Early satellite cell communication creates a permissive environment for long-term muscle growth
Open accessAbstract
Using in vivo muscle stem cell (satellite cell)-specific extracellular vesicle (EV) tracking, satellite cell depletion, in vitro cell culture, and single-cell RNA sequencing, we show satellite cells communicate with other cells in skeletal muscle during mechanical overload. Early satellite cell EV communication primes the muscle milieu for proper long-term extracellular matrix (ECM) deposition and is sufficient to support sustained hypertrophy in adult mice, even in the absence of fusion to muscle fibers. Satellite cells modulate chemokine gene expression across cell types within the first few days of loading, and EV delivery of miR-206 to fibrogenic cells represses Wisp1 expression required for appropriate ECM remodeling. Late-stage communication from myogenic cells during loading is widespread but may be targeted toward endothelial cells. Satellite cells coordinate adaptation by influencing the phenotype of recipient cells, which extends our understanding of their role in muscle adaptation beyond regeneration and myonuclear donation.
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This facilitates an explosive re-accumulation of translational capacity, a process further optimized by early, fusion-independent communication from resident satellite cells that creates a highly permissive environment for long-term growth.
“This facilitates an explosive re-accumulation of translational capacity, a process further optimized by early, fusion-independent communication from resident satellite cells that creates a highly permissive environment for long-term growth [122,123,124].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [122]
The Abstract and Introduction report that early, fusion-independent satellite-cell communication supports sustained muscle growth in adult mice by promoting appropriate extracellular-matrix remodeling. Our copy does not establish that this communication optimizes an explosive re-accumulation of translational capacity; the Discussion mentions protein-synthetic demands only as a possible limit on growth. (LLM, conf=0.84)
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Matthews, B. G., Torreggiani, E., Roeder, E., Matić, I., Grčević, D., & Kalajzić, I. (2015) · Bone · doi:10.1016/j.bone.2015.12.010 · Cited by 45 · see citing works
Making Mice Mighty: recent advances in translational models of load-induced muscle hypertrophy
Murach, K. A., McCarthy, J. J., Peterson, C. A., & Dungan, C. M. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00319.2020 · Cited by 43 · see citing works
Self-citationInkson, C. A., Ono, M., Bi, Y., et al. (2008) · Cells Tissues Organs · doi:10.1159/000151377 · Cited by 42 · see citing works
Synergist Ablation as a Rodent Model to Study Satellite Cell Dynamics in Adult Skeletal Muscle
Kirby, T. J., McCarthy, J. J., Peterson, C. A., & Fry, C. S. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3810-0_4 · Cited by 37 · see citing works
Self-citationPrenatal myonuclei play a crucial role in skeletal muscle hypertrophy in rodents
Kawano, F., Ono, Y., Fujita, R., Watanabe, A., Masuzawa, R., Shibata, K., Hasegawa, S., Nakata, K., & Nakai, N. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00151.2016 · Cited by 10 · see citing works
Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells
Wang, H., Qiu, Y., & Zhong, X. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152641 · Cited by 7 · see citing works
MiR-206 Target Prediction in Breast Cancer Subtypes by Bioinformatics Tools
Seifi‐Alan, M., Shams, R., Behmanesh, A., et al. (2018) · International Journal of Cancer Management · doi:10.5812/ijcm.69554 · Cited by 4 · see citing works
Limitations of the Pax7-creER T2 transgene for driving deletion of Nf1 in adult mouse muscle
Summers, M. A., Mikulec, K., Peacock, L., Little, D. G., & Schindeler, A. (2017) · The International Journal of Developmental Biology · doi:10.1387/ijdb.170182as · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Roberts, M. D., McCarthy, J. J., Hornberger, T. A., Phillips, S. M., Mackey, A. L., Nader, G. A., Boppart, M. D., Kavazis, A. N., Reidy, P. T., Ogasawara, R., et al. (2023) · Physiological Reviews · doi:10.1152/physrev.00039.2022 · Cited by 214 · see citing works
Self-citationFusion and beyond: Satellite cell contributions to loading-induced skeletal muscle adaptation
Murach, K. A., Fry, C. S., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2021) · The FASEB Journal · doi:10.1096/fj.202101096r · Cited by 120 · see citing works
Self-citationMurach, K. A., Englund, D. A., Chambers, T. L., Dungan, C. M., Porter, H. L., Wren, J. D., Freeman, W. M., Dupont‐Versteegden, E. E., & Wen, Y. (2025) · The FASEB Journal · doi:10.1096/fj.202500177r · Cited by 12 · see citing works
Self-citationMuñoz López, M., López-Gil, J. F., Ramírez de la piscina Viúdez, X., Baz-Valle, E., & Tornero Aguilera, J. F. (2026) · Cells · doi:10.3390/cells15111041 · Cited by 1 · see citing works
“This facilitates an explosive re-accumulation of translational capacity, a process further optimized by early, fusion-independent communication from resident satellite cells that creates a highly permissive environment for long-term growth [122–124].”
- Authors
- Murach, K. A., Peck, B. D., Policastro, R. A., Vechetti, I. J., Van Pelt, D. W., Dungan, C. M., Denes, L. T., Fu, X., Brightwell, C. R., Zentner, G. E., Dupont-Versteegden, E. E., Richards, C. I., Smith, J. J., Fry, C. S., McCarthy, J. J., & Peterson, C. A.
- Affiliations
- University of Kentucky (US)
- Indiana University Bloomington (US)
- University of Nebraska–Lincoln (US)
- University of Florida (US)
- Corresponding author
- McCarthy, John J.
- Peterson, Charlotte A.
- ORCID
- Venue
- iScience
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 24
- Issue
- 4
- Pages
- 102372
- ISSN
- 2589-0042 (ISSN-L)
- PMC
- PMC8080523
- OpenAlex
- W3140020746
- Cited by
- 75
- References
- 90
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 13 · 2023: 14 · 2022: 18 · 2021: 8
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- iScience (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Lincoln (University of Nebraska) (submittedVersion, cc-by-nc-nd)
- UKnowledge (University of Kentucky) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR060701, AR071753)
- University of Kentucky
- National Institutes of Health
- National Institute on Aging (AG049086, AG063994)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK119619)
- National Institute of General Medical Sciences (GM130349)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- satellite cells, extracellular vesicles, skeletal muscle hypertrophy, mechanical overload, extracellular matrix deposition, miR-206, WISP1, chemokine expression, endothelial cells, muscle adaptation, intercellular communication, myogenic cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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