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Cited by 221Anesthesia and Sedative AgentsAnesthesia and Neurotoxicity ResearchBiomedical and Chemical Research

The DOI matches its Crossref record, with a small difference in title or year; 25 of the 25 references it cites were found in a registry or an index.

Functional Brain Imaging during Anesthesia in Humans: Effects of Halothane on Global and Regional Cerebral Glucose Metabolism

Alkire, Michael T., Pomfrett, Chris J. D., Haier, Richard J., Gianzero, Marc V., Chan, Candice M., Jacobsen, Bradley P., Fallon, James H.·1999·Anesthesiology
DOI 10.1097/00000542-199903000-00011
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Abstract

Background: Propofol and isoflurane anesthesia were studied previously with functional brain imaging in humans to begin identifying key brain areas involved with mediating anesthetic-induced unconsciousness. The authors describe an additional positron emission tomography study of halothane's in vivo cerebral metabolic effects. Methods: Five male volunteers each underwent two positron emission tomography scans. One scan assessed awake-baseline metabolism, and the other scan assessed metabolism during halothane anesthesia titrated to the point of unresponsiveness (mean +/- SD, expired = 0.7+/-0.2%). Scans were obtained using a GE2048 scanner and the F-18 fluorodeoxyglucose technique. Regions of interest were analyzed for changes in both absolute and relative glucose metabolism. In addition, relative changes in metabolism were evaluated using statistical parametric mapping. Results: Awake whole-brain metabolism averaged 6.3+/-1.2 mg x 100 g(-1) x min(-1) (mean +/- SD). Halothane reduced metabolism 40+/-9% to 3.7+/-0.6 mg x 100 g(-1) x min(-1) (P< or =0.005). Regional metabolism did not increase in any brain areas for any volunteer. The statistical parametric mapping analysis revealed significantly less relative metabolism in the basal forebrain, thalamus, limbic system, cerebellum, and occiput during halothane anesthesia. Conclusions: Halothane caused a global whole-brain metabolic reduction with significant shifts in regional metabolism. Comparisons with previous studies reveal similar absolute and relative metabolic effects for halothane and isoflurane. Propofol, however, was associated with larger absolute metabolic reductions, suppression of relative cortical metabolism more than either inhalational agent, and significantly less suppression of relative basal ganglia and midbrain metabolism.

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Crossref · 10.1097/00000542-199903000-00011

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Metadata

Authors
Alkire, M. T., Pomfrett, C. J. D., Haier, R. J., Gianzero, M. V., Chan, C. M., Jacobsen, B. P., & Fallon, J. H.
Affiliations
  • University of California, Irvine Medical Center (US)
  • University of Manchester (GB)
ORCID
Pomfrett, Chris J. D.
Venue
Anesthesiology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1999-03-01
Volume
90
Issue
3
Pages
701-709
ISSN
0003-3022 (ISSN-L)
DOI
10.1097/00000542-199903000-00011
OpenAlex
W2025465757
Cited by
221
References
25
Citations by year
2026: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 6 · 2014: 10 · 2013: 10 · 2012: 13
FWCI
9.42
Type
journal article
Language
en
Open access
closed
Locations
  • Anesthesiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
  • Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
  • Health Sciences › Medicine › Physiology (medical) › Biomedical and Chemical Research
Keywords
halothane, isoflurane, propofol, brain glucose metabolism, anesthetic-induced unconsciousness, regional brain metabolism, basal forebrain, thalamus, limbic system, cerebellum, occipital cortex, inhalational anesthetics
MeSH terms
Anesthesia, General, Brain, Glucose, Halothane, Humans, Image Processing, Computer-Assisted, Male, Radiography, Tomography, Emission-Computed, Anesthetics, Inhalation

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