The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Mitochondrial fusion and fission: The fine‐tune balance for cellular homeostasis
Open accessAbstract
Mitochondria are highly dynamic, maternally inherited cytoplasmic organelles, which fulfill cellular energy demand through the oxidative phosphorylation system. Besides, they play an active role in calcium and damage‐associated molecular patterns signaling, amino acid, and lipid metabolism, and apoptosis. Thus, the maintenance of mitochondrial integrity and homeostasis is extremely critical, which is achieved through continual fusion and fission. Mitochondrial fusion allows the transfer of gene products between mitochondria for optimal functioning, especially under metabolic and environmental stress. On the other hand, fission is crucial for mitochondrial division and quality control. The imbalance between these two processes is associated with various ailments such as cancer, neurodegenerative and cardiovascular diseases. This review discusses the molecular mechanisms that control mitochondrial fusion and fission and how the disruption of mitochondrial dynamics manifests into various disease conditions.
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“Oxidative stress leads to oxidative damage to biomolecules (especially DNA),201 causing endogenous damage-associated molecular patterns (DAMPs) production and cytokine release in the organism.202,203”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [203]
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“Cytokines activate downstream signaling pathways of pattern recognition receptors,203 causing systemic chronic inflammatory responses in the body.204”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [203]
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Citations
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Metadata
- Authors
- Adebayo, M., Singh, S., Singh, A. P., & Dasgupta, S.
- Affiliations
- USA Mitchell Cancer Institute (US)
- Corresponding author
- Singh, Ajay Pratap
- Dasgupta, Santanu
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2021-05-28
- Volume
- 35
- Issue
- 6
- Pages
- e21620-e21620
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- PMC
- PMC8415099
- OpenAlex
- W3164775823
- Cited by
- 733
- References
- 103
- Citations by year
- 2026: 189 · 2025: 235 · 2024: 183 · 2023: 83 · 2022: 38 · 2021: 4
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (CA185490, CA224306, CA204801, CA231925)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- mitochondrial fusion, mitochondrial fission, mitochondrial dynamics, mitochondrial homeostasis, mitochondrial quality control, mitochondrial division, oxidative phosphorylation, calcium signaling, damage-associated molecular patterns, apoptosis, mitochondrial metabolism, neurodegenerative diseases, cardiovascular disease, cancer
- MeSH terms
- Animals, Homeostasis, Humans, Mitochondria, Mitochondrial Dynamics
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