The DOI matches its Crossref record; 233 of the 234 references it cites were found in a registry or an index.
Fusion and beyond: Satellite cell contributions to loading-induced skeletal muscle adaptation
Open accessAbstract
Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous ways. The fusion of satellite cells, driven by cell-autonomous and/or extrinsic factors, contributes new myonuclei to muscle fibers, associates with load-induced hypertrophy, and may support focal membrane damage repair and long-term myonuclear transcriptional output. Recent studies have also revealed that satellite cells communicate within their niche to mediate muscle remodeling in response to resistance exercise, regulating the activity of numerous cell types through various mechanisms such as secretory signaling and cell-cell contact. Muscular adaptation to resistance and endurance activity can be initiated and sustained for a period of time in the absence of satellite cells, but satellite cell participation is ultimately required to achieve full adaptive potential, be it growth, function, or proprioceptive coordination. While significant progress has been made in understanding the roles of satellite cells in adult muscle over the last few decades, many conclusions have been extrapolated from regeneration studies. This review highlights our current understanding of satellite cell behavior and contributions to adaptation outside of regeneration in adult muscle, as well as the roles of satellite cells beyond fusion and myonuclear accretion, which are gaining broader recognition.
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“Rather than acting as an obligatory requirement at all stages of hypertrophy, satellite cell fusion is better interpreted as a mechanism that becomes increasingly relevant when sustained loading pushes existing myonuclei toward their functional limits [22,68].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [68]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Once the initial gains supported by existing myonuclei have been largely realized, further adaptation may require a slower phase of structural remodeling involving satellite cell participation and myonuclear expansion [66,68].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [68]
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In the citing paper
“Alternatively, emerging isolated single-fiber transcriptomics, which report absolute RNA content per isolated myofiber segment, entirely bypasses the tissue-denominator problem [68].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [68]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“RNA:DNA is therefore not a universally superior method but a useful adjunct whose interpretation depends on the experimental question and timeframe [37,68].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [68]
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1 retracted
Pisconti, A., Brunelli, S., Padova, M. D., Palma, C. D., Deponti, D., Baesso, S., Sartorelli, V., Cossu, G., & Clementi, E. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200507083 · Cited by 107
RetractedSATELLITE CELL OF SKELETAL MUSCLE FIBERS
Mauro, A. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.9.2.493 · Cited by 3,683
Pax7 Is Required for the Specification of Myogenic Satellite Cells
Seale, P., Sabourin, L. A., Girgis-Gabardo, A., Mansouri, A., Gruß, P., & Rudnicki, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00066-0 · Cited by 2,345
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
Joe, A. W. B., Yi, L., Natarajan, A., Le Grand, F., So, L., Wang, J., Rudnicki, M. A., & Rossi, F. M. V. (2010) · Nature Cell Biology · doi:10.1038/ncb2015 · Cited by 1,690
Uezumi, A., Fukada, S., Yamamoto, N., Takeda, S., & Tsuchida, K. (2010) · Nature Cell Biology · doi:10.1038/ncb2014 · Cited by 1,315
Murphy, M. M., Lawson, J. A., Mathew, S. J., Hutcheson, D. A., & Kardon, G. (2011) · Development · doi:10.1242/dev.064162 · Cited by 1,249
A Pax3/Pax7-dependent population of skeletal muscle progenitor cells
Relaix, F., Rocancourt, D., Mansouri, A., & BUCKINGHAM, M. E. (2005) · Nature · doi:10.1038/nature03594 · Cited by 1,167
Lepper, C., Partridge, T. A., & Fan, C.-M. (2011) · Development · doi:10.1242/dev.067595 · Cited by 1,105
Satellite cells as the source of nuclei in muscles of growing rats
Moss, F. P., & Leblond, C. P. (1971) · The Anatomical Record · doi:10.1002/ar.1091700405 · Cited by 1,025
Defective membrane repair in dysferlin-deficient muscular dystrophy
Bansal, D., Miyake, K., Vogel, S. S., Groh, S., Chen, C.-C., Williamson, R., McNeil, P. L., & Campbell, K. P. (2003) · Nature · doi:10.1038/nature01573 · Cited by 1,022
Research works printed but not linked: 1
- 10.1152/japplphysiol.00466.2007 · DOI
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Egan, B., & Sharples, A. P. (2023) · Physiological Reviews · doi:10.1152/physrev.00054.2021 · Cited by 278
Roberts, M. D., McCarthy, J. J., Hornberger, T. A., Phillips, S. M., Mackey, A. L., Nader, G. A., Boppart, M. D., Kavazis, A. N., Reidy, P. T., Ogasawara, R., et al. (2023) · Physiological Reviews · doi:10.1152/physrev.00039.2022 · Cited by 214
Self-citationMolecular mechanisms of exercise contributing to tissue regeneration
Chen, J., Zhou, R. J., Ye, F., & Cheng, L. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01233-2 · Cited by 185
Hamstring Strain Injury in Athletes
Martin, R. L., Cibulka, M. T., Bolgla, L. A., Koc, T. A., Jr., Loudon, J. K., Manske, R. C., Weiss, L., Christoforetti, J. J., & Heiderscheit, B. C. (2022) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2022.0301 · Cited by 87
The myonuclear domain in adult skeletal muscle fibres: past, present and future
Bagley, J. R., Denes, L. T., McCarthy, J. J., Wang, E. T., & Murach, K. A. (2023) · The Journal of Physiology · doi:10.1113/jp283658 · Cited by 61
Self-citation
Metadata
- Authors
- Murach, K. A., Fry, C. S., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Murach, Kevin A.
- Peterson, Charlotte A.
- ORCID
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2021-09-04
- Volume
- 35
- Issue
- 10
- Pages
- e21893-e21893
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- PMC
- PMC9293230
- OpenAlex
- W3197320781
- Cited by
- 120
- References
- 234
- Citations by year
- 2026: 22 · 2025: 22 · 2024: 25 · 2023: 26 · 2022: 21 · 2021: 4
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The FASEB Journal (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Journal of the Arkansas Academy of Science (submittedVersion, cc-by-nc)
- UKnowledge (University of Kentucky) (submittedVersion, cc-by-nc)
- Funders
- National Institutes of Health
- National Institute on Aging (AG049086, AG063994)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- satellite cells, skeletal muscle adaptation, myonuclear accretion, muscle hypertrophy, resistance training, endurance exercise, muscle remodeling, extrinsic signaling, cell-cell contact, proprioception, muscle regeneration
- MeSH terms
- Adaptation, Physiological, Animals, Humans, Signal Transduction, Muscle Fibers, Skeletal, Satellite Cells, Skeletal Muscle
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