Cited by 145Adenosine and Purinergic SignalingInflammasome and immune disordersPain Mechanisms and Treatments

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P2X7 receptor‐stimulation causes fever via PGE2 and IL‐1β release

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Barberà‐Cremades, Maria, Baroja‐Mazo, Alberto, Gomez, Ana I., Machado, Francisco, Di Virgilio, Francesco, Pelegrín, Pablo·2012·The FASEB Journal

DOI 10.1096/fj.12-205765

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Abstract

Prostaglandins (PGs) are important lipid mediators involved in the development of inflammatory associated pain and fever. PGE2 is a well‐established endogenous pyrogen activated by proinflammatory cytokine interleukin (IL)‐1β. P2X7 receptors (P2X7Rs) expressed by inflammatory cells are stimulated by the danger signal extracellular ATP to activate the inflammasome and release IL‐1β. Here we show that P2X7R activation is required for the release of PGE2 and other autacoids independent of inflammasome activation, with an ATP EC 50 for PGE2 and IL‐1β release of 1.58 and 1.23 mM, respectively. Furthermore, lack of P2X7R or specific antagonism of P2X7R decreased the febrile response in mice triggered after intraperitoneal LPS or IL‐1β inoculation. Accordingly, LPS inoculation caused intraperitoneal ATP accumulation. Therefore, P2X7R antagonists emerge as novel therapeutics for the treatment for acute inflammation, pain and fever, with wider anti‐inflammatory activity than currently used cyclooxygenase inhibitors.—Barberà‐Cremades, M., Baroja‐Mazo, A., Gomez, A. I., Machado, F., Di Virgilio, F., Pelegrín, P. P2X7 receptor‐stimulation causes fever via PGE2 and IL‐1β release. FASEB J. 26, 2951–2962 (2012). www.fasebj.org

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Authors: Barberà‐Cremades, M., Baroja‐Mazo, A., Gomez, A. I., Machado, F., Di Virgilio, F., & Pelegrín, P.
Affiliations: Inflammation and Experimental Surgery Unit Centro de Investigación Biomédica en Red de Enfermedades Hepaticas y Digestivas (CIBERhed)
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
Hospital Universitario Virgen de la Arrixaca (ES)
Section of General Pathology, Department of Experimental and Diagnostic Medicine University of Ferrara Ferrara Italy
ORCID: Baroja‐Mazo, Alberto
Venue: The FASEB Journal
Publisher: Wiley
Published: 2012-04-06
Volume: 26
Issue: 7
Pages: 2951-2962
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fj.12-205765
OpenAlex: W2147692999
Cited by: 142
References: 62
Citations by year: 2026: 7 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 5 · 2019: 18 · 2018: 4 · 2017: 16 · 2016: 13 · 2015: 12 · 2014: 17 · 2013: 11 · 2012: 3
FWCI: 9.66
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
Hispana (publishedVersion, cc-by-nc-nd)
Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords: P2X7 receptor, fever, prostaglandin E2, IL-1β, extracellular ATP, inflammasome, lipopolysaccharide, endogenous pyrogen, P2X7 receptor antagonists, acute inflammation, inflammatory pain, autacoids
MeSH terms: Adenosine Triphosphate, Animals, Fever, Humans, Injections, Intraperitoneal, Leukotriene B4, Lipopolysaccharides, Macrophages, Mice, Inbred C57BL, Recombinant Proteins, Thromboxane B2, Dinoprostone, Mice, Knockout, Inflammation Mediators, Calcium Signaling, MAP Kinase Signaling System, Mice, Cyclooxygenase 2, Interleukin-1beta, Receptors, Purinergic P2X7, Receptors, Purinergic P2X4, Purinergic P2X Receptor Agonists, Purinergic P2X Receptor Antagonists, In Vitro Techniques

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P2X7 receptor‐stimulation causes fever via PGE2 and IL‐1β release

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