A Review of Oxytocin’s Effects on the Positive, Negative, and Cognitive Domains of Schizophrenia
Open accessAbstract
Schizophrenia is a disabling, heterogeneous disorder with clinical features that can be parsed into three domains: positive symptoms, negative symptoms, and cognitive deficits. Current antipsychotic drugs produce fairly robust clinical benefit against positive symptoms but typically have minimal therapeutic effects on negative symptoms and cognitive deficits. Oxytocin (OT) is a nonapeptide that, in addition to its role as a hormone regulating peripheral reproductive-relevant functions, acts as a neurotransmitter in the brain. Several lines of preclinical and clinical research suggest that the OT system may play a role in regulating the expression of schizophrenia spectrum disorders and that targeting the central OT system may yield novel treatments to address these symptoms. In this review, we summarize the extant preclinical and clinical evidence relevant to the role of OT in schizophrenia with particular emphasis on its putative therapeutic effects on each of the three above-mentioned clinical domains.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Exogenous oxytocin has behavioural effects in humans, particularly in social deficit-related psychiatric disorders such as autism and schizophrenia.
“Exogenous oxytocin in humans also appears to have behavioural effects, particularly in such social deficit-related psychiatric disorders as autism and schizophrenia9–13.”
From Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Geyer, M. A., Krebs-Thomson, K., Braff, D. L., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100811 · Cited by 1,484 · see citing works
Jentsch, J., & Roth, R. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00060-8 · Cited by 1,349 · see citing works
Sensorimotor Gating and Schizophrenia
Braff, D. L. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810140081011 · Cited by 1,312 · see citing works
The NIMH-MATRICS Consensus Statement on Negative Symptoms
Kirkpatrick, B., Fenton, W. S., Carpenter, W. T., & Marder, S. R. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj053 · Cited by 1,311 · see citing works
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258 · see citing works
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130 · see citing works
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043 · see citing works
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945 · see citing works
Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., Onaka, T., Yanagisawa, T., Kimura, T., Matzuk, M. M., Young, L. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505312102 · Cited by 806 · see citing works
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804 · see citing works
Liu, Y., & Wang, Z. X. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00555-4 · Cited by 580 · see citing works
Miyamoto, S., Miyake, N., Jarskog, L. F., Fleischhacker, W. W., & Lieberman, J. A. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.47 · Cited by 576 · see citing works
Realistic expectations of prepulse inhibition in translational models for schizophrenia research
Swerdlow, N. R., Weber, M., Qu, Y., Light, G. A., & Braff, D. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1072-4 · Cited by 529 · see citing works
Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
Neumann, I. D., Maloumby, R., Beiderbeck, D. I., Lukas, M., & Landgraf, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.003 · Cited by 511 · see citing works
Neuromodulation by Oxytocin and Vasopressin
Stoop, R. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.025 · Cited by 506 · see citing works
Cortical maldevelopment, anti-psychotic drugs, and schizophrenia: a search for common ground
Weinberger, D. R., & Lipska, B. K. (1995) · Schizophrenia Research · doi:10.1016/0920-9964(95)00013-c · Cited by 468 · see citing works
Modulating social behavior with oxytocin: How does it work? What does it mean?
Churchland, P. S., & Winkielman, P. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.003 · Cited by 464 · see citing works
Oxytocin, vasopressin, and social recognition in mammals
Bielsky, I. F., & Young, L. J. (2004) · Peptides · doi:10.1016/j.peptides.2004.05.019 · Cited by 460 · see citing works
Strauss, G. P., Horan, W. P., Kirkpatrick, B. W., Fischer, B. A., Keller, W. R., Miski, P., Buchanan, R. W., Green, M. F., & Carpenter, W. T. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.01.015 · Cited by 424 · see citing works
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Manning, M., Misicka, A., Olma, A., Bankowski, K., Stoev, S., Chini, B., Durroux, T., Mouillac, B., Corbani, M., & Guillon, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02303.x · Cited by 423 · see citing works
Marder, S. R., & Fenton, W. S. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.09.010 · Cited by 419 · see citing works
Lukas, M., Toth, I., Reber, S. O., Slattery, D. A., Veenema, A. H., & Neumann, I. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.95 · Cited by 403 · see citing works
Kantrowitz, J. T., & Javitt, D. C. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.04.006 · Cited by 397 · see citing works
Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390 · cited 1× · see citing works
“Building on OT’s potential as a “cognitive/plasticity enhancer,” (39) two studies have investigated the benefits of OT added to a potent psychosocial treatment.”
BackgroundOxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala
Viviani, D., Charlet, A., van den Burg, E., Robinet, C., Hurni, N., Abatis, M., Magara, F., & Stoop, R. (2011) · Science · doi:10.1126/science.1201043 · Cited by 381 · see citing works
Loup, F., Tribollet, E., Dubois-Dauphin, M., & Dreifuss, J. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90345-v · Cited by 378 · see citing works
Exogenous and evoked oxytocin restores social behavior in the <i>Cntnap2</i> mouse model of autism
Peñagarikano, O., Lázaro, M. T., Lu, X.-H., Gordon, A., Dong, H., Lam, H. A., Peles, E., Maidment, N. T., Murphy, N. P., Yang, X. W., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010257 · Cited by 378 · see citing works
Baskerville, T. A., & Douglas, A. J. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00154.x · Cited by 377 · see citing works
Sala, M., Braida, D., Lentini, D., Busnelli, M., Bulgheroni, E., Capurro, V., Finardi, A., Donzelli, A., Pattini, L., Rubino, T., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.022 · Cited by 375 · see citing works
Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade
Tomizawa, K., Iga, N., Lü, Y.-F., Moriwaki, A., Matsushita, M., Li, S., Miyamoto, O., Itano, T., & Matsui, H. (2003) · Nature Neuroscience · doi:10.1038/nn1023 · Cited by 372 · see citing works
Oxytocin–dopamine interactions mediate variations in maternal behavior in the rat
Shahrokh, D. K., Zhang, T.-Y., Diorio, J., Gratton, A., & Meaney, M. J. (2010) · Endocrinology · doi:10.1210/en.2009-1271 · Cited by 366 · see citing works
Millan, M. J., Fone, K. C. F., Steckler, T., & Horan, W. P. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.03.008 · Cited by 354 · see citing works
Infant vocalization, adult aggression, and fear behavior of an oxytocin null mutant mouse
Winslow, J. T., Hearn, E. F., Ferguson, J., Young, L. J., Matzuk, M. M., & Insel, T. R. (2000) · Hormones and Behavior · doi:10.1006/hbeh.1999.1566 · Cited by 348 · see citing works
Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients
Feifel, D., Macdonald, K., Nguyen, A., Cobb, P., Warlan, H., Galangue, B., Minassian, A., Becker, O., Cooper, J., Perry, W., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.039 · Cited by 308 · see citing works
Self-citationPedersen, C. A., Gibson, C. M., Rau, S. W., Salimi, K., Smedley, K. L., Casey, R. L., Leserman, J., Jarskog, L. F., & Penn, D. L. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.07.027 · Cited by 305 · see citing works
Bethlehem, R. A. I., van Honk, J., Auyeung, B., & Baron-Cohen, S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.10.011 · Cited by 285 · see citing works
Immunohistochemical localization of oxytocin receptors in human brain
Boccia, M. L., Petrusz, P., Suzuki, K., Marson, L., & Pedersen, C. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.048 · Cited by 276 · see citing works
A conditional knockout mouse line of the oxytocin receptor
Lee, H.-J., Caldwell, H. K., Macbeth, A. H., Tolu, S. G., & Young, W. S. (2008) · Endocrinology · doi:10.1210/en.2007-1710 · Cited by 269 · see citing works
Bales, K. L., Perkeybile, A. M., Conley, O. G., Lee, M. H., Guoynes, C. D., Downing, G. M., Yun, C. R., Solomon, M., Jacob, S., & Mendoza, S. P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.025 · Cited by 265 · see citing works
Chang, S. W. C., Barter, J. W., Ebitz, R. B., Watson, K. K., & Platt, M. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114621109 · Cited by 252 · cited 3× · see citing works
“For example, Probabilistic Learning, a task used to measure cross-species reinforcement learning (56), and could be used to test the effects of OT in an animal model with relevance to anhedonia (45).”
BackgroundMethodWhere in the brain is morality? Everywhere and maybe nowhere
Young, L., & Dungan, J. A. (2011) · Social Neuroscience · doi:10.1080/17470919.2011.569146 · Cited by 239 · see citing works
Crawley, J. N., Chen, T., Puri, A., Washburn, R., Sullivan, T. L., Hill, J. M., Young, N. B., Nadler, J. J., Moy, S. S., Young, L. J., et al. (2007) · Neuropeptides · doi:10.1016/j.npep.2007.02.002 · Cited by 232 · see citing works
Dopaminergic basis of salience dysregulation in psychosis
Winton-Brown, T. T., Fusar-Poli, P., Ungless, M. A., & Howes, O. D. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2013.11.003 · Cited by 231 · see citing works
Puglia, M. H., Lillard, T. S., Morris, J. P., & Connelly, J. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422096112 · Cited by 216 · see citing works
The Evolution of Drug Development in Schizophrenia: Past Issues and Future Opportunities
Carpenter, W. T., & Koenig, J. I. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301639 · Cited by 210 · see citing works
Social Interaction Deficits Caused by Chronic Phencyclidine Administration are Reversed by Oxytocin
Lee, P. R., Brady, D. L., Shapiro, R. A., Dorsa, D. M., & Koenig, J. I. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300722 · Cited by 199 · see citing works
Chronic and acute intranasal oxytocin produce divergent social effects in mice
Huang, H., Michetti, C., Busnelli, M., Managò, F., Sannino, S., Scheggia, D., Giancardo, L., Sona, D., Murino, V., Chini, B., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.310 · Cited by 199 · see citing works
Animal models for the negative symptoms of schizophrenia
Ellenbroek, B. A., & Cools, A. R. (2000) · Behavioural Pharmacology · doi:10.1097/00008877-200006000-00006 · Cited by 198 · see citing works
Méziane, H., Schaller, F., Bauer, Š., Villard, C., Matarazzo, V. A., Riet, F., Guillon, G., Lafitte, D., Desarménien, M. G., Tauber, M., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.010 · Cited by 194 · see citing works
Oxytocin-Induced Analgesia and Scratching Are Mediated by the Vasopressin-1A Receptor in the Mouse
Schorscher-Petcu, A., Sotocinal, S., Ciura, S., Dupre, A., Ritchie, J., Sorge, R. E., Crawley, J. N., Hu, S.-B., Nishimori, K., Young, L. J., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1594-10.2010 · Cited by 189 · see citing works
Freeman, S. M., Inoue, K., Smith, A. L., Goodman, M. M., & Young, L. J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.023 · Cited by 185 · see citing works
MacDonald, K., & Feifel, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00035 · Cited by 181 · see citing works
Self-citationNeuroendocrine basis of social recognition
Winslow, J. T., & Insel, T. R. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.03.009 · Cited by 180 · see citing works
Wigton, R., Radua, J., Allen, P., Averbeck, B., Meyer-Lindenberg, A., McGuire, P., Shergill, S. S., & Fusar-Poli, P. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130289 · Cited by 179 · see citing works
Rosenfeld, A. J., Lieberman, J. A., & Jarskog, L. F. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq015 · Cited by 178 · see citing works
Human neuroimaging of oxytocin and vasopressin in social cognition
Zink, C. F., & Meyer-Lindenberg, A. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.016 · Cited by 176 · see citing works
Animal models for the study of human disease
Conn, P. (2013) · Elsevier eBooks · doi:10.1016/c2011-0-05225-0 · Cited by 169 · see citing works
Hirota, T., Schwartz, S., & Correll, C. U. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.11.009 · Cited by 161 · see citing works
Keebaugh, A. C., Barrett, C. E., Laprairie, J. L., Jenkins, J. J., & Young, L. J. (2015) · Social Neuroscience · doi:10.1080/17470919.2015.1040893 · Cited by 150 · see citing works
Oxytocin-Augmented Social Cognitive Skills Training in Schizophrenia
Davis, M. C., Green, M. F., Lee, J., Horan, W. P., Senturk, D., Clarke, A. D., & Marder, S. R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.68 · Cited by 149 · see citing works
