Morimoto, Y. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.019 · Cited by 213

P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis

Panupinthu, N., Rogers, J. T., Zhao, L., Solano-Flores, L. P., Possmayer, F., Sims, S. M., & Dixon, S. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708037 · Cited by 175

Pseudoapoptosis Induced by Brief Activation of ATP-gated P2X7 Receptors

Mackenzie, A. B., Young, M. T., Adinolfi, E., & Surprenant, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502705200 · Cited by 174

Painful Purinergic Receptors

Donnelly‐Roberts, D. L., McGaraughty, S., Shieh, C., Honoré, P., & Jarvis, M. F. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.105890 · Cited by 170

Ca2+ Stores and Ca2+ Entry Differentially Contribute to the Release of IL-1β and IL-1α from Murine Macrophages

Brough, D., Feuvre, R. A. L., Wheeler, R. D., Solovyova, N. A., Hilfiker, S., Rothwell, N. J., & Verkhratsky, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3029 · Cited by 168

Selective COX-2 Inhibitors and Dual Acting Anti-inflammatory Drugs: Critical Remarks

Bertolini, A., Ottani, A., & Sandrini, M. (2002) · Current Medicinal Chemistry · doi:10.2174/0929867024606650 · Cited by 158

Inhibition of Chlamydial Infectious Activity due to P2X7R-Dependent Phospholipase D Activation

Coutinho‐Silva, R., Welter-Stahl, L., Raymond, M., Jungas, T., Verbeke, P., Burnstock, G., Darville, T. L., & Ojcius, D. M. (2003) · Immunity · doi:10.1016/s1074-7613(03)00235-8 · Cited by 157

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

Shiratori, M., Tozaki‐Saitoh, H., Yoshitake, M., Tsuda, M., & Inoue, K. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06809.x · Cited by 153

Regulation of prostaglandin endoperoxide synthase (cyclooxygenase) isozyme expression

Goppelt‐Struebe, M. (1995) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(95)90039-x · Cited by 134

P2X7 Receptor-Mediated Release of Cathepsins from Macrophages Is a Cytokine-Independent Mechanism Potentially Involved in Joint Diseases

López‐Castejón, G., Theaker, J., Pelegrı́n, P., Clifton, A. D., Braddock, M., & Surprenant, A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000436 · Cited by 130

Prostaglandin E2, an Immunoactivator

Sakata, D., Yao, C., & Narumiya, S. (2010) · Journal of Pharmacological Sciences · doi:10.1254/jphs.09r03cp · Cited by 128

The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1αβ knockout mice

Honoré, P., Donnelly‐Roberts, D. L., Namovic, M. T., Zhong, C., Wade, C. L., Chandran, P., Zhu, C., Carroll, W. A., Perez‐Medrano, A., Iwakura, Y., et al. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.05.018 · Cited by 117

Regulation of P2X7 nucleotide receptor function in human monocytes by extracellular ions and receptor density

Gudipaty, L., Humphreys, B. D., Buell, G. N., & Dubyak, G. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.4.c943 · Cited by 117

Mitogen-Activated Protein Kinase and Caspase Signaling Pathways Are Required for P2X7 Receptor (P2X7R)-Induced Pore Formation in Human THP-1 Cells

Donnelly‐Roberts, D. L., Namovic, M. T., Faltynek, C. R., & Jarvis, M. F. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.059600 · Cited by 114

Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1β

Li, S., Ballou, L. R., Morham, S. G., & Blatteis, C. M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02707-x · Cited by 105

Activation by P2X7 Agonists of Two Phospholipases A2 (PLA2) in Ductal Cells of Rat Submandibular Gland

Alzola, E., Pérez-Etxebarria, A., Kabré, E., Fogarty, D. J., Métioui, M., Chaı̈b, N., Macarulla, J. M., Matute, C., Dehaye, J., & Marino, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30208 · Cited by 98

Non-canonical YXXGΦ endocytic motifs: recognition by AP2 and preferential utilization in P2X4 receptors

Royle, S., Qureshi, O., Bobanović, L. K., Evans, P. R., Owen, D. J., & Murrell‐Lagnado, R. D. (2005) · Journal of Cell Science · doi:10.1242/jcs.02451 · Cited by 89

NADPH Oxidase NOX2 Mediates Rapid Cellular Oxidation following ATP Stimulation of Endotoxin-Primed Macrophages

Moore, S., & Mackenzie, A. B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900394 · Cited by 87

Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules

López‐Castejón, G., Baroja‐Mazo, A., & Pelegrı́n, P. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0609-y · Cited by 79

C-terminal Calmodulin-binding Motif Differentially Controls Human and Rat P2X7 Receptor Current Facilitation

Roger, S., Gillet, L., Baroja‐Mazo, A., Surprenant, A., & Pelegrı́n, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053082 · Cited by 76

Stimulation of rat erythrocyte P2X7receptor induces the release of epoxyeicosatrienoic acids

Jiang, H., Zhu, A. G., Mamczur, M., Falck, J. R., Lerea, K. M., & McGiff, J. C. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707311 · Cited by 75

Cytokines and cytokine inducers stimulate prostaglandin E 2 entry into the brain

Davidson, J., Abul, H., Milton, A. S., & Rotondo, D. (2001) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240100572 · Cited by 75

Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions

Lenertz, L. Y., Gavala, M. L., Zhu, Y., & Bertics, P. J. (2011) · Immunologic Research · doi:10.1007/s12026-011-8203-4 · Cited by 71

Targeting Interleukin-1 Signaling in Chronic Inflammation: Focus on P2X7 Receptor and Pannexin-1

Pelegrı́n, P. (2008) · Drug News & Perspectives · doi:10.1358/dnp.2008.21.8.1265800 · Cited by 66

Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts

Armstrong, S., Pereverzev, A., Dixon, S. J., & Sims, S. M. (2008) · Journal of Cell Science · doi:10.1242/jcs.031534 · Cited by 56

P2X7 Receptor-Dependent Intestinal Afferent Hypersensitivity in a Mouse Model of Postinfectious Irritable Bowel Syndrome

Keating, C. D., Pelegrı́n, P., Martínez, C. M., & Grundy, D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100423 · Cited by 56

Central sensitization of nociceptive neurons in rat medullary dorsal horn involves purinergic P2X7 receptors

Itoh, K., Chiang, C., Li, Z., Lee, J., Dostrovsky, J. O., & Sessle, B. J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.083 · Cited by 56

Signaling pathways of ATP‐induced PGE2 release in spinal cord astrocytes are EGFR transactivation‐dependent

Xia, M., & Zhu, Y. (2011) · Glia · doi:10.1002/glia.21138 · Cited by 53

Fever

Bartfai, T., & Conti, B. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.50 · Cited by 52

P2 receptor blockade attenuates fever and cytokine responses induced by lipopolysaccharide in rats

Gourine, A. V., Poputnikov, D. M., Zhernosek, N., Melenchuk, E. V., Gerstberger, R., Spyer, K. M., & Gourine, V. N. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706287 · Cited by 48

JNK inhibitor SP600125 reduces COX-2 expression by attenuating mRNA in activated murine J774 macrophages

Nieminen, R. M., Lahti, A., Jalonen, U., Kankaanranta, H., & Moilanen, E. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.01.009 · Cited by 45

Novel P2X7 receptor antagonists ease the pain

King, B. F. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707266 · Cited by 36

Purinergic Signaling Induces Cyclooxygenase-1-Dependent Prostanoid Synthesis in Microglia: Roles in the Outcome of Excitotoxic Brain Injury

Anrather, J., Gallo, E. F., Kawano, T., Orio, M., Abe, T., Gooden, C., Zhou, P., & Iadecola, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025916 · Cited by 36

Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view

Costa‐Junior, H. M., Marques-da-Silva, C., Vieira, F. S., Monção-Ribeiro, L. C., & Coutinho‐Silva, R. (2011) · Purinergic Signalling · doi:10.1007/s11302-011-9255-6 · Cited by 32

Permeability of brain structures and other peripheral tissues to prostaglandins D2, E2 and F2 alpha in rats.

Eguchi, N., Kaneko, T., Urade, Y., Hayashi, H., & Hayaishi, O. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10906-3 · Cited by 32

Inflammasome Activation by Danger Signals

Pelegrı́n, P. (2011) · Springer eBooks · doi:10.1007/978-3-0348-0148-5_7 · Cited by 9

The P2X7 Receptor in Infection and Inflammation

Di Virgilio, F., Dal Ben, D., Sarti, A. C., Giuliani, A. L., & Falzoni, S. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.020 · Cited by 1,267

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

Abais, J. M., Xia, M., Zhang, Y., Boini, K. M., & Li, P. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5994 · Cited by 936

Extracellular purines, purinergic receptors and tumor growth

Virgilio, F. D., & Adinolfi, E. (2016) · Oncogene · doi:10.1038/onc.2016.206 · Cited by 567

The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease

Bartlett, R., Stokes, L., & Sluyter, R. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008003 · Cited by 409

P2X7 receptor: an emerging target in central nervous system diseases

Sperlágh, B., & Illes, P. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.08.002 · Cited by 390

P2 receptor blockade attenuates fever and cytokine responses induced by lipopolysaccharide in rats

Gourine, A. V., Poputnikov, D. M., Zhernosek, N., Melenchuk, E. V., Gerstberger, R., Spyer, K. M., & Gourine, V. N. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706287 · Cited by 48

Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

Alves, L. A., Soares‐Bezerra, R. J., Faria, R. X., Ferreira, L., & Frutuoso, V. D. S. (2013) · Molecules · doi:10.3390/molecules180910953 · Cited by 97

Liaisons dangereuses: P2X7 and the inflammasome

Di Virgilio, F. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.07.002 · Cited by 493

Pharmacological characterization of P2X7 receptors in rat peritoneal cells

Chen, Y.-W., Donnelly‐Roberts, D. L., Namovic, M. T., Gintant, G. A., Cox, B. F., Jarvis, M. F., & Harris, R. R. (2005) · Inflammation Research · doi:10.1007/s00011-004-1332-7 · Cited by 9

The role of P2X7 in pain and inflammation

Hughes, J. P., Hatcher, J. P., & Chessell, I. P. (2007) · Purinergic Signalling · doi:10.1007/s11302-006-9031-1 · Cited by 78