A maternal Western diet during gestation and lactation modifies offspring's microbiota activity, blood lipid levels, cognitive responses, and hippocampal neurogenesis in Yucatan pigs
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ABSTRACT A suboptimal early nutritional environment ( i.e. , excess of energy, sugar, and fat intake) can increase susceptibility to diseases and neurocognitive disorders. The purpose of this study was to investigate in nonobese Yucatan minipigs ( Sus scrofa ) the impact of maternal diet [standard diet (SD) vs. Western diet (WD)] during gestation and 25 d of lactation on milk composition, blood metabolism, and microbiota activity of sows (n = 17) and their piglets (n = 65), and on spatial cognition (n = 51), hippocampal plasticity (n = 17), and food preferences/motivation (n = 51) in the progeny. Milk dry matter and lipid content, as well as plasma total cholesterol and free fatty acid (FFA) concentrations (P < 0.05) were higher in WD than in SD sows. Microbiota activity decreased in both WD sows and 100‐d‐old piglets (P < 0.05 or P < 0.10, depending on short‐chain FAs [SCFAs]). At weaning [postnatal day (PND) 25], WD piglets had increased blood triglyceride and FFA levels (P < 0.01). Both SD and WD piglets consumed more of a known SD than an unknown high‐fat and ‐sucrose (HFS) diet (P < 0.0001), but were quicker to obtain HFS rewards compared with SD rewards (P < 0.01). WD piglets had higher working memory (P = 0.015) and reference memory (P < 0.001) scores, which may reflect better cognitive abilities in the task context and a higher motivation for the food rewards. WD piglets had a smaller hippocampal granular cell layer (P = 0.03) and decreased neurogenesis (P < 0.005), but increased cell proliferation (P < 0.001). A maternal WD during gestation and lactation, even in the absence of obesity, has significant consequences for piglets’ blood lipid levels, microbiota activity, gut–brain axis, and neurocognitive abilities after weaning.—Val‐Laillet, D., Besson, M., Guérin, S., Coquery, N., Randuineau, G., Kanzari, A., Quesnel, H., Bonhomme, N., Bolhuis, J. E., Kemp, B., Blat, S., Le Huërou‐Luron, I., Clouard, C. A maternal Western diet during gestation and lactation modifies offspring's microbiota activity, blood lipid levels, cognitive responses, and hippocampal neurogenesis in Yucatan pigs. FASEB J. 31, 2037–2049 (2017). www.fasebj.org
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Official Methods of Analysis of the Association of Official Analytical Chemists
(1971) · Soil Science Society of America Journal · doi:10.2136/sssaj1971.03615995003500050003x · Cited by 6,367 · see citing works
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works
WEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE
Barker, D. J. P., Osmond, C., Winter, P. D., Margetts, B., & Simmonds, S. J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90710-1 · Cited by 3,574 · see citing works
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
(2015) · PubMed Central · Cited by 2,540 · see citing works
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
Prinz, M., & Priller, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3722 · Cited by 1,329 · see citing works
Early Life Programming and Neurodevelopmental Disorders
Bale, T. L., Baram, T. Z., Brown, A. S., Goldstein, J. M., Insel, T. R., McCarthy, M. M., Nemeroff, C. B., Reyes, T. M., Simerly, R. B., Susser, E. S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.028 · Cited by 961 · see citing works
Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R. P., Horvat, V., Volk, B., & Kempermann, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008809 · Cited by 650 · see citing works
Enduring consequences of maternal obesity for brain inflammation and behavior of offspring
Bilbo, S. D., & Tsang, V. (2010) · The FASEB Journal · doi:10.1096/fj.09-144014 · Cited by 489 · see citing works
Placental regulation of fatty acid delivery and its effect on fetal growth--a review.