Emotion recognition and oxytocin in patients with schizophrenia
Averbeck, B. B., Bobin, T., Evans, S., & Shergill, S. S. (2011) · Psychological Medicine · doi:10.1017/s0033291711001413 · Cited by 144 · see citing works
Bowen, M. T., Carson, D. S., Spiro, A., Arnold, J. C., & McGregor, I. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027237 · Cited by 143 · see citing works
Cognitive function in schizophrenia
Weinberger, D. R., & Gallhofer, B. (1997) · International Clinical Psychopharmacology · doi:10.1097/00004850-199709004-00006 · Cited by 139 · see citing works
Peripheral Pulses of Oxytocin Increase Partner Preferences in Female, but Not Male, Prairie Voles
Cushing, B. S., & Carter, C. S. (2000) · Hormones and Behavior · doi:10.1006/hbeh.1999.1558 · Cited by 136 · see citing works
Long-term exposure to intranasal oxytocin in a mouse autism model
Bales, K. L., Solomon, M., Jacob, S., Crawley, J. N., Silverman, J. L., Larke, R. H., Sahagún, E., Puhger, K. R., Pride, M. C., & Mendoza, S. P. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.117 · Cited by 131 · see citing works
Qi, J., Yang, J.-Y., Song, M., Li, Y., Wang, F., & Wu, C.-F. (2008) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0245-8 · Cited by 129 · see citing works
Oxytocin-messages via the cerebrospinal fluid: Behavioral effects; a review
Veening, J. G., A, T. R. D. J., & Barendregt, H. P. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.05.004 · Cited by 126 · see citing works
Effects of single dose intranasal oxytocin on social cognition in schizophrenia
Davis, M. C., Lee, J., Horan, W. P., Clarke, A. D., McGee, M. R., Green, M. F., & Marder, S. R. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.04.023 · Cited by 124 · see citing works
Intranasal oxytocin selectively attenuates rhesus monkeys’ attention to negative facial expressions
Parr, L. A., Modi, M., Siebert, E., & Young, L. J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.02.011 · Cited by 124 · see citing works
Typical and atypical neuroleptics antagonize MK-801-induced locomotion and stereotypy in rats
Hoffman, D. (1992) · Journal of Neural Transmission · doi:10.1007/bf01245347 · Cited by 122 · see citing works
Greenwood, T. A., Swerdlow, N. R., Gur, R. E., Cadenhead, K. S., Calkins, M. E., Dobie, D. J., Freedman, R., Green, M. F., Gur, R. C., Lazzeroni, L. C., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12020186 · Cited by 122 · see citing works
Oxytocin modulates psychotomimetic-induced deficits in sensorimotor gating
Feifel, D., & Reza, T. L. (1999) · Psychopharmacology · doi:10.1007/s002130050811 · Cited by 121 · see citing works
Self-citationKumari, V., Antonova, E., Geyer, M. A., Ffytche, D. H., Williams, S., & Sharma, T. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145706007139 · Cited by 121 · see citing works
Cacciotti-Saija, C., Langdon, R., Ward, P. B., Hickie, I. B., Scott, E. M., Naismith, S. L., Moore, L., Alvares, G. A., Redoblado Hodge, M. A., & Guastella, A. J. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu094 · Cited by 119 · see citing works
Adjunctive intranasal oxytocin improves verbal memory in people with schizophrenia
Feifel, D., MacDonald, K. S., Cobb, P., & Minassian, A. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.05.018 · Cited by 117 · see citing works
Self-citationMillan, M. J., & Bales, K. L. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.09.012 · Cited by 116 · see citing works
Oxytocin administration enhances controlled social cognition in patients with schizophrenia
Woolley, J. D., Chuang, B., Lam, O., Lai, W., O’Donovan, A., Rankin, K. P., Mathalon, D. H., & Vinogradov, S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.04.024 · Cited by 116 · see citing works
Popik, P., & van Ree, J. M. (1991) · European Neuropsychopharmacology · doi:10.1016/0924-977x(91)90010-r · Cited by 114 · see citing works
Mikell, C. B., McKhann, G. M., Segal, S., McGovern, R. A., Wallenstein, M. B., & Moore, H. M. (2009) · Stereotactic and Functional Neurosurgery · doi:10.1159/000225979 · Cited by 113 · see citing works
Goldman, M. B., Gomes, A. M., Carter, C. S., & Lee, R. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2193-8 · Cited by 112 · see citing works
Oxytocin in schizophrenia: a review of evidence for its therapeutic effects
MacDonald, K. S., & Feifel, D. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00634.x · Cited by 111 · see citing works
Self-citationSong, Z., McCann, K. E., McNeill, J. K., Larkin, T. E., Huhman, K. L., & Albers, H. E. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.08.005 · Cited by 111 · see citing works
Drago, F., Leo, F., & Giardina, L. (1999) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(98)00032-7 · Cited by 111 · see citing works
Developing treatments for cognitive deficits in schizophrenia: The challenge of translation
Young, J. W., & Geyer, M. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114555252 · Cited by 110 · see citing works
Oxytocin as a natural antipsychotic: a study using oxytocin knockout mice
Caldwell, H. K., Stephens, S. L., & Young, W. S. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002150 · Cited by 108 · see citing works
Intranasal Oxytocin as an Adjunct to Risperidone in Patients with Schizophrenia
Modabbernia, A., Rezaei, F., Salehi, B., Jafarinia, M., Ashrafi, M., Tabrizi, M. H., Hosseini, S. M. R., Tajdini, M., Ghaleiha, A., & Akhondzadeh, S. (2012) · CNS Drugs · doi:10.1007/s40263-012-0022-1 · Cited by 107 · see citing works
Oxytocin in learning and addiction: From early discoveries to the present
Sarnyai, Z., & Kovács, G. L. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.019 · Cited by 106 · see citing works
The role of oxytocin-dopamine interactions in cocaine-induced locomotor hyperactivity
Kovàcs, G. L., Sarnyai, Z., Babarczi, E., Szabó, G., & Telegdy, G. (1990) · Neuropharmacology · doi:10.1016/0028-3908(90)90095-9 · Cited by 101 · see citing works
Dopamine modulates synaptic plasticity in dendrites of rat and human dentate granule cells
Hamilton, T. J., Wheatley, B. M., Sinclair, D. B., Bachmann, M., Larkum, M. E., & Colmers, W. F. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011558107 · Cited by 99 · see citing works
Prosocial effects of oxytocin in two mouse models of autism spectrum disorders
Teng, B. L., Nonneman, R. J., Agster, K. L., Nikolova, V. D., Davis, T. T., Riddick, N. V., Baker, L. K., Pedersen, C. A., Jarstfer, M. B., & Moy, S. S. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.038 · Cited by 98 · see citing works
Intranasal oxytocin effects on social cognition: A critique
Evans, S. L., Dal Monte, O., Noble, P., & Averbeck, B. B. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.008 · Cited by 97 · see citing works
Rault, J.-L., Carter, C. S., Garner, J. P., Marchant, J. N., Richert, B. T., & Lay, D. C. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.007 · Cited by 94 · see citing works
Calcagnoli, F., Kreutzmann, J. C., de Boer, S. F., Althaus, M., & Koolhaas, J. M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.019 · Cited by 92 · see citing works
Gibson, C. M., Penn, D. L., Smedley, K. L., Leserman, J., Elliott, T., & Pedersen, C. A. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.04.009 · Cited by 88 · see citing works
Improving social perception in schizophrenia: The role of oxytocin
Fischer-Shofty, M., Brüne, M., Ebert, A., Shefet, D., Levkovitz, Y., & Shamay‐Tsoory, S. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.01.006 · Cited by 83 · see citing works
Action of Modafinil—Increased Motivation Via the Dopamine Transporter Inhibition and D1 Receptors?
