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Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle
Abstract
Increased mitochondrial content and respiration have both been reported after exercise training. However, no study has directly compared how different training volumes influence mitochondrial respiration and markers of mitochondrial biogenesis. Ten healthy men performed high‐intensity interval cycling during 3 consecutive training phases; 4 wk of normal‐volume training (NVT; 3/wk), followed by 20 d of high‐volume training (HVT; 2/d) and 2 wk of reduced‐volume training (RVT; 5 sessions). Resting biopsy samples (vastus lateralis) were obtained at baseline and after each phase. No mitochondrial parameter changed after NVT. After HVT, mitochondrial respiration and citrate synthase activity (~40–50%), as well as the protein content of electron transport system (ETS) subunits (~10–40%), and that of peroxisome proliferator‐activated receptor γ coactivator‐1a (PGC‐1a), NRF1, mitochondrial transcription factor A (TFAM), PHF20, and p53 (~65–170%) all increased compared to baseline; mitochondrial specific respiration remained unchanged. After RVT, all the mitochondrial parameters measured except citrate synthase activity (~36% above initial) were not significantly different compared to baseline (all P >0.05). Our findings demonstrate that training volume is an important determinant of training‐induced mitochondrial adaptations and highlight the rapid reversibility of human skeletal muscle to a reduction in training volume.—Granata, C., Oliveira, R. S. F., Little, J. P., Renner, K., Bishop, D. J. Mitochondrial adaptations to high‐volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle. FASEB J. 30, 3413–3423 (2016). www.fasebj.org
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“Physical activity is known to boost mitochondrial biogenesis and turnover, as well as respiration [161] and mitochondrial quality is positively associated with physical performance [162,163,164].”
From Nutrition for Older Athletes: Focus on Sex-Differences (2021) · cites this paper as [162]
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“After HVT, and similar to CS activity, we observed a 9–41% increase in the protein content of subunits of the ETS complexes, another valid biomarker ofmitochondrial content, even though the strength of this relationship is weaker than that for CS activity and varies between complexes (12).”
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Cited by
Physiological adaptations to interval training and the role of exercise intensity
MacInnis, M. J., & Gibala, M. J. (2017) · The Journal of Physiology · doi:10.1113/jp273196 · Cited by 1,124
Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
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Self-citationAn Examination and Critique of Current Methods to Determine Exercise Intensity
Jamnick, N. A., Pettitt, R. W., Granata, C., Pyne, D. B., & Bishop, D. J. (2020) · Sports Medicine · doi:10.1007/s40279-020-01322-8 · Cited by 424
Self-citationTraining-Induced Changes in Mitochondrial Content and Respiratory Function in Human Skeletal Muscle
Granata, C., Jamnick, N. A., & Bishop, D. J. (2018) · Sports Medicine · doi:10.1007/s40279-018-0936-y · Cited by 247
Self-citationBishop, D. J., Botella, J., Genders, A. J., Lee, M. J.-C., Saner, N. J., Kuang, J., Yan, X., & Granata, C. (2019) · Physiology · doi:10.1152/physiol.00038.2018 · Cited by 180
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Metadata
- Authors
- Granata, C., Oliveira, R. S. F., Little, J. P., Renner, K., & Bishop, D. J.
- Affiliations
- Institute of Sport, Exercise, and Active Living College of Sport and Exercise Science Victoria University Melbourne Victoria Australia
- School of Health and Exercise Sciences University of British Columbia Okanagan Kelowna British Columbia Canada
- Department of Internal Medicine III University Hospital of Regensburg Regensburg Germany
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2016-07-11
- Volume
- 30
- Issue
- 10
- Pages
- 3413-3423
- ISSN
- 0892-6638
- 1530-6860
- Cited by
- 138
- References
- 8
- Language
- en
- Funders
- Judith Jane Mason and Harold Stannett Williams Memorial Foundation
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