Haggarty, P. (2002) · Placenta · doi:10.1053/plac.2002.0791 · Cited by 349 · see citing works
Critical review evaluating the pig as a model for human nutritional physiology
Roura, E., Koopmans, S. J., Lallès, J. P., Huërou‐Luron, I. L., de Jager, N., Schuurman, T., & Val‐Laillet, D. (2016) · Nutrition Research Reviews · doi:10.1017/s0954422416000020 · Cited by 301 · see citing works
Monk, C. E., Georgieff, M., & Osterholm, E. A. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12000 · Cited by 260 · see citing works
Tozuka, Y., Kumon, M., Wada, E., Onodera, M., Mochizuki, H., & Wada, K. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.05.015 · Cited by 260 · see citing works
White, C. L., Pistell, P. J., Purpera, M. N., Gupta, S., Fernandez-Kim, S.-O., Hise, T. L., Keller, J. N., Ingram, D. K., Morrison, C. D., & Bruce-Keller, A. J. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.04.002 · Cited by 245 · see citing works
Microbiota and the gut–brain axis
Bienenstock, J., Kunze, W., & Forsythe, P. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv019 · Cited by 234 · see citing works
Animal models of in utero exposure to a high fat diet: A review
Williams, L., Seki, Y., Vuguin, P. M., & Charron, M. J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.07.006 · Cited by 223 · see citing works
Microbiota-gut-brain axis and cognitive function
Gareau, M. G. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_16 · Cited by 189 · see citing works
Hermans, M. P., Lévy, J., Morris, R. J., & Turner, R. C. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1779 · Cited by 185 · see citing works
Maternal Obesity Is Associated with Alterations in the Gut Microbiome in Toddlers
Galley, J. D., Bailey, M. T., Dush, C. M. K., Schoppe‐Sullivan, S. J., & Christian, L. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113026 · Cited by 180 · see citing works
Parental Dietary Fat Intake Alters Offspring Microbiome and Immunity
Myles, I. A., Fontecilla, N. M., Janelsins, B., Vithayathil, P. J., Segre, J. A., & Datta, S. K. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301057 · Cited by 174 · see citing works
Maternal high-fat diet in mice programs emotional behavior in adulthood
Peleg-Raibstein, D., Luca, E., & Wolfrum, C. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.027 · Cited by 167 · see citing works
The malnourished baby and infant
Barker, D. J. P. (2001) · British Medical Bulletin · doi:10.1093/bmb/60.1.69 · Cited by 159 · see citing works
Metabolic Imprinting by Prenatal, Perinatal, and Postnatal Overnutrition: A Review
Dyer, J., & Rosenfeld, C. R. (2011) · Seminars in Reproductive Medicine · doi:10.1055/s-0031-1275521 · Cited by 145 · see citing works
Metabolic syndrome and coronary artery disease in Ossabaw compared with Yucatan swine.
Neeb, Z. P., Edwards, J. M., Alloosh, M., Long, X., Mokelke, E. A., & Sturek, M. S. (2010) · Europe PMC (PubMed Central) · Cited by 128 · see citing works
Naef, L., Moquin, L., Bo, G. D., Bruno Giros, A., Gratton, A. P., & Walker, C. D. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.12.037 · Cited by 126 · see citing works
Teegarden, S. L., Scott, A., & Bale, T. L. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.029 · Cited by 119 · see citing works
Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research
Kornum, B. R., & Knudsen, G. M. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.05.004 · Cited by 110 · see citing works
Placental accommodations for transport and metabolism during intra-uterine crowding in pigs
Vallet, J. L., McNeel, A. K., Miles, J. R., & Freking, B. A. (2014) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/2049-1891-5-55 · Cited by 86 · see citing works
Changes in Brain Activity After a Diet‐Induced Obesity
