Training intensity modulates changes in PGC‐1α and p53 protein content and mitochondrial respiration, but not markers of mitochondrial content in human skeletal muscle

Granata, Cesare; Oliveira, Rodrigo S. F.; Little, Jonathan P.; Renner, Kathrin; Bishop, David J.

doi:10.1096/fj.15-276907

Cited by 215Cardiovascular and exercise physiologyAdipose Tissue and MetabolismExercise and Physiological Responses

Training intensity modulates changes in PGC‐1α and p53 protein content and mitochondrial respiration, but not markers of mitochondrial content in human skeletal muscle

Granata, Cesare, Oliveira, Rodrigo S. F., Little, Jonathan P., Renner, Kathrin, Bishop, David J.·2016·The FASEB Journal

DOI 10.1096/fj.15-276907

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Abstract

Exercise training has been associated with increased mitochondrial content and respiration. However, no study to date has compared in parallel how training at different intensities affects mitochondrial respiration and markers of mitochondrial biogenesis. Twenty‐nine healthy men performed 4 wk (12 cycling sessions) of either sprint interval training [SIT; 4–10 × 30‐s all‐out bouts at ~200% of peak power output ( W Peak )], high‐intensity interval training (HIIT; 4–7 × 4‐min intervals at ~90% W Peak ), or sublactate threshold continuous training (STCT; 20–36 min at ~65% W Peak ). The STCT and HIIT groups were matched for total work. Resting biopsy samples (vastus lateralis) were obtained before and after training. The maximal mitochondrial respiration in permeabilized muscle fibers increased significantly only after SIT (25%). Similarly, the protein content of peroxisome proliferator‐activated receptor g coactivator (PGC)‐1α, p53, and plant homeodomain finger‐containing protein 20 (PHF20) increased only after SIT (60–90%). Conversely, citrate synthase activity, and the protein content of TFAM and subunits of the electron transport system complexes remained unchanged throughout. Our findings suggest that training intensity is an important factor that regulates training‐induced changes in mitochondrial respiration and that there is an apparent dissociation between training‐induced changes in mitochondrial respiration and mitochondrial content. Moreover, changes in the protein content of PGC‐1α, p53, and PHF20 are more strongly associated with training‐induced changes in mitochondrial respiration than mitochondrial content.—Granata, C., Oliveira, R. S. F., Little, J. P., Renner, K., Bishop, D. J. Training intensity modulates changes in PGC‐1α and p53 protein content and mitochondrial respiration, but not markers of mitochondrial content in human skeletal muscle. FASEB J. 30, 959–970 (2016). www.fasebj.org

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The maintenance of mitochondrial respiratory function in the SR+EX group is consistent with previous reports of the potency of HIIE for improving mitochondrial respiratory function.
“The maintenance of mitochondrial respiratory function in the SR+EX group is consistent with previous reports of the potency of HIIE for improving mitochondrial respiratory function [26,55]”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [26]
A dissociation between changes in mitochondrial content and respiratory function has previously been reported, and these properties may be differentially regulated.
“This dissociation between changes in mitochondrial content and respiratory function has previously been reported, and it has been suggested that these properties may be differentially regulated [26,56].”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [26]

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Effects of different exercise intensity and volume on markers of mitochondrial biogenesis in human skeletal muscle
Granata, C. (2015) · Victoria University Research Repository (Victoria University)
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HUMAN SKELETAL MUSCLE MITOCHONDRIAL RESPONSE TO INTERVAL TRAINING: ROLE OF EXERCISE INTENSITY
Jenkins, E. (2019) · MacSphere (McMaster University) · doi:10.71548/23844
Forty high-intensity interval training sessions blunt exercise-induced changes in the nuclear protein content of PGC-1α and p53 in human skeletal muscle
Granata, C., Oliveira, R. S. F., Little, J. P., & Bishop, D. J. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00233.2019 · Cited by 38 · see citing works
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Sprint-interval but not continuous exercise increases PGC-1α protein content and p53 phosphorylation in nuclear fractions of human skeletal muscle
Granata, C., Oliveira, R. S. F., Little, J. P., Renner, K., & Bishop, D. J. (2017) · Scientific Reports · doi:10.1038/srep44227 · Cited by 78 · see citing works
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Extremely low-volume, high-intensity interval training improves exercise capacity and increases mitochondrial protein content in human skeletal muscle
K. Ma, J., D. Scribbans, T., A. Edgett, B., Colin Boyd, J., A. Simpson, C., P. Little, J., & J. Gurd, B. (2013) · Open Journal of Molecular and Integrative Physiology · doi:10.4236/ojmip.2013.34027 · Cited by 47 · see citing works
Self-citation

Authors: Granata, C., Oliveira, R. S. F., Little, J. P., Renner, K., & Bishop, D. J.
Affiliations: Victoria University (AU)
University of British Columbia, Okanagan Campus (CA)
University Hospital Regensburg (DE)
Corresponding author: Bishop, David J.
ORCID: Granata, Cesare
Little, Jonathan P.
Renner, Kathrin
Bishop, David J.
Venue: The FASEB Journal
Publisher: Wiley
Published: 2015-11-16
Volume: 30
Issue: 2
Pages: 959-970
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fj.15-276907
OpenAlex: W2260205858
Cited by: 215
References: 37
Citations by year: 2026: 18 · 2025: 19 · 2024: 20 · 2023: 12 · 2022: 19 · 2021: 27 · 2020: 22 · 2019: 23 · 2018: 22 · 2017: 19 · 2016: 14
FWCI: 35.98
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
Victoria University Research Repository (Victoria University) (submittedVersion)
University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: exercise intensity, mitochondrial respiration, mitochondrial biogenesis, PGC-1α, p53, high-intensity interval training, sprint interval training, continuous training, skeletal muscle, vastus lateralis, citrate synthase, TFAM, electron transport chain, exercise training
MeSH terms: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Adolescent, Adult, Antigens, Neoplasm, DNA-Binding Proteins, Humans, Male, Mitochondria, Muscle, Muscle Proteins, Oxygen Consumption, Transcription Factors, Biomarkers, Tumor, Exercise, Tumor Suppressor Protein p53, Muscle, Skeletal

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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

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Training intensity modulates changes in PGC‐1α and p53 protein content and mitochondrial respiration, but not markers of mitochondrial content in human skeletal muscle

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