Cited by 110Schizophrenia research and treatmentNeuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on Behavior

A Review of Oxytocin’s Effects on the Positive, Negative, and Cognitive Domains of Schizophrenia

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Feifel, David, Shilling, Paul D., MacDonald, Kai·2016·Biological Psychiatry

Abstract

Schizophrenia is a disabling, heterogeneous disorder with clinical features that can be parsed into three domains: positive symptoms, negative symptoms, and cognitive deficits. Current antipsychotic drugs produce fairly robust clinical benefit against positive symptoms but typically have minimal therapeutic effects on negative symptoms and cognitive deficits. Oxytocin (OT) is a nonapeptide that, in addition to its role as a hormone regulating peripheral reproductive-relevant functions, acts as a neurotransmitter in the brain. Several lines of preclinical and clinical research suggest that the OT system may play a role in regulating the expression of schizophrenia spectrum disorders and that targeting the central OT system may yield novel treatments to address these symptoms. In this review, we summarize the extant preclinical and clinical evidence relevant to the role of OT in schizophrenia with particular emphasis on its putative therapeutic effects on each of the three above-mentioned clinical domains.

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Authors
Feifel, D., Shilling, P. D., & MacDonald, K.
Affiliations
University of California San Diego (US)
Corresponding author
Feifel, David
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2016-02
Volume
79
Issue
3
Pages
222-233
ISSN
0006-3223 (ISSN-L)
OpenAlex
W1441608289
Cited by
110
References
132
Citations by year
2026: 2 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 12 · 2020: 11 · 2019: 11 · 2018: 10 · 2017: 17 · 2016: 18 · 2015: 2
FWCI
2.15
Type
journal article
Language
en
Open access
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
Goodenough Neuroscience Research Fund
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
oxytocin, schizophrenia, positive symptoms, negative symptoms, cognitive impairment, oxytocinergic system, antipsychotic drugs, new drugs, schizophrenia spectrum disorders
MeSH terms
Animals, Brain, Cognition, Cognition Disorders, Disease Models, Animal, Humans, Oxytocin, Schizophrenia, Schizophrenic Psychology

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