Val‐Laillet, D., Layec, S., Guérin, S., Meurice, P., & Malbert, C. (2011) · Obesity · doi:10.1038/oby.2010.292 · Cited by 79 · see citing works
Clouard, C., Meunier‐Salaün, M. C., & Val‐Laillet, D. (2011) · animal · doi:10.1017/s1751731111001315 · Cited by 73 · see citing works
Bourgot, C. L., Ferret‐Bernard, S., Normand, L. L., Savary, G., Aparicio, E. M., Blat, S., Apper-Bossard, E., Respondek, F., & Huërou‐Luron, I. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107508 · Cited by 71 · see citing works
van der Staay, F. J., Gieling, E. T., Pinzón, N. E., Nordquist, R. E., & Ohl, F. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.008 · Cited by 70 · see citing works
Responses of conventional pigs and Göttingen miniature pigs in an active choice judgement bias task
Murphy, E., Nordquist, R. E., & van der Staay, F. J. (2013) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2013.07.011 · Cited by 61 · see citing works
de Albuquerque, K. T., Sardinha, F. L. C., Telles, M. M., Watanabe, R. L. H., do Nascimento, C. M. O., do Carmo, M. G. T., & Ribeiro, E. B. (2006) · Nutrition · doi:10.1016/j.nut.2006.04.009 · Cited by 58 · see citing works
Gieling, E. T., Park, S. Y., Nordquist, R. E., & van der Staay, F. J. (2011) · Pediatric Research · doi:10.1038/pr.2011.5 · Cited by 53 · see citing works
Ochoa, M., Lallès, J. P., Malbert, C., & Val‐Laillet, D. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0776-y · Cited by 52 · see citing works
Maternal obesity: consequences for children, challenges for clinicians and carers
McGuire, W. L., Dyson, L., & Renfrew, M. J. (2009) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2009.09.005 · Cited by 50 · see citing works
Bolhuis, J. E., Oostindjer, M., Hoeks, C., Haas, E. N. D., Bartels, A. C., Ooms, M., & Kemp, B. (2013) · Animal Cognition · doi:10.1007/s10071-013-0646-7 · Cited by 50 · see citing works
Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicityPreprint
Du, Y., Yang, M., Lee, S., Behrendt, C. L., Hooper, L. V., Saghatelian, A., & Wan, Y. (2012) · Genes & Development · doi:10.1101/gad.191031.112 · Cited by 47 · see citing works
Feed preference in pigs: Relationship with feed particle size and texture1
Solà‐Oriol, D., Roura, E., & Torrallardona, D. (2008) · Journal of Animal Science · doi:10.2527/jas.2008-0951 · Cited by 45 · see citing works
A computed tomography scan application to evaluate adiposity in a minipig model of human obesity
Val‐Laillet, D., Blat, S., Louveau, I., & Malbert, C. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510002667 · Cited by 44 · see citing works
Antonides, A., Schoonderwoerd, A. C., Scholz, G., Berg, B. M., Nordquist, R. E., & van der Staay, F. J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00291 · Cited by 41 · see citing works
Sebert, S. P., Lecannu, G., Kozlowski, F., Siliart, B. S., Bard, J., Krempf, M., & Champ, M. M. J. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802823 · Cited by 38 · see citing works
Antonides, A., Schoonderwoerd, A. C., Nordquist, R. E., & van der Staay, F. J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00043 · Cited by 35 · see citing works
Šefčíková, Z., Bujňáková, D., Raček, Ľ., Kmeť, V., & Mozeš, Š. (2011) · Physiological Research · doi:10.33549/physiolres.931939 · Cited by 35 · see citing works
Liquid diets reduce cell proliferation but not neurogenesis in the adult rat hippocampus
Patten, A. R., Moller, D. J., Graham, J., Gil‐Mohapel, J., & Christie, B. R. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.024 · Cited by 30 · see citing works
Ong, Z. Y., & Mühlhäusler, B. S. (2013) · Acta Physiologica · doi:10.1111/apha.12132 · Cited by 28 · see citing works
Are pigs sensitive to variability in food rewards?