Young, J. W., & Geyer, M. A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.015 · Cited by 82 · see citing works
DUNCAN, G., MOY, S., LIEBERMAN, J., & KOLLER, B. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.09.017 · Cited by 82 · see citing works
Neuroimaging studies of social cognition in schizophrenia
Fujiwara, H., Yassin, W., & Murai, T. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12258 · Cited by 81 · see citing works
Fuxe, K., Borroto-Escuela, D. O., Romero-Fernandez, W., Ciruela, F., Manger, P., Leo, G., Díaz-Cabiale, Z., & Agnati, L. F. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.062 · Cited by 81 · see citing works
Lee, M. R., Wehring, H. J., McMahon, R. P., Linthicum, J., Cascella, N., Liu, F., Bellack, A., Buchanan, R. W., Strauss, G. P., Contoreggi, C., et al. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.01.001 · Cited by 80 · see citing works
Oxytocin attenuates neural reactivity to masked threat cues from the eyes
Kanat, M., Heinrichs, M., Schwarzwald, R., & Domes, G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.183 · Cited by 77 · see citing works
Havránek, T., Zatkova, M., Lestanova, Z., Bačová, Z., Mravec, B., Hodosy, J., Štrbák, V., & Bakoš, J. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23559 · Cited by 71 · see citing works
Chang, S. W. C., & Platt, M. L. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.006 · Cited by 71 · see citing works
Effects of Oxytocin on Neural Response to Facial Expressions in Patients with Schizophrenia
Shin, N. Y., Park, H. Y., Jung, W. H., Park, J. W., Yun, J., Jang, J. H., Kim, S. N., Han, H. J., Kim, S.-Y., Kang, D., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.41 · Cited by 69 · see citing works
Uvnäs‐Moberg, K., Alster, P., & Svensson, T. H. (1992) · Psychopharmacology · doi:10.1007/bf02247726 · Cited by 68 · see citing works
Oxytocin modulates amygdala reactivity to masked fearful eyes
Kanat, M., Heinrichs, M., Mader, I., van Elst, L. T., & Domes, G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.111 · Cited by 65 · see citing works
Stimulant-induced psychosis: an evaluation of animal methods.
Segal, D. S., Geyer, M. A., & Schuckit, M. A. (1981) · PubMed · Cited by 63 · see citing works
CNTRICS Final Task Selection: Long-Term Memory
Ragland, J. D., Cools, R., Frank, M. J., Pizzagalli, D. A., Preston, A. R., Ranganath, C., & Wagner, A. D. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn134 · Cited by 57 · see citing works
Calcagnoli, F., Meyer, N., de Boer, S. F., Althaus, M., & Koolhaas, J. M. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.03.008 · Cited by 49 · see citing works
Hormones in the treatment of psychoses.
Bujanow, W. (1972) · BMJ · doi:10.1136/bmj.4.5835.298-c · Cited by 47 · see citing works
Drago, F., Caldwell, J. D., Pedersen, C. A., Continella, G., Scapagnini, U., & Prange, A. J. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90168-1 · Cited by 45 · see citing works
Is Oxytocin an Anti-Schizophrenic Hormone?
Bujanow, W. (1974) · Canadian Psychiatric Association Journal · doi:10.1177/070674377401900323 · Cited by 45 · see citing works
Kiss, A., Bundzikova, J., Pirník, Z., & Mikkelsen, J. D. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22226 · Cited by 43 · see citing works
The effects of a single dose of oxytocin on working memory in schizophrenia
Michalopoulou, P. G., Averbeck, B. B., Kalpakidou, A. K., Evans, S., Bobin, T., Kapur, S., & Shergill, S. S. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.029 · Cited by 41 · see citing works
Schiller, D., ZUCKERMAN, L., & Weiner, I. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.03.002 · Cited by 40 · see citing works
Oxytocin enhances the inhibitory effects of diazepam in the rat central medial amygdala
Viviani, D., Terrettaz, T., Magara, F., & Stoop, R. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.039 · Cited by 40 · see citing works
Add‐on or step‐up trials for new drug development in rheumatoid arthritis: A new standard?
Boers, M. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11141 · Cited by 38 · see citing works
Oxytocin attenuates the cocaine-induced exploratory hyperactivity in mice
Sarnyai, Z., Szabó, G., Kovács, G. L., & Telegdy, G. (1990) · NeuroReport · doi:10.1097/00001756-199011000-00006 · Cited by 37 · see citing works
The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor gating
Feifel, D., Shilling, P. D., & Belcher, A. M. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.09.004 · Cited by 37 · see citing works
Self-citationRoles of oxytocin in spatial learning and memory in the nucleus basalis of Meynert in rats
Wu, W., & Yu, L. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.02.017 · Cited by 32 · see citing works
Modeling combined schizophrenia-related behavioral and metabolic phenotypes in rodents
Sarnyai, Z., Jashar, C., & Olivier, B. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.016 · Cited by 22 · see citing works
Kovács, G. L., & Telegdy, G. (1983) · Brain Research · doi:10.1016/0006-8993(83)90497-3 · Cited by 20 · see citing works
Clozapine and PD149163 elevate prepulse inhibition in Brown Norway rats.
