CoChat
Sign Up
Cited by 182

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Cell Biology of Heme

PONKA, PREM·1999·The American Journal of the Medical Sciences
DOI 10.1097/00000441-199910000-00004
Open this paper in CoChat — free account

Abstract

Heme is a complex of iron with protoporphyrin IX that is essential for the function of all aerobic cells. Heme serves as the prosthetic group of numerous hemoproteins (eg, hemoglobin, myoglobin, cytochromes, guanylate cyclase, and nitric oxide synthase) and plays an important role in controlling protein synthesis and cell differentiation. Cellular heme levels are tightly controlled; this is achieved by a fine balance between heme biosynthesis and catabolism by the enzyme heme oxygenase. On a per-cell basis, the rate of heme synthesis in the developing erythroid cells is at least 1 order of magnitude higher than in the liver, which is in turn the second most active heme producer in the organism. Differences in iron metabolism and in genes for 5-aminolevulinic acid synthase (ALA-S, the first enzyme in heme biosynthesis) are responsible for the differences in regulation and rates of heme synthesis in erythroid and nonerythroid cells. There are 2 different genes for ALA-S, one of which is expressed ubiquitously (ALA-S1), whereas the expression of the other (ALA-S2) is specific to erythroid cells. Because the 5'-untranslated region of the erythroid-specific ALA-S2 mRNA contains the iron-responsive element, a cis-acting sequence responsible for translational induction of erythroid ALA-S2 by iron, the availability of iron controls protoporphyrin IX levels in hemoglobin-synthesizing cells. In nonerythroid cells, the rate-limiting step of heme production is catalyzed by ALA-S1, whose…