de Jonge, F. H., Ooms, M., Kuurman, W. W., Maes, J. H. R., & Spruijt, B. M. (2008) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2008.01.004 · Cited by 26 · see citing works
Clouard, C., Kemp, B., Val‐Laillet, D., Gerrits, W. J. J., Bartels, A. C., & Bolhuis, J. E. (2016) · The FASEB Journal · doi:10.1096/fj.201500208r · Cited by 24 · see citing works
Central nervous system regulation of intestinal lipid and lipoprotein metabolism
Farr, S., Taher, J., & Adeli, K. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000254 · Cited by 21 · see citing works
Haagensen, A. M. J., Klein, A. B., Ettrup, A., Matthews, L. R., & Sørensen, D. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079429 · Cited by 16 · see citing works
Clouard, C., Gerrits, W. J. J., Kemp, B., Val‐Laillet, D., & Bolhuis, J. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154698 · Cited by 15 · see citing works
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Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
The Role of the Microbiome in the Developmental Origins of Health and Disease
Stiemsma, L. T., & Michels, K. B. (2018) · PEDIATRICS · doi:10.1542/peds.2017-2437 · Cited by 357 · see citing works
Interplay between the gut-brain axis, obesity and cognitive function
Agustí, A., García-Pardo, M. P., López-Almela, I., Campillo, I., Maes, M., Romaní-Pérez, M., & Sanz, Y. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00155 · Cited by 294 · see citing works
Contu, L., & Hawkes, C. A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18051093 · Cited by 162 · see citing works
Influence of the microbiota-gut-brain axis on behavior and welfare in farm animals: A review
Kraïmi, N., Dawkins, M. S., Gebhardt‐Henrich, S. G., Velge, P., Rychlı́k, I., Volf, J., Créach, P., Smith, A. L., Colles, F. M., & Leterrier, C. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112658 · Cited by 145 · see citing works
Microbial and metabolic alterations in gut microbiota of sows during pregnancy and lactation
Liu, H., Hou, C., Li, N., Zhang, X., Zhang, G., Yang, F., Zeng, X., Liu, Z., & Qiao, S. (2019) · The FASEB Journal · doi:10.1096/fj.201801221rr · Cited by 130 · see citing works
Early‐Life Gut Microbiome—The Importance of Maternal and Infant Factors in Its Establishment
Kapourchali, F. R., & Cresci, G. (2020) · Nutrition in Clinical Practice · doi:10.1002/ncp.10490 · Cited by 133 · see citing works
Xie, R., Sun, Y., Wu, J., Huang, S., Jin, G., Guo, Z., Zhang, Y., Liu, T., Liu, X., Cao, X., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02608 · Cited by 126 · see citing works
Denizli, M., Capitano, M. L., & Kua, K. L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.940937 · Cited by 117 · see citing works
Gut Microbiota Implications for Health and Welfare in Farm Animals: A Review
Chen, S., Luo, S., & Yan, C. (2021) · Animals · doi:10.3390/ani12010093 · Cited by 106 · see citing works
Targeting the gut microbiota to influence brain development and function in early life
Wang, S., Harvey, L., Martı́n, R., van der Beek, E. M., Knol, J., Cryan, J. F., & Renes, I. B. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.002 · Cited by 92 · see citing works
Tang, W., Meng, Z., Li, N., Liu, Y., Li, L., Chen, D., & Yang, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.611014 · Cited by 89 · see citing works
Val‐Laillet, D., Guérin, S., Coquery, N., Nogret, I., Formal, M., Rome, V., Normand, L. L., Meurice, P., Randuineau, G., Guilloteau, P., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700547rr · Cited by 73 · see citing works
Impacts of Diet and Exercise on Maternal Gut Microbiota Are Transferred to Offspring
Srinivasan, S. P. B., Raipuria, M., Bahari, H., Kaakoush, N. O., & Morris, M. J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00716 · Cited by 70 · see citing works
Desai, M., Ferrini, M. G., Han, G., Jellyman, J. K., & Ross, M. G. (2018) · Environmental Research · doi:10.1016/j.envres.2018.02.011 · Cited by 62 · see citing works
Perinatal Nutrition and Programmed Risk for Neuropsychiatric Disorders: A Focus on Animal Models
