Cited by 222Circadian rhythm and melatoninDietary Effects on HealthSleep and Work-Related Fatigue

Regulation of metabolism: the circadian clock dictates the time

Open access
Sahar, Saurabh, Sassone-Corsi, Paolo·2012·Trends in Endocrinology & Metabolism

Abstract

Circadian rhythms occur with a periodicity of approximately 24h and regulate a wide array of metabolic and physiologic functions. Accumulating epidemiological and genetic evidence indicates that disruption of circadian rhythms can be directly linked to many pathological conditions, including sleep disorders, depression, metabolic syndrome and cancer. Intriguingly, several molecular gears constituting the clock machinery have been found to establish functional interplays with regulators of cellular metabolism. Although the circadian clock regulates multiple metabolic pathways, metabolite availability and feeding behavior can in turn regulate the circadian clock. An in-depth understanding of this reciprocal regulation of circadian rhythms and cellular metabolism may provide insights into the development of therapeutic intervention against specific metabolic disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.tem.2011.10.005

Cites

84 of 84 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Sahar, S., & Sassone-Corsi, P.
Affiliations
University of California, Irvine (US)
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2012-01
Volume
23
Issue
1
Pages
1-8
ISSN
1043-2760 (ISSN-L)
OpenAlex
W2052844204
Cited by
222
References
84
Citations by year
2026: 9 · 2025: 17 · 2024: 11 · 2023: 13 · 2022: 14 · 2021: 16 · 2020: 6 · 2019: 14 · 2018: 20 · 2017: 12 · 2016: 18 · 2015: 19 · 2014: 20 · 2013: 24 · 2012: 8
FWCI
1.78
Type
journal article
Language
en
Open access
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (R21AG041504, R21AG033888)
  • National Institute of General Medical Sciences (R01GM081634)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
circadian clock, circadian rhythm, metabolism, clock genes, feeding behavior, metabolic disorders, sleep disorders, depression, metabolic syndrome, cancer
MeSH terms
Animals, Circadian Rhythm, Energy Metabolism, Humans, Chronobiology Disorders, Metabolome, Circadian Rhythm Signaling Peptides and Proteins, Circadian Clocks

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review