Oxytocin attenuates the cocaine-induced exploratory hyperactivity in mice
Abstract
The effects of pimozide, a dopamine-receptor blocker and oxytocin, a neurohypophyseal neuropeptide were investigated in mice on the cocaine-induced exploratory hyperactivity. The action of oxytocin on changes of dopaminergic neurotransmission induced by cocaine was also measured. Cocaine-induced exploratory hyperactivity could be blocked by pimozide (1 mg kg-1, s.c.). Oxytocin (0.05-1.0 micrograms) inhibited the cocaine-induced hyperactivity in an U-shaped dose-response manner. In the nucleus accumbens, oxytocin antagonized the increased dopamine disappearance, elicited by cocaine, but not in the nucleus caudatus. The data suggest that oxytocin may influence the behavioural effect of cocaine by modulating dopaminergic neurotransmission in mesolimbic dopaminergic terminal region of the brain.
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Exogenous OT attenuates many immediate behavioral effects of drugs of abuse, including reducing drug consumption, with some effects localized to the NAC.
“Exogenous OT attenuates many of the immediate behavioral effects of drugs of abuse, including reducing drug consumption, and some of the attenuating effects of OT are localized to the NAC (Kovacs et al 1990; Sarnyai et al 1990; Sarnyai et al 1991; Qi et al 2009; Carson et al 2010a; Baracz et al 2012).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Sarnyai et al 1990
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depue, R. A., & morrone-strupinsky, J. V. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000063 · Cited by 958 · see citing works
Gingrich, B., Liu, Y., Cascio, C., Wang, Z., & Insel, T. R. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.1.173 · Cited by 339 · see citing works
Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307 · see citing works
“This may be through OT’s modulatory effects on multiple aspects of both normal and drug-induced DA neurotransmission in the NAC (Kovacs et al. 1986, 1990; Szabo et al. 1988; Sarnyai et al. 1990; Carson et al. 2010b).”
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L. Kovács, G., Sarnyai, Z., & Szabó, G. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00064-x · Cited by 195 · see citing works
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Sarnyai, Z., & Kovács, G. L. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.019 · Cited by 106 · see citing works
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Carson, D. S., Guastella, A. J., Taylor, E. R., & McGregor, I. S. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881112473788 · Cited by 105 · see citing works
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Figueira, R. J., Peabody, M. F., & Lonstein, J. S. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.3.618 · Cited by 101 · see citing works
Johns, J. M., Noonan, L. R., Zimmerman, L. I., Li, L., & al, E. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.1.107 · Cited by 100 · see citing works
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Love, T. M., Enoch, M.-A., Hodgkinson, C. A., Peciña, M., Mickey, B., Koeppe, R. A., Stohler, C. S., Goldman, D., & Zubieta, J.-K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.033 · Cited by 97 · see citing works
Sarnyai, Z., Vecsernyés, M., Laczi, F., Bíró, É., Szabó, G., & Kovács, G. L. (1992) · Neuropeptides · doi:10.1016/0143-4179(92)90006-i · Cited by 66 · see citing works
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Leong, K.-C., Zhou, L., Ghee, S. M., See, R. E., & Reichel, C. M. (2015) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000058 · Cited by 62 · see citing works
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Rich, M. E., & Caldwell, H. K. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00090 · Cited by 55 · see citing works
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Pedersen, C. A. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.08.003 · Cited by 58 · see citing works
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Sarnyai, Z. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61587-3 · Cited by 51 · see citing works
Self-citationHicks, C., Cornish, J. L., Baracz, S. J., Suraev, A. S., & McGregor, I. S. (2014) · Addiction Biology · doi:10.1111/adb.12197 · Cited by 51 · see citing works
McMurray, M. S., Williams, S. K., Jarrett, T. M., Cox, E., Fay, E., Overstreet, D. H., Walker, C. H., & Johns, J. M. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2008.07.001 · Cited by 43 · see citing works
Oxytocin prevents the increase of cocaine-related responses produced by social defeat
Perez, C. F., Castro‐Zavala, A., Luján, M. Á., Filarowska, J., Ballestín, R., Miñarro, J., Valverde, O., & Rodríguez‐Arias, M. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.011 · Cited by 40 · see citing works
Cid-Jofré, V., Moreno, M., Reyes-Parada, M. I., & Renard, G. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222112077 · Cited by 39 · see citing works
Oxytocin as a potential mediator and modulator of drug addiction
Sarnyai, Z. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00332.x · Cited by 38 · see citing works
Self-citationSarnyai, Z., Szabó, G., Kovács, G. L., & Telegdy, G. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90182-f · Cited by 35 · see citing works
Self-citationOxytocin signaling in the treatment of drug addiction: Therapeutic opportunities and challenges
Che, X., Cai, J., Liu, Y., Xu, T., Yang, J., & Wu, C. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107820 · Cited by 28 · see citing works
Bowen, M. T., & Neumann, I. D. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_17 · Cited by 28 · see citing works
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Johns, J. M., Caldwell, J. D., & Pedersen, C. A. (1993) · Neuropeptides · doi:10.1016/0143-4179(93)90081-k · Cited by 24 · see citing works
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Perez, C. F., Reguilón, M. D., Miñarro, J., & Rodríguez‐Arias, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052372 · Cited by 14 · see citing works
Pedersen, C. A. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.050 · Cited by 12 · see citing works
Mousavi, A., Askari, N., & Mahdavi, M. R. V. (2019) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2019.1648483 · Cited by 8 · see citing works
Bensing, P. C., Moye, C., & Leong, K.-C. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114599 · Cited by 3 · see citing works
Esmaili‐Shahzade‐Ali‐Akbari, P., Bozorgnia, A., Shaterian, M., Jandaghian, S., & Shahri, S. M. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70197 · Cited by 3 · see citing works
Four hypothalamic peptides and their impact on drug-seeking behaviour: A prefrontal cortex view
Perry, C. J., & Cornish, J. L. (2022) · Addiction Neuroscience · doi:10.1016/j.addicn.2022.100018 · Cited by 1 · see citing works
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Lee, M. R., Rohn, M. C. H., Tanda, G., & Leggio, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803750-8.00023-3 · Cited by 1 · see citing works
Neurohypophyseal Hormones and Drugs of Misuse
Johnson, J. L., Johnson, M., & Buisman‐Pijlman, F. T. A. (2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781782621577-00346
- Authors
- Sarnyai, Z., Szabó, G., Kovács, G. L., & Telegdy, G.
- Affiliations
- University of Szeged (HU)
- ORCID
- Szabó, Gyula
- Venue
- NeuroReport
- Published
- 1990-11
- Volume
- 1
- Issue
- 3
- Pages
- 200-202
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1972393301
- Cited by
- 37
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, cocaine, pimozide, dopamine receptor blockade, dopamine signaling, nucleus accumbens, nucleus caudatus, mesolimbic dopamine system, cocaine-induced locomotor activity
- MeSH terms
- Animals, Caudate Nucleus, Cocaine, Dopamine, Dose-Response Relationship, Drug, Exploratory Behavior, Male, Methyltyrosines, Mice, Inbred Strains, Nucleus Accumbens, Oxytocin, Pimozide, Tyrosine 3-Monooxygenase, alpha-Methyltyrosine, Mice
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