Overview

Integrity signals

Registry

Crossref · 10.1097/00000441-199910000-00004

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 6 references

Research works printed but not linked: 129

  1. Dumont, 1991, Mol Cell Biol, 11, 5487???96, 10.1128/MCB.11.11.5487 · DOI
  2. Steiner, 1996, J Biol Chem, 271, 32605???11, 10.1074/jbc.271.51.32605 · DOI
  3. Wang, 1996, J Biol Chem, 271, 6594???604
  4. Howe, 1994, J Biol Chem, 269, 5824???32, 10.1016/S0021-9258(17)37536-1 · DOI
  5. Grandchamp, 1981, J Biol Chem, 256, 11677???83, 10.1016/S0021-9258(19)68459-0 · DOI
  6. Ponka, 1973, Biochim Biophys Acta, 304, 715???8
  7. Vincent, 1985, J Biol Chem, 260, 14521???8, 10.1016/S0021-9258(17)38600-3 · DOI
  8. Harvey, 1982, Blood, 60, 1227???30, 10.1182/blood.V60.5.1227.1227 · DOI
  9. Iwahara, 1995, Biochemistry, 34, 13398???406, 10.1021/bi00041a017 · DOI
  10. Ishii, 1993, J Biol Chem, 268, 18633???6
  11. Ishii, 1995, Biochem Biophys Res Commun, 216, 970???5, 10.1006/bbrc.1995.2715 · DOI
  12. Taketani, 1998, J Biol Chem, 273, 31388???94
  13. Lo, 1981, Cancer Res, 41, 864???70
  14. Bottomley, 1988, Semin Hematol, 25, 282???302
  15. May, 1990, Mol Biol Med, 7, 405???21
  16. Bonkovsky, 1991, Gastroenterol Intern, 4, 179???85
  17. Moore, 1993, Int J Biochem, 25, 1353???68, 10.1016/0020-711X(93)90683-6 · DOI
  18. May, 1995, Prog Nucleic Acid Res Mol Biol, 51, 1???51
  19. Ponka, 1997, Blood, 89, 1???25, 10.1182/blood.V89.1.1 · DOI
  20. Maines, 1997, Annu Rev Pharmacol Toxicol, 37, 517???54, 10.1146/annurev.pharmtox.37.1.517 · DOI
  21. Abraham, 1996, Cell Physiol Biochem, 6, 129???68, 10.1159/000154819 · DOI
  22. Lutton, 1991, Proc Soc Exp Biol Med, 196, 260???9, 10.3181/00379727-196-43186A · DOI
  23. Sassa, 1996, Int J Hematol, 63, 167???78, 10.1016/0925-5710(96)00449-5 · DOI
  24. Goya, 1972, Blood, 40, 239???45, 10.1182/blood.V40.2.239.239 · DOI
  25. Bernstein, 1987, J Lab Clin Med, 110, 690???705
  26. Richardson, 1997, Biochim Biophys Acta, 1331, 1???40, 10.1016/S0304-4157(96)00014-7 · DOI
  27. Bali, 1991, Biochemistry, 30, 324???8
  28. Fleming, 1998, Proc Natl Acad Sci U S A, 95, 1148???53
  29. Richardson, 1996, Blood, 87, 3477???88, 10.1182/blood.V87.8.3477.bloodjournal8783477 · DOI
  30. Ponka, 1985, J Biol Chem, 260, 14717???21, 10.1016/S0021-9258(17)38631-3 · DOI
  31. Laskey, 1986, J Cell Physiol, 129, 185???92, 10.1002/jcp.1041290209 · DOI
  32. Klausner, 1993, Cell, 72, 19???28, 10.1016/0092-8674(93)90046-S · DOI · Paper page
  33. Hentze, 1996, Proc Natl Acad Sci U S A, 93, 8175???82, 10.1073/pnas.93.16.8175 · DOI · Paper page
  34. Haile, 1999, Am J Med Sci, 318, 230???40, 10.1016/S0002-9629(15)40627-5 · DOI
  35. Chan, 1994, Eur J Biochem, 220, 683???92, 10.1111/j.1432-1033.1994.tb18669.x · DOI
  36. Chan, 1992, J Biol Chem, 267, 8254???9
  37. Zhang, 1997, Blood, 90, 6a, 10.1182/blood.V90.12.4842 · DOI
  38. Ponka, 1969, Blood, 33, 690???707, 10.1182/blood.V33.5.690.690 · DOI
  39. Ponka, 1974, Enzyme, 17, 91???9, 10.1159/000459313 · DOI
  40. Schulman, 1974, Biochem Biophys Acta, 343, 529???34, 10.1016/0304-4165(74)90270-0 · DOI
  41. Iacopetta, 1984, Biochem Biophys Acta, 805, 211???6, 10.1016/0167-4889(84)90170-8 · DOI
  42. Cox, 1985, Proc Natl Acad Sci U S A, 82, 5170???4, 10.1073/pnas.82.15.5170 · DOI
  43. Ponka, 1988, Biochem J, 251, 105???9, 10.1042/bj2510105 · DOI