DeCapo, M., Thompson, J. R., Dunn, G. A., & Sullivan, E. L. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.08.006 · Cited by 59 · see citing works
Reynolds, C. M., Segovia, S. A., & Vickers, M. H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00245 · Cited by 46 · see citing works
Raspini, B., Porri, D., Giuseppe, R. D., Chieppa, M., Liso, M., Cerbo, R. M., Civardi, E., Garofoli, F., Monti, M. C., Vacca, M., et al. (2020) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-020-0794-8 · Cited by 41 · see citing works
Malnutrition and the microbiome as modifiers of early neurodevelopment
Coley, E. J. L., & Hsiao, E. Y. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.06.004 · Cited by 40 · see citing works
Dietary fiber during gestation improves lactational feed intake of sows by modulating gut microbiota
Li, S., Zheng, J., He, J., Liu, H., Huang, Y., Huang, L., Wang, K., Zhao, X., Feng, B., Che, L., et al. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00870-z · Cited by 40 · see citing works
Carbohydrates and cognitive function
Hawkins, M. A. W., Keirns, N. G., & Helms, Z. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000471 · Cited by 40 · see citing works
Bushby, E. V., Friel, M., Goold, C. M., Gray, H. E., Smith, L., & Collins, L. (2018) · Frontiers in Veterinary Science · doi:10.3389/fvets.2018.00193 · Cited by 36 · see citing works
Amaro, A., Baptista, F. I., & Matafome, P. N. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120526 · Cited by 33 · see citing works
Menneson, S., Ménicot, S., Ferret‐Bernard, S., Guérin, S., Rome, V., Normand, L. L., Randuineau, G., Gambarota, G., Noirot, V., Etienne, P. L., et al. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00161 · Cited by 32 · see citing works
Lin, C., Lin, Y., Yu, J., Yu, J., Cheng, Y., Wu, X., Lin, Y., & Lin, Y. (2020) · Endocrinology · doi:10.1210/endocr/bqaa214 · Cited by 32 · see citing works
Role of Maternal Microbiota and Nutrition in Early-Life Neurodevelopmental Disorders
Daliry, A., & Pereira, E. N. G. D. S. (2021) · Nutrients · doi:10.3390/nu13103533 · Cited by 28 · see citing works
Epigenetic Aberrations in Major Psychiatric Diseases Related to Diet and Gut Microbiome Alterations
Nohesara, S., Abdolmaleky, H. M., & Thiagalingam, S. (2023) · Genes · doi:10.3390/genes14071506 · Cited by 29 · see citing works
Sun, S., Meng, Q., Luo, Z., Shi, B., Bi, C., & Shan, A. (2019) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13064 · Cited by 27 · see citing works
Val‐Laillet, D. (2019) · animal · doi:10.1017/s1751731119001745 · Cited by 27 · see citing works
Lewis, N., Villani, A., & Lagopoulos, J. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.01.031 · Cited by 25 · see citing works
Frapin, M., Guignard, S., Meistermann, D., Grit, I., Moullé, V. S. F., Paillé, V., Parnet, P., & Amarger, V. (2020) · Nutrients · doi:10.3390/nu12051464 · Cited by 23 · see citing works
Castillo, P., Kuda, O., Kopecký, J., Pomar, C. A., Palou, A., Palou, M., & Picó, C. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200204 · Cited by 23 · see citing works
Contu, L., Nizari, S., Heath, C. J., & Hawkes, C. A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01045 · Cited by 22 · see citing works
The gut microbiome and adult hippocampal neurogenesis: A new focal point for epilepsy?
Dohm-Hansen, S., Donoso, F., Lucassen, P. J., Clarke, G. A., & Nolan, Y. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105746 · Cited by 20 · see citing works
Milk lipid regulation at the maternal-offspring interface
Yang, D., Huynh, H., & Wan, Y. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.10.012 · Cited by 19 · see citing works
Coquery, N., Adam, J., Némoz, C., Janvier, R., Livingstone, J., Chauvin, A., Kefs, S., Guerineau, C., Jean, L. D. S., Ocadiz, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-53518-2 · Cited by 18 · see citing works
Alemohammad, S. M. A., Noori, S. M. R., Samarbafzadeh, E., & Noori, S. M. A. (2022) · Molecular Biology Reports · doi:10.1007/s11033-021-07078-2 · Cited by 18 · see citing works