Feifel, D., Shilling, P. D., & Melendez, G. (2011) · Behavioral Neuroscience · doi:10.1037/a0022691 · Cited by 19 · see citing works
Self-citationFeifel, D., Shilling, P. D., Hillman, J., Maisel, M., Winfield, J., & Melendez, G. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.10.023 · Cited by 13 · see citing works
Self-citationDose-dependent and time-dependent action of oxytocin on chick memory
Davis, J. L., Pico, R. M., & Cherkin, A. (1983) · Brain Research · doi:10.1016/0006-8993(83)90669-8 · Cited by 11 · see citing works
[Psychotropic properties of oxytocin].
Vd, B., Sm, T., & Tk, L. (1984) · PubMed · Cited by 11 · see citing works
Erratum: Effects of Oxytocin on Neural Response to Facial Expressions in Patients with Schizophrenia
Shin, N. Y., Park, H. Y., Jung, W. H., Park, J. W., Yun, J., Jang, J. H., Kim, S. N., Han, H. J., Kim, S.-Y., Kang, D., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.78 · Cited by 11 · see citing works
Modeling Schizophrenia in Animals
Feifel, D., & Shilling, P. D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415894-8.00030-0 · Cited by 7 · see citing works
Self-citationLimits of add-on trials: antirheumatic drugs
Ottolenghi, L., Bertelè, V., & Garattini, S. K. (2008) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-008-0545-z · Cited by 5 · see citing works
Feifel, D. (2009) · PubMed · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
1 of the 132 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Quintana, D. S., Lischke, A., Grace, S., Scheele, D., Ma, Y., & Becker, B. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00864-7 · Cited by 263 · see citing works
Freeman, S. M., & Young, L. J. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12382 · Cited by 196 · see citing works
“Clinical trials are in progress that aim to explore the therapeutic potential of OT in ASD (67,69), and considerable work is being carried out to examine its potential use to treat schizophrenia as well (70).”
BackgroundBrain oxytocin: how puzzle stones from animal studies translate into psychiatry
Grinevich, V., & Neumann, I. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0802-9 · Cited by 189 · see citing works
Treatment of negative symptoms: Where do we stand, and where do we go?
Aleman, A., Lincoln, T. M., Bruggeman, R., Melle, I. S., Arends, J., Arango, C., & Knegtering, H. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.05.015 · Cited by 177 · see citing works
Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice
Yamamoto, Y., Liang, M., Munesue, S., Deguchi, K., Harashima, A., Furuhara, K., Yuhi, T., Zhong, J., Akther, S., Goto, H., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0325-6 · Cited by 171 · see citing works
Treating Negative Symptoms in Schizophrenia: an Update
Remington, G. J., Foussias, G., Fervaha, G., Agid, O., Takeuchi, H., Lee, J., & Hahn, M. (2016) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-016-0075-8 · Cited by 167 · see citing works
Molecular Basis of Oxytocin Receptor Signalling in the Brain: What We Know and What We Need to Know
Busnelli, M., & Chini, B. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_6 · Cited by 161 · see citing works
Attachment, Neurobiology, and Mentalizing along the Psychosis Continuum
Debbané, M., Salaminios, G., Luyten, P., Badoud, D., Armando, M., Solida-Tozzi, A., Fonagy, P., & Brent, B. K. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00406 · Cited by 163 · see citing works
Oxytocin and social functioning
Jones, C., Barrera, I., Brothers, S., Ring, R., & Wahlestedt, C. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.2/cjones · Cited by 132 · see citing works
Overview of human oxytocin research
Kendrick, K. M., Guastella, A. J., & Becker, B. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_19 · Cited by 121 · see citing works
Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward
Bradley, E., & Woolley, J. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.007 · Cited by 88 · see citing works
Emran, T. B., Islam, F., Nath, N., Sutradhar, H., Das, R. C., Mitra, S., Alshahrani, M. M., Alhasaniah, A. H., & Sharma, R. (2022) · Life · doi:10.3390/life13010099 · Cited by 86 · see citing works
Potential of Oxytocin in the Treatment of Schizophrenia
Shilling, P. D., & Feifel, D. (2016) · CNS Drugs · doi:10.1007/s40263-016-0315-x · Cited by 82 · see citing works
Self-citationOxytocin and behavior: lessons from knockout mice
Caldwell, H. K., Aulino, E. A., Freeman, A. R., Miller, T. V., & Witchey, S. K. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22431 · Cited by 79 · see citing works
Bürkner, P., Williams, D. R., Simmons, T. C., & Woolley, J. D. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx053 · Cited by 80 · see citing works
Passoni, I. P., Leonzino, M., Gigliucci, V., Chini, B., & Busnelli, M. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12363 · Cited by 76 · see citing works
Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment
Goh, K. K., Chen, C.-H., & Lane, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042146 · Cited by 78 · see citing works
Oxytocin reversed MK-801-induced social interaction and aggression deficits in zebrafish
Zimmermann, F. F., Gaspary, K. V., Siebel, A. M., & Bonan, C. D. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.059 · Cited by 75 · see citing works
Personalized medicine in psychiatry
Wium‐Andersen, I. K., Vinberg, M., Kessing, L. V., & McIntyre, R. S. (2016) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2016.1216163 · Cited by 91 · see citing works
Peled‐Avron, L., Abu-Akel, A. M., & Shamay‐Tsoory, S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.023 · Cited by 73 · see citing works
Sannino, S., Chini, B., & Grinevich, V. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22450 · Cited by 70 · see citing works