  44. Hradilek, 1989, Br J Haematol, 73, 410???5, 10.1111/j.1365-2141.1989.tb07762.x · DOI
  45. Cox, 1991, EMBO J, 10, 1891???902, 10.1002/j.1460-2075.1991.tb07715.x · DOI
  46. Dandekar, 1991, EMBO J, 10, 1903???9, 10.1002/j.1460-2075.1991.tb07716.x · DOI
  47. Bishop, 1981, Arch Biochem Biophys, 206, 380???91, 10.1016/0003-9861(81)90105-3 · DOI
  48. Riddle, 1989, Proc Natl Acad Sci U S A, 86, 792???6, 10.1073/pnas.86.3.792 · DOI · Paper page
  49. Granick, 1966, J Biol Chem, 241, 1359???75, 10.1016/S0021-9258(18)96783-9 · DOI
  50. Tyrrell, 1972, Biochem Pharmacol, 21, 2077???93, 10.1016/0006-2952(72)90161-X · DOI
  51. Kikuchi, 1981, Mol Cell Biochem, 37, 27???41, 10.1007/BF02354935 · DOI
  52. Hamilton, 1991, Arch Biochem Biophys, 289, 387???92, 10.1016/0003-9861(91)90428-L · DOI
  53. Surinya, 1998, J Biol Chem, 273, 16798???809, 10.1074/jbc.273.27.16798 · DOI
  54. Duncan, 1999, Mol Biol Evol, 16, 383???96
  55. Furuyama, 1998, Blood, 92, 669a
  56. Melefors, 1993, J Biol Chem, 268, 5974???8, 10.1016/S0021-9258(18)53414-1 · DOI
  57. Beaumont, 1984, Exp Cell Res, 154, 474???84, 10.1016/0014-4827(84)90171-X · DOI
  58. Elferink, 1988, J Biol Chem, 263, 13012???6, 10.1016/S0021-9258(18)37664-6 · DOI
  59. Burnham, 1963, Biochem J, 87, 462???72, 10.1042/bj0870462 · DOI
  60. Cox, 1985, J Clin Invest, 76, 2144???50
  61. Grdisa, 1993, J Cell Physiol, 155, 349???57, 10.1002/jcp.1041550216 · DOI
  62. Hradilek, 1992, J Cell Physiol, 150, 327???33, 10.1002/jcp.1041500216 · DOI
  63. Lok, 1997, Blood, 90, 6a???7a
  64. Ingi, 1966, J Neurosci, 16, 5621???8
  65. May, 1994, Baillieres Clin Haematol, 7, 851???79, 10.1016/S0950-3536(05)80128-3 · DOI
  66. Gattermann, 1997, Blood, 90, 4961???72, 10.1182/blood.V90.12.4961 · DOI
  67. Hartman, 1996, Am J Hematol, 51, 269???75, 10.1002/(SICI)1096-8652(199604)51:4<269::AID-AJH4>3.0.CO;2-U · DOI
  68. Friend, 1971, Proc Natl Acad Sci U S A, 68, 378???82, 10.1073/pnas.68.2.378 · DOI
  69. Ross, 1972, Proc Natl Acad Sci U S A, 69, 3620???3
  70. Ross, 1976, Cell, 8, 513???20, 10.1016/0092-8674(76)90219-1 · DOI
  71. Dabney, 1977, Arch Biochem Biophys, 179, 106???12, 10.1016/0003-9861(77)90092-3 · DOI
  72. Fuchs, 1981, J Supramol Struct Cell Biochem, 15, 73???81, 10.1002/jsscb.1981.380150108 · DOI
  73. Solomon, 1993, J Biol Chem, 268, 5089???96, 10.1016/S0021-9258(18)53506-7 · DOI
  74. Nagai, 1995, Blood, 86, 676a
  75. Andrews, 1994, Pediatr Res, 36, 419???23, 10.1203/00006450-199410000-00001 · DOI
  76. Porter, 1979, Exp Hematol, 7, 11???6
  77. Monette, 1982, Blood, 60, 527???30, 10.1182/blood.V60.2.527.527 · DOI
  78. Fibach, 1995, Blood, 85, 2967???74, 10.1182/blood.V85.10.2967.bloodjournal85102967 · DOI
  79. Yin, 1998, Blood Cells Mol Dis, 24, 41???53, 10.1006/bcmd.1998.0169 · DOI
  80. Harigae, 1998, Blood, 91, 798???805, 10.1182/blood.V91.3.798 · DOI
  81. Zhu, 1999, Biochem Biophys Res Commun, 258, 87???93, 10.1006/bbrc.1999.0586 · DOI
  82. Bruns, 1965, Biochem Biophys Res Commun, 18, 236???42, 10.1016/0006-291X(65)90746-1 · DOI
  83. Zucker, 1968, Proc Natl Acad Sci U S A, 59, 582???9, 10.1073/pnas.59.2.582 · DOI
  84. Chen, 1995, Trends Biochem Sci, 20, 105???8
  85. Chefalo, 1998, Eur J Biochem, 258, 820???30, 10.1046/j.1432-1327.1998.2580820.x · DOI
  86. Wek, 1994, Trends Biochem Sci, 19, 491???6, 10.1016/0968-0004(94)90136-8 · DOI
  87. Crosby, 1994, Mol Cell Biol, 14, 3906???14, 10.1128/MCB.14.6.3906 · DOI