Impact of diet-derived signaling molecules on human cognition: exploring the food–brain axis
Rodriguez, R. L., Albeck, J. G., Taha, A. Y., Ori-McKenney, K. M., Recanzone, G. H., Stradleigh, T. W., Hernandez, B. C., Tang, F., Chiang, E. I., & Cruz‐Orengo, L. (2017) · npj Science of Food · doi:10.1038/s41538-017-0002-4 · Cited by 18 · see citing works
Lewis, N., Lagopoulos, J., & Villani, A. M. (2025) · Metabolites · doi:10.3390/metabo15050335 · Cited by 18 · see citing works
Gautier, Y., Luneau, I., Coquery, N., Meurice, P., Malbert, C., Guérin, S., Kemp, B., Bolhuis, J. E., Clouard, C., Huërou‐Luron, I. L., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201701541 · Cited by 17 · see citing works
Ke, X., Huang, Y., Fu, Q., Lane, R. H., & Majnik, A. V. (2021) · Developmental Neuroscience · doi:10.1159/000515750 · Cited by 14 · see citing works
Rodrigues, E. L., Figueiredo, P. S., Marcelino, G., Guimarães, R. D. C. A., Pott, A., Santana, L. F., Hiane, P. A., do Nascimento, V. A., Bogo, D., & Freitas, K. D. C. (2023) · Nutrients · doi:10.3390/nu15071551 · Cited by 14 · see citing works
The Role of Livestock Antibiotic Use in Microbiota Dysbiosis and Neuroinflammation
Silvestro, S., Biondo, C., Midiri, A., Lucia, B. P. A., & Mancuso, G. (2025) · Antibiotics · doi:10.3390/antibiotics14060608 · Cited by 13 · see citing works
Wang, S., He, X., Wang, Y., Zeng, Y., Pei, P., Zhan, X., Zhang, M., & Zhang, T. (2023) · iScience · doi:10.1016/j.isci.2023.107514 · Cited by 12 · see citing works
Sun, Y., Huang, S., Li, M., Yang, Y., Ma, J., Xie, R., Wang, J., Zhao, Q.-J., Qin, S., He, L., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07836-z · Cited by 12 · see citing works
Donovan, B., Suárez-Trujillo, A., Casey, T., Aryal, U. K., Conklin, D. R., Williams, L. L., & Minor, R. C. (2021) · Animals · doi:10.3390/ani11020497 · Cited by 12 · see citing works
Carucci, L. R., Coppola, S., Luzzetti, A., Giglio, V., Vanderhoof, J. A., & Canani, R. B. (2021) · Minerva Pediatrics · doi:10.23736/s2724-5276.21.06188-0 · Cited by 12 · see citing works
Jantsch, J., Tassinari, I. D., Giovenardi, M., Bambini-Júnior, V., Guedes, R. P., & de Fraga, L. S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.795384 · Cited by 11 · see citing works
Early life microbial exposure shapes subsequent animal health
Marcolla, C. S., Alvarado, C. S., & Willing, B. P. (2019) · Canadian Journal of Animal Science · doi:10.1139/cjas-2019-0029 · Cited by 11 · see citing works
Csongová, M., Renczés, E., Šarayová, V., Mihalovičová, L., Janko, J., Gurecká, R., Troise, A. D., Vitaglione, P., & Šebeková, K. (2019) · Foods · doi:10.3390/foods8050168 · Cited by 11 · see citing works
Nurturing development: how a mother's nutrition shapes offspring's brain through the gut
Ionescu, M.-I., Zahiu, C. D. M., Vlad, A., Galoş, F., Pîrcălăbioru, G. G., Zăgrean, A., & O’Mahony, S. M. (2024) · Nutritional Neuroscience · doi:10.1080/1028415x.2024.2349336 · Cited by 11 · see citing works
Menneson, S., Serrand, Y., Janvier, R., Noirot, V., Etienne, P. L., Coquery, N., & Val‐Laillet, D. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243893 · Cited by 10 · see citing works
Robinson, J. L., McBreairty, L. E., Ryan, R. A., Randunu, R., Walsh, C. J., Martin, G. M., Brunton, J. A., & Bertolo, R. F. (2020) · PLOS ONE · doi:10.1371/journal.pone.0226806 · Cited by 9 · see citing works
Huguet, G., Puig-Parnau, I., Serrano, J. C. E., Martin‐Garí, M., Rodrı́guez-Palmero, M., Moreno-Muñoz, J. A., Tibau, J., & Kádár, E. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03165-1 · Cited by 8 · see citing works
Gut Microbial Compositions in Four Age Groups of Tibetan Minipigs
Jiang, X., Chen, B., GU, D., Rong, Z., Su, X., Yue, M., Zhou, H., & Gu, W. (2018) · Polish Journal of Microbiology · doi:10.21307/pjm-2018-038 · Cited by 7 · see citing works
Val‐Laillet, D., Kanzari, A., Guérin, S., Randuineau, G., & Coquery, N. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135395 · Cited by 7 · see citing works
Zhang, X., Chen, H., & Val‐Laillet, D. (2020) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-020-00864-0 · Cited by 5 · see citing works
