Maternal high-fat diet in mice programs emotional behavior in adulthood
Open accessAbstract
The maternal environment has a significant role in the normal development of the fetus and may have long-term impact on brain development including critical central pathways such as the gamma-aminobutyric acid (GABA), serotonergic and the neurotrophin systems. For example, maternal malnutrition plays an important role in programming many aspects of physiology and behavior including predisposition to mental-health related disorders such as anxiety. Here we investigated the effects of maternal high-fat diet or control diet for nine weeks (prior to gestation, gestation and lactation) on the adult offspring with respect to anxiety related behaviors as well as exploration and conditioned fear response. We found that offspring born to high-fat diet mothers showed increased anxiety-like behaviors, but intact conditioned fear response and exploratory behavior. In addition, brain-derived neurotrophic factor (BDNF) was significantly increased in the dorsal hippocampus, while GABA(A) alpha2 receptor subunit and 5-hydroxytryptamine 1A (5-HT1A) receptor showed increased levels in the ventral hippocampus. In summary, these findings suggest that maternal high-fat diet consumption during critical periods in the development of the fetus, might increase the risk of abnormal behaviors in adulthood related to anxiety.
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Maternal physiology, particularly stress and nutrition, can greatly impact the neural and behavioral development of offspring.
“This is in keeping with a large body of research showing that maternal physiology, particularly stress (85–87) and nutrition (88–90), can greatly impact the neural and behavioral development of offspring.”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [89]
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- Authors
- Peleg-Raibstein, D., Luca, E., & Wolfrum, C.
- Affiliations
- ETH Zurich (CH)
- ORCID
- Wolfrum, Christian
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 233
- Issue
- 2
- Pages
- 398-404
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2143676524
- Cited by
- 167
- References
- 61
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 9 · 2023: 5 · 2022: 17 · 2021: 16 · 2020: 18 · 2019: 12 · 2018: 13 · 2017: 14 · 2016: 14 · 2015: 13 · 2014: 12 · 2013: 8
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- maternal high-fat diet, maternal programming, anxiety-like behavior, conditioned fear response, exploratory behavior, brain-derived neurotrophic factor, dorsal hippocampus, ventral hippocampus, 5-HT1A receptor, fetal development, maternal nutrition, offspring behavior
- MeSH terms
- Analysis of Variance, Animals, Animals, Newborn, Brain, Conditioning, Classical, Emotions, Exploratory Behavior, Female, Male, Mice, Inbred C57BL, Pregnancy, Prenatal Exposure Delayed Effects, Maze Learning, Brain-Derived Neurotrophic Factor, Mood Disorders, Transition Temperature, Mice, Diet, High-Fat
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