  88. Zerez, 1987, Trans Assoc Am Physicians, 100, 329???38
  89. Shaklai, 1985, Biochim Biophys Acta, 821, 355???66, 10.1016/0005-2736(85)90106-3 · DOI
  90. Liu, 1988, Blood, 71, 1755???8, 10.1182/blood.V71.6.1755.1755 · DOI
  91. Pfeifer, 1987, Cell, 49, 19???27
  92. Creusot, 1988, J Mol Biol, 204, 263???76, 10.1016/0022-2836(88)90574-8 · DOI
  93. Zhang, 1995, EMBO J, 14, 313???20
  94. Zhang, 1998, Mol Cell Biol, 18, 3819???28
  95. Rangarajan, 1989, Proc Natl Acad Sci U S A, 86, 3963???7, 10.1073/pnas.86.11.3963 · DOI
  96. Sultana, 1997, J Biol Chem, 272, 8895???900, 10.1074/jbc.272.14.8895 · DOI
  97. Srivastava, 1989, Eur J Biochem, 178, 689???92, 10.1111/j.1432-1033.1989.tb14499.x · DOI
  98. Nauseef, 1992, Blood, 80, 2622???33, 10.1182/blood.V80.10.2622.2622 · DOI
  99. Pinnix, 1994, Arch Biochem Biophys, 312, 447???58, 10.1006/abbi.1994.1331 · DOI
  100. Nauseef, 1998, J Biol Chem, 273, 7107???11, 10.1074/jbc.273.12.7107 · DOI
  101. Fayadat, 1999, J Biol Chem, 274, 10522???38, 10.1074/jbc.274.15.10533 · DOI
  102. Ishii, 1978, Nature, 274, 372???4, 10.1038/274372a0 · DOI
  103. Bonyhady, 1982, Dev Neurosci, 5, 125???9, 10.1159/000112669 · DOI · Paper page
  104. Smith, 1992, Vitro Cell Dev Biol, 28A, 387???90
  105. Lepp??, 1997, J Biol Chem, 272, 30400???4
  106. Reddy, 1996, Blood, 88, 2288???97, 10.1182/blood.V88.6.2288.bloodjournal8862288 · DOI
  107. Reddy, 1998, Blood, 91, 1793???801, 10.1182/blood.V91.5.1793 · DOI
  108. Lathorp, 1993, Science, 259, 522???5
  109. Triggs-Raine, 1988, J Bacteriol, 170, 4415???9, 10.1128/jb.170.9.4415-4419.1988 · DOI
  110. McCoubrey, 1997, J Biol Chem, 272, 12568???74, 10.1074/jbc.272.19.12568 · DOI
  111. Marks, 1991, Trends Pharmacol Sci, 12, 185???8, 10.1016/0165-6147(91)90544-3 · DOI
  112. Verma, 1993, Science, 259, 381???4, 10.1126/science.7678352 · DOI
  113. Glaum, 1993, Mol Pharmacol, 43, 965???9
  114. Cook, 1995, Can J Physiol Pharmacol, 73, 515???8, 10.1139/y95-065 · DOI
  115. Zakhary, 1996, Proc Natl Acad Sci U S A, 93, 795???8, 10.1073/pnas.93.2.795 · DOI
  116. Whetsell, 1978, J Neuropathol Exp Neurol, 37, 497???507, 10.1097/00005072-197809000-00005 · DOI
  117. Deinum, 1996, Biochemistry, 35, 1540???7
  118. Friebe, 1996, EMBO J, 15, 6863???8, 10.1002/j.1460-2075.1996.tb01078.x · DOI
  119. Stone, 1998, Chem Biol, 5, 255???61
  120. Applegate, 1991, Cancer Res, 51, 974???8
  121. Poss, 1997, Proc Natl Acad Sci U S A, 94, 10925???30
  122. Stocker, 1987, Science, 235, 1043???6, 10.1126/science.3029864 · DOI · Paper page
  123. Balla, 1993, Proc Natl Acad Sci U S A, 90, 9285???9, 10.1073/pnas.90.20.9285 · DOI
  124. Poss, 1997, Proc Natl Acad Sci U S A, 94, 10919???24
  125. Yachie, 1999, J Clin Invest, 103, 129???35, 10.1172/JCI4165 · DOI
  126. Dennery, 1998, J Clin Invest, 101, 1001???11, 10.1172/JCI448 · DOI
  127. Juckett, 1998, J Biol Chem, 273, 23388???97, 10.1074/jbc.273.36.23388 · DOI
  128. Andersson, 1998, J Biol Chem, 273, 4747???53
  129. Garrick, 1999, Biochim Biophys Acta, 1449, 125???36

Cited by

Sorted by citations

Metadata

Authors
PONKA, P.
Venue
The American Journal of the Medical Sciences
Publisher
Elsevier BV
Published
1999-10
Volume
318
Issue
4
Pages
241
ISSN
0002-9629
DOI
10.1097/00000441-199910000-00004
Cited by
182
References
6
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review