Fabianová, K., Babeľová, J., Fabián, D., Popovičová, A., Martončíková, M., Raček, A., & Račeková, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105564 · Cited by 5 · see citing works
Hillerer, K. M., & Gimsa, U. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1493605 · Cited by 4 · see citing works
Inter-relationship of the Intestinal Microbiome, Diet, and Mental Health
Pizarro, N., & de la Torre, R. (2018) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-018-0147-8 · Cited by 4 · see citing works
Obesity Animal Models for Acupuncture and Related Therapy Research Studies
Zhang, X., & Val‐Laillet, D. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6663397 · Cited by 4 · see citing works
Tretola, M., Mazzoleni, S., Bee, G., Silacci, P., & Pinotti, L. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.07.032 · Cited by 4 · see citing works
Maternal Obesity in Pregnancy: Risk Factor for Neurodevelopmental Outcomes in Offspring
Schmitt, L. O., Faraco, G., Stivanin, T. S., & Gaspar, J. M. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70333 · Cited by 3 · see citing works
Li, Y. P., Yang, Y., Ye, B., & Lin, Y. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114580 · Cited by 2 · see citing works
Ward-Flanagan, R., Scavuzzo, C. J., Mandhane, P. J., Bolduc, F. V., & Dickson, C. T. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227938 · Cited by 2 · see citing works
Merle, L., Rastelli, M., Datiche, F., Véjux, A., Jacquin, A., Bouret, S. G., & Bénani, A. (2025) · Neuroendocrinology · doi:10.1159/000543499 · Cited by 1 · see citing works
Contu, L., Johnson, A., Heath, C. J., & Hawkes, C. A. (2025) · Aging Cell · doi:10.1111/acel.70223
Gauvrit, T., Benderradji, H., Pelletier, A., Carvalho, K., Aboulouard, S., Faivre, É., Chatelain, E., Cannafarina, H., Labous, L., Launay, A., et al. (2025) · Brain · doi:10.1093/brain/awaf417
Raspini, B., Porri, D., Giuseppe, R. D., Chieppa, M., Liso, M., Cerbo, R. M., Civardi, E., Garofoli, F., Monti, M. C., Vacca, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12134154
Contu, L., Johnson, A., Heath, C., & Hawkes, C. (2025) · Open Research Online (The Open University)
Gautier, Y. (2018) · doi:10.70675/1169b49bz1289z4c70za20dz2e2032cbff00
The maternal gut–fetal brain axis: role of maternal microbial metabolome in early neurodevelopment
Scoglio, M. J., Samala, T., Ghalat, N. J., Jayaraman, A., & Pettersson, S. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1903574
- Authors
- Val-Laillet, D., Besson, M., Guérin, S., Coquery, N., Randuineau, G., Kanzari, A., Quesnel, H., Bonhomme, N., Bolhuis, J. E., Kemp, B., Blat, S., Le Huërou-Luron, I., & Clouard, C.
- Affiliations
- Institut National de la Recherche Agronomique (INRA) Unité de Recherche 1341 Alimentation et Adaptations Digestives Nerveuses et Comportementales (ADNC) Saint‐Gilles France
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Institut Agro Rennes-Angers (FR)
- Wageningen University & Research (NL)
- Corresponding author
- Clouard, Caroline
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2017-02-06
- Volume
- 31
- Issue
- 5
- Pages
- 2037-2049
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2587151628
- Cited by
- 75
- References
- 51
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 13 · 2017: 5
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- HAL (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Institut National de la Recherche Agronomique
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- gestation, lactation, gut microbiota, serum lipids, spatial cognition, hippocampal neurogenesis, milk composition, free fatty acids, short-chain fatty acids, gut-brain axis, Yucatan minipig, high-fat high-sugar diet, working memory, reference memory, cell proliferation, offspring neurodevelopment
- MeSH terms
- Animals, Animal Nutritional Physiological Phenomena, Animals, Suckling, Cognition, Female, Hippocampus, Lactation, Lipids, Milk, Swine, Dietary Supplements, Maternal Nutritional Physiological Phenomena, Microbiota, Diet, Western
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