Oxytocin and Serotonin Brain Mechanisms in the Nonhuman Primate
Lefèvre, A., Richard, N., Jazayeri, M., Beuriat, P.-A., Fieux, S., Zimmer, L., Duhamel, J., & Angela Sirigu, B. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0659-17.2017 · Cited by 71 · see citing works
Horta, M., Kaylor, K., Feifel, D., & Ebner, N. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.012 · Cited by 62 · see citing works
Self-citationKohli, S., King, M. V., Williams, S. A., Edwards, A., Ballard, T. M., Steward, L. J., Alberati, D., & Fone, K. C. F. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0171-0 · Cited by 60 · see citing works
DNA Methylation and Schizophrenia: Current Literature and Future Perspective
Magwai, T., Shangase, K. B., Oginga, F. O., Chiliza, B., Mpofana, T., & Xulu, K. R. (2021) · Cells · doi:10.3390/cells10112890 · Cited by 62 · see citing works
Effects of intranasal oxytocin on symptoms of schizophrenia: A multivariate Bayesian meta-analysis
Williams, D. R., & Bürkner, P. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.10.013 · Cited by 58 · see citing works
Zhao, Z., Ma, X., Geng, Y., Zhao, W., Zhou, F., Wang, J., Markett, S. A., Biswal, B. B., Ma, Y., Kendrick, K. M., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.09.067 · Cited by 55 · see citing works
Jarskog, L. F., Pedersen, C. A., Johnson, J. L., Hamer, R. M., Rau, S. W., Elliott, T., & Penn, D. L. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.01.008 · Cited by 55 · see citing works
Zoratto, F., Sbriccoli, M., Martinelli, A., Glennon, J. C., Macrı̀, S., & Giovanni Laviola, A. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.010 · Cited by 51 · see citing works
Naringenin: its chemistry and roles in neuroprotection
Atoki, A. V., Aja, P. M., Shinkafi, T. S., Ondari, E. N., & Awuchi, C. G. (2023) · Nutritional Neuroscience · doi:10.1080/1028415x.2023.2243089 · Cited by 46 · see citing works
Kozela, E., Krawczyk, M., Kos, T., Juknat, A., Vogel, Z., & Popik, P. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01831-2 · Cited by 44 · see citing works
George, M. Y., Menze, E. T., Esmat, A., Tadros, M. G., & El‐Demerdash, E. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117535 · Cited by 43 · see citing works
Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates
Galbusera, A., Felice, A. D., Girardi, S., Bassetto, G., Maschietto, M., Nishimori, K., Chini, B., Papaleo, F., Vassanelli, S., & Gozzi, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.283 · Cited by 38 · see citing works
Potasiewicz, A., Hołuj, M., Litwa, E., Gzieło, K., Socha, L., Popik, P., & Nikiforuk, A. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108040 · Cited by 39 · see citing works
Understanding the Oxytocin System and Its Relevance to Psychiatry
Shamay‐Tsoory, S., & Young, L. J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.014 · Cited by 39 · see citing works
Bang, M., Kang, J. I., Kim, S. J., Park, J. Y., Kim, K. R., Lee, S. Y., Park, K., Lee, E. M., Lee, S., & An, S. K. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz016 · Cited by 39 · see citing works
Role of neurotransmitters in schizophrenia: a comprehensive study
Bansal, V., & Chatterjee, I. (2021) · Kuwait Journal of Science · doi:10.48129/kjs.v48i2.9264 · Cited by 37 · see citing works
Kim, S., & Strathearn, L. (2017) · The Psychoanalytic Study of the Child · doi:10.1080/00797308.2016.1277897 · Cited by 35 · see citing works
Woolley, J. D., Chuang, B., Fussell, C., Scherer, S. J., Biagianti, B., Fulford, D., Mathalon, D. H., & Vinogradov, S. (2017) · Psychological Medicine · doi:10.1017/s0033291716003433 · Cited by 34 · see citing works
Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients
Liu, Y., Tao, H., Yang, X., Huang, K., Zhang, X., & Li, C. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00217 · Cited by 32 · see citing works
Brambilla, M., Cotelli, M., Manenti, R., Dagani, J., Sisti, D., Rocchi, M., Balestrieri, M., Pini, S., Raimondi, S., Saviotti, F. M., et al. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.08.001 · Cited by 31 · see citing works
Halverson, T. F., Jarskog, L. F., Pedersen, C. A., & Penn, D. L. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.09.013 · Cited by 30 · see citing works
Wiśniewski, K. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9504-2_11 · Cited by 28 · see citing works
Role of Oxytocin in Different Neuropsychiatric, Neurodegenerative, and Neurodevelopmental Disorders
Ghazy, A. A., Soliman, O., Elbahnasi, A. I., Alawy, A. Y., Mansour, A. M., & Gowayed, M. A. (2022) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2022_72 · Cited by 27 · see citing works
Oxytocin modulates hippocampal perfusion in people at clinical high risk for psychosis
Davies, C., Paloyelis, Y., Rutigliano, G., Cappucciati, M., Micheli, A. D., Ramella‐Cravaro, V., Provenzani, U., Antoniades, M., Modinos, G., Oliver, D., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0311-6 · Cited by 28 · see citing works
Moy, S. S., Teng, B. L., Nikolova, V. D., Riddick, N. V., Simpson, C. D., Deusen, A. L. V., Janzen, W. P., Sassano, M. F., Pedersen, C. A., & Jarstfer, M. B. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.10.036 · Cited by 26 · see citing works
Fulford, D., Treadway, M. T., & Woolley, J. D. (2018) · Journal of Abnormal Psychology · doi:10.1037/abn0000320 · Cited by 25 · see citing works
Carter, C. S. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_18 · Cited by 25 · see citing works
Montag, C., Schöner, J., Speck, L. G., Just, S. A., Stuke, F., Rentzsch, J., Gallinat, J., & Majić, T. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231257 · Cited by 21 · see citing works
Hernández‐Díaz, Y., González‐Castro, T. B., Tovilla‐Zárate, C. A., López‐Narváez, M. L., Mendoza, A. D. G., Castillo-Ávila, R. G., Ramos-Méndez, M. Á., & Juárez‐Rojop, I. E. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00836-y · Cited by 21 · see citing works
Hidalgo‐Figueroa, M., Salazar, A., Romero-López-Alberca, C., MacDowell, K. S., García‐Bueno, B., Bioque, M., Bernardo, M., Parellada, M., González-Pinto, A. M., García‐Portilla, M. P., et al. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac023 · Cited by 20 · see citing works
Esquizofrenia: O Que o Médico Não Psiquiatra Precisa de Saber
Queirós, T. P., Coelho, F., Linhares, L., & Telles‐Correia, D. (2019) · Acta Médica Portuguesa · doi:10.20344/amp.10768 · Cited by 20 · see citing works
Bernstein, H., Müller, S., Dobrowolny, H., Wolke, C., Lendeckel, U., Bukowska, A., Keilhoff, G., Becker, A., Trübner, K., Steiner, J. H., et al. (2016) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-016-0757-7 · Cited by 19 · see citing works
Festante, F., Ferrari, P. F., Thorpe, S., Buchanan, R. W., & Fox, N. A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104467 · Cited by 18 · see citing works
Oxytocin in dorsal hippocampus facilitates auditory fear memory extinction in rats
Bazaz, A., Ghanbari, A., Vafaei, A. A., Khaleghian, A., & Rashidy‐Pour, A. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108844 · Cited by 18 · see citing works
Busnelli, M., Dagani, J., de Girolamo, G., Balestrieri, M., Pini, S., Saviotti, F. M., Scocco, P., Sisti, D., Rocchi, M., & Chini, B. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12359 · Cited by 18 · see citing works
Wang, F., Yin, X.-S., Lu, J., Cen, C., & Wang, Y. (2022) · Science Signaling · doi:10.1126/scisignal.abd0033 · Cited by 15 · see citing works
Goh, K. K., & Lu, M. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.09.013 · Cited by 16 · see citing works
Linking childhood trauma to the psychopathology of schizophrenia: the role of oxytocin
Chen, Y.-J., Lu, M., Chiu, Y.-H., Chen, C., Santos, V. H. J., & Goh, K. K. (2024) · Schizophrenia · doi:10.1038/s41537-024-00433-9 · Cited by 16 · see citing works
Peptide synthesis: a review of classical and emerging methods
Cai, Z. Y., Liu, L., Zou, C. H., Jiang, X. P., Wang, G., He, X. J., Zhuang, W., Yang, C., Yao, Y., Sun, X., et al. (2025) · Biofabrication · doi:10.1088/1758-5090/ae1bdc · Cited by 15 · see citing works
Endogenous oxytocin response to film scenes of attachment and loss is pronounced in schizophrenia
Speck, L. G., Schöner, J., Bermpohl, F., Heinz, A., Gallinat, J., Majić, T., & Montag, C. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy110 · Cited by 15 · see citing works
Oxytocin Receptor (OXTR) Methylation and Cognition in Psychotic Disorders
Grove, T. B., Burghardt, K. J., Kraal, A. Z., Dougherty, R. J., Taylor, S. F., & Ellingrod, V. L. (2016) · Complex Psychiatry · doi:10.1159/000448173 · Cited by 15 · see citing works
Intranasal oxytocin modulates higher order social cognition in body dysmorphic disorder
Fang, A., Lawson, E. A., & Wilhelm, S. (2019) · Depression and Anxiety · doi:10.1002/da.22876 · Cited by 14 · see citing works
Wigton, R. L., Tracy, D. K., Verneuil, T., Johns, M., White, T. P., Michalopoulou, P. G., Averbeck, B. B., & Shergill, S. S. (2021) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2021.100221 · Cited by 14 · see citing works
Taylor, J. H., Schulte, N. A., French, J. A., & Toews, M. L. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.250852 · Cited by 14 · see citing works
Haram, M., Bettella, F., Brandt, C. L., Quintana, D. S., Nerhus, M., Bjella, T., Djurovic, S., Westlye, L. T., Andreassen, O. A., Melle, I., et al. (2016) · BJPsych Open · doi:10.1192/bjpo.bp.116.003376 · Cited by 13 · see citing works
The implications of hypothalamic abnormalities for schizophrenia
Bernstein, H., Keilhoff, G., & Steiner, J. H. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819973-2.00008-3 · Cited by 13 · see citing works
Feroz, F. S., Leicht, G., Rauh, J., & Mulert, C. (2018) · Brain Topography · doi:10.1007/s10548-018-0677-0 · Cited by 13 · see citing works
Schmidt, A., Davies, C., Paloyelis, Y., Meyer, N., Micheli, A. D., Ramella‐Cravaro, V., Provenzani, U., Aoki, Y. Y., Rutigliano, G., Cappucciati, M., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00885-4 · Cited by 13 · see citing works
Talpos, J. C. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.04.014 · Cited by 11 · see citing works
Zhu, W., Ding, Z., Zhang, Z., Wu, X. A., Liu, X., Zhang, Y., Li, S., Zhou, L., Tian, G., & Qin, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.723064 · Cited by 10 · see citing works
Approaches to Improve the Quantitation of Oxytocin in Human Serum by Mass Spectrometry
Hering, A., Jieu, B., Jones, A., & Muttenthaler, M. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.889154 · Cited by 9 · see citing works
Preliminary evidence that oxytocin does not improve mentalizing in women with schizophrenia
Bradley, E., Tai, M. L., Hankin, M., & Woolley, J. D. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104915 · Cited by 9 · see citing works
Chu, M., Hu, H., Ni, H., Lu, W., Lui, S. S. Y., Yi, Z.-H., Cheung, E. F. C., & Chan, R. C. K. (2019) · PsyCh Journal · doi:10.1002/pchj.300 · Cited by 9 · see citing works
Antipsychotic lurasidone: Behavioural and pharmacokinetic data in C57BL/6 mice
Percelay, S., Since, M., Lagadu, S., Fréret, T., Bouët, V., & Boulouard, M. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172933 · Cited by 8 · see citing works
Rodent models of genetic and chromosomal variations in psychiatric disorders
Nomura, J., Kannan, G., & Takumi, T. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12524 · Cited by 8 · see citing works
Ricchiuti, G., Tuerlinckx, E., Taillieu, A., Prinsen, J., Steyaert, J. G., Boets, B., & Alaerts, K. (2025) · Journal of Psychopharmacology · doi:10.1177/02698811241309621 · Cited by 7 · see citing works
Perini, F., Nazimek, J. M., McKie, S., Capitão, L. P., Scaife, J. C., Pal, D., Browning, M. D., Dawson, G. R., Nishikawa, H., Campbell, U. C., et al. (2023) · Schizophrenia · doi:10.1038/s41537-023-00385-6 · Cited by 8 · see citing works
Zhang, H., Chen, K., Bao, J., & Wu, H. (2023) · Human Brain Mapping · doi:10.1002/hbm.26498 · Cited by 7 · see citing works
The Effects of Augmenting Clozapine with Oxytocin in Schizophrenia: An Initial Case Series
Marotta, R. F., Buono, F. D., Garakani, A., Collins, E. D., Cerrito, B., & Rowe, D. (2020) · Annals of Clinical Psychiatry · doi:10.1177/104012372003200211 · Cited by 7 · see citing works
From Parental Behavior to Sexual Function: Recent Advances in Oxytocin Research
Dale, J. K., Harberson, M. T., & Hill, J. W. (2024) · Current Sexual Health Reports · doi:10.1007/s11930-024-00386-1 · Cited by 7 · see citing works
Piotrowska, D., Potasiewicz, A., Popik, P., & Nikiforuk, A. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.09.005 · Cited by 7 · see citing works
Lipid-based nanostructures in targeted management of neurological disorders: A comprehensive review
Guleria, M., Kamble, A., Upadhyay, M., Sethi, P., Patel, M. B., Malhan, A., Rastogi, S., Datta, D., Singh, S. A., & Prajapati, B. G. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126530 · Cited by 6 · see citing works
Becker, B., & Montag, C. (2017) · Studies in neuroscience, psychology and behavioral economics · doi:10.1007/978-3-319-46276-9_18 · Cited by 5 · see citing works
Municchi, D., Mancini, C., Nutarelli, S., Tiberi, M., D’Addario, S. L., Chila, G., Passeri, A., Massa, G., Segni, M. D., Babicola, L., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03437-8 · Cited by 4 · see citing works
Yu, X., Zhang, W., & Gao, Y. (2024) · Actas Españolas de Psiquiatría · doi:10.62641/aep.v52i3.1627 · Cited by 4 · see citing works
Add-on Oxytocin in the Treatment of Postpartum Acute Schizophrenia: A Case Report
Medved, S., Janović, M. B., Štimac, Z., & Mihaljević-Peleš, A. (2021) · Journal of Psychiatric Practice · doi:10.1097/pra.0000000000000557 · Cited by 4 · see citing works
Doshi, G., Bhatia, N. Y., Ved, H. S., Pandya, A., Kulkarni, D., Naik, J., Bandiwadekar, T., Godad, A. P., & Kale, P. P. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220817161035 · Cited by 3 · see citing works
Sampedro-Viana, D., Cañete, T., Ancil-Gascón, P., Cisci, S., Tobeña, A., & Fernández‐Teruel, A. (2024) · Brain Sciences · doi:10.3390/brainsci14090920 · Cited by 3 · see citing works
Epigenetic Control in Schizophrenia
D’Addario, C., & Bartolomeo, M. D. (2025) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-75980-2_5 · Cited by 3 · see citing works
Serum Oxytocin Concentration in Patients Receiving Electroconvulsive Therapy
Barhale, C., Raju, M. S. V. K., Pawar, A. V., Kadam, K., Sousa, A. D., & Andrade, C. (2017) · Journal of Ect · doi:10.1097/yct.0000000000000388 · Cited by 3 · see citing works
Sorenson, K., Kendall, E., Grell, H., Kang, M., Shaffer, C. L., & Hwang, S. (2023) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20230008 · Cited by 3 · see citing works
Higashida, H., Gerasimenko, M., & Yamamoto, Y. (2022) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2022.100146 · Cited by 3 · see citing works
Oxytocin and postpartum depression - a possible treatment for depressed mothers
Leziak, M., Niedobylski, S., Żak, K., Piwoński, M., Krasowska, D., & Skórzyńska-Dziduszko, K. (2020) · Journal of Education Health and Sport · doi:10.12775/jehs.2020.10.07.016 · Cited by 2 · see citing works
A new two-hit animal model for schizophrenia research: Consequences on social behavior
Hakenova, K., Mikulecká, A., Holubová, K., Chvojková, M., Šlamberová, R., Jur̀čovičová, J., Čechová, B., Poništ, S., Horáček, J., & Valeš, K. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.05.012 · Cited by 2 · see citing works
Yan, Z., & Kirsch, P. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108770880.018 · Cited by 2 · see citing works
External stress, formaldehyde, and schizophrenia: a new mouse model for mental illness research
Cheng, J., Sun, Z., Zhang, H., Zhao, D., Wang, P., Chen, H., Lyv, W., Deng, Q., Fu, Y., Lyv, X., et al. (2025) · Schizophrenia · doi:10.1038/s41537-025-00603-3 · Cited by 1 · see citing works
Zhang, Y., Hao, M., & Hu, Y. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02431-7 · Cited by 1 · see citing works
The role of oxytocin in the pathogenesis and treatment of schizophrenia
Jusiak, K., Brudkowska, Ż., Gołębiowska, M., Morylowska-Topolska, J., Gołębiowska, B., Próchnicki, M., Próchnicka, A., & Karakuła‐Juchnowicz, H. (2017) · Current Problems of Psychiatry · doi:10.1515/cpp-2017-0023 · Cited by 1 · see citing works
Gul, O., Gul, S., & Aziz, A. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s183645 · Cited by 1 · see citing works
- Authors
- Feifel, D., Shilling, P. D., & MacDonald, K.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Feifel, David
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 79
- Issue
- 3
- Pages
- 222-233
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC5673255
- OpenAlex
- W1441608289
- Cited by
- 110
- References
- 132
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 12 · 2020: 11 · 2019: 11 · 2018: 10 · 2017: 17 · 2016: 18 · 2015: 2
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Goodenough Neuroscience Research Fund
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, schizophrenia, positive symptoms, negative symptoms, cognitive impairment, oxytocinergic system, antipsychotic drugs, new drugs, schizophrenia spectrum disorders
- MeSH terms
- Animals, Brain, Cognition, Cognition Disorders, Disease Models, Animal, Humans, Oxytocin, Schizophrenia, Schizophrenic